Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01111:Zfp976'

51564

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp976

Ensembl Gene

ENSMUSG00000074158

Gene Name

zinc finger protein 976

Synonyms

9830147E19Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.102) question?

Stock #

IGL01111

Quality Score

Status

Chromosome

Chromosomal Location

42609526-42642588 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 42616287 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Glutamic Acid at position 25 (K25E)

Ref Sequence

ENSEMBL: ENSMUSP00000141023 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098503] [ENSMUST00000187616]

AlphaFold

E9Q981

Predicted Effect

possibly damaging
Transcript: ENSMUST00000098503
AA Change: K26E

PolyPhen 2 Score 0.955 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000096105
Gene: ENSMUSG00000074158
AA Change: K26E

Domain	Start	End	E-Value	Type
KRAB	4	66	1.73e-18	SMART
ZnF_C2H2	131	153	7.78e-3	SMART
ZnF_C2H2	159	181	1.67e-2	SMART
ZnF_C2H2	187	209	5.9e-3	SMART
ZnF_C2H2	215	237	1.38e-3	SMART
ZnF_C2H2	243	265	8.94e-3	SMART
ZnF_C2H2	271	293	2.24e-3	SMART
ZnF_C2H2	299	321	1.03e-2	SMART
ZnF_C2H2	327	349	1.58e-3	SMART
ZnF_C2H2	355	377	7.9e-4	SMART
ZnF_C2H2	383	405	5.9e-3	SMART
ZnF_C2H2	411	433	2.57e-3	SMART
ZnF_C2H2	439	461	3.16e-3	SMART
ZnF_C2H2	467	489	1.26e-2	SMART
ZnF_C2H2	495	517	8.34e-3	SMART
ZnF_C2H2	523	545	3.63e-3	SMART
ZnF_C2H2	551	573	4.79e-3	SMART
ZnF_C2H2	579	601	9.73e-4	SMART
ZnF_C2H2	607	629	3.63e-3	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000107994

Predicted Effect

probably damaging
Transcript: ENSMUST00000187616
AA Change: K25E

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000141023
Gene: ENSMUSG00000074158
AA Change: K25E

Domain	Start	End	E-Value	Type
KRAB	3	65	7.4e-21	SMART
ZnF_C2H2	130	152	3.2e-5	SMART
ZnF_C2H2	158	180	7.1e-5	SMART
ZnF_C2H2	186	208	2.4e-5	SMART
ZnF_C2H2	214	236	5.7e-6	SMART
ZnF_C2H2	242	264	3.8e-5	SMART
ZnF_C2H2	270	292	9.7e-6	SMART
ZnF_C2H2	298	320	4.2e-5	SMART
ZnF_C2H2	326	348	6.6e-6	SMART
ZnF_C2H2	354	376	3.3e-6	SMART
ZnF_C2H2	382	404	2.5e-5	SMART
ZnF_C2H2	410	432	1e-5	SMART
ZnF_C2H2	438	460	1.3e-5	SMART
ZnF_C2H2	466	488	5.2e-5	SMART
ZnF_C2H2	494	516	3.6e-5	SMART
ZnF_C2H2	522	544	1.6e-5	SMART
ZnF_C2H2	550	572	2e-5	SMART
ZnF_C2H2	578	600	4e-6	SMART
ZnF_C2H2	606	628	1.5e-5	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930402H24Rik	G	T	2: 130,736,598	D655E	possibly damaging	Het
Ammecr1l	T	A	18: 31,772,070	Y121*	probably null	Het
Apc	C	T	18: 34,315,136	T1661I	possibly damaging	Het
Ccdc13	T	C	9: 121,810,084		probably benign	Het
Cfap206	C	T	4: 34,721,562	S162N	probably damaging	Het
Cpt1c	T	C	7: 44,965,554	H325R	possibly damaging	Het
Cyp2a22	T	C	7: 26,936,458	K227E	probably damaging	Het
Ddx10	T	C	9: 53,159,948	K682E	possibly damaging	Het
Dlg2	T	C	7: 91,449,763	Y123H	possibly damaging	Het
Dnah11	A	T	12: 118,142,934		probably benign	Het
Dpysl2	T	C	14: 66,834,232	E153G	probably damaging	Het
Edrf1	T	A	7: 133,658,553	Y64*	probably null	Het
Ephb2	A	T	4: 136,657,410	S897T	probably benign	Het
Flt1	A	G	5: 147,578,336	I1092T	probably damaging	Het
Gabra4	T	C	5: 71,633,629	Y290C	probably damaging	Het
Gm853	T	A	4: 130,221,725	D10V	probably benign	Het
Hectd2	A	T	19: 36,597,120	H67L	probably damaging	Het
Itgb2	T	C	10: 77,542,000	L11P	probably damaging	Het
Jmy	T	C	13: 93,441,021	R880G	probably damaging	Het
Klhl2	A	G	8: 64,749,047	C532R	probably damaging	Het
Kpna1	A	G	16: 36,012,889		probably benign	Het
L3mbtl2	T	C	15: 81,684,898	V591A	possibly damaging	Het
Lepr	A	T	4: 101,814,655	N959Y	possibly damaging	Het
Man1a	A	T	10: 53,977,013		probably benign	Het
Mov10	A	T	3: 104,801,405	S431T	possibly damaging	Het
Mx2	A	T	16: 97,558,719	Q563L	probably benign	Het
Nrap	A	T	19: 56,345,558	Y874N	probably damaging	Het
Nup160	T	C	2: 90,733,209	I1373T	probably benign	Het
Nwd2	A	T	5: 63,807,300	D1409V	probably damaging	Het
Obsl1	A	T	1: 75,497,145	V744E	possibly damaging	Het
Olfr630	T	A	7: 103,755,373	T71S	probably benign	Het
Pgap1	T	C	1: 54,530,943	K315R	probably benign	Het
Rab8a	T	C	8: 72,175,856	V114A	probably damaging	Het
Sh2d6	T	C	6: 72,519,829	T73A	probably benign	Het
Shroom1	A	G	11: 53,464,048	E265G	probably damaging	Het
Slc8b1	G	A	5: 120,532,935	V529M	probably damaging	Het
Srbd1	G	T	17: 86,098,533	A613E	probably benign	Het
Stat1	G	A	1: 52,142,961		probably null	Het
Tbck	A	G	3: 132,694,407	H73R	probably damaging	Het
Thg1l	A	T	11: 45,948,224	D220E	probably damaging	Het
Ttn	C	T	2: 76,778,323	G16037D	probably damaging	Het
Unc13b	A	G	4: 43,096,927	E100G	possibly damaging	Het
Vmn2r81	T	A	10: 79,247,997	D68E	probably benign	Het
Xpo6	T	C	7: 126,129,568	T505A	probably benign	Het

