Incidental Mutation 'R6384:Pdcl2'
ID 515495
Institutional Source Beutler Lab
Gene Symbol Pdcl2
Ensembl Gene ENSMUSG00000029235
Gene Name phosducin-like 2
Synonyms 1700016K07Rik, 1700010B22Rik, Mgcphlp
MMRRC Submission 044533-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.105) question?
Stock # R6384 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 76459963-76479003 bp(-) (GRCm39)
Type of Mutation splice site (5 bp from exon)
DNA Base Change (assembly) C to T at 76478855 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000113699 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031145] [ENSMUST00000031146] [ENSMUST00000122213]
AlphaFold Q78Y63
Predicted Effect probably null
Transcript: ENSMUST00000031145
SMART Domains Protein: ENSMUSP00000031145
Gene: ENSMUSG00000029235

DomainStartEndE-ValueType
Pfam:Phosducin 8 208 3.8e-20 PFAM
low complexity region 229 236 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000031146
SMART Domains Protein: ENSMUSP00000031146
Gene: ENSMUSG00000029236

DomainStartEndE-ValueType
signal peptide 1 40 N/A INTRINSIC
low complexity region 45 56 N/A INTRINSIC
low complexity region 121 137 N/A INTRINSIC
Pfam:NMU 144 166 1.2e-15 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000122213
SMART Domains Protein: ENSMUSP00000113699
Gene: ENSMUSG00000029235

