Incidental Mutation 'R6381:Vmn2r57'
ID 515316
Institutional Source Beutler Lab
Gene Symbol Vmn2r57
Ensembl Gene ENSMUSG00000066537
Gene Name vomeronasal 2, receptor 57
Synonyms EG269902
MMRRC Submission 044530-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.106) question?
Stock # R6381 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 41049156-41098065 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 41078242 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 72 (N72S)
Ref Sequence ENSEMBL: ENSMUSP00000125817 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094532] [ENSMUST00000165029]
AlphaFold L7N269
Predicted Effect probably benign
Transcript: ENSMUST00000094532
Predicted Effect probably benign
Transcript: ENSMUST00000165029
AA Change: N72S

PolyPhen 2 Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000125817
Gene: ENSMUSG00000066537
AA Change: N72S

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 471 1.4e-44 PFAM
Pfam:NCD3G 514 567 2.7e-23 PFAM
Pfam:7tm_3 600 835 1.8e-52 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.2%
Validation Efficiency 97% (56/58)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930503L19Rik T A 18: 70,600,788 (GRCm39) M365L probably damaging Het
Aars2 A G 17: 45,829,471 (GRCm39) E786G probably benign Het
Adamts12 G T 15: 11,257,080 (GRCm39) V478F possibly damaging Het
Akr1c21 T A 13: 4,624,183 (GRCm39) D12E probably damaging Het
Aplf A T 6: 87,635,959 (GRCm39) M118K probably damaging Het
Apobec1 A G 6: 122,555,890 (GRCm39) L189P probably damaging Het
BC061237 A G 14: 44,741,713 (GRCm39) Q152R possibly damaging Het
Bche A G 3: 73,609,132 (GRCm39) I98T probably benign Het
Cc2d2a G T 5: 43,873,118 (GRCm39) R983L possibly damaging Het
Ccnd3 T C 17: 47,816,149 (GRCm39) probably benign Het
Cd74 G T 18: 60,944,435 (GRCm39) C215F probably damaging Het
Cep97 C T 16: 55,742,534 (GRCm39) A138T probably damaging Het
Ces1e T A 8: 93,944,206 (GRCm39) N204I probably damaging Het
Dicer1 T C 12: 104,662,721 (GRCm39) D1620G probably benign Het
Dnah17 A G 11: 118,020,011 (GRCm39) V12A probably benign Het
Dstyk T A 1: 132,384,503 (GRCm39) probably null Het
Elapor1 T C 3: 108,389,130 (GRCm39) K222E possibly damaging Het
Eml2 G A 7: 18,935,088 (GRCm39) V432I probably damaging Het
Entr1 A G 2: 26,275,093 (GRCm39) probably null Het
Gm10570 G T 4: 130,202,021 (GRCm39) probably benign Het
Gm7145 C T 1: 117,913,669 (GRCm39) Q184* probably null Het
Gpat2 G C 2: 127,273,838 (GRCm39) G294R possibly damaging Het
Gtse1 G A 15: 85,746,349 (GRCm39) R55H probably benign Het
Hdac4 G T 1: 91,912,247 (GRCm39) Q381K possibly damaging Het
Ifit3b T C 19: 34,589,871 (GRCm39) I349T probably benign Het
Inpp5a A T 7: 138,980,589 (GRCm39) D9V probably benign Het
Irs1 T C 1: 82,265,405 (GRCm39) N937S possibly damaging Het
Kcna4 T C 2: 107,125,317 (GRCm39) M17T probably benign Het
Lipa T A 19: 34,502,146 (GRCm39) M33L probably benign Het
Marchf6 G T 15: 31,467,838 (GRCm39) Q790K probably benign Het
Mccc1 G A 3: 36,030,876 (GRCm39) P397S probably benign Het
Mrgprb2 T C 7: 48,202,138 (GRCm39) I196V probably benign Het
Myh15 T A 16: 48,921,844 (GRCm39) S463R probably damaging Het