Other mutations in Zfp976

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00465:Zfp976	APN	7	42613685	missense	unknown
IGL01102:Zfp976	APN	7	42613909	nonsense	probably null
IGL01628:Zfp976	APN	7	42612511	missense	unknown
IGL02008:Zfp976	APN	7	42614232	splice site	probably benign
IGL02548:Zfp976	APN	7	42612529	missense	unknown
R0190:Zfp976	UTSW	7	42642524	start gained	probably benign
R0685:Zfp976	UTSW	7	42613717	missense	probably damaging	0.98
R1310:Zfp976	UTSW	7	42613186	missense	probably damaging	1.00
R1353:Zfp976	UTSW	7	42616018	missense	probably damaging	0.99
R1447:Zfp976	UTSW	7	42612599	missense	possibly damaging	0.79
R1569:Zfp976	UTSW	7	42613382	missense	probably damaging	1.00
R1702:Zfp976	UTSW	7	42616000	missense	possibly damaging	0.86
R1829:Zfp976	UTSW	7	42616311	missense	probably damaging	1.00
R1939:Zfp976	UTSW	7	42613681	missense	unknown
R1978:Zfp976	UTSW	7	42613841	missense	probably damaging	1.00
R1981:Zfp976	UTSW	7	42613622	missense	probably damaging	0.99
R2160:Zfp976	UTSW	7	42613930	missense	probably benign
R2192:Zfp976	UTSW	7	42613271	missense	probably damaging	1.00
R3121:Zfp976	UTSW	7	42613514	missense	probably damaging	1.00
R4210:Zfp976	UTSW	7	42616325	missense	probably damaging	0.99
R4724:Zfp976	UTSW	7	42613033	missense	possibly damaging	0.91
R4943:Zfp976	UTSW	7	42612422	unclassified	probably benign
R5047:Zfp976	UTSW	7	42613419	nonsense	probably null
R5071:Zfp976	UTSW	7	42612930	nonsense	probably null
R5125:Zfp976	UTSW	7	42612501	splice site	probably null
R5178:Zfp976	UTSW	7	42612501	splice site	probably null
R5305:Zfp976	UTSW	7	42613478	missense	probably benign	0.00
R5777:Zfp976	UTSW	7	42614080	missense	probably benign	0.00
R6153:Zfp976	UTSW	7	42614186	missense	probably damaging	0.99
R6694:Zfp976	UTSW	7	42614186	missense	probably damaging	0.99
R7226:Zfp976	UTSW	7	42613260	nonsense	probably null
R7479:Zfp976	UTSW	7	42613179	missense	probably benign	0.01
R7561:Zfp976	UTSW	7	42616277	missense	probably damaging	1.00
R8178:Zfp976	UTSW	7	42613535	missense	probably benign	0.03
R8261:Zfp976	UTSW	7	42612701	missense	unknown
R8715:Zfp976	UTSW	7	42613445	missense	possibly damaging	0.89
R8921:Zfp976	UTSW	7	42613151	missense	possibly damaging	0.57
R9168:Zfp976	UTSW	7	42613587	nonsense	probably null
R9575:Zfp976	UTSW	7	42612617	missense	unknown
Z1088:Zfp976	UTSW	7	42612760	missense	possibly damaging	0.71

Posted On

2013-06-21