Incidental Mutation 'IGL01101:Foxi2'
| ID |
51538 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Foxi2
|
| Ensembl Gene |
ENSMUSG00000048377 |
| Gene Name |
forkhead box I2 |
| Synonyms |
B130055A05Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
IGL01101
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
135012096-135015351 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 135013736 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 322
(Y322C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000053641
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000060356]
|
| AlphaFold |
Q3I5G5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000060356
AA Change: Y322C
PolyPhen 2
Score 0.071 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000053641
Gene: ENSMUSG00000048377
AA Change: Y322C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
64 |
82 |
N/A |
INTRINSIC |
|
low complexity region
|
87 |
108 |
N/A |
INTRINSIC |
|
FH
|
115 |
205 |
1.29e-58 |
SMART |
|
low complexity region
|
207 |
213 |
N/A |
INTRINSIC |
|
low complexity region
|
237 |
249 |
N/A |
INTRINSIC |
|
low complexity region
|
262 |
278 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele are viable and fertile with no gross abnormalities. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 27 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts20 |
T |
A |
15: 94,241,923 (GRCm39) |
D695V |
probably damaging |
Het |
| Ahnak |
T |
C |
19: 8,990,251 (GRCm39) |
|
probably benign |
Het |
| Akap4 |
T |
A |
X: 6,942,423 (GRCm39) |
M242K |
probably benign |
Het |
| Cd207 |
T |
C |
6: 83,652,839 (GRCm39) |
D97G |
probably benign |
Het |
| Cdc20 |
A |
G |
4: 118,292,749 (GRCm39) |
V333A |
possibly damaging |
Het |
| Cdhr2 |
A |
G |
13: 54,865,948 (GRCm39) |
|
probably benign |
Het |
| Cfhr1 |
T |
A |
1: 139,481,322 (GRCm39) |
Y186F |
probably benign |
Het |
| Cnbd1 |
T |
A |
4: 18,907,098 (GRCm39) |
I159F |
probably benign |
Het |
| Cyp2j11 |
A |
C |
4: 96,227,332 (GRCm39) |
M228R |
probably benign |
Het |
| Dach1 |
C |
A |
14: 98,077,640 (GRCm39) |
S581I |
possibly damaging |
Het |
| Dbnl |
A |
G |
11: 5,743,722 (GRCm39) |
D71G |
possibly damaging |
Het |
| F8 |
T |
A |
X: 74,330,993 (GRCm39) |
T966S |
possibly damaging |
Het |
| Filip1 |
T |
A |
9: 79,805,528 (GRCm39) |
L75F |
probably benign |
Het |
| Ftsj3 |
A |
G |
11: 106,146,458 (GRCm39) |
V7A |
probably benign |
Het |
| Gm8362 |
A |
T |
14: 18,145,196 (GRCm39) |
S204T |
probably benign |
Het |
| Ibtk |
C |
A |
9: 85,614,675 (GRCm39) |
|
probably benign |
Het |
| Marf1 |
C |
T |
16: 13,964,600 (GRCm39) |
V267I |
possibly damaging |
Het |
| Mmp27 |
T |
A |
9: 7,573,416 (GRCm39) |
D169E |
probably damaging |
Het |
| Or10ag53 |
C |
A |
2: 87,082,806 (GRCm39) |
T175K |
probably damaging |
Het |
| Or4a74 |
C |
T |
2: 89,440,191 (GRCm39) |
C85Y |
probably benign |
Het |
| Or4k1 |
A |
T |
14: 50,377,511 (GRCm39) |
M195K |
probably benign |
Het |
| P4ha2 |
G |
T |
11: 54,010,131 (GRCm39) |
C296F |
probably damaging |
Het |
| Scart2 |
A |
T |
7: 139,876,017 (GRCm39) |
Q543L |
probably benign |
Het |
| Slc38a5 |
T |
C |
X: 8,137,750 (GRCm39) |
|
probably benign |
Het |
| Sorbs2 |
G |
T |
8: 46,198,460 (GRCm39) |
R36L |
possibly damaging |
Het |
| Tmem207 |
A |
C |
16: 26,336,627 (GRCm39) |
Y42* |
probably null |
Het |
| Vmn2r115 |
G |
A |
17: 23,564,971 (GRCm39) |
R286K |
probably benign |
Het |
|
| Other mutations in Foxi2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02984:Foxi2
|
UTSW |
7 |
135,012,127 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0030:Foxi2
|
UTSW |
7 |
135,013,345 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0030:Foxi2
|
UTSW |
7 |
135,013,345 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0121:Foxi2
|
UTSW |
7 |
135,013,640 (GRCm39) |
missense |
probably benign |
|
|
R0830:Foxi2
|
UTSW |
7 |
135,013,459 (GRCm39) |
missense |
probably benign |
|
|
R2059:Foxi2
|
UTSW |
7 |
135,012,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3615:Foxi2
|
UTSW |
7 |
135,012,180 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R3616:Foxi2
|
UTSW |
7 |
135,012,180 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4021:Foxi2
|
UTSW |
7 |
135,012,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4764:Foxi2
|
UTSW |
7 |
135,012,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5048:Foxi2
|
UTSW |
7 |
135,013,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5257:Foxi2
|
UTSW |
7 |
135,012,256 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5258:Foxi2
|
UTSW |
7 |
135,012,256 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5561:Foxi2
|
UTSW |
7 |
135,013,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5611:Foxi2
|
UTSW |
7 |
135,013,433 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5667:Foxi2
|
UTSW |
7 |
135,012,668 (GRCm39) |
splice site |
probably null |
|
|
R7492:Foxi2
|
UTSW |
7 |
135,012,301 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8726:Foxi2
|
UTSW |
7 |
135,012,133 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9205:Foxi2
|
UTSW |
7 |
135,013,525 (GRCm39) |
missense |
probably benign |
|
|
R9644:Foxi2
|
UTSW |
7 |
135,013,727 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
Z1177:Foxi2
|
UTSW |
7 |
135,013,687 (GRCm39) |
missense |
probably benign |
0.32 |
|
Z1177:Foxi2
|
UTSW |
7 |
135,012,144 (GRCm39) |
missense |
probably benign |
0.40 |
|
| Posted On |
2013-06-21 |
Incidental Mutation