Incidental Mutation 'R6377:Or4c11c'
ID 515025
Institutional Source Beutler Lab
Gene Symbol Or4c11c
Ensembl Gene ENSMUSG00000057447
Gene Name olfactory receptor family 4 subfamily C member 11C
Synonyms GA_x6K02T2Q125-50336588-50337313, MOR230-1, MOR230-3, Olfr1205, GA_x6K02T2Q125-50304328-50305251, Olfr1203
MMRRC Submission 044527-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R6377 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 88660101-88662386 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 88661613 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Stop codon at position 51 (R51*)
Ref Sequence ENSEMBL: ENSMUSP00000150206 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076438] [ENSMUST00000215929]
AlphaFold A2ATJ7
Predicted Effect probably null
Transcript: ENSMUST00000076438
AA Change: R51*
SMART Domains Protein: ENSMUSP00000075769
Gene: ENSMUSG00000057447
AA Change: R51*

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 5e-45 PFAM
Pfam:7tm_1 39 285 9.1e-21 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000215929
AA Change: R51*
Meta Mutation Damage Score 0.9756 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.8%
Validation Efficiency 94% (59/63)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankib1 A G 5: 3,743,855 (GRCm39) S812P possibly damaging Het
Atp2c2 A G 8: 120,453,093 (GRCm39) E159G probably benign Het
Atrn A G 2: 130,821,889 (GRCm39) I861V probably damaging Het
Clip1 A G 5: 123,741,717 (GRCm39) V1053A possibly damaging Het
Cngb1 C A 8: 95,975,608 (GRCm39) G629C probably damaging Het
Cntn5 A T 9: 9,743,657 (GRCm39) F540Y probably damaging Het
Cpb1 A C 3: 20,329,748 (GRCm39) probably null Het
Cyp4a14 A G 4: 115,353,280 (GRCm39) Y11H probably benign Het
Dact2 A G 17: 14,419,450 (GRCm39) S103P probably damaging Het
Dcstamp A T 15: 39,618,317 (GRCm39) Y242F probably benign Het
Drd3 G T 16: 43,641,670 (GRCm39) G329* probably null Het
Duxf1 T C 10: 58,059,494 (GRCm39) probably benign Het
Dysf T A 6: 83,985,945 (GRCm39) S17T probably benign Het
Eno1 A T 4: 150,333,009 (GRCm39) K366N possibly damaging Het
Ffar2 C T 7: 30,518,971 (GRCm39) V190I probably benign Het
Fkbp15 T C 4: 62,242,429 (GRCm39) T508A probably damaging Het
Fndc1 A G 17: 7,988,567 (GRCm39) V1165A unknown Het
Foxj3 A T 4: 119,430,945 (GRCm39) probably null Het
Gabarap T C 11: 69,882,630 (GRCm39) probably null Het
Gm19410 T A 8: 36,270,736 (GRCm39) L1221* probably null Het
Gpat2 G C 2: 127,273,838 (GRCm39) G294R possibly damaging Het
Igf1r A T 7: 67,850,998 (GRCm39) Y931F probably benign Het
Il23r A T 6: 67,400,636 (GRCm39) S565T probably damaging Het
Ipo8 A T 6: 148,717,995 (GRCm39) Y209* probably null Het
Jph2 C T 2: 163,181,632 (GRCm39) G511R probably benign Het
Khdrbs1 C A 4: 129,635,890 (GRCm39) D22Y probably damaging Het
Kif5b A T 18: 6,212,562 (GRCm39) L754Q probably damaging Het
Ksr1 C T 11: 78,927,320 (GRCm39) probably null Het
L3mbtl4 G T 17: 69,084,918 (GRCm39) V610F probably benign Het
Lars2 A G 9: 123,283,825 (GRCm39) T698A probably benign Het
Lonp1 A G 17: 56,928,961 (GRCm39) V267A possibly damaging Het
Loxhd1 T A 18: 77,468,128 (GRCm39) D925E probably damaging Het
Lsg1 A G 16: 30,393,386 (GRCm39) L187P possibly damaging Het
Mki67 A T 7: 135,298,050 (GRCm39) V2328E possibly damaging Het
Mlh3 A G 12: 85,315,271 (GRCm39) I305T probably damaging Het
Mtbp A G 15: 55,421,016 (GRCm39) M1V probably null Het
Myadml2 C A 11: 120,538,538 (GRCm39) C99F probably benign Het
Ncbp1 A G 4: 46,150,703 (GRCm39) Y185C probably damaging Het
Ndufaf7 A T 17: 79,250,739 (GRCm39) Q222L probably null Het
