Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01101:Scart2'

51537

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Scart2

Ensembl Gene

ENSMUSG00000054672

Gene Name

scavenger receptor family member expressed on T cells 2

Synonyms

5830411N06Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01101

Quality Score

Status

Chromosome

Chromosomal Location

139827197-139880649 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 139876017 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 543 (Q543L)

Ref Sequence

ENSEMBL: ENSMUSP00000131905 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000093984] [ENSMUST00000164583]

AlphaFold

B3F5L4

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000059882

SMART Domains

Protein: ENSMUSP00000061346
Gene: ENSMUSG00000054672

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
SR	29	130	1.49e-18	SMART
SR	137	233	2.53e-4	SMART
SR	238	336	1.65e-34	SMART
SR	340	440	4.53e-32	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000093984
AA Change: Q427L

PolyPhen 2 Score 0.349 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000091520
Gene: ENSMUSG00000054672
AA Change: Q427L

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
SR	29	130	1.49e-18	SMART
SR	137	233	2.53e-4	SMART
SR	238	336	1.65e-34	SMART
SR	340	440	4.53e-32	SMART
SR	446	546	8.78e-30	SMART
SR	551	651	1.26e-53	SMART
SR	656	756	2.88e-16	SMART
SR	783	883	7.62e-48	SMART
transmembrane domain	903	925	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000164583
AA Change: Q543L

PolyPhen 2 Score 0.349 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000131905
Gene: ENSMUSG00000054672
AA Change: Q543L

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
SR	29	130	1.49e-18	SMART
SR	137	233	2.53e-4	SMART
Blast:SR	291	349	5e-12	BLAST
SR	354	452	1.65e-34	SMART
SR	456	556	4.53e-32	SMART
SR	562	662	8.78e-30	SMART
SR	667	767	1.26e-53	SMART
SR	772	872	2.88e-16	SMART
SR	899	999	7.62e-48	SMART
transmembrane domain	1019	1041	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000210212

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000211749

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts20	T	A	15: 94,241,923 (GRCm39)	D695V	probably damaging	Het
Ahnak	T	C	19: 8,990,251 (GRCm39)		probably benign	Het
Akap4	T	A	X: 6,942,423 (GRCm39)	M242K	probably benign	Het
Cd207	T	C	6: 83,652,839 (GRCm39)	D97G	probably benign	Het
Cdc20	A	G	4: 118,292,749 (GRCm39)	V333A	possibly damaging	Het
Cdhr2	A	G	13: 54,865,948 (GRCm39)		probably benign	Het
Cfhr1	T	A	1: 139,481,322 (GRCm39)	Y186F	probably benign	Het
Cnbd1	T	A	4: 18,907,098 (GRCm39)	I159F	probably benign	Het
Cyp2j11	A	C	4: 96,227,332 (GRCm39)	M228R	probably benign	Het
Dach1	C	A	14: 98,077,640 (GRCm39)	S581I	possibly damaging	Het
Dbnl	A	G	11: 5,743,722 (GRCm39)	D71G	possibly damaging	Het
F8	T	A	X: 74,330,993 (GRCm39)	T966S	possibly damaging	Het
Filip1	T	A	9: 79,805,528 (GRCm39)	L75F	probably benign	Het
Foxi2	A	G	7: 135,013,736 (GRCm39)	Y322C	probably benign	Het
Ftsj3	A	G	11: 106,146,458 (GRCm39)	V7A	probably benign	Het
Gm8362	A	T	14: 18,145,196 (GRCm39)	S204T	probably benign	Het
Ibtk	C	A	9: 85,614,675 (GRCm39)		probably benign	Het
Marf1	C	T	16: 13,964,600 (GRCm39)	V267I	possibly damaging	Het
Mmp27	T	A	9: 7,573,416 (GRCm39)	D169E	probably damaging	Het
Or10ag53	C	A	2: 87,082,806 (GRCm39)	T175K	probably damaging	Het
Or4a74	C	T	2: 89,440,191 (GRCm39)	C85Y	probably benign	Het
Or4k1	A	T	14: 50,377,511 (GRCm39)	M195K	probably benign	Het
P4ha2	G	T	11: 54,010,131 (GRCm39)	C296F	probably damaging	Het
Slc38a5	T	C	X: 8,137,750 (GRCm39)		probably benign	Het
Sorbs2	G	T	8: 46,198,460 (GRCm39)	R36L	possibly damaging	Het
Tmem207	A	C	16: 26,336,627 (GRCm39)	Y42*	probably null	Het
Vmn2r115	G	A	17: 23,564,971 (GRCm39)	R286K	probably benign	Het

