Incidental Mutation 'R6382:Or7a35'
ID 515380
Institutional Source Beutler Lab
Gene Symbol Or7a35
Ensembl Gene ENSMUSG00000063216
Gene Name olfactory receptor family 7 subfamily A member 35
Synonyms Olfr1351, GA_x6K02T2QGN0-2794907-2793948, MOR139-4
MMRRC Submission 044531-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.145) question?
Stock # R6382 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 78853158-78854117 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 78853351 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Tyrosine at position 65 (S65Y)
Ref Sequence ENSEMBL: ENSMUSP00000149241 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080730] [ENSMUST00000216030]
AlphaFold Q8VGU6
Predicted Effect probably damaging
Transcript: ENSMUST00000080730
AA Change: S65Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000079555
Gene: ENSMUSG00000063216
AA Change: S65Y

DomainStartEndE-ValueType
low complexity region 9 19 N/A INTRINSIC
Pfam:7tm_4 32 308 2e-49 PFAM
Pfam:7tm_1 42 291 1.9e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216030
AA Change: S65Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219714
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.5%
Validation Efficiency 100% (55/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abat T A 16: 8,418,850 (GRCm39) M148K probably benign Het
Aldoc T C 11: 78,216,568 (GRCm39) I242T probably benign Het
Camta2 T C 11: 70,562,867 (GRCm39) T927A probably damaging Het
Ccdc30 T C 4: 119,261,363 (GRCm39) R25G possibly damaging Het
Cdh16 T A 8: 105,348,175 (GRCm39) M181L possibly damaging Het
Clstn1 A T 4: 149,710,577 (GRCm39) probably null Het
Cnot6l C A 5: 96,276,858 (GRCm39) R110L probably damaging Het
Col7a1 G A 9: 108,804,461 (GRCm39) S2264N unknown Het
Cspp1 A G 1: 10,153,700 (GRCm39) probably null Het
Cul1 T A 6: 47,479,373 (GRCm39) L213Q probably damaging Het
Cuta T C 17: 27,157,428 (GRCm39) Q124R probably benign Het
Cyp1a1 T A 9: 57,607,973 (GRCm39) N200K probably damaging Het
Dag1 C A 9: 108,085,336 (GRCm39) A602S possibly damaging Het
Ftdc1 T C 16: 58,434,273 (GRCm39) E148G possibly damaging Het
Gm4707 G A 17: 71,766,238 (GRCm39) probably benign Het
Gpat2 G C 2: 127,273,838 (GRCm39) G294R possibly damaging Het
H2-T23 T C 17: 36,342,724 (GRCm39) Y138C probably damaging Het
Hnf4a A T 2: 163,410,926 (GRCm39) M408L probably benign Het
Hpse2 A G 19: 43,376,641 (GRCm39) L37P possibly damaging Het
Hsd17b6 A T 10: 127,827,196 (GRCm39) I292N probably damaging Het
Hsp90aa1 A T 12: 110,661,951 (GRCm39) probably null Het
Ifit1bl1 T A 19: 34,572,283 (GRCm39) Y58F probably benign Het
Igkv10-95 A G 6: 68,657,672 (GRCm39) T43A probably benign Het
Igkv6-17 C T 6: 70,348,814 (GRCm39) Q62* probably null Het
Jakmip2 A G 18: 43,704,244 (GRCm39) S367P possibly damaging Het
Lrrc40 A G 3: 157,764,333 (GRCm39) D416G probably damaging Het
Mdm2 A G 10: 117,528,626 (GRCm39) V177A probably benign Het
Mpp1 TGAGACGAACTCTCCGAG TGAG X: 74,169,375 (GRCm39) probably null Het
Myo1b C T 1: 51,813,466 (GRCm39) probably null Het
Notch2 A G 3: 98,048,859 (GRCm39) D1799G probably damaging Het
Obscn C T 11: 58,890,239 (GRCm39) G7431D unknown Het