Nab2 T C 10: 127,500,220 (GRCm39) K291E probably damaging Het
Neto2 T C 8: 86,369,138 (GRCm39) T294A probably damaging Het
Nkx1-1 T C 5: 33,591,320 (GRCm39) M1V probably null Het
Or2h2 C T 17: 37,396,977 (GRCm39) V27I probably benign Het
Pla2g4c C T 7: 13,077,933 (GRCm39) T357I probably benign Het
Psmd2 A G 16: 20,474,023 (GRCm39) E242G probably benign Het
Rnase12 A C 14: 51,294,551 (GRCm39) Y43D probably damaging Het
Rpl18 T A 7: 45,369,016 (GRCm39) F58I probably damaging Het
Ryr1 T G 7: 28,774,682 (GRCm39) M2313L possibly damaging Het
Scn4a G T 11: 106,211,137 (GRCm39) Q1627K probably damaging Het
Scnn1g A G 7: 121,366,722 (GRCm39) S640G probably benign Het
Sdr9c7 T A 10: 127,739,542 (GRCm39) M219K probably benign Het
Soat1 A T 1: 156,263,373 (GRCm39) M392K probably damaging Het
Spata18 G T 5: 73,832,559 (GRCm39) K337N probably damaging Het
Supt16 A G 14: 52,417,003 (GRCm39) V325A probably benign Het
Syt2 A G 1: 134,674,588 (GRCm39) E342G probably damaging Het
Tars2 A T 3: 95,661,799 (GRCm39) L37* probably null Het
Tep1 T C 14: 51,082,888 (GRCm39) D1040G probably damaging Het
Tmc8 A T 11: 117,682,426 (GRCm39) S613C probably null Het
Top3a C T 11: 60,634,849 (GRCm39) C660Y probably damaging Het
Tpsg1 C T 17: 25,591,543 (GRCm39) R48C probably damaging Het
Whrn G A 4: 63,390,921 (GRCm39) T269I probably benign Het
Zfp759 T A 13: 67,286,969 (GRCm39) Y173* probably null Het
Other mutations in Vmn2r57
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00159:Vmn2r57 APN 7 41,078,209 (GRCm39) missense probably benign
IGL01108:Vmn2r57 APN 7 41,077,008 (GRCm39) missense probably benign 0.01
IGL01112:Vmn2r57 APN 7 41,074,467 (GRCm39) missense probably damaging 1.00
IGL01516:Vmn2r57 APN 7 41,049,370 (GRCm39) missense probably damaging 1.00
IGL01880:Vmn2r57 APN 7 41,049,619 (GRCm39) missense possibly damaging 0.73
IGL02117:Vmn2r57 APN 7 41,049,874 (GRCm39) missense probably benign 0.00
IGL02500:Vmn2r57 APN 7 41,077,650 (GRCm39) missense probably benign
IGL02801:Vmn2r57 APN 7 41,098,056 (GRCm39) missense probably benign 0.13
IGL02993:Vmn2r57 APN 7 41,077,498 (GRCm39) missense probably benign 0.04
IGL02996:Vmn2r57 APN 7 41,049,165 (GRCm39) missense probably benign 0.02
R0008:Vmn2r57 UTSW 7 41,050,076 (GRCm39) missense probably damaging 1.00
R0032:Vmn2r57 UTSW 7 41,049,157 (GRCm39) splice site probably null
R0305:Vmn2r57 UTSW 7 41,076,967 (GRCm39) missense probably benign 0.00
R0469:Vmn2r57 UTSW 7 41,077,216 (GRCm39) missense possibly damaging 0.58
R0510:Vmn2r57 UTSW 7 41,077,216 (GRCm39) missense possibly damaging 0.58
R0847:Vmn2r57 UTSW 7 41,078,225 (GRCm39) missense probably benign 0.00
R1025:Vmn2r57 UTSW 7 41,077,228 (GRCm39) missense probably benign 0.24
R1081:Vmn2r57 UTSW 7 41,077,635 (GRCm39) missense possibly damaging 0.47
R1479:Vmn2r57 UTSW 7 41,077,254 (GRCm39) missense possibly damaging 0.45
R1579:Vmn2r57 UTSW 7 41,049,548 (GRCm39) missense probably benign 0.38
R1764:Vmn2r57 UTSW 7 41,050,067 (GRCm39) missense probably damaging 1.00
R1848:Vmn2r57 UTSW 7 41,077,531 (GRCm39) missense probably damaging 1.00
R2006:Vmn2r57 UTSW 7 41,098,001 (GRCm39) missense probably benign 0.00
