Incidental Mutation 'R6389:Fpr-rs3'
ID 515713
Institutional Source Beutler Lab
Gene Symbol Fpr-rs3
Ensembl Gene ENSMUSG00000060701
Gene Name formyl peptide receptor, related sequence 3
Synonyms
MMRRC Submission 044538-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.098) question?
Stock # R6389 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 20844108-20845139 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 20844230 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 304 (F304I)
Ref Sequence ENSEMBL: ENSMUSP00000071179 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071189]
AlphaFold O88537
Predicted Effect probably damaging
Transcript: ENSMUST00000071189
AA Change: F304I

PolyPhen 2 Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000071179
Gene: ENSMUSG00000060701
AA Change: F304I

DomainStartEndE-ValueType
Pfam:7tm_1 43 297 1.8e-36 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 96.9%
Validation Efficiency 100% (57/57)
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4931406B18Rik A C 7: 43,147,254 (GRCm39) L326R possibly damaging Het
Abcb11 A T 2: 69,154,238 (GRCm39) N109K probably damaging Het
Actn1 T A 12: 80,221,296 (GRCm39) M586L probably benign Het
Ago4 T A 4: 126,401,037 (GRCm39) I603F probably damaging Het
Bicc1 A T 10: 70,794,752 (GRCm39) V135D probably damaging Het
Bms1 T C 6: 118,380,196 (GRCm39) N704D possibly damaging Het
Cadm4 A C 7: 24,198,959 (GRCm39) Q78P probably benign Het
Cfap74 T C 4: 155,507,793 (GRCm39) I248T possibly damaging Het
Clu G C 14: 66,208,771 (GRCm39) probably benign Het
Cnnm3 T C 1: 36,559,603 (GRCm39) V514A probably damaging Het
Cntd1 A T 11: 101,176,577 (GRCm39) I225F probably damaging Het
Col20a1 T C 2: 180,634,376 (GRCm39) probably null Het
Ctnnal1 A G 4: 56,813,849 (GRCm39) V640A probably benign Het
Cul4a A G 8: 13,190,278 (GRCm39) T572A probably benign Het
D16Ertd472e A G 16: 78,342,071 (GRCm39) S270P probably damaging Het
Dmp1 A T 5: 104,360,788 (GRCm39) N488I probably damaging Het
Dnah14 G A 1: 181,478,767 (GRCm39) probably null Het
Dst T C 1: 34,232,265 (GRCm39) L3464P probably damaging Het
Fnbp4 C T 2: 90,575,879 (GRCm39) P27S unknown Het
Gm13941 T C 2: 110,928,734 (GRCm39) Q108R unknown Het
Hcn3 C T 3: 89,058,240 (GRCm39) A339T possibly damaging Het
Inpp5f A G 7: 128,279,780 (GRCm39) D460G probably damaging Het
Ism2 T C 12: 87,329,145 (GRCm39) E253G possibly damaging Het
Klrg1 T C 6: 122,248,431 (GRCm39) N156S probably damaging Het
Ksr2 A G 5: 117,552,907 (GRCm39) N5S probably benign Het
Lrrc7 T G 3: 157,891,063 (GRCm39) E368A probably damaging Het
Ly9 G C 1: 171,424,105 (GRCm39) S482C probably damaging Het
Map3k1 T C 13: 111,905,975 (GRCm39) D289G probably damaging Het
Mcub T C 3: 129,712,357 (GRCm39) T173A probably benign Het
Mup16 T C 4: 61,437,177 (GRCm39) E48G probably damaging Het
Naf1 C T 8: 67,313,680 (GRCm39) S24L possibly damaging Het
Ncoa6 A G 2: 155,237,736 (GRCm39) S2024P probably damaging Het
Nop56 C A 2: 130,119,807 (GRCm39) Q83K probably damaging Het
Nt5e T C 9: 88,245,524 (GRCm39) Y265H probably damaging Het
Odad1 G T 7: 45,597,940 (GRCm39) V617F probably benign Het
Or4a27 A G 2: 88,559,016 (GRCm39) V309A probably benign Het
Or52p2 A T 7: 102,237,679 (GRCm39) N90K probably benign Het
Or5w8 C T 2: 87,688,367 (GRCm39) P283S probably damaging Het
