Incidental Mutation 'IGL01090:Vmn2r53'
ID 51497
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r53
Ensembl Gene ENSMUSG00000096002
Gene Name vomeronasal 2, receptor 53
Synonyms EG637908
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # IGL01090
Quality Score
Status
Chromosome 7
Chromosomal Location 12315397-12342583 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 12334835 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 275 (E275G)
Ref Sequence ENSEMBL: ENSMUSP00000126979 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170412]
AlphaFold A0A3B2W4A7
Predicted Effect noncoding transcript
Transcript: ENSMUST00000118665
Predicted Effect possibly damaging
Transcript: ENSMUST00000170412
AA Change: E275G

PolyPhen 2 Score 0.702 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000126979
Gene: ENSMUSG00000096002
AA Change: E275G

DomainStartEndE-ValueType
Pfam:ANF_receptor 5 397 3.6e-58 PFAM
Pfam:NCD3G 442 495 2.2e-19 PFAM
Pfam:7tm_3 526 763 3.1e-53 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930590J08Rik T C 6: 91,896,099 (GRCm39) S316P possibly damaging Het
Actn1 A T 12: 80,245,846 (GRCm39) probably null Het
Agbl3 T C 6: 34,776,822 (GRCm39) Y443H probably benign Het
Akap13 T A 7: 75,316,279 (GRCm39) D578E probably benign Het
Aldoa A T 7: 126,395,207 (GRCm39) H292Q probably benign Het
Als2 T C 1: 59,254,775 (GRCm39) K194R possibly damaging Het
Bivm C A 1: 44,168,451 (GRCm39) H244N probably damaging Het
Cabp5 G A 7: 13,139,412 (GRCm39) E146K probably damaging Het
Cfap206 C T 4: 34,721,562 (GRCm39) S162N probably damaging Het
Cfap251 A C 5: 123,418,052 (GRCm39) probably benign Het
Clcn4 A G 7: 7,297,035 (GRCm39) V129A probably benign Het
Clec4g A G 8: 3,769,482 (GRCm39) S54P probably damaging Het
Crim1 G T 17: 78,654,658 (GRCm39) V645L probably damaging Het
Csta1 T C 16: 35,945,421 (GRCm39) T31A probably damaging Het
D930048N14Rik T C 11: 51,544,610 (GRCm39) probably benign Het
Dhx34 G T 7: 15,950,181 (GRCm39) P329Q probably damaging Het
Dusp16 T C 6: 134,702,912 (GRCm39) N193S probably benign Het
Fbn1 A G 2: 125,236,696 (GRCm39) probably benign Het
Fbxo46 A G 7: 18,870,728 (GRCm39) Y449C probably damaging Het
Fmo4 C A 1: 162,637,354 (GRCm39) probably null Het
Foxi3 C A 6: 70,937,729 (GRCm39) N320K probably damaging Het
Gm9964 A G 11: 79,187,210 (GRCm39) L79P unknown Het
Gpr161 T C 1: 165,134,149 (GRCm39) I137T probably damaging Het
Herc1 C T 9: 66,376,457 (GRCm39) Q3426* probably null Het
Hps5 C T 7: 46,437,751 (GRCm39) R108H probably benign Het
Itch T A 2: 155,048,256 (GRCm39) V540E probably damaging Het
L3mbtl1 C A 2: 162,807,925 (GRCm39) P520H probably damaging Het
Mvp A G 7: 126,588,859 (GRCm39) V636A probably benign Het
Odf4 A G 11: 68,812,778 (GRCm39) probably benign Het
Or7g18 A G 9: 18,787,538 (GRCm39) K305R probably benign Het
Pld1 T C 3: 28,142,816 (GRCm39) S675P probably benign Het
Plod3 A G 5: 137,019,090 (GRCm39) D325G probably benign Het
