Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01109:Zfp324'

51560

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp324

Ensembl Gene

ENSMUSG00000004500

Gene Name

zinc finger protein 324

Synonyms

D430030K24Rik, ZF5128

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL01109

Quality Score

Status

Chromosome

Chromosomal Location

12699765-12707749 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 12703362 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 95 (T95A)

Ref Sequence

ENSEMBL: ENSMUSP00000041944 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038701] [ENSMUST00000124387] [ENSMUST00000128293] [ENSMUST00000210619]

AlphaFold

Q78F42

Predicted Effect

probably benign
Transcript: ENSMUST00000038701
AA Change: T95A

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)

SMART Domains

Protein: ENSMUSP00000041944
Gene: ENSMUSG00000004500
AA Change: T95A

Domain	Start	End	E-Value	Type
KRAB	31	91	8.89e-30	SMART
ZnF_C2H2	291	313	2.95e-3	SMART
ZnF_C2H2	319	341	1.82e-3	SMART
ZnF_C2H2	347	369	6.88e-4	SMART
ZnF_C2H2	375	397	1.95e-3	SMART
ZnF_C2H2	403	425	2.71e-2	SMART
ZnF_C2H2	431	453	2.95e-3	SMART
ZnF_C2H2	459	481	2.75e-3	SMART
ZnF_C2H2	487	509	1.25e-1	SMART
ZnF_C2H2	515	537	7.37e-4	SMART
low complexity region	564	579	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000124387

Predicted Effect

probably benign
Transcript: ENSMUST00000128293

SMART Domains

Protein: ENSMUSP00000124620
Gene: ENSMUSG00000004500

Domain	Start	End	E-Value	Type
KRAB	31	75	3.83e-11	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000210619

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alpk2	T	C	18: 65,440,211 (GRCm39)	D861G	probably benign	Het
Anapc4	A	G	5: 53,005,970 (GRCm39)	T326A	probably damaging	Het
Atm	T	C	9: 53,401,593 (GRCm39)	I1425M	probably damaging	Het
Bend5	T	C	4: 111,305,838 (GRCm39)	L294P	probably damaging	Het
Casp7	T	A	19: 56,425,177 (GRCm39)	D193E	probably benign	Het
Cdc16	T	C	8: 13,814,606 (GRCm39)	V130A	probably benign	Het
Chl1	T	G	6: 103,692,354 (GRCm39)	Y331D	probably damaging	Het
Cntn1	C	A	15: 92,237,458 (GRCm39)	Y1017*	probably null	Het
Cyb5d1	C	A	11: 69,284,610 (GRCm39)		probably null	Het
Cyp2c38	A	G	19: 39,451,329 (GRCm39)		probably null	Het
Dzip3	T	C	16: 48,750,037 (GRCm39)	M827V	probably benign	Het
Ehd1	T	A	19: 6,348,177 (GRCm39)	M385K	possibly damaging	Het
Eya3	C	A	4: 132,420,311 (GRCm39)	Y52*	probably null	Het
Itsn1	C	T	16: 91,603,089 (GRCm39)		probably benign	Het
Ktn1	A	T	14: 47,952,178 (GRCm39)	N983I	probably damaging	Het
Lrrk2	T	A	15: 91,623,035 (GRCm39)	N1068K	probably damaging	Het
Mup6	T	A	4: 60,006,001 (GRCm39)	N156K	probably damaging	Het
Nedd9	T	A	13: 41,469,710 (GRCm39)	H481L	probably benign	Het
Obscn	T	C	11: 59,024,588 (GRCm39)	D484G	probably damaging	Het
Ogdh	T	C	11: 6,298,790 (GRCm39)	V674A	probably damaging	Het
Or4a27	T	C	2: 88,559,409 (GRCm39)	D178G	probably damaging	Het
Or4f54	G	A	2: 111,122,864 (GRCm39)	D84N	probably benign	Het
Or5b113	A	G	19: 13,342,063 (GRCm39)	I24V	probably benign	Het
Or5d38	T	C	2: 87,955,023 (GRCm39)	Q102R	probably damaging	Het
Or8g53	T	C	9: 39,683,293 (GRCm39)	M268V	probably benign	Het
Or8k32	T	A	2: 86,368,674 (GRCm39)	D195V	probably benign	Het
Osbpl6	A	G	2: 76,379,871 (GRCm39)	T154A	probably damaging	Het
P2rx1	T	C	11: 72,899,041 (GRCm39)	V84A	probably damaging	Het
Pcdh11x	G	A	X: 119,310,611 (GRCm39)	V685I	possibly damaging	Het
Ppp4r3b	T	A	11: 29,138,288 (GRCm39)	V212E	probably damaging	Het
Prune2	A	G	19: 17,101,243 (GRCm39)	D2249G	probably benign	Het
Slc5a8	T	A	10: 88,742,254 (GRCm39)	S317T	possibly damaging	Het
Ssc5d	T	A	7: 4,940,111 (GRCm39)	L822*	probably null	Het
Swt1	A	G	1: 151,286,890 (GRCm39)	S201P	probably damaging	Het
Tet1	T	A	10: 62,715,553 (GRCm39)	M81L	probably benign	Het
Tex9	T	A	9: 72,395,349 (GRCm39)	N39I	probably damaging	Het
Ttc4	T	C	4: 106,520,360 (GRCm39)	Y378C	probably damaging	Het
Ubap2	T	C	4: 41,195,155 (GRCm39)	N1131S	probably damaging	Het
Ugt2b35	C	T	5: 87,156,165 (GRCm39)	T419I	probably damaging	Het
Ugt3a1	T	G	15: 9,367,354 (GRCm39)	F366V	probably damaging	Het

