Incidental Mutation 'R6388:Or1e35'
ID 515642
Institutional Source Beutler Lab
Gene Symbol Or1e35
Ensembl Gene ENSMUSG00000062186
Gene Name olfactory receptor family 1 subfamily E member 35
Synonyms MOR135-10, GA_x6K02T2P1NL-4062605-4061667, Olfr395
MMRRC Submission 044537-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.081) question?
Stock # R6388 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 73797378-73798316 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 73798118 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 67 (S67P)
Ref Sequence ENSEMBL: ENSMUSP00000149064 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072991] [ENSMUST00000215690]
AlphaFold Q8VGR3
Predicted Effect probably damaging
Transcript: ENSMUST00000072991
AA Change: S67P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000072756
Gene: ENSMUSG00000062186
AA Change: S67P

DomainStartEndE-ValueType
low complexity region 8 17 N/A INTRINSIC
Pfam:7tm_4 31 309 6.2e-56 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.8e-8 PFAM
Pfam:7tm_1 41 290 3.7e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215690
AA Change: S67P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.5745 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.1%
  • 20x: 96.8%
Validation Efficiency 100% (35/35)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik C T 13: 77,410,230 (GRCm39) R560W probably benign Het
Abi3 A G 11: 95,724,464 (GRCm39) probably null Het
Ap1b1 T C 11: 4,976,319 (GRCm39) I449T probably damaging Het
Atpaf2 C A 11: 60,307,833 (GRCm39) probably benign Het
Car5a T C 8: 122,653,910 (GRCm39) Y118C probably damaging Het
Ccdc18 A G 5: 108,349,214 (GRCm39) D1002G possibly damaging Het
Ciao1 A T 2: 127,088,396 (GRCm39) C142* probably null Het
Clec14a A G 12: 58,314,243 (GRCm39) *460R probably null Het
Defb30 T A 14: 63,287,213 (GRCm39) probably benign Het
Dnah10 A G 5: 124,906,710 (GRCm39) K4247R probably benign Het
Eif5b G A 1: 38,058,081 (GRCm39) A128T unknown Het
Fam3b T C 16: 97,279,591 (GRCm39) T113A probably benign Het
Fam98c C T 7: 28,854,728 (GRCm39) R126Q probably damaging Het
Fastkd3 C T 13: 68,738,319 (GRCm39) L623F probably damaging Het
Golga1 T C 2: 38,913,183 (GRCm39) D543G probably benign Het
Gpatch8 A T 11: 102,369,314 (GRCm39) V1408E probably damaging Het
Icosl T A 10: 77,905,366 (GRCm39) L3Q possibly damaging Homo
Igf2r A G 17: 12,902,787 (GRCm39) V2421A probably benign Het
Iglon5 T C 7: 43,127,556 (GRCm39) T165A possibly damaging Het
Map3k11 A G 19: 5,740,279 (GRCm39) E2G probably damaging Het
Nipbl A T 15: 8,330,268 (GRCm39) C2386S probably damaging Het
Nos1 A G 5: 118,052,501 (GRCm39) E837G possibly damaging Het
Npc1l1 T C 11: 6,174,145 (GRCm39) E720G probably damaging Het
Pla1a T A 16: 38,217,834 (GRCm39) M385L probably benign Het
Saxo4 A G 19: 10,459,665 (GRCm39) V14A probably damaging Het
Setdb2 T C 14: 59,662,146 (GRCm39) T82A probably benign Het
Smarcd3 A G 5: 24,801,024 (GRCm39) F128L possibly damaging Het
