Incidental Mutation 'R6379:Tas2r120'
ID 515198
Institutional Source Beutler Lab
Gene Symbol Tas2r120
Ensembl Gene ENSMUSG00000059382
Gene Name taste receptor, type 2, member 120
Synonyms Tas2r20, mGR20, mt2r47, T2R20
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # R6379 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 132633920-132634807 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 132634773 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 285 (V285A)
Ref Sequence ENSEMBL: ENSMUSP00000071626 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071707]
AlphaFold Q7M721
Predicted Effect probably benign
Transcript: ENSMUST00000071707
AA Change: V285A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000071626
Gene: ENSMUSG00000059382
AA Change: V285A

DomainStartEndE-ValueType
Pfam:TAS2R 1 294 2.4e-77 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 96.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] TAS2R46 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Sep 2009]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6820408C15Rik A T 2: 152,269,912 (GRCm39) R21S probably benign Het
Aadacl4fm1 G T 4: 144,248,912 (GRCm39) R93L probably benign Het
Adcy5 A T 16: 35,114,369 (GRCm39) T991S probably benign Het
Aldh18a1 A T 19: 40,566,214 (GRCm39) probably null Het
Anxa1 T C 19: 20,351,079 (GRCm39) *347W probably null Het
Aopep T A 13: 63,216,057 (GRCm39) I443K probably damaging Het
Arid1a G T 4: 133,408,238 (GRCm39) L2090I unknown Het
Armh3 A T 19: 45,910,136 (GRCm39) V472D possibly damaging Het
Bambi T A 18: 3,512,198 (GRCm39) L194Q probably damaging Het
Card9 A G 2: 26,246,789 (GRCm39) V353A probably damaging Het
Ccdc198 T A 14: 49,481,191 (GRCm39) I99F probably benign Het
Ccdc60 C A 5: 116,269,082 (GRCm39) probably null Het
Ccdc71 A G 9: 108,340,811 (GRCm39) K208R possibly damaging Het
Cdh12 T C 15: 21,492,743 (GRCm39) V254A probably benign Het
Cep295nl T A 11: 118,224,556 (GRCm39) N96I probably benign Het
Ces1f C A 8: 94,006,279 (GRCm39) C17F probably benign Het
Clic6 C A 16: 92,336,423 (GRCm39) T577K probably damaging Het
Col28a1 T C 6: 8,012,996 (GRCm39) M1019V probably benign Het
Ctnnd2 C A 15: 30,634,844 (GRCm39) S73Y probably damaging Het
Daam1 C T 12: 71,998,712 (GRCm39) L556F unknown Het
Dchs2 A C 3: 83,262,453 (GRCm39) N2907T probably damaging Het
Dlgap3 A C 4: 127,128,767 (GRCm39) E829A probably damaging Het
Dpysl5 A T 5: 30,935,317 (GRCm39) probably null Het
Draxin C A 4: 148,192,400 (GRCm39) C304F probably damaging Het
Eif3j1 A G 2: 121,878,005 (GRCm39) D131G possibly damaging Het
Fads1 T C 19: 10,160,551 (GRCm39) Y46H probably damaging Het
Fcgbpl1 A C 7: 27,857,017 (GRCm39) T2122P probably damaging Het
Figla T A 6: 85,995,562 (GRCm39) I72K probably damaging Het
Fnbp4 T A 2: 90,581,468 (GRCm39) S174T probably benign Het
Foxn3 C A 12: 99,162,537 (GRCm39) A455S probably benign Het
Fyn C T 10: 39,331,070 (GRCm39) probably benign Het
Gtse1 G A 15: 85,748,425 (GRCm39) G277S probably benign Het
H2bc15 T A 13: 21,938,588 (GRCm39) V99E probably benign Het
Icam4 C A 9: 20,941,078 (GRCm39) A110E probably damaging Het
Itih3 G A 14: 30,631,681 (GRCm39) S802L probably damaging Het
Kcng4 T A 8: 120,360,359 (GRCm39) R6* probably null Het
Kmt2c A T 5: 25,564,339 (GRCm39) C977S probably damaging Het
Lrrc8d A T 5: 105,960,675 (GRCm39) M362L probably benign Het
Mtus2 T C 5: 148,014,008 (GRCm39) I267T probably benign Het
Nab1 A G 1: 52,520,156 (GRCm39) V275A probably damaging Het
Nfasc G A 1: 132,498,280 (GRCm39) Q1308* probably null Het
Nop9 T C 14: 55,983,249 (GRCm39) S7P possibly damaging Het
Npbwr1 G T 1: 5,987,438 (GRCm39) N25K probably benign Het
Nptx2 T C 5: 144,490,252 (GRCm39) L227P probably damaging Het