Obscn A T 11: 58,933,034 (GRCm39) C4781S probably damaging Het
Or2a14 T A 6: 43,130,899 (GRCm39) I220N probably damaging Het
Pard3 T A 8: 128,103,264 (GRCm39) V411D probably damaging Het
Pfkl T C 10: 77,835,671 (GRCm39) R246G probably damaging Het
Pgs1 T C 11: 117,894,186 (GRCm39) Y238H probably damaging Het
Pik3c2g A G 6: 139,665,724 (GRCm39) E15G possibly damaging Het
Pja2 A G 17: 64,616,610 (GRCm39) V95A probably benign Het
Ripor2 T C 13: 24,861,828 (GRCm39) I207T possibly damaging Het
Rps15 A G 10: 80,129,820 (GRCm39) Y115C probably damaging Het
Shkbp1 C A 7: 27,051,484 (GRCm39) E192* probably null Het
Slc23a4 T A 6: 34,933,978 (GRCm39) M42L probably benign Het
Snx25 T A 8: 46,509,028 (GRCm39) S373C probably benign Het
Sppl2a A T 2: 126,758,949 (GRCm39) probably null Het
Tektl1 G A 10: 78,588,675 (GRCm39) T45I possibly damaging Het
Tpcn2 A G 7: 144,823,486 (GRCm39) S256P possibly damaging Het
Txk C T 5: 72,893,823 (GRCm39) probably benign Het
Ubr2 C G 17: 47,268,241 (GRCm39) W991S possibly damaging Het
Ufc1 A G 1: 171,122,248 (GRCm39) W28R probably damaging Het
Unc93b1 C A 19: 3,985,297 (GRCm39) A35E probably benign Het
Ush2a A G 1: 188,546,499 (GRCm39) N3425S probably benign Het
Vmn1r32 A G 6: 66,530,345 (GRCm39) Y144H probably benign Het
Vmn1r76 A G 7: 11,664,426 (GRCm39) F228L probably damaging Het
Zfc3h1 A G 10: 115,243,813 (GRCm39) N715D probably benign Het
Zfp933 T C 4: 147,910,325 (GRCm39) S424G probably benign Het
Other mutations in Or7a35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00913:Or7a35 APN 10 78,854,085 (GRCm39) missense probably benign 0.00
IGL01833:Or7a35 APN 10 78,853,770 (GRCm39) missense probably benign
IGL02141:Or7a35 APN 10 78,853,555 (GRCm39) missense probably damaging 1.00
IGL02178:Or7a35 APN 10 78,853,554 (GRCm39) missense possibly damaging 0.59
R1070:Or7a35 UTSW 10 78,853,684 (GRCm39) missense probably damaging 0.99
R1631:Or7a35 UTSW 10 78,853,239 (GRCm39) missense probably benign 0.00
R1646:Or7a35 UTSW 10 78,853,340 (GRCm39) nonsense probably null
R1781:Or7a35 UTSW 10 78,853,159 (GRCm39) start codon destroyed probably null 0.89
R2358:Or7a35 UTSW 10 78,854,022 (GRCm39) missense probably damaging 1.00
R3161:Or7a35 UTSW 10 78,853,438 (GRCm39) missense probably benign
R3162:Or7a35 UTSW 10 78,853,438 (GRCm39) missense probably benign
R3162:Or7a35 UTSW 10 78,853,438 (GRCm39) missense probably benign
R5874:Or7a35 UTSW 10 78,853,191 (GRCm39) missense possibly damaging 0.95
R7108:Or7a35 UTSW 10 78,853,483 (GRCm39) nonsense probably null
R7567:Or7a35 UTSW 10 78,853,379 (GRCm39) missense probably benign 0.04
R7568:Or7a35 UTSW 10 78,853,341 (GRCm39) missense probably benign
R7915:Or7a35 UTSW 10 78,853,264 (GRCm39) missense probably damaging 1.00
R7936:Or7a35 UTSW 10 78,853,872 (GRCm39) missense probably damaging 1.00
R9687:Or7a35 UTSW 10 78,853,843 (GRCm39) missense probably damaging 1.00
Z1176:Or7a35 UTSW 10 78,854,039 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCATAGGCGTGTCAAACAC -3'
(R):5'- TGACAGATGGCCACATAGTG -3'

Sequencing Primer
(F):5'- GGAAATGACACTCAGCTTTCAG -3'
(R):5'- TAGTGGTCATAGGCCATCACAGTC -3'
Posted On 2018-05-04