Mutagenetix > Incidental Mutation

Incidental Mutation 'R6376:Itpr3'

515015

Institutional Source

Beutler Lab

Gene Symbol

Itpr3

Ensembl Gene

ENSMUSG00000042644

Gene Name

inositol 1,4,5-triphosphate receptor 3

Synonyms

tf, Ip3r3, Itpr-3

MMRRC Submission

044526-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R6376 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

27057304-27122223 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 27095475 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 633 (Y633C)

Ref Sequence

ENSEMBL: ENSMUSP00000038150 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049308]

AlphaFold

P70227

PDB Structure

Crystal structure of the ligand binding suppressor domain of type 3 inositol 1,4,5-trisphosphate receptor [X-RAY DIFFRACTION]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000049308
AA Change: Y633C

PolyPhen 2 Score 0.944 (Sensitivity: 0.80; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000038150
Gene: ENSMUSG00000042644
AA Change: Y633C

Domain	Start	End	E-Value	Type
MIR	113	167	7.75e-6	SMART
MIR	174	224	1.16e-4	SMART
MIR	232	288	1.21e-7	SMART
MIR	295	402	9.38e-14	SMART
Pfam:RYDR_ITPR	473	670	7.8e-64	PFAM
low complexity region	881	889	N/A	INTRINSIC
Pfam:RYDR_ITPR	1175	1333	5.8e-16	PFAM
low complexity region	1549	1567	N/A	INTRINSIC
low complexity region	1831	1851	N/A	INTRINSIC
Pfam:RIH_assoc	1863	1973	2.6e-34	PFAM
transmembrane domain	2203	2225	N/A	INTRINSIC
Pfam:Ion_trans	2235	2527	8.1e-20	PFAM
coiled coil region	2631	2660	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000143605

