Incidental Mutation 'R6383:Zfp882'
ID 515445
Institutional Source Beutler Lab
Gene Symbol Zfp882
Ensembl Gene ENSMUSG00000089857
Gene Name zinc finger protein 882
Synonyms ENSMUSG00000052439
MMRRC Submission 044532-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R6383 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 71908608-71916354 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 71914640 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 437 (H437R)
Ref Sequence ENSEMBL: ENSMUSP00000105629 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110002] [ENSMUST00000125802] [ENSMUST00000126607] [ENSMUST00000131544]
AlphaFold E9Q4R4
Predicted Effect probably damaging
Transcript: ENSMUST00000110002
AA Change: H437R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000105629
Gene: ENSMUSG00000089857
AA Change: H437R

DomainStartEndE-ValueType
KRAB 4 61 8.58e-14 SMART
ZnF_C2H2 84 106 1.47e-3 SMART
ZnF_C2H2 168 190 8.47e-4 SMART
ZnF_C2H2 196 218 2.27e-4 SMART
ZnF_C2H2 224 246 6.31e1 SMART
ZnF_C2H2 251 273 1.16e-1 SMART
ZnF_C2H2 279 301 1.25e-1 SMART
ZnF_C2H2 307 329 5.42e-2 SMART
ZnF_C2H2 335 357 1.47e-3 SMART
ZnF_C2H2 363 385 7.26e-3 SMART
ZnF_C2H2 391 413 1.26e-2 SMART
ZnF_C2H2 419 441 3.29e1 SMART
ZnF_C2H2 447 469 2.67e-1 SMART
ZnF_C2H2 475 497 1.04e-3 SMART
ZnF_C2H2 503 525 4.11e-2 SMART
ZnF_C2H2 531 553 4.87e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000118290
Predicted Effect probably benign
Transcript: ENSMUST00000125802
SMART Domains Protein: ENSMUSP00000121316
Gene: ENSMUSG00000089857

DomainStartEndE-ValueType
KRAB 12 69 8.58e-14 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000126607
SMART Domains Protein: ENSMUSP00000119978
Gene: ENSMUSG00000089857

DomainStartEndE-ValueType
KRAB 44 101 8.58e-14 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000131544
SMART Domains Protein: ENSMUSP00000120213
Gene: ENSMUSG00000066880

