|Institutional Source||Beutler Lab|
|Gene Name||hyaluronan mediated motility receptor (RHAMM)|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R6414 (G1)|
|Chromosomal Location||40701395-40733422 bp(-) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||A to G at 40715867 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000020579 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000020579]|
|Predicted Effect||probably null
|Coding Region Coverage||
|Validation Efficiency||98% (57/58)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]
PHENOTYPE: Mice homozygous for mutations of this gene exhibit impaired fertility and are less susceptible to the formation of aggressive fibromatosis. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Hmmr||
(F):5'- CACTTGATCAGATGCACAGCTG -3'
(R):5'- TTGACCTCTAGTGTTACCTTACATG -3'
(F):5'- TGCACCACATGTATGCAGTG -3'
(R):5'- CTTTTTCAGTGTTTCAATAGAGA -3'