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000184226

Meta Mutation Damage Score

0.9471

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.4%
20x: 97.8%

Validation Efficiency

100% (81/81)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile and exhibit no apparent abnormalities in pancreatic and salivary secretion. However, one mutation in this gene results in alternating abnormal hair loss and normal hair growth throughout the life of the mouse and low sweet preference. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 83 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930550C14Rik	A	T	9: 53,428,156 (GRCm38)	E106D	probably damaging	Het
A830018L16Rik	A	T	1: 11,798,494 (GRCm38)	N333Y	probably damaging	Het
Abca4	T	A	3: 122,123,660 (GRCm38)	M1007K	possibly damaging	Het
Accsl	T	A	2: 93,856,998 (GRCm38)	I495F	probably damaging	Het
Acsl3	T	C	1: 78,696,465 (GRCm38)	S373P	possibly damaging	Het
Adam7	A	G	14: 68,505,097 (GRCm38)	I689T	possibly damaging	Het
Akap11	G	A	14: 78,514,896 (GRCm38)	T179I	probably damaging	Het
Ankmy1	T	C	1: 92,888,465 (GRCm38)	K309R	possibly damaging	Het
Apaf1	A	T	10: 91,023,811 (GRCm38)	I824N	probably damaging	Het
Apc2	T	A	10: 80,312,654 (GRCm38)	C1152S	probably damaging	Het
Arhgap17	C	A	7: 123,300,504 (GRCm38)	W409L	probably damaging	Het
Arhgef15	T	C	11: 68,954,970 (GRCm38)	I19V	unknown	Het
Arnt	C	A	3: 95,490,625 (GRCm38)	P573H	probably damaging	Het
Arvcf	G	A	16: 18,405,132 (GRCm38)	G932R	probably damaging	Het
Atg4a-ps	C	T	3: 103,645,728 (GRCm38)	W99*	probably null	Het
Atp13a5	T	A	16: 29,237,252 (GRCm38)	D1052V	probably benign	Het
Atp2b4	T	C	1: 133,715,059 (GRCm38)	T1103A	probably damaging	Het
B4galnt4	C	A	7: 141,067,422 (GRCm38)	Q362K	possibly damaging	Het
Cd320	T	A	17: 33,847,517 (GRCm38)	N90K	probably benign	Het
Cep170b	A	T	12: 112,732,068 (GRCm38)	I87F	probably damaging	Het
Coq3	T	G	4: 21,900,486 (GRCm38)	C238G	probably benign	Het
Cpa5	A	T	6: 30,614,045 (GRCm38)	Q62L	probably benign	Het
Ctsg	A	T	14: 56,101,653 (GRCm38)	C49*	probably null	Het
Cul9	T	C	17: 46,508,563 (GRCm38)	T2000A	probably damaging	Het
Dedd	C	T	1: 171,340,222 (GRCm38)	P155S	probably benign	Het
Dnah1	A	G	14: 31,275,608 (GRCm38)	S2598P	probably damaging	Het
Dnah14	C	T	1: 181,605,894 (GRCm38)	P379S	possibly damaging	Het
Dync2h1	A	T	9: 7,165,703 (GRCm38)	S519R	probably benign	Het
Eea1	A	G	10: 96,038,798 (GRCm38)	S1192G	probably benign	Het
Eif5b	T	C	1: 38,045,679 (GRCm38)	I869T	probably damaging	Het
Elavl4	C	A	4: 110,255,454 (GRCm38)		probably benign	Het
Eml2	G	A	7: 19,201,163 (GRCm38)	V432I	probably damaging	Het
Ets2	G	A	16: 95,718,993 (GRCm38)	R421H	probably damaging	Het
Exoc3l2	G	A	7: 19,469,710 (GRCm38)	A76T	possibly damaging	Het
Fam89b	T	C	19: 5,728,729 (GRCm38)	Y144C	probably damaging	Het
Greb1	T	C	12: 16,699,579 (GRCm38)	E1082G	probably damaging	Het