DomainStartEndE-ValueType
KRAB 4 56 1.08e-10 SMART
ZnF_C2H2 167 189 8.47e-4 SMART
ZnF_C2H2 195 217 8.34e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000170898
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 97.9%
Validation Efficiency 97% (73/75)
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 A T 1: 71,247,184 (GRCm38) M2497K probably benign Het
Abtb2 C T 2: 103,567,376 (GRCm38) T217I probably damaging Het
Adam29 T A 8: 55,871,508 (GRCm38) N637I probably damaging Het
Adgb T A 10: 10,450,028 (GRCm38) E59V probably damaging Het
Adh7 C T 3: 138,228,017 (GRCm38) R312C probably benign Het
Adprh A G 16: 38,447,452 (GRCm38) I157T probably damaging Het
Ap2b1 T C 11: 83,346,825 (GRCm38) S572P probably damaging Het
Asic1 T C 15: 99,698,880 (GRCm38) L519P probably damaging Het
Atp2a2 G C 5: 122,501,649 (GRCm38) L13V probably benign Het
Bst2 A T 8: 71,537,288 (GRCm38) I47N possibly damaging Het
Cacng6 G A 7: 3,424,993 (GRCm38) probably null Het
Cenpe A G 3: 135,251,528 (GRCm38) E1849G probably damaging Het
Cep295 T A 9: 15,332,754 (GRCm38) T213S probably damaging Het
Chia1 A G 3: 106,131,811 (GRCm38) T406A probably benign Het
Chmp4c G T 3: 10,367,217 (GRCm38) K62N probably damaging Het
Cldn15 A G 5: 136,968,125 (GRCm38) T7A probably benign Het
Cmpk2 T A 12: 26,478,020 (GRCm38) M412K probably benign Het
Cnnm1 T C 19: 43,465,266 (GRCm38) probably null Het
Cubn A C 2: 13,427,835 (GRCm38) probably null Het
Dopey2 T C 16: 93,782,248 (GRCm38) V1668A possibly damaging Het
Erg28 T A 12: 85,816,429 (GRCm38) Y77F probably damaging Het
F830045P16Rik C T 2: 129,536,438 (GRCm38) A9T probably benign Het
Gli3 A G 13: 15,723,555 (GRCm38) D740G probably damaging Het
Gm13128 A T 4: 144,333,147 (GRCm38) *476L probably null Het
Gm14085 T C 2: 122,524,807 (GRCm38) I555T probably benign Het
Gpat2 G C 2: 127,431,918 (GRCm38) G294R possibly damaging Het
Gpat3 A T 5: 100,893,144 (GRCm38) M357L probably benign Het
Gpr179 A G 11: 97,337,147 (GRCm38) V1394A possibly damaging Het
Grn T A 11: 102,436,795 (GRCm38) probably benign Het
H2-Q6 G A 17: 35,428,383 (GRCm38) probably null Het
Igsf3 A G 3: 101,435,648 (GRCm38) T514A probably benign Het
Il1r1 A G 1: 40,313,335 (GRCm38) D558G possibly damaging Het
Irx4 T C 13: 73,267,713 (GRCm38) M207T possibly damaging Het
Kap T C 6: 133,851,957 (GRCm38) I54V probably benign Het
Kdm2b G A 5: 122,934,778 (GRCm38) R340C probably damaging Het
Lipo3 T A 19: 33,556,431 (GRCm38) M334L probably benign Het
Lmbrd1 C T 1: 24,706,034 (GRCm38) L152F probably damaging Het
Ltbp1 G A 17: 75,359,457 (GRCm38) V1382I probably damaging Het
Map3k4 C T 17: 12,249,583 (GRCm38) D1008N possibly damaging Het
Mcf2l T C 8: 12,879,912 (GRCm38) probably benign Het
Mecom T G 3: 29,997,726 (GRCm38) D180A probably damaging Het
Meis1 T C 11: 18,941,741 (GRCm38) D269G probably benign Het
Myh7 A C 14: 54,988,894 (GRCm38) S430A probably benign Het
Myo1h A G 5: 114,336,264 (GRCm38) I439V probably damaging Het
Nat1 T C 8: 67,491,482 (GRCm38) V170A possibly damaging Het
Nlrp12 A G 7: 3,234,043 (GRCm38) L742P probably damaging Het
Nlrp4c A G 7: 6,066,053 (GRCm38) T318A probably benign Het
Olfr1297 T A 2: 111,621,186 (GRCm38) N296I probably benign Het
Olfr1425 T A 19: 12,074,363 (GRCm38) I90F probably damaging Het
Olfr632 A G 7: 103,937,823 (GRCm38) I148V probably benign Het
