Incidental Mutation 'R6386:Fstl5'
ID 515595
Institutional Source Beutler Lab
Gene Symbol Fstl5
Ensembl Gene ENSMUSG00000034098
Gene Name follistatin-like 5
Synonyms 9130207J01Rik
MMRRC Submission 044535-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R6386 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 75981582-76617317 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 76229373 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 58 (H58L)
Ref Sequence ENSEMBL: ENSMUSP00000125393 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038364] [ENSMUST00000160261]
AlphaFold Q8BFR2
Predicted Effect probably benign
Transcript: ENSMUST00000038364
AA Change: H58L

PolyPhen 2 Score 0.130 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000038506
Gene: ENSMUSG00000034098
AA Change: H58L

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
KAZAL 88 133 2.16e-9 SMART
IGc2 261 328 1.11e-5 SMART
IGc2 353 420 3.85e-14 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000159686
Predicted Effect probably benign
Transcript: ENSMUST00000160261
AA Change: H58L

PolyPhen 2 Score 0.130 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000125393
Gene: ENSMUSG00000034098
AA Change: H58L

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
KAZAL 88 133 2.16e-9 SMART
IGc2 261 328 1.11e-5 SMART
IGc2 353 420 3.85e-14 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.1%
  • 20x: 96.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ak6 TGACGA TGA 13: 100,792,311 (GRCm39) probably benign Het
Arap2 A T 5: 62,761,865 (GRCm39) N1620K possibly damaging Het
Atf6b T C 17: 34,870,825 (GRCm39) S396P probably damaging Het
Cc2d1a A G 8: 84,865,166 (GRCm39) M469T probably damaging Het
Ceacam3 A G 7: 16,892,144 (GRCm39) N296D probably benign Het
Cep57l1 A T 10: 41,619,128 (GRCm39) S80T probably damaging Het
Clip4 C A 17: 72,141,189 (GRCm39) Y514* probably null Het
Cop1 T C 1: 159,116,601 (GRCm39) I125T probably damaging Het
Cstf1 T C 2: 172,219,816 (GRCm39) V309A probably damaging Het
Cyp4a29 T G 4: 115,104,272 (GRCm39) probably null Het
F830045P16Rik G A 2: 129,314,738 (GRCm39) H180Y probably damaging Het
Foxp4 T C 17: 48,189,387 (GRCm39) K237E unknown Het
Gje1 A G 10: 14,592,365 (GRCm39) F139S probably damaging Het
Gpatch1 T C 7: 34,991,265 (GRCm39) D593G probably damaging Het
Inpp5d T A 1: 87,627,397 (GRCm39) L566Q probably damaging Het
Mtch2 A G 2: 90,679,739 (GRCm39) T38A probably benign Het
Mvb12b A T 2: 33,717,754 (GRCm39) I129N probably damaging Het
Npffr2 T C 5: 89,730,556 (GRCm39) V162A probably benign Het
Or4d10b A T 19: 12,036,920 (GRCm39) N65K probably damaging Het
Or5p61 A T 7: 107,758,409 (GRCm39) Y224N probably damaging Het
Pkhd1 G A 1: 20,621,244 (GRCm39) R805C probably damaging Het
Ppp4r4 T C 12: 103,559,364 (GRCm39) L406P probably damaging Het
Prl3d2 A G 13: 27,311,286 (GRCm39) D186G probably damaging Het
Rfc5 T C 5: 117,523,463 (GRCm39) T112A probably benign Het
Rnf148 A G 6: 23,654,483 (GRCm39) L171P probably damaging Het