Gtf3a	A	T	5: 146,953,988 (GRCm38)		probably null	Het
Hoxc12	C	A	15: 102,937,089 (GRCm38)	F79L	possibly damaging	Het
Hspb8	G	T	5: 116,409,432 (GRCm38)	L164I	probably damaging	Het
Ina	C	T	19: 47,015,125 (GRCm38)	A124V	probably benign	Het
Inhbb	T	A	1: 119,417,681 (GRCm38)	I293F	probably damaging	Het
Jag2	C	T	12: 112,909,329 (GRCm38)	V1102I	probably benign	Het
Kalrn	A	T	16: 33,975,991 (GRCm38)	F1138Y	probably benign	Het
Large2	T	A	2: 92,370,508 (GRCm38)		probably benign	Het
Lats2	A	G	14: 57,722,509 (GRCm38)	S177P	probably benign	Het
Lims2	G	A	18: 31,954,462 (GRCm38)	R124H	possibly damaging	Het
Lrp2	T	A	2: 69,483,443 (GRCm38)	T2315S	probably benign	Het
Lrrc4c	A	C	2: 97,629,046 (GRCm38)	T6P	probably benign	Het
Lrrk2	T	C	15: 91,742,266 (GRCm38)	L1171S	possibly damaging	Het
Man2b2	A	T	5: 36,821,034 (GRCm38)	M302K	probably damaging	Het
Mocos	G	A	18: 24,701,485 (GRCm38)	G860R	possibly damaging	Het
Mylk3	T	A	8: 85,358,942 (GRCm38)	D258V	possibly damaging	Het
Nkx1-2	C	T	7: 132,599,511 (GRCm38)	D6N	probably damaging	Het
Nrp2	A	G	1: 62,719,017 (GRCm38)	N54S	possibly damaging	Het
Nt5el	T	C	13: 105,119,965 (GRCm38)	I514T	possibly damaging	Het
Or2d2	A	G	7: 107,128,641 (GRCm38)	F251L	probably benign	Het
Pacsin1	A	T	17: 27,707,905 (GRCm38)	T195S	probably benign	Het
Pank4	T	C	4: 154,972,236 (GRCm38)		probably null	Het
Pdgfra	A	T	5: 75,166,519 (GRCm38)	M126L	probably benign	Het
Podxl	T	A	6: 31,528,497 (GRCm38)	T204S	probably benign	Het
Pole	G	A	5: 110,336,374 (GRCm38)	D2175N	probably damaging	Het
Pramel16	C	T	4: 143,950,697 (GRCm38)	G104E	probably benign	Het
Prkdc	A	G	16: 15,769,885 (GRCm38)	K2545E	probably benign	Het
Prodh	T	C	16: 18,079,985 (GRCm38)	I183V	probably benign	Het
Ptch1	T	C	13: 63,543,608 (GRCm38)	D277G	possibly damaging	Het
Rapgef5	G	A	12: 117,721,253 (GRCm38)	V246M	probably damaging	Het
Rubcnl	A	G	14: 75,032,394 (GRCm38)	N164S	probably benign	Het
Samd4	A	T	14: 47,052,962 (GRCm38)	L175F	probably damaging	Het
Scart1	G	A	7: 140,228,729 (GRCm38)	G851D	probably damaging	Het
Scimp	C	A	11: 70,798,067 (GRCm38)	W41L	possibly damaging	Het
Scn3a	T	A	2: 65,461,499 (GRCm38)	K1634N	possibly damaging	Het
Spta1	A	G	1: 174,203,322 (GRCm38)	R957G	probably benign	Het
Sptlc3	T	A	2: 139,636,772 (GRCm38)	N550K	probably benign	Het
Srebf1	T	C	11: 60,203,535 (GRCm38)	N609D	probably null	Het
Styxl1	A	T	5: 135,747,810 (GRCm38)	L164H	probably benign	Het
Synpo2l	A	T	14: 20,660,634 (GRCm38)	D865E	probably damaging	Het
Tnfsf15	T	C	4: 63,745,030 (GRCm38)	M19V	probably damaging	Het
Trappc8	G	C	18: 20,837,075 (GRCm38)	R953G	probably benign	Het
Trav13-1	A	G	14: 53,545,343 (GRCm38)	N50S	probably benign	Het
Trim12a	T	C	7: 104,306,034 (GRCm38)	K161E	probably benign	Het
Vipr1	C	A	9: 121,664,574 (GRCm38)	N230K	probably damaging	Het
Xirp1	A	T	9: 120,018,491 (GRCm38)	V3E	probably damaging	Het
Zfp768	A	G	7: 127,344,720 (GRCm38)	F82L	probably benign	Het

