Incidental Mutation 'IGL01129:Vmn1r78'
| ID |
51611 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn1r78
|
| Ensembl Gene |
ENSMUSG00000061602 |
| Gene Name |
vomeronasal 1 receptor 78 |
| Synonyms |
V1rg7 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.067)
|
| Stock # |
IGL01129
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
11886391-11887332 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 11887165 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 259
(T259S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154797
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000078039]
[ENSMUST00000228244]
[ENSMUST00000228664]
|
| AlphaFold |
K7N608 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000078039
AA Change: T259S
PolyPhen 2
Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000077186
Gene: ENSMUSG00000061602
AA Change: T259S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:TAS2R
|
3 |
304 |
5.7e-8 |
PFAM |
|
Pfam:V1R
|
12 |
301 |
1.5e-29 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000209489
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228244
AA Change: T259S
PolyPhen 2
Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228664
AA Change: T259S
PolyPhen 2
Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933436I01Rik |
A |
T |
X: 66,964,210 (GRCm39) |
F216L |
possibly damaging |
Het |
| Bace2 |
T |
G |
16: 97,209,630 (GRCm39) |
N181K |
probably damaging |
Het |
| Cc2d1a |
G |
T |
8: 84,870,033 (GRCm39) |
H161N |
probably benign |
Het |
| Ckap2 |
C |
T |
8: 22,659,774 (GRCm39) |
G569D |
probably damaging |
Het |
| Col11a1 |
T |
C |
3: 113,979,522 (GRCm39) |
|
probably benign |
Het |
| Col1a2 |
G |
A |
6: 4,535,846 (GRCm39) |
D939N |
unknown |
Het |
| Creb3l2 |
A |
T |
6: 37,330,569 (GRCm39) |
|
probably benign |
Het |
| Cuedc1 |
T |
A |
11: 88,074,080 (GRCm39) |
S205T |
possibly damaging |
Het |
| Cux1 |
G |
A |
5: 136,333,572 (GRCm39) |
|
probably benign |
Het |
| Cyp3a59 |
A |
G |
5: 146,035,089 (GRCm39) |
M256V |
probably benign |
Het |
| Gzf1 |
C |
A |
2: 148,532,916 (GRCm39) |
P690Q |
probably damaging |
Het |
| Lrch3 |
T |
A |
16: 32,815,335 (GRCm39) |
D575E |
probably benign |
Het |
| Lypd3 |
A |
G |
7: 24,340,018 (GRCm39) |
M362V |
probably benign |
Het |
| Mppe1 |
C |
A |
18: 67,370,515 (GRCm39) |
G61* |
probably null |
Het |
| Nr2c2 |
T |
A |
6: 92,135,397 (GRCm39) |
D328E |
probably benign |
Het |
| Or6b9 |
T |
C |
7: 106,555,634 (GRCm39) |
N170D |
probably damaging |
Het |
| Pfn4 |
T |
A |
12: 4,825,505 (GRCm39) |
V114E |
probably damaging |
Het |
| Rab14 |
T |
C |
2: 35,073,398 (GRCm39) |
|
probably benign |
Het |
| Slc30a9 |
G |
T |
5: 67,499,486 (GRCm39) |
G315C |
probably damaging |
Het |
| Spag16 |
A |
T |
1: 69,935,681 (GRCm39) |
S303C |
probably benign |
Het |
| Spata16 |
C |
T |
3: 26,967,333 (GRCm39) |
|
probably benign |
Het |
| Srcap |
T |
C |
7: 127,120,823 (GRCm39) |
V161A |
probably damaging |
Het |
| Srd5a3 |
A |
G |
5: 76,297,593 (GRCm39) |
|
probably benign |
Het |
| Vmn1r18 |
A |
T |
6: 57,367,482 (GRCm39) |
F24Y |
probably benign |
Het |
| Zc3h13 |
G |
A |
14: 75,573,439 (GRCm39) |
D1527N |
probably damaging |
Het |
|
| Other mutations in Vmn1r78 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02019:Vmn1r78
|
APN |
7 |
11,886,634 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02143:Vmn1r78
|
APN |
7 |
11,886,407 (GRCm39) |
missense |
probably benign |
|
|
IGL02154:Vmn1r78