Nlrp4b A T 7: 10,449,339 (GRCm39) Y147F probably benign Het
Pet100 T C 8: 3,672,370 (GRCm39) V15A probably benign Het
Pot1a A G 6: 25,778,869 (GRCm39) V75A probably benign Het
Ptprs A T 17: 56,725,935 (GRCm39) M1043K probably damaging Het
Rnf31 A G 14: 55,832,984 (GRCm39) T413A probably damaging Het
Rsf1 ATGGCG ATGGCGACGGTGGCG 7: 97,229,111 (GRCm39) probably benign Homo
Rsf1 CG CGACGGCGGTG 7: 97,229,115 (GRCm39) probably benign Het
Rubcnl A T 14: 75,287,635 (GRCm39) probably null Het
Ryr3 A T 2: 112,462,530 (GRCm39) C4839S probably damaging Het
Scai A C 2: 38,992,340 (GRCm39) D379E probably benign Het
Scd2 G T 19: 44,288,198 (GRCm39) G197* probably null Het
Sdr39u1 A C 14: 56,135,166 (GRCm39) I259S probably benign Het
Slco1a5 A T 6: 142,187,906 (GRCm39) probably null Het
Sp1 A T 15: 102,339,318 (GRCm39) T733S probably benign Het
Tecta A G 9: 42,255,051 (GRCm39) S1711P probably damaging Het
Tedc1 G T 12: 113,124,975 (GRCm39) W240L probably damaging Het
Trarg1 T C 11: 76,571,355 (GRCm39) S124P probably damaging Het
Trim50 A G 5: 135,382,454 (GRCm39) K102R probably benign Het
Utrn A G 10: 12,619,827 (GRCm39) Y278H probably damaging Het
Vinac1 T A 2: 128,878,731 (GRCm39) D1065V unknown Het
Vmn2r109 A C 17: 20,784,796 (GRCm39) probably null Het
Zbed5 T C 5: 129,932,210 (GRCm39) S720P possibly damaging Het
Zc3h3 A G 15: 75,711,304 (GRCm39) S386P probably damaging Het
Zscan4-ps1 C T 7: 10,802,418 (GRCm39) probably null Het
Other mutations in Or4c11c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00923:Or4c11c APN 2 88,661,456 (GRCm39) splice site probably null
IGL02079:Or4c11c APN 2 88,661,991 (GRCm39) missense probably damaging 1.00
IGL02183:Or4c11c APN 2 88,662,372 (GRCm39) missense probably benign
IGL02813:Or4c11c APN 2 88,661,495 (GRCm39) missense probably benign 0.34
IGL02839:Or4c11c APN 2 88,661,992 (GRCm39) missense probably damaging 1.00
IGL02895:Or4c11c APN 2 88,661,986 (GRCm39) missense probably damaging 1.00
R0680:Or4c11c UTSW 2 88,662,124 (GRCm39) missense probably benign
R2029:Or4c11c UTSW 2 88,661,749 (GRCm39) missense possibly damaging 0.88
R2095:Or4c11c UTSW 2 88,661,634 (GRCm39) missense probably damaging 1.00
R6158:Or4c11c UTSW 2 88,661,490 (GRCm39) missense probably damaging 1.00
R6216:Or4c11c UTSW 2 88,661,655 (GRCm39) missense probably damaging 1.00
R6240:Or4c11c UTSW 2 88,661,707 (GRCm39) missense probably benign 0.22
R6429:Or4c11c UTSW 2 88,661,869 (GRCm39) missense probably benign 0.01
R6521:Or4c11c UTSW 2 88,661,700 (GRCm39) missense probably benign 0.03
R7065:Or4c11c UTSW 2 88,661,730 (GRCm39) missense probably damaging 1.00
R7343:Or4c11c UTSW 2 88,662,190 (GRCm39) missense probably damaging 1.00
R7476:Or4c11c UTSW 2 88,661,932 (GRCm39) missense probably benign 0.07
R7570:Or4c11c UTSW 2 88,661,472 (GRCm39) missense possibly damaging 0.82
R8303:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8306:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8307:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8308:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8344:Or4c11c UTSW 2 88,661,727 (GRCm39) missense probably benign 0.00
R8386:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8387:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8809:Or4c11c UTSW 2 88,662,256 (GRCm39) missense probably benign 0.01
R8894:Or4c11c UTSW 2 88,661,809 (GRCm39) missense probably benign 0.12
Z1176:Or4c11c UTSW 2 88,661,922 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ATGTGAGTTCCTCTCTTGGAC -3'
(R):5'- GATGGCCACATAACGGTCAAC -3'

Sequencing Primer
(F):5'- TCTCTTGGACTGACACAATGCAG -3'
(R):5'- CGGTCAACAGCCATGAAAATG -3'
Posted On 2018-05-04