Rps24 G A 14: 24,542,116 (GRCm39) G71S possibly damaging Het
Slco2a1 G A 9: 102,954,187 (GRCm39) V453I probably benign Het
Spidr T C 16: 15,786,424 (GRCm39) K440E probably benign Het
Syndig1 C A 2: 149,741,496 (GRCm39) N27K probably damaging Het
Tmem62 C T 2: 120,829,595 (GRCm39) T316I probably benign Het
Tpgs2 A T 18: 25,272,081 (GRCm39) I258N possibly damaging Het
Vmn2r78 A T 7: 86,571,545 (GRCm39) R452* probably null Het
Wasf3 A T 5: 146,390,227 (GRCm39) I124F possibly damaging Het
Wbp11 T C 6: 136,797,523 (GRCm39) T299A probably benign Het
Wdr25 T C 12: 108,990,991 (GRCm39) S41P probably damaging Het
Zfp874b T C 13: 67,622,962 (GRCm39) D116G possibly damaging Het
Other mutations in Fstl5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01632:Fstl5 APN 3 76,615,135 (GRCm39) missense probably benign 0.30
IGL01658:Fstl5 APN 3 76,389,562 (GRCm39) missense possibly damaging 0.70
IGL01917:Fstl5 APN 3 76,615,153 (GRCm39) missense probably damaging 1.00
IGL02073:Fstl5 APN 3 76,566,959 (GRCm39) splice site probably benign
IGL02329:Fstl5 APN 3 76,496,302 (GRCm39) missense probably damaging 1.00
IGL02651:Fstl5 APN 3 76,500,841 (GRCm39) missense probably damaging 1.00
IGL02967:Fstl5 APN 3 76,229,498 (GRCm39) missense probably damaging 1.00
IGL03004:Fstl5 APN 3 76,555,738 (GRCm39) splice site probably benign
IGL03107:Fstl5 APN 3 76,443,618 (GRCm39) missense probably damaging 1.00
IGL03113:Fstl5 APN 3 76,337,099 (GRCm39) nonsense probably null
P0038:Fstl5 UTSW 3 76,052,369 (GRCm39) missense probably damaging 1.00
PIT4131001:Fstl5 UTSW 3 76,567,006 (GRCm39) missense probably damaging 0.99
R0015:Fstl5 UTSW 3 76,229,498 (GRCm39) missense probably damaging 1.00
R0015:Fstl5 UTSW 3 76,229,498 (GRCm39) missense probably damaging 1.00
R0032:Fstl5 UTSW 3 76,555,742 (GRCm39) splice site probably benign
R0032:Fstl5 UTSW 3 76,555,742 (GRCm39) splice site probably benign
R0078:Fstl5 UTSW 3 76,566,952 (GRCm39) splice site probably benign
R0137:Fstl5 UTSW 3 76,614,786 (GRCm39) missense probably damaging 1.00
R0183:Fstl5 UTSW 3 76,229,579 (GRCm39) missense possibly damaging 0.86
R0330:Fstl5 UTSW 3 76,615,060 (GRCm39) missense possibly damaging 0.80
R0427:Fstl5 UTSW 3 76,615,034 (GRCm39) nonsense probably null
R0687:Fstl5 UTSW 3 76,615,119 (GRCm39) missense possibly damaging 0.62
R1642:Fstl5 UTSW 3 76,317,929 (GRCm39) missense possibly damaging 0.80
R1765:Fstl5 UTSW 3 76,500,783 (GRCm39) missense possibly damaging 0.90
R1900:Fstl5 UTSW 3 76,615,467 (GRCm39) missense probably damaging 1.00
R1996:Fstl5 UTSW 3 76,615,141 (GRCm39) missense probably benign 0.19
R2157:Fstl5 UTSW 3 76,615,372 (GRCm39) missense possibly damaging 0.46
R2228:Fstl5 UTSW 3 76,389,659 (GRCm39) missense probably damaging 1.00
R2851:Fstl5 UTSW 3 76,337,045 (GRCm39) splice site probably benign
R4021:Fstl5 UTSW 3 76,536,282 (GRCm39) missense probably benign 0.00
R4086:Fstl5 UTSW 3 76,555,593 (GRCm39) missense probably damaging 1.00
R4777:Fstl5 UTSW 3 76,500,807 (GRCm39) missense probably damaging 1.00