Other mutations in Itpr3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00715:Itpr3	APN	17	27,083,629 (GRCm38)	missense	probably benign	0.05
IGL00980:Itpr3	APN	17	27,110,956 (GRCm38)	missense	probably benign
IGL01151:Itpr3	APN	17	27,091,529 (GRCm38)	missense	probably damaging	1.00
IGL01289:Itpr3	APN	17	27,099,765 (GRCm38)	missense	probably damaging	0.99
IGL01403:Itpr3	APN	17	27,118,595 (GRCm38)	missense	probably damaging	0.97
IGL01666:Itpr3	APN	17	27,117,178 (GRCm38)	missense	probably benign	0.02
IGL01897:Itpr3	APN	17	27,111,262 (GRCm38)	missense	probably damaging	1.00
IGL02003:Itpr3	APN	17	27,121,475 (GRCm38)	missense	probably damaging	1.00
IGL02012:Itpr3	APN	17	27,104,095 (GRCm38)	missense	probably benign
IGL02063:Itpr3	APN	17	27,120,023 (GRCm38)	missense	probably benign	0.01
IGL02146:Itpr3	APN	17	27,117,275 (GRCm38)	missense	probably damaging	1.00
IGL02158:Itpr3	APN	17	27,098,442 (GRCm38)	missense	probably damaging	1.00
IGL02177:Itpr3	APN	17	27,099,614 (GRCm38)	missense	possibly damaging	0.74
IGL02247:Itpr3	APN	17	27,098,179 (GRCm38)	missense	probably damaging	1.00
IGL02606:Itpr3	APN	17	27,114,512 (GRCm38)	splice site	probably benign
IGL02651:Itpr3	APN	17	27,106,398 (GRCm38)	missense	probably damaging	0.99
IGL02902:Itpr3	APN	17	27,104,556 (GRCm38)	missense	probably benign	0.21
IGL03001:Itpr3	APN	17	27,089,612 (GRCm38)	splice site	probably benign
IGL03004:Itpr3	APN	17	27,097,978 (GRCm38)	missense	possibly damaging	0.90
IGL03065:Itpr3	APN	17	27,091,933 (GRCm38)	missense	probably damaging	1.00
IGL03117:Itpr3	APN	17	27,119,266 (GRCm38)	missense	probably damaging	1.00
IGL03181:Itpr3	APN	17	27,111,268 (GRCm38)	missense	probably benign
IGL03404:Itpr3	APN	17	27,091,518 (GRCm38)	missense	probably damaging	1.00
Allure	UTSW	17	27,107,303 (GRCm38)	missense	probably damaging	1.00
alopecia	UTSW	17	27,095,478 (GRCm38)	missense	probably damaging	0.98
Beauty	UTSW	17	27,106,342 (GRCm38)	missense	probably damaging	1.00
Opuesto	UTSW	17	27,087,592 (GRCm38)	missense	probably damaging	1.00
Paradox	UTSW	17	27,098,171 (GRCm38)	missense	probably damaging	1.00
Pulchritude	UTSW	17	27,086,960 (GRCm38)	missense	probably damaging	0.97
R0010:Itpr3	UTSW	17	27,120,977 (GRCm38)	missense	probably damaging	1.00
R0055:Itpr3	UTSW	17	27,098,322 (GRCm38)	missense	probably damaging	1.00
R0068:Itpr3	UTSW	17	27,104,060 (GRCm38)	splice site	probably benign
R0068:Itpr3	UTSW	17	27,104,060 (GRCm38)	splice site	probably benign
R0104:Itpr3	UTSW	17	27,095,992 (GRCm38)	missense	probably benign	0.01
R0195:Itpr3	UTSW	17	27,114,114 (GRCm38)	missense	probably damaging	1.00
R0212:Itpr3	UTSW	17	27,089,319 (GRCm38)	missense	probably damaging	1.00
R0454:Itpr3	UTSW	17	27,113,819 (GRCm38)	missense	probably benign
R0485:Itpr3	UTSW	17	27,111,929 (GRCm38)	missense	probably damaging	0.98
R0501:Itpr3	UTSW	17	27,107,289 (GRCm38)	missense	probably benign	0.09
R0781:Itpr3	UTSW	17	27,110,555 (GRCm38)	missense	probably benign	0.00
R0890:Itpr3	UTSW	17	27,089,011 (GRCm38)	nonsense	probably null
R1028:Itpr3	UTSW	17	27,091,369 (GRCm38)	missense	probably benign	0.04
R1144:Itpr3	UTSW	17	27,114,923 (GRCm38)	missense	probably benign	0.01
R1347:Itpr3	UTSW	17	27,111,561 (GRCm38)	missense	probably benign	0.02
R1347:Itpr3	UTSW	17	27,111,561 (GRCm38)	missense	probably benign	0.02
R1458:Itpr3	UTSW	17	27,118,372 (GRCm38)	missense	probably benign	0.01
R1463:Itpr3	UTSW	17	27,117,154 (GRCm38)	splice site	probably benign
R1472:Itpr3	UTSW	17	27,114,225 (GRCm38)	missense	probably benign	0.09
R1529:Itpr3	UTSW	17	27,105,485 (GRCm38)	splice site	probably null
R1533:Itpr3	UTSW	17	27,095,560 (GRCm38)	missense	possibly damaging	0.71
R1537:Itpr3	UTSW	17	27,114,147 (GRCm38)	missense	possibly damaging	0.96
R1618:Itpr3	UTSW	17	27,116,607 (GRCm38)	critical splice acceptor site	probably null
R1672:Itpr3	UTSW	17	27,089,013 (GRCm38)	missense	probably benign
R1726:Itpr3	UTSW	17	27,111,690 (GRCm38)	missense	probably damaging	0.96
R1865:Itpr3	UTSW	17	27,120,023 (GRCm38)	missense	probably benign	0.01
R1940:Itpr3	UTSW	17	27,111,217 (GRCm38)	missense	probably damaging	1.00
R2023:Itpr3	UTSW	17	27,102,811 (GRCm38)	missense	possibly damaging	0.76