DomainStartEndE-ValueType
Pfam:Phosducin 1 178 2.3e-19 PFAM
low complexity region 181 188 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132154
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad10 T A 5: 121,790,066 (GRCm39) T97S probably benign Het
Adam34 T A 8: 44,103,836 (GRCm39) D603V probably benign Het
Adamts5 C T 16: 85,659,716 (GRCm39) V859I probably benign Het
Alb T A 5: 90,620,499 (GRCm39) D536E possibly damaging Het
Amz2 A G 11: 109,319,860 (GRCm39) Y82C probably damaging Het
Asxl1 T C 2: 153,233,744 (GRCm39) probably null Het
Bach1 C T 16: 87,516,745 (GRCm39) Q429* probably null Het
Bcl6 A G 16: 23,793,615 (GRCm39) Y111H probably damaging Het
Ccnj T C 19: 40,834,451 (GRCm39) V338A probably benign Het
Cdca3 C T 6: 124,809,382 (GRCm39) P174L probably damaging Het
Cdk17 T C 10: 93,047,827 (GRCm39) L25P probably damaging Het
Cdr2 G A 7: 120,581,351 (GRCm39) probably null Het
Cyp2c38 A T 19: 39,380,737 (GRCm39) probably null Het
Ednra T C 8: 78,415,723 (GRCm39) N175D probably damaging Het
Elp3 T C 14: 65,797,660 (GRCm39) Y337C probably damaging Het
Eml2 G A 7: 18,935,088 (GRCm39) V432I probably damaging Het
Eps15l1 A T 8: 73,122,554 (GRCm39) probably null Het
F11r A G 1: 171,288,508 (GRCm39) N117S probably benign Het
Foxp2 C T 6: 15,437,947 (GRCm39) T716I probably damaging Het
Gnaq A G 19: 16,293,377 (GRCm39) probably null Het
Gpat2 G C 2: 127,273,838 (GRCm39) G294R possibly damaging Het
Gpr158 T C 2: 21,831,099 (GRCm39) M733T probably damaging Het
Hdac7 G A 15: 97,709,387 (GRCm39) Q48* probably null Het
Hmga2 G A 10: 120,206,612 (GRCm39) probably benign Het
Itgb7 A G 15: 102,132,886 (GRCm39) V142A probably benign Het
Kif5a T C 10: 127,078,644 (GRCm39) N334D probably damaging Het
Lrrc47 T C 4: 154,100,317 (GRCm39) S298P probably benign Het
Map3k1 A T 13: 111,887,064 (GRCm39) S1415R probably damaging Het
Mdn1 T A 4: 32,670,607 (GRCm39) L424Q probably damaging Het
Numb A C 12: 83,850,748 (GRCm39) L154R probably damaging Het
Or8g27 T C 9: 39,129,274 (GRCm39) V207A probably benign Het
Or8k30 A G 2: 86,339,381 (GRCm39) K193E probably benign Het
Pdcd5 G T 7: 35,346,334 (GRCm39) A92E possibly damaging Het
Rbfa T C 18: 80,235,996 (GRCm39) Y251C probably damaging Het
Rgsl1 G A 1: 153,703,291 (GRCm39) T120I possibly damaging Het
Serpina3g A G 12: 104,206,655 (GRCm39) Q152R probably null Het
Setx T C 2: 29,063,570 (GRCm39) S2289P probably damaging Het
Slc6a16 A G 7: 44,907,017 (GRCm39) probably null Het
Slco1a6 C T 6: 142,055,105 (GRCm39) D280N probably benign Het
Syde2 T A 3: 145,704,568 (GRCm39) Y240N probably damaging Het
Synpo2 G A 3: 122,906,698 (GRCm39) Q873* probably null Het
Tlr2 A G 3: 83,744,301 (GRCm39) V594A probably benign Het
Ttc16 C T 2: 32,657,561 (GRCm39) A512T probably damaging Het
Tubb5 T C 17: 36,148,938 (GRCm39) E3G probably damaging Het
Vmn2r112 T C 17: 22,824,136 (GRCm39) Y464H probably damaging Het
Xcr1 T A 9: 123,684,847 (GRCm39) H305L probably damaging Het
Yars1 T G 4: 129,090,771 (GRCm39) probably null Het
Other mutations in Pdcl2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00509:Pdcl2 APN 5 76,472,959 (GRCm39) missense probably damaging 1.00
IGL00796:Pdcl2 APN 5 76,467,022 (GRCm39) missense probably damaging 0.99
IGL02310:Pdcl2 APN 5 76,465,728 (GRCm39) missense probably damaging 1.00
IGL02332:Pdcl2 APN 5 76,466,982 (GRCm39) nonsense probably null
IGL02562:Pdcl2 APN 5 76,467,038 (GRCm39) missense probably damaging 1.00
R0288:Pdcl2 UTSW 5 76,460,344 (GRCm39) missense possibly damaging 0.80
R0606:Pdcl2 UTSW 5 76,460,328 (GRCm39) missense probably benign
R2070:Pdcl2 UTSW 5 76,472,838 (GRCm39) critical splice donor site probably null
R7055:Pdcl2 UTSW 5 76,465,771 (GRCm39) missense probably benign 0.00
R7414:Pdcl2 UTSW 5 76,460,359 (GRCm39) missense possibly damaging 0.74
R7638:Pdcl2 UTSW 5 76,465,675 (GRCm39) missense probably damaging 1.00
R7688:Pdcl2 UTSW 5 76,465,770 (GRCm39) missense probably benign 0.44
R7718:Pdcl2 UTSW 5 76,465,846 (GRCm39) missense probably damaging 1.00
R7766:Pdcl2 UTSW 5 76,465,743 (GRCm39) missense probably benign 0.00
R8798:Pdcl2 UTSW 5 76,472,947 (GRCm39) missense probably damaging 1.00
R8945:Pdcl2 UTSW 5 76,465,675 (GRCm39) missense probably damaging 1.00
Z1177:Pdcl2 UTSW 5 76,465,779 (GRCm39) missense possibly damaging 0.87
Predicted Primers PCR Primer
(F):5'- GGCGATACTGAACCACTAAGTG -3'
(R):5'- TTGCCTGGCAACTGAGCTAC -3'

Sequencing Primer
(F):5'- CTTTCAGCTTCACATGAGACTCAAG -3'
(R):5'- ACTGAGCTACCGTTGCACATG -3'
Posted On 2018-05-04