R4829:Fstl5 UTSW 3 76,229,489 (GRCm39) missense probably damaging 1.00
R4934:Fstl5 UTSW 3 76,496,272 (GRCm39) missense probably damaging 1.00
R4955:Fstl5 UTSW 3 76,131,183 (GRCm39) critical splice donor site probably null
R4977:Fstl5 UTSW 3 76,317,801 (GRCm39) nonsense probably null
R5166:Fstl5 UTSW 3 76,536,267 (GRCm39) missense possibly damaging 0.86
R5232:Fstl5 UTSW 3 76,052,284 (GRCm39) missense possibly damaging 0.89
R5313:Fstl5 UTSW 3 76,500,812 (GRCm39) missense possibly damaging 0.90
R5584:Fstl5 UTSW 3 76,229,574 (GRCm39) missense probably damaging 1.00
R5647:Fstl5 UTSW 3 76,496,399 (GRCm39) missense probably damaging 1.00
R5842:Fstl5 UTSW 3 76,229,590 (GRCm39) missense possibly damaging 0.94
R5978:Fstl5 UTSW 3 76,052,392 (GRCm39) missense probably damaging 1.00
R6007:Fstl5 UTSW 3 76,317,899 (GRCm39) missense probably damaging 1.00
R6064:Fstl5 UTSW 3 76,229,605 (GRCm39) missense probably benign 0.13
R6327:Fstl5 UTSW 3 76,615,108 (GRCm39) missense probably benign 0.31
R6523:Fstl5 UTSW 3 76,443,641 (GRCm39) missense probably benign 0.00
R6852:Fstl5 UTSW 3 76,615,162 (GRCm39) missense probably damaging 1.00
R6861:Fstl5 UTSW 3 76,229,523 (GRCm39) missense probably damaging 1.00
R6866:Fstl5 UTSW 3 76,229,532 (GRCm39) missense probably damaging 0.99
R7100:Fstl5 UTSW 3 76,443,600 (GRCm39) missense probably benign 0.11
R7341:Fstl5 UTSW 3 76,389,704 (GRCm39) splice site probably null
R7495:Fstl5 UTSW 3 76,615,099 (GRCm39) missense possibly damaging 0.85
R7558:Fstl5 UTSW 3 76,337,092 (GRCm39) missense possibly damaging 0.95
R7731:Fstl5 UTSW 3 76,569,069 (GRCm39) missense probably damaging 1.00
R7787:Fstl5 UTSW 3 76,337,131 (GRCm39) missense probably damaging 1.00
R7852:Fstl5 UTSW 3 76,615,275 (GRCm39) missense probably benign 0.00
R7874:Fstl5 UTSW 3 76,569,093 (GRCm39) missense probably benign 0.10
R7881:Fstl5 UTSW 3 76,443,605 (GRCm39) missense probably damaging 1.00
R7986:Fstl5 UTSW 3 76,337,097 (GRCm39) missense probably damaging 0.98
R8039:Fstl5 UTSW 3 76,555,725 (GRCm39) missense possibly damaging 0.69
R8050:Fstl5 UTSW 3 76,614,810 (GRCm39) missense probably benign 0.00
R8844:Fstl5 UTSW 3 76,337,154 (GRCm39) missense possibly damaging 0.71
R8929:Fstl5 UTSW 3 76,615,138 (GRCm39) missense probably damaging 0.98
R9012:Fstl5 UTSW 3 76,567,027 (GRCm39) missense probably damaging 1.00
R9069:Fstl5 UTSW 3 76,615,416 (GRCm39) missense probably damaging 0.99
R9221:Fstl5 UTSW 3 76,569,114 (GRCm39) missense probably damaging 0.98
R9373:Fstl5 UTSW 3 76,555,669 (GRCm39) nonsense probably null
R9427:Fstl5 UTSW 3 76,229,583 (GRCm39) missense
R9490:Fstl5 UTSW 3 76,615,060 (GRCm39) missense possibly damaging 0.80
R9603:Fstl5 UTSW 3 76,496,260 (GRCm39) missense probably damaging 1.00
Z1176:Fstl5 UTSW 3 76,615,289 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCGGTATGCTTCCTCTGAGG -3'
(R):5'- GCAGTCTTCATTGTGAACGATGG -3'

Sequencing Primer
(F):5'- CCTCTGAGGGTTTTGTGCCAAG -3'
(R):5'- TTAAGACAGGCAGCTCTGTGC -3'
Posted On 2018-05-04