St3gal1 A G 15: 66,983,195 (GRCm39) V187A possibly damaging Het
Syvn1 T A 19: 6,102,381 (GRCm39) V483E probably damaging Het
Timm22 G A 11: 76,297,945 (GRCm39) V19I probably benign Het
Ttn C A 2: 76,621,189 (GRCm39) D15716Y probably damaging Het
Ube3a C T 7: 58,954,669 (GRCm39) probably null Het
Ugp2 A G 11: 21,272,051 (GRCm39) probably null Het
Vmn1r13 T A 6: 57,186,903 (GRCm39) F21I probably benign Het
Vps13d T C 4: 144,882,144 (GRCm39) S1150G probably benign Het
Zp3 T C 5: 136,011,548 (GRCm39) V122A probably benign Het
Other mutations in Or1e35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01288:Or1e35 APN 11 73,798,139 (GRCm39) missense probably damaging 1.00
IGL01618:Or1e35 APN 11 73,798,303 (GRCm39) missense probably damaging 1.00
IGL01995:Or1e35 APN 11 73,798,261 (GRCm39) missense possibly damaging 0.52
IGL02494:Or1e35 APN 11 73,797,550 (GRCm39) missense possibly damaging 0.55
IGL02995:Or1e35 APN 11 73,798,045 (GRCm39) missense possibly damaging 0.90
IGL03256:Or1e35 APN 11 73,797,522 (GRCm39) missense probably benign 0.07
R0018:Or1e35 UTSW 11 73,797,452 (GRCm39) missense probably damaging 1.00
R0701:Or1e35 UTSW 11 73,797,655 (GRCm39) missense probably damaging 1.00
R0839:Or1e35 UTSW 11 73,798,138 (GRCm39) missense probably damaging 0.99
R1222:Or1e35 UTSW 11 73,798,240 (GRCm39) missense probably damaging 1.00
R1737:Or1e35 UTSW 11 73,797,911 (GRCm39) missense possibly damaging 0.69
R1819:Or1e35 UTSW 11 73,797,505 (GRCm39) missense probably benign 0.02
R2994:Or1e35 UTSW 11 73,797,541 (GRCm39) missense probably damaging 1.00
R3195:Or1e35 UTSW 11 73,797,484 (GRCm39) missense possibly damaging 0.91
R4622:Or1e35 UTSW 11 73,797,737 (GRCm39) missense possibly damaging 0.55
R4753:Or1e35 UTSW 11 73,797,677 (GRCm39) missense probably damaging 1.00
R5137:Or1e35 UTSW 11 73,797,452 (GRCm39) missense probably damaging 1.00
R5448:Or1e35 UTSW 11 73,797,437 (GRCm39) missense probably damaging 1.00
R5604:Or1e35 UTSW 11 73,797,853 (GRCm39) missense probably benign 0.02
R5748:Or1e35 UTSW 11 73,797,721 (GRCm39) missense probably damaging 0.98
R5899:Or1e35 UTSW 11 73,797,755 (GRCm39) missense probably damaging 1.00
R6156:Or1e35 UTSW 11 73,797,447 (GRCm39) nonsense probably null
R6572:Or1e35 UTSW 11 73,797,629 (GRCm39) missense possibly damaging 0.91
R7241:Or1e35 UTSW 11 73,798,058 (GRCm39) missense probably benign 0.05
R8870:Or1e35 UTSW 11 73,797,725 (GRCm39) missense probably benign 0.03
R9358:Or1e35 UTSW 11 73,797,451 (GRCm39) missense probably damaging 1.00
R9544:Or1e35 UTSW 11 73,797,637 (GRCm39) missense probably benign 0.14
R9645:Or1e35 UTSW 11 73,797,713 (GRCm39) missense probably benign
R9667:Or1e35 UTSW 11 73,798,097 (GRCm39) missense possibly damaging 0.83
R9707:Or1e35 UTSW 11 73,798,090 (GRCm39) missense possibly damaging 0.79
Z1177:Or1e35 UTSW 11 73,797,439 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAAGCAGATGGCCACATAGC -3'
(R):5'- TTAAGTCATTGGAAGCATGGCTG -3'

Sequencing Primer
(F):5'- CACATAGCGGTCATAGGCCATG -3'
(R):5'- TGGAAAGAACCAAACTCTCATCTTGG -3'
Posted On 2018-05-04