Other mutations in Zfp324

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01943:Zfp324	APN	7	12,702,713 (GRCm39)	splice site	probably benign
IGL02668:Zfp324	APN	7	12,704,773 (GRCm39)	missense	probably damaging	1.00
R0883:Zfp324	UTSW	7	12,704,951 (GRCm39)	missense	probably damaging	1.00
R0931:Zfp324	UTSW	7	12,700,185 (GRCm39)	missense	probably benign	0.05
R1164:Zfp324	UTSW	7	12,705,551 (GRCm39)	missense	probably benign	0.02
R1587:Zfp324	UTSW	7	12,704,570 (GRCm39)	missense	possibly damaging	0.63
R1837:Zfp324	UTSW	7	12,704,156 (GRCm39)	missense	probably benign	0.15
R1982:Zfp324	UTSW	7	12,705,145 (GRCm39)	missense	probably damaging	1.00
R2333:Zfp324	UTSW	7	12,705,172 (GRCm39)	missense	possibly damaging	0.93
R3155:Zfp324	UTSW	7	12,702,817 (GRCm39)	missense	probably damaging	1.00
R4050:Zfp324	UTSW	7	12,704,794 (GRCm39)	missense	probably damaging	1.00
R4784:Zfp324	UTSW	7	12,705,233 (GRCm39)	missense	probably damaging	1.00
R4992:Zfp324	UTSW	7	12,703,300 (GRCm39)	missense	probably benign	0.02
R5970:Zfp324	UTSW	7	12,703,293 (GRCm39)	missense	probably benign	0.28
R6767:Zfp324	UTSW	7	12,704,527 (GRCm39)	missense	probably null	0.13
R7007:Zfp324	UTSW	7	12,705,142 (GRCm39)	missense	probably damaging	1.00
R7152:Zfp324	UTSW	7	12,700,198 (GRCm39)	missense	probably benign	0.07
R7164:Zfp324	UTSW	7	12,702,810 (GRCm39)	missense	probably damaging	0.97
R7233:Zfp324	UTSW	7	12,704,524 (GRCm39)	nonsense	probably null
R9039:Zfp324	UTSW	7	12,705,455 (GRCm39)	missense	probably benign	0.19
R9172:Zfp324	UTSW	7	12,704,689 (GRCm39)	missense	probably damaging	1.00
X0062:Zfp324	UTSW	7	12,705,316 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-06-21