Prss12 T C 3: 123,276,388 (GRCm39) V339A possibly damaging Het
Ptpn13 T A 5: 103,689,180 (GRCm39) L991Q probably null Het
Ptpn3 T A 4: 57,240,833 (GRCm39) I261F probably damaging Het
Rab3gap1 T C 1: 127,858,124 (GRCm39) probably benign Het
Rasa4 A G 5: 136,130,847 (GRCm39) R373G possibly damaging Het
Rmi1 T C 13: 58,557,208 (GRCm39) S486P probably damaging Het
Slc25a23 A G 17: 57,354,233 (GRCm39) I139T probably benign Het
Sspo T A 6: 48,467,059 (GRCm39) S4017T probably benign Het
Tcaf1 C A 6: 42,663,556 (GRCm39) C108F probably benign Het
Tnc T C 4: 63,918,317 (GRCm39) Q1198R probably damaging Het
Tnni3k G T 3: 154,645,320 (GRCm39) Q522K possibly damaging Het
Trio T A 15: 27,773,093 (GRCm39) E713V probably damaging Het
Ugt2b34 C A 5: 87,041,679 (GRCm39) V338F probably damaging Het
Usp40 T A 1: 87,890,187 (GRCm39) M892L probably benign Het
Usp54 A T 14: 20,636,225 (GRCm39) probably benign Het
Vmn2r87 A G 10: 130,333,247 (GRCm39) M1T probably null Het
Wdr83os A T 8: 85,808,476 (GRCm39) D76V probably damaging Het
Other mutations in Vmn2r53
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01997:Vmn2r53 APN 7 12,316,373 (GRCm39) missense possibly damaging 0.54
IGL02442:Vmn2r53 APN 7 12,315,656 (GRCm39) missense probably damaging 1.00
IGL02449:Vmn2r53 APN 7 12,316,288 (GRCm39) missense probably damaging 1.00
IGL02589:Vmn2r53 APN 7 12,315,872 (GRCm39) missense possibly damaging 0.93
IGL02986:Vmn2r53 APN 7 12,315,393 (GRCm39) unclassified probably benign
IGL03064:Vmn2r53 APN 7 12,334,937 (GRCm39) missense possibly damaging 0.89
IGL03093:Vmn2r53 APN 7 12,334,791 (GRCm39) missense probably benign 0.03
IGL03244:Vmn2r53 APN 7 12,340,435 (GRCm39) missense probably damaging 1.00
IGL03252:Vmn2r53 APN 7 12,340,318 (GRCm39) missense probably damaging 1.00
IGL03264:Vmn2r53 APN 7 12,315,819 (GRCm39) missense possibly damaging 0.95
IGL03293:Vmn2r53 APN 7 12,332,349 (GRCm39) missense probably benign 0.34
R0109:Vmn2r53 UTSW 7 12,315,993 (GRCm39) missense probably damaging 1.00
R0453:Vmn2r53 UTSW 7 12,316,338 (GRCm39) missense probably damaging 1.00
R0735:Vmn2r53 UTSW 7 12,315,707 (GRCm39) missense probably benign
R0881:Vmn2r53 UTSW 7 12,334,859 (GRCm39) missense probably benign 0.01
R0894:Vmn2r53 UTSW 7 12,335,141 (GRCm39) missense probably benign 0.00
R0973:Vmn2r53 UTSW 7 12,335,319 (GRCm39) missense probably damaging 1.00
R0973:Vmn2r53 UTSW 7 12,335,319 (GRCm39) missense probably damaging 1.00
R0974:Vmn2r53 UTSW 7 12,335,319 (GRCm39) missense probably damaging 1.00
R0990:Vmn2r53 UTSW 7 12,315,429 (GRCm39) missense probably benign
R1102:Vmn2r53 UTSW 7 12,332,410 (GRCm39) missense possibly damaging 0.94
R1141:Vmn2r53 UTSW 7 12,334,673 (GRCm39) missense possibly damaging 0.54
R1263:Vmn2r53 UTSW 7 12,315,533 (GRCm39) missense probably benign 0.41
R1343:Vmn2r53 UTSW 7 12,318,701 (GRCm39) missense probably benign 0.08
R1750:Vmn2r53 UTSW 7 12,315,632 (GRCm39) missense probably damaging 1.00
R1836:Vmn2r53 UTSW 7 12,334,812 (GRCm39) missense probably damaging 1.00