Other mutations in Scart2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00465:Scart2	APN	7	139,874,755 (GRCm39)	missense	probably damaging	0.99
IGL01120:Scart2	APN	7	139,876,472 (GRCm39)	missense	probably benign	0.02
IGL01958:Scart2	APN	7	139,854,040 (GRCm39)	missense	probably damaging	1.00
IGL02150:Scart2	APN	7	139,877,772 (GRCm39)	missense	possibly damaging	0.84
IGL02193:Scart2	APN	7	139,828,913 (GRCm39)	missense	probably benign	0.17
IGL02239:Scart2	APN	7	139,875,756 (GRCm39)	missense	probably damaging	1.00
IGL02335:Scart2	APN	7	139,876,453 (GRCm39)	missense	probably damaging	1.00
IGL02569:Scart2	APN	7	139,878,275 (GRCm39)	missense	probably benign	0.01
IGL02993:Scart2	APN	7	139,876,486 (GRCm39)	missense	probably benign	0.07
IGL03261:Scart2	APN	7	139,874,746 (GRCm39)	missense	probably benign	0.00
IGL03365:Scart2	APN	7	139,876,682 (GRCm39)	missense	probably damaging	1.00
IGL03399:Scart2	APN	7	139,827,869 (GRCm39)	missense	probably benign	0.00
IGL03052:Scart2	UTSW	7	139,828,827 (GRCm39)	missense	probably damaging	1.00
PIT4791001:Scart2	UTSW	7	139,853,975 (GRCm39)	missense	possibly damaging	0.53
R0021:Scart2	UTSW	7	139,876,310 (GRCm39)	missense	probably benign	0.15
R0021:Scart2	UTSW	7	139,876,310 (GRCm39)	missense	probably benign	0.15
R0347:Scart2	UTSW	7	139,877,767 (GRCm39)	missense	probably damaging	1.00
R0374:Scart2	UTSW	7	139,828,874 (GRCm39)	missense	probably damaging	1.00
R0639:Scart2	UTSW	7	139,827,872 (GRCm39)	missense	probably benign	0.01
R0667:Scart2	UTSW	7	139,841,450 (GRCm39)	missense	possibly damaging	0.73
R0789:Scart2	UTSW	7	139,828,133 (GRCm39)	missense	probably damaging	1.00
R0959:Scart2	UTSW	7	139,874,704 (GRCm39)	missense	probably damaging	1.00
R1316:Scart2	UTSW	7	139,879,583 (GRCm39)	missense	probably benign	0.09
R1764:Scart2	UTSW	7	139,877,178 (GRCm39)	missense	probably benign	0.00
R2247:Scart2	UTSW	7	139,829,042 (GRCm39)	missense	probably null	0.96
R2379:Scart2	UTSW	7	139,879,682 (GRCm39)	missense	probably benign	0.15
R4112:Scart2	UTSW	7	139,878,281 (GRCm39)	nonsense	probably null
R4114:Scart2	UTSW	7	139,877,823 (GRCm39)	missense	probably damaging	1.00
R4346:Scart2	UTSW	7	139,827,878 (GRCm39)	missense	probably damaging	0.97
R4836:Scart2	UTSW	7	139,879,021 (GRCm39)	missense	probably benign
R4956:Scart2	UTSW	7	139,878,275 (GRCm39)	missense	probably benign	0.00
R5208:Scart2	UTSW	7	139,877,949 (GRCm39)	missense	probably benign	0.00
R5571:Scart2	UTSW	7	139,829,036 (GRCm39)	missense	probably damaging	1.00
R5583:Scart2	UTSW	7	139,876,739 (GRCm39)	missense	probably damaging	1.00
R5645:Scart2	UTSW	7	139,828,853 (GRCm39)	missense	possibly damaging	0.95
R6183:Scart2	UTSW	7	139,875,947 (GRCm39)	missense	possibly damaging	0.82
R6995:Scart2	UTSW	7	139,841,514 (GRCm39)	missense	probably benign
R7436:Scart2	UTSW	7	139,841,520 (GRCm39)	missense	probably benign
R7621:Scart2	UTSW	7	139,876,742 (GRCm39)	missense	probably damaging	1.00
R7662:Scart2	UTSW	7	139,874,725 (GRCm39)	missense	possibly damaging	0.58
R7669:Scart2	UTSW	7	139,876,234 (GRCm39)	missense	possibly damaging	0.47
R7686:Scart2	UTSW	7	139,828,965 (GRCm39)	missense	probably benign	0.00
R7985:Scart2	UTSW	7	139,876,806 (GRCm39)	missense	probably damaging	1.00
R8330:Scart2	UTSW	7	139,876,231 (GRCm39)	nonsense	probably null
R8843:Scart2	UTSW	7	139,828,913 (GRCm39)	missense	possibly damaging	0.93
R8888:Scart2	UTSW	7	139,841,532 (GRCm39)	missense	possibly damaging	0.93
R8895:Scart2	UTSW	7	139,841,532 (GRCm39)	missense	possibly damaging	0.93
R9044:Scart2	UTSW	7	139,828,010 (GRCm39)	missense	probably damaging	1.00
R9142:Scart2	UTSW	7	139,877,806 (GRCm39)	missense	probably damaging	1.00
R9152:Scart2	UTSW	7	139,877,256 (GRCm39)	missense	possibly damaging	0.55
R9470:Scart2	UTSW	7	139,827,345 (GRCm39)	missense	probably benign	0.07
R9509:Scart2	UTSW	7	139,879,644 (GRCm39)	nonsense	probably null
R9522:Scart2	UTSW	7	139,853,987 (GRCm39)	missense	possibly damaging	0.73
R9755:Scart2	UTSW	7	139,841,544 (GRCm39)	critical splice donor site	probably null
R9794:Scart2	UTSW	7	139,874,716 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-06-21