R2063:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2064:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2065:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2067:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2068:Itpr3	UTSW	17	27,098,076 (GRCm38)	missense	probably benign	0.19
R2219:Itpr3	UTSW	17	27,115,053 (GRCm38)	missense	probably benign
R2248:Itpr3	UTSW	17	27,115,059 (GRCm38)	missense	probably damaging	1.00
R2291:Itpr3	UTSW	17	27,113,579 (GRCm38)	missense	possibly damaging	0.92
R2320:Itpr3	UTSW	17	27,095,915 (GRCm38)	missense	probably benign
R2864:Itpr3	UTSW	17	27,091,551 (GRCm38)	missense	probably benign	0.01
R2865:Itpr3	UTSW	17	27,091,551 (GRCm38)	missense	probably benign	0.01
R3778:Itpr3	UTSW	17	27,095,472 (GRCm38)	missense	possibly damaging	0.57
R3881:Itpr3	UTSW	17	27,113,840 (GRCm38)	missense	probably benign	0.01
R3979:Itpr3	UTSW	17	27,091,572 (GRCm38)	missense	probably damaging	1.00
R3979:Itpr3	UTSW	17	27,085,131 (GRCm38)	missense	probably benign	0.23
R4224:Itpr3	UTSW	17	27,107,258 (GRCm38)	missense	probably damaging	1.00
R4259:Itpr3	UTSW	17	27,106,324 (GRCm38)	missense	probably damaging	1.00
R4321:Itpr3	UTSW	17	27,111,974 (GRCm38)	missense	probably benign	0.00
R4466:Itpr3	UTSW	17	27,106,342 (GRCm38)	missense	probably damaging	1.00
R4493:Itpr3	UTSW	17	27,104,612 (GRCm38)	missense	probably damaging	1.00
R4597:Itpr3	UTSW	17	27,093,283 (GRCm38)	missense	probably damaging	1.00
R4823:Itpr3	UTSW	17	27,085,147 (GRCm38)	missense	probably benign	0.30
R4921:Itpr3	UTSW	17	27,098,005 (GRCm38)	missense	probably damaging	1.00
R4974:Itpr3	UTSW	17	27,083,608 (GRCm38)	missense	probably damaging	0.96
R5063:Itpr3	UTSW	17	27,089,911 (GRCm38)	missense	possibly damaging	0.94
R5079:Itpr3	UTSW	17	27,098,423 (GRCm38)	missense	probably damaging	1.00
R5303:Itpr3	UTSW	17	27,116,689 (GRCm38)	missense	probably benign	0.38
R5518:Itpr3	UTSW	17	27,087,592 (GRCm38)	missense	probably damaging	1.00
R5521:Itpr3	UTSW	17	27,107,334 (GRCm38)	missense	probably benign	0.09
R5566:Itpr3	UTSW	17	27,115,952 (GRCm38)	missense	possibly damaging	0.71
R5567:Itpr3	UTSW	17	27,103,906 (GRCm38)	missense	possibly damaging	0.66
R5579:Itpr3	UTSW	17	27,113,519 (GRCm38)	missense	probably damaging	1.00
R5610:Itpr3	UTSW	17	27,118,566 (GRCm38)	missense	probably benign	0.42
R5658:Itpr3	UTSW	17	27,107,878 (GRCm38)	missense	possibly damaging	0.74
R5856:Itpr3	UTSW	17	27,106,405 (GRCm38)	missense	probably damaging	1.00
R5872:Itpr3	UTSW	17	27,086,976 (GRCm38)	missense	probably benign	0.02
R5878:Itpr3	UTSW	17	27,110,862 (GRCm38)	missense	probably benign	0.01
R5889:Itpr3	UTSW	17	27,115,065 (GRCm38)	missense	probably damaging	0.99
R5907:Itpr3	UTSW	17	27,117,893 (GRCm38)	missense	probably damaging	1.00
R5930:Itpr3	UTSW	17	27,110,921 (GRCm38)	missense	possibly damaging	0.49
R5987:Itpr3	UTSW	17	27,104,601 (GRCm38)	missense	probably damaging	1.00
R6029:Itpr3	UTSW	17	27,098,171 (GRCm38)	missense	probably damaging	1.00
R6195:Itpr3	UTSW	17	27,086,960 (GRCm38)	missense	probably damaging	0.97
R6213:Itpr3	UTSW	17	27,111,200 (GRCm38)	missense	probably benign	0.03
R6233:Itpr3	UTSW	17	27,086,960 (GRCm38)	missense	probably damaging	0.97
R6514:Itpr3	UTSW	17	27,091,370 (GRCm38)	missense	probably benign
R6515:Itpr3	UTSW	17	27,091,370 (GRCm38)	missense	probably benign
R6516:Itpr3	UTSW	17	27,091,370 (GRCm38)	missense	probably benign
R6955:Itpr3	UTSW	17	27,121,467 (GRCm38)	missense	probably damaging	1.00
R7002:Itpr3	UTSW	17	27,110,580 (GRCm38)	missense	probably benign	0.00
R7064:Itpr3	UTSW	17	27,089,295 (GRCm38)	missense	probably damaging	1.00
R7257:Itpr3	UTSW	17	27,118,561 (GRCm38)	missense	probably benign	0.00
R7349:Itpr3	UTSW	17	27,107,812 (GRCm38)	splice site	probably null
R7469:Itpr3	UTSW	17	27,121,054 (GRCm38)	missense	possibly damaging	0.74
R7493:Itpr3	UTSW	17	27,094,800 (GRCm38)	missense	probably benign	0.09
R7510:Itpr3	UTSW	17	27,089,039 (GRCm38)	missense	probably damaging	0.97
R7565:Itpr3	UTSW	17	27,110,888 (GRCm38)	missense	probably benign	0.01
R7616:Itpr3	UTSW	17	27,088,977 (GRCm38)	missense	probably damaging	1.00