Oxct2a T A 4: 123,217,220 (GRCm39) K54* probably null Het
Oxct2b G T 4: 123,010,367 (GRCm39) D96Y probably benign Het
Pisd A G 5: 32,922,191 (GRCm39) Y250H probably damaging Het
Plekhm1 G T 11: 103,257,720 (GRCm39) N1071K probably benign Het
Prr11 G A 11: 86,989,564 (GRCm39) T269I possibly damaging Het
Ptpn4 T A 1: 119,649,684 (GRCm39) H304L probably damaging Het
Rrp1b A G 17: 32,275,601 (GRCm39) K383E possibly damaging Het
Sel1l2 C A 2: 140,087,274 (GRCm39) A466S probably damaging Het
Slc9a4 A G 1: 40,619,844 (GRCm39) I57V probably benign Het
Spag9 A G 11: 93,977,137 (GRCm39) E81G probably damaging Het
Tbr1 A G 2: 61,636,631 (GRCm39) probably benign Het
Tnrc6c A G 11: 117,613,567 (GRCm39) D735G probably damaging Het
Tspan17 A T 13: 54,943,429 (GRCm39) probably null Het
Tyw5 T C 1: 57,430,658 (GRCm39) K175R probably damaging Het
Ube2o A C 11: 116,439,684 (GRCm39) I162R probably null Het
Ubr1 G T 2: 120,711,520 (GRCm39) T1458K probably benign Het
Vmn2r16 A T 5: 109,478,344 (GRCm39) Q33L probably benign Het
Zfp1007 G A 5: 109,823,885 (GRCm39) P522S possibly damaging Het
Zfp799 A G 17: 33,039,552 (GRCm39) L238P probably damaging Het
Other mutations in Fpr-rs3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01561:Fpr-rs3 APN 17 20,844,859 (GRCm39) missense probably damaging 1.00
IGL02230:Fpr-rs3 APN 17 20,844,190 (GRCm39) missense probably damaging 1.00
IGL02503:Fpr-rs3 APN 17 20,844,817 (GRCm39) missense probably damaging 1.00
IGL02809:Fpr-rs3 APN 17 20,844,225 (GRCm39) missense probably damaging 0.99
IGL03212:Fpr-rs3 APN 17 20,844,121 (GRCm39) missense probably benign 0.00
I2288:Fpr-rs3 UTSW 17 20,844,757 (GRCm39) missense probably damaging 0.99
R0318:Fpr-rs3 UTSW 17 20,844,410 (GRCm39) missense probably benign 0.02
R0565:Fpr-rs3 UTSW 17 20,844,283 (GRCm39) missense probably damaging 1.00
R1005:Fpr-rs3 UTSW 17 20,844,346 (GRCm39) missense probably benign 0.04
R1986:Fpr-rs3 UTSW 17 20,844,103 (GRCm39) splice site probably null
R3941:Fpr-rs3 UTSW 17 20,845,111 (GRCm39) missense probably benign 0.42
R4297:Fpr-rs3 UTSW 17 20,845,008 (GRCm39) missense probably damaging 1.00
R4809:Fpr-rs3 UTSW 17 20,844,683 (GRCm39) missense probably benign 0.00
R4959:Fpr-rs3 UTSW 17 20,844,211 (GRCm39) missense possibly damaging 0.73
R4973:Fpr-rs3 UTSW 17 20,844,211 (GRCm39) missense possibly damaging 0.73
R5116:Fpr-rs3 UTSW 17 20,844,562 (GRCm39) missense probably benign 0.12
R5356:Fpr-rs3 UTSW 17 20,844,596 (GRCm39) missense probably damaging 0.98
R5394:Fpr-rs3 UTSW 17 20,844,470 (GRCm39) missense probably benign 0.00
R5779:Fpr-rs3 UTSW 17 20,844,488 (GRCm39) missense possibly damaging 0.53
R6091:Fpr-rs3 UTSW 17 20,844,532 (GRCm39) missense probably benign 0.30
R6860:Fpr-rs3 UTSW 17 20,844,560 (GRCm39) missense possibly damaging 0.68
R7578:Fpr-rs3 UTSW 17 20,844,293 (GRCm39) missense possibly damaging 0.81
R8153:Fpr-rs3 UTSW 17 20,844,685 (GRCm39) missense probably damaging 1.00
R8711:Fpr-rs3 UTSW 17 20,844,554 (GRCm39) missense probably benign
R8768:Fpr-rs3 UTSW 17 20,844,944 (GRCm39) missense probably damaging 1.00
X0018:Fpr-rs3 UTSW 17 20,844,899 (GRCm39) missense probably benign 0.30
Predicted Primers PCR Primer
(F):5'- GAATAAGCTAGCACAGAAAGCATTC -3'
(R):5'- GACTCATGGCTGCCAAGATTTG -3'

Sequencing Primer
(F):5'- AGCATTCCACTGGCCTTACAG -3'
(R):5'- GAAAAGGCTTTCTGAACTCCAG -3'
Posted On 2018-05-04