Olfr952 G T 9: 39,426,234 (GRCm38) T279N probably damaging Het
Olfr955 A T 9: 39,470,630 (GRCm38) L32Q probably damaging Het
Otop3 A G 11: 115,345,072 (GRCm38) E529G probably damaging Het
Parp6 T C 9: 59,623,939 (GRCm38) Y35H probably damaging Het
Pcdhb4 A C 18: 37,308,021 (GRCm38) D128A probably damaging Het
Phldb2 C T 16: 45,748,750 (GRCm38) D1249N probably damaging Het
Ptpn12 T A 5: 20,987,468 (GRCm38) K765* probably null Het
Ptprb T A 10: 116,347,007 (GRCm38) Y1529* probably null Het
Ptprc A T 1: 138,078,451 (GRCm38) Y798N possibly damaging Het
Sdk2 G A 11: 113,832,265 (GRCm38) T1300I probably damaging Het
Sptbn2 G A 19: 4,732,496 (GRCm38) V487I possibly damaging Het
Sptbn5 A G 2: 120,046,269 (GRCm38) probably benign Het
Srpk1 A G 17: 28,590,062 (GRCm38) S648P probably damaging Het
Stard9 T C 2: 120,666,407 (GRCm38) probably null Het
Tmem135 A T 7: 89,144,670 (GRCm38) I388N probably damaging Het
Top3a A T 11: 60,749,459 (GRCm38) I446N probably benign Het
Trpv1 T C 11: 73,246,036 (GRCm38) S482P probably damaging Het
Ugt3a1 C T 15: 9,306,455 (GRCm38) A230V probably benign Het
Vmn2r15 A C 5: 109,293,226 (GRCm38) Y255* probably null Het
Vmn2r60 A G 7: 42,116,471 (GRCm38) M1V probably null Het
Vmn2r87 A G 10: 130,479,000 (GRCm38) V239A probably damaging Het
Vwce T A 19: 10,659,592 (GRCm38) C679* probably null Het
Zfp385b C T 2: 77,415,841 (GRCm38) A281T probably benign Het
Zfp398 T G 6: 47,866,595 (GRCm38) L395W probably damaging Het
Zfp442 C T 2: 150,451,401 (GRCm38) probably null Het
Zfp606 A G 7: 12,492,944 (GRCm38) S331G probably benign Het
Other mutations in Zfp882
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00676:Zfp882 APN 8 71,913,827 (GRCm38) missense probably benign
R0244:Zfp882 UTSW 8 71,913,523 (GRCm38) missense possibly damaging 0.79
R0270:Zfp882 UTSW 8 71,914,615 (GRCm38) missense probably benign 0.05
R0636:Zfp882 UTSW 8 71,914,337 (GRCm38) missense probably benign 0.01
R0840:Zfp882 UTSW 8 71,914,686 (GRCm38) nonsense probably null
R1299:Zfp882 UTSW 8 71,913,473 (GRCm38) missense probably damaging 1.00
R4439:Zfp882 UTSW 8 71,913,609 (GRCm38) missense probably damaging 0.97
R4829:Zfp882 UTSW 8 71,914,389 (GRCm38) missense probably damaging 1.00
R5028:Zfp882 UTSW 8 71,914,654 (GRCm38) missense possibly damaging 0.70
R5296:Zfp882 UTSW 8 71,914,360 (GRCm38) missense probably damaging 1.00
R5882:Zfp882 UTSW 8 71,913,459 (GRCm38) critical splice acceptor site probably null
R5974:Zfp882 UTSW 8 71,913,155 (GRCm38) missense probably damaging 1.00
R6052:Zfp882 UTSW 8 71,914,505 (GRCm38) missense probably benign 0.01
R6888:Zfp882 UTSW 8 71,914,286 (GRCm38) missense probably benign 0.01
R6987:Zfp882 UTSW 8 71,914,673 (GRCm38) missense probably benign 0.01
R7045:Zfp882 UTSW 8 71,913,249 (GRCm38) critical splice donor site probably null
R7780:Zfp882 UTSW 8 71,914,229 (GRCm38) missense possibly damaging 0.89
R7793:Zfp882 UTSW 8 71,913,141 (GRCm38) missense probably damaging 1.00
R8386:Zfp882 UTSW 8 71,914,118 (GRCm38) missense probably benign 0.00
R9452:Zfp882 UTSW 8 71,914,987 (GRCm38) missense probably damaging 1.00
R9694:Zfp882 UTSW 8 71,914,071 (GRCm38) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TTTGAGGAAGGTTGAAAGTCATGA -3'
(R):5'- GGCTTACACACAGTGCACTT -3'

Sequencing Primer
(F):5'- TGGGAAAGCCTTCATGCATC -3'
(R):5'- GGAACCATGAGTACTGTAGGATTTCC -3'
Posted On 2018-05-04