R7728:Itpr3	UTSW	17	27,098,114 (GRCm38)	missense	probably damaging	1.00
R7779:Itpr3	UTSW	17	27,096,063 (GRCm38)	missense	probably damaging	1.00
R7788:Itpr3	UTSW	17	27,118,597 (GRCm38)	nonsense	probably null
R7871:Itpr3	UTSW	17	27,117,179 (GRCm38)	missense	probably damaging	1.00
R7889:Itpr3	UTSW	17	27,116,777 (GRCm38)	missense	probably damaging	1.00
R7966:Itpr3	UTSW	17	27,112,028 (GRCm38)	critical splice donor site	probably null
R8065:Itpr3	UTSW	17	27,110,862 (GRCm38)	missense	probably benign	0.01
R8067:Itpr3	UTSW	17	27,110,862 (GRCm38)	missense	probably benign	0.01
R8230:Itpr3	UTSW	17	27,107,737 (GRCm38)	critical splice donor site	probably null
R8263:Itpr3	UTSW	17	27,115,913 (GRCm38)	nonsense	probably null
R8264:Itpr3	UTSW	17	27,104,112 (GRCm38)	synonymous	silent
R8269:Itpr3	UTSW	17	27,093,284 (GRCm38)	missense	possibly damaging	0.60
R8271:Itpr3	UTSW	17	27,087,648 (GRCm38)	missense	probably damaging	1.00
R8316:Itpr3	UTSW	17	27,106,225 (GRCm38)	missense	possibly damaging	0.50
R8354:Itpr3	UTSW	17	27,115,919 (GRCm38)	missense	possibly damaging	0.74
R8413:Itpr3	UTSW	17	27,111,926 (GRCm38)	missense	probably damaging	1.00
R8437:Itpr3	UTSW	17	27,107,303 (GRCm38)	missense	probably damaging	1.00
R8676:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8679:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8846:Itpr3	UTSW	17	27,112,022 (GRCm38)	missense	probably damaging	1.00
R8884:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8885:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8886:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8887:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8888:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8891:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8896:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R8975:Itpr3	UTSW	17	27,116,654 (GRCm38)	missense	possibly damaging	0.56
R9025:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9026:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9063:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9087:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9088:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9089:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9090:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9091:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9200:Itpr3	UTSW	17	27,107,662 (GRCm38)	missense	probably damaging	0.99
R9270:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9271:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9294:Itpr3	UTSW	17	27,111,217 (GRCm38)	missense	probably damaging	1.00
R9389:Itpr3	UTSW	17	27,095,925 (GRCm38)	missense	possibly damaging	0.84
R9433:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9434:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9443:Itpr3	UTSW	17	27,105,549 (GRCm38)	missense	probably damaging	1.00
R9472:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9474:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9475:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9476:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9477:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9507:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9508:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9511:Itpr3	UTSW	17	27,118,677 (GRCm38)	unclassified	probably benign
R9694:Itpr3	UTSW	17	27,115,953 (GRCm38)	missense	probably damaging	0.99
R9789:Itpr3	UTSW	17	27,089,941 (GRCm38)	missense	probably benign	0.15
V7732:Itpr3	UTSW	17	27,111,026 (GRCm38)	splice site	probably null
V7732:Itpr3	UTSW	17	27,111,024 (GRCm38)	splice site	probably benign
Z1088:Itpr3	UTSW	17	27,113,528 (GRCm38)	missense	possibly damaging	0.50
Z1177:Itpr3	UTSW	17	27,119,987 (GRCm38)	missense	probably damaging	1.00
Z1177:Itpr3	UTSW	17	27,114,929 (GRCm38)	missense	probably damaging	1.00
Z31818:Itpr3	UTSW	17	27,095,478 (GRCm38)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- GAGATGCAAATTCCCATTCCATG -3'
(R):5'- TAAAGCTGGGCACTACAGGC -3'

Sequencing Primer
(F):5'- ATTCCATGGTGAGCCCCAAG -3'
(R):5'- AGGCACTGCGCACACAC -3'

Posted On

2018-05-04