R2197:Vmn2r57 UTSW 7 41,078,249 (GRCm39) critical splice acceptor site probably null
R2242:Vmn2r57 UTSW 7 41,077,498 (GRCm39) missense probably benign 0.00
R2394:Vmn2r57 UTSW 7 41,049,619 (GRCm39) missense possibly damaging 0.73
R3937:Vmn2r57 UTSW 7 41,077,554 (GRCm39) missense probably damaging 0.97
R4193:Vmn2r57 UTSW 7 41,077,663 (GRCm39) missense probably benign
R4423:Vmn2r57 UTSW 7 41,076,064 (GRCm39) missense probably damaging 1.00
R4865:Vmn2r57 UTSW 7 41,049,892 (GRCm39) missense probably damaging 1.00
R4947:Vmn2r57 UTSW 7 41,049,919 (GRCm39) missense probably damaging 1.00
R5042:Vmn2r57 UTSW 7 41,078,086 (GRCm39) missense probably benign 0.06
R5084:Vmn2r57 UTSW 7 41,075,974 (GRCm39) critical splice donor site probably null
R5177:Vmn2r57 UTSW 7 41,049,664 (GRCm39) missense probably benign 0.31
R5192:Vmn2r57 UTSW 7 41,077,363 (GRCm39) missense probably damaging 0.96
R5289:Vmn2r57 UTSW 7 41,049,398 (GRCm39) missense probably damaging 0.99
R5745:Vmn2r57 UTSW 7 41,097,895 (GRCm39) missense possibly damaging 0.51
R6051:Vmn2r57 UTSW 7 41,097,896 (GRCm39) missense probably benign 0.00
R6155:Vmn2r57 UTSW 7 41,078,114 (GRCm39) missense probably benign 0.14
R6248:Vmn2r57 UTSW 7 41,049,284 (GRCm39) missense probably benign
R7019:Vmn2r57 UTSW 7 41,078,089 (GRCm39) missense probably damaging 1.00
R7126:Vmn2r57 UTSW 7 41,049,218 (GRCm39) missense possibly damaging 0.93
R7146:Vmn2r57 UTSW 7 41,097,895 (GRCm39) missense possibly damaging 0.51
R7215:Vmn2r57 UTSW 7 41,049,710 (GRCm39) missense probably benign 0.00
R7432:Vmn2r57 UTSW 7 41,076,148 (GRCm39) missense probably benign 0.01
R7633:Vmn2r57 UTSW 7 41,074,513 (GRCm39) missense possibly damaging 0.76
R7811:Vmn2r57 UTSW 7 41,074,439 (GRCm39) nonsense probably null
R8025:Vmn2r57 UTSW 7 41,076,183 (GRCm39) missense probably benign 0.00
R8332:Vmn2r57 UTSW 7 41,049,677 (GRCm39) missense probably benign 0.01
R8345:Vmn2r57 UTSW 7 41,076,968 (GRCm39) missense possibly damaging 0.81
R8360:Vmn2r57 UTSW 7 41,049,640 (GRCm39) missense probably damaging 1.00
R8738:Vmn2r57 UTSW 7 41,077,020 (GRCm39) missense probably benign 0.00
R8758:Vmn2r57 UTSW 7 41,078,163 (GRCm39) missense probably damaging 1.00
R8955:Vmn2r57 UTSW 7 41,049,571 (GRCm39) missense possibly damaging 0.64
R8985:Vmn2r57 UTSW 7 41,049,259 (GRCm39) missense probably benign
R9108:Vmn2r57 UTSW 7 41,078,192 (GRCm39) missense possibly damaging 0.87
R9160:Vmn2r57 UTSW 7 41,076,159 (GRCm39) missense possibly damaging 0.48
R9354:Vmn2r57 UTSW 7 41,049,663 (GRCm39) missense probably benign 0.01
R9566:Vmn2r57 UTSW 7 41,077,089 (GRCm39) missense probably benign 0.32
R9633:Vmn2r57 UTSW 7 41,076,006 (GRCm39) missense probably benign 0.00
X0026:Vmn2r57 UTSW 7 41,077,985 (GRCm39) missense possibly damaging 0.91
X0026:Vmn2r57 UTSW 7 41,077,549 (GRCm39) missense probably benign 0.03
X0065:Vmn2r57 UTSW 7 41,077,395 (GRCm39) missense probably benign 0.09
Z1176:Vmn2r57 UTSW 7 41,049,922 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GCAGGTAAATTTCTCTTCTGGCC -3'
(R):5'- TTCTCCACTCAATATACTAAGAGTCCC -3'

Sequencing Primer
(F):5'- CTCTTCTGGCCACAGTTATAATTAAC -3'
(R):5'- GTCCCAGAGACCATGATTAATAAATG -3'
Posted On 2018-05-04