R2035:Vmn2r53 UTSW 7 12,332,438 (GRCm39) missense possibly damaging 0.76
R2202:Vmn2r53 UTSW 7 12,335,366 (GRCm39) missense probably damaging 1.00
R3707:Vmn2r53 UTSW 7 12,315,981 (GRCm39) missense possibly damaging 0.95
R4372:Vmn2r53 UTSW 7 12,315,656 (GRCm39) missense probably damaging 0.98
R4615:Vmn2r53 UTSW 7 12,316,229 (GRCm39) missense probably damaging 1.00
R4655:Vmn2r53 UTSW 7 12,315,932 (GRCm39) missense possibly damaging 0.83
R4663:Vmn2r53 UTSW 7 12,334,901 (GRCm39) missense probably benign 0.21
R4708:Vmn2r53 UTSW 7 12,335,129 (GRCm39) missense probably benign
R4710:Vmn2r53 UTSW 7 12,335,129 (GRCm39) missense probably benign
R4774:Vmn2r53 UTSW 7 12,334,692 (GRCm39) nonsense probably null
R4859:Vmn2r53 UTSW 7 12,335,330 (GRCm39) missense probably damaging 1.00
R5061:Vmn2r53 UTSW 7 12,315,741 (GRCm39) missense probably benign 0.01
R5561:Vmn2r53 UTSW 7 12,335,347 (GRCm39) missense probably damaging 1.00
R5729:Vmn2r53 UTSW 7 12,334,733 (GRCm39) missense probably damaging 1.00
R6004:Vmn2r53 UTSW 7 12,316,328 (GRCm39) missense probably benign 0.12
R6083:Vmn2r53 UTSW 7 12,315,808 (GRCm39) missense probably benign
R6312:Vmn2r53 UTSW 7 12,332,566 (GRCm39) critical splice acceptor site probably null
R6700:Vmn2r53 UTSW 7 12,315,633 (GRCm39) missense probably damaging 0.96
R6783:Vmn2r53 UTSW 7 12,335,360 (GRCm39) missense probably damaging 1.00
R6852:Vmn2r53 UTSW 7 12,340,441 (GRCm39) missense probably damaging 0.99
R6889:Vmn2r53 UTSW 7 12,335,069 (GRCm39) missense probably benign 0.10
R6940:Vmn2r53 UTSW 7 12,316,343 (GRCm39) missense probably benign 0.19
R7100:Vmn2r53 UTSW 7 12,315,513 (GRCm39) nonsense probably null
R7174:Vmn2r53 UTSW 7 12,315,628 (GRCm39) missense probably benign 0.01
R7213:Vmn2r53 UTSW 7 12,334,983 (GRCm39) missense probably benign 0.17
R7276:Vmn2r53 UTSW 7 12,340,359 (GRCm39) missense probably damaging 0.99
R7515:Vmn2r53 UTSW 7 12,315,846 (GRCm39) missense probably benign 0.05
R7678:Vmn2r53 UTSW 7 12,332,425 (GRCm39) missense probably benign 0.04
R7714:Vmn2r53 UTSW 7 12,340,418 (GRCm39) missense probably damaging 1.00
R7843:Vmn2r53 UTSW 7 12,316,026 (GRCm39) missense probably damaging 1.00
R8208:Vmn2r53 UTSW 7 12,335,322 (GRCm39) missense probably damaging 1.00
R8211:Vmn2r53 UTSW 7 12,315,843 (GRCm39) missense probably benign 0.01
R8478:Vmn2r53 UTSW 7 12,340,281 (GRCm39) missense probably benign 0.01
R8853:Vmn2r53 UTSW 7 12,315,737 (GRCm39) missense probably damaging 1.00
R8924:Vmn2r53 UTSW 7 12,334,752 (GRCm39) missense probably benign 0.17
R8963:Vmn2r53 UTSW 7 12,315,926 (GRCm39) missense probably damaging 1.00
R9042:Vmn2r53 UTSW 7 12,315,435 (GRCm39) missense probably benign
R9076:Vmn2r53 UTSW 7 12,340,231 (GRCm39) missense probably damaging 1.00
R9407:Vmn2r53 UTSW 7 12,335,124 (GRCm39) missense probably damaging 0.99
R9690:Vmn2r53 UTSW 7 12,315,912 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r53 UTSW 7 12,335,231 (GRCm39) missense probably damaging 1.00
Posted On 2013-06-21