Incidental Mutation 'IGL01100:Vmn1r176'
ID51536
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn1r176
Ensembl Gene ENSMUSG00000096859
Gene Namevomeronasal 1 receptor 176
SynonymsGm5998
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.087) question?
Stock #IGL01100
Quality Score
Status
Chromosome7
Chromosomal Location23833840-23837372 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 23835624 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 35 (F35I)
Ref Sequence ENSEMBL: ENSMUSP00000153879 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171073] [ENSMUST00000226319] [ENSMUST00000226767] [ENSMUST00000227129] [ENSMUST00000227661] [ENSMUST00000228280] [ENSMUST00000228793]
Predicted Effect probably benign
Transcript: ENSMUST00000171073
AA Change: F35I

PolyPhen 2 Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000132168
Gene: ENSMUSG00000096859
AA Change: F35I

DomainStartEndE-ValueType
Pfam:7tm_1 5 288 5.4e-6 PFAM
Pfam:TAS2R 8 295 1.8e-13 PFAM
Pfam:V1R 41 295 1.7e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226319
AA Change: F35I

PolyPhen 2 Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000226767
AA Change: F35I

PolyPhen 2 Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000227129
AA Change: F35I

PolyPhen 2 Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000227661
AA Change: F35I

PolyPhen 2 Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000228280
AA Change: F35I

PolyPhen 2 Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
Predicted Effect probably benign
Transcript: ENSMUST00000228793
AA Change: F35I

PolyPhen 2 Score 0.035 (Sensitivity: 0.94; Specificity: 0.82)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 T G 11: 9,274,673 probably null Het
Abca8a C T 11: 110,058,423 probably null Het
Acad11 A G 9: 104,076,408 T32A probably damaging Het
Ak7 T A 12: 105,713,574 N122K probably benign Het
Arrb1 A T 7: 99,587,213 probably null Het
Csde1 C A 3: 103,040,525 R132S possibly damaging Het
Emilin1 A G 5: 30,918,404 H663R probably benign Het
Etaa1 A G 11: 17,952,576 probably null Het
Fat3 A T 9: 16,375,228 F1000I probably damaging Het
Foxj2 T C 6: 122,828,391 L74P probably damaging Het
Gas6 C T 8: 13,475,118 V289M probably benign Het
Gm10801 A T 2: 98,663,983 Y135F probably benign Het
Ihh C T 1: 74,946,442 A295T probably damaging Het
Ip6k2 G T 9: 108,805,744 S305I probably damaging Het
Kcnk2 A G 1: 189,339,936 V65A probably damaging Het
Kif26b G A 1: 178,917,244 C1635Y probably benign Het
Klhdc4 G A 8: 121,821,843 Q44* probably null Het
Madd C A 2: 91,158,040 R1216L probably damaging Het
Myo15 T A 11: 60,511,158 C3076S probably damaging Het
Olfr365 A T 2: 37,201,640 H133L possibly damaging Het
Olfr670 T A 7: 104,959,995 I246F probably benign Het
Polq C A 16: 37,061,112 P934T probably benign Het
Prkaa1 A T 15: 5,174,318 K227M probably damaging Het
Psap G A 10: 60,299,929 G388S probably benign Het
Repin1 A G 6: 48,596,905 E200G probably damaging Het
Samd9l C A 6: 3,375,863 S466I possibly damaging Het
Slc5a3 A G 16: 92,079,222 probably benign Het
Smg9 G A 7: 24,416,951 V314M probably damaging Het
Tktl1 G A X: 74,200,626 R352H probably benign Het
Ube2z A G 11: 96,063,023 V123A probably damaging Het
Zdhhc18 A T 4: 133,612,958 Y293N probably damaging Het
Other mutations in Vmn1r176
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03004:Vmn1r176 APN 7 23835277 missense probably damaging 1.00
PIT4151001:Vmn1r176 UTSW 7 23835383 missense probably damaging 1.00
R0195:Vmn1r176 UTSW 7 23835585 missense probably benign 0.10
R1186:Vmn1r176 UTSW 7 23835626 missense probably damaging 1.00
R1531:Vmn1r176 UTSW 7 23835111 missense possibly damaging 0.95
R1680:Vmn1r176 UTSW 7 23835381 missense probably damaging 0.99
R1770:Vmn1r176 UTSW 7 23835521 missense probably benign 0.06
R1803:Vmn1r176 UTSW 7 23835184 missense probably damaging 1.00
R1970:Vmn1r176 UTSW 7 23834948 missense probably benign 0.01
R2092:Vmn1r176 UTSW 7 23835153 missense probably damaging 1.00
R3498:Vmn1r176 UTSW 7 23835242 missense probably benign 0.12
R4832:Vmn1r176 UTSW 7 23835038 missense possibly damaging 0.67
R5712:Vmn1r176 UTSW 7 23835500 missense probably benign 0.00
R6965:Vmn1r176 UTSW 7 23835674 missense possibly damaging 0.78
R7105:Vmn1r176 UTSW 7 23835323 nonsense probably null
R7839:Vmn1r176 UTSW 7 23834969 missense possibly damaging 0.91
R7922:Vmn1r176 UTSW 7 23834969 missense possibly damaging 0.91
Z1088:Vmn1r176 UTSW 7 23835173 missense probably benign
Posted On2013-06-21