Nrg1 T C 8: 33,373,749 (GRCm39) probably benign Het
Nup160 T A 2: 90,532,753 (GRCm39) C571* probably null Het
Nynrin T C 14: 56,107,848 (GRCm39) L985P probably damaging Het
Obsl1 A C 1: 75,479,787 (GRCm39) L341R probably damaging Het
Or1r1 T G 11: 73,875,099 (GRCm39) S112R probably damaging Het
Pate7 T A 9: 35,689,381 (GRCm39) probably benign Het
Phip G T 9: 82,795,910 (GRCm39) N570K probably damaging Het
Pigx A T 16: 31,903,341 (GRCm39) I240N probably damaging Het
Platr25 T C 13: 62,854,051 (GRCm39) D37G probably damaging Het
Ppl A T 16: 4,915,555 (GRCm39) M639K probably benign Het
Scnn1b T G 7: 121,514,551 (GRCm39) M441R probably benign Het
Sh3gl1 A T 17: 56,326,143 (GRCm39) M121K probably damaging Het
Slc30a4 A T 2: 122,531,469 (GRCm39) V132D probably damaging Het
Slc38a7 A G 8: 96,575,155 (GRCm39) S42P probably benign Het
Slc66a1 G A 4: 139,027,296 (GRCm39) L349F probably benign Het
Srp68 A G 11: 116,156,227 (GRCm39) C172R probably damaging Het
Suz12 A T 11: 79,906,014 (GRCm39) D292V possibly damaging Het
Sv2b A T 7: 74,786,048 (GRCm39) D457E possibly damaging Het
Tdo2 T A 3: 81,866,102 (GRCm39) probably benign Het
Them7 G T 2: 105,115,031 (GRCm39) probably null Het
Tnip2 T C 5: 34,660,979 (GRCm39) T158A probably damaging Het
Tonsl C T 15: 76,513,942 (GRCm39) R1209H probably benign Het
Trpc2 T A 7: 101,745,298 (GRCm39) L838* probably null Het
Trpm1 A G 7: 63,848,942 (GRCm39) I63V probably benign Het
Vps13d A T 4: 144,814,828 (GRCm39) N90K probably benign Het
Ylpm1 C T 12: 85,077,574 (GRCm39) S1433F probably damaging Het
Zbtb18 A G 1: 177,275,141 (GRCm39) D158G probably damaging Het
Zfhx2 T A 14: 55,311,795 (GRCm39) T300S probably benign Het
Zscan2 T A 7: 80,513,085 (GRCm39) D23E probably benign Het
Other mutations in Tas2r120
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00694:Tas2r120 APN 6 132,634,238 (GRCm39) missense probably benign 0.01
IGL01725:Tas2r120 APN 6 132,634,052 (GRCm39) nonsense probably null
IGL01860:Tas2r120 APN 6 132,634,227 (GRCm39) missense probably damaging 0.99
IGL01891:Tas2r120 APN 6 132,634,807 (GRCm39) makesense probably null
PIT4519001:Tas2r120 UTSW 6 132,634,297 (GRCm39) missense probably benign
R0104:Tas2r120 UTSW 6 132,634,809 (GRCm39) splice site probably null
R0108:Tas2r120 UTSW 6 132,634,809 (GRCm39) splice site probably null
R0123:Tas2r120 UTSW 6 132,634,552 (GRCm39) nonsense probably null
R0225:Tas2r120 UTSW 6 132,634,552 (GRCm39) nonsense probably null
R1812:Tas2r120 UTSW 6 132,634,564 (GRCm39) missense probably benign 0.02
R2254:Tas2r120 UTSW 6 132,634,572 (GRCm39) missense probably benign
R3110:Tas2r120 UTSW 6 132,634,731 (GRCm39) missense probably damaging 1.00
R3112:Tas2r120 UTSW 6 132,634,731 (GRCm39) missense probably damaging 1.00
R4829:Tas2r120 UTSW 6 132,634,331 (GRCm39) missense probably benign 0.03
R5248:Tas2r120 UTSW 6 132,634,110 (GRCm39) missense probably damaging 0.97
R5372:Tas2r120 UTSW 6 132,634,446 (GRCm39) missense possibly damaging 0.54
R7015:Tas2r120 UTSW 6 132,634,128 (GRCm39) missense possibly damaging 0.48
R7615:Tas2r120 UTSW 6 132,634,773 (GRCm39) missense probably benign 0.00
R8004:Tas2r120 UTSW 6 132,634,390 (GRCm39) missense possibly damaging 0.82
R8796:Tas2r120 UTSW 6 132,634,081 (GRCm39) missense probably damaging 1.00
R9207:Tas2r120 UTSW 6 132,634,626 (GRCm39) nonsense probably null
R9250:Tas2r120 UTSW 6 132,633,954 (GRCm39) missense probably benign 0.02
R9792:Tas2r120 UTSW 6 132,634,528 (GRCm39) missense possibly damaging 0.93
Z1176:Tas2r120 UTSW 6 132,634,148 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AGGCCTTGCAAACTGTGGTC -3'
(R):5'- AATGAGGGACAATTCATTGCCC -3'

Sequencing Primer
(F):5'- GCAAACTGTGGTCTCTTTTCTCTTG -3'
(R):5'- GGGACAATTCATTGCCCTTATAATG -3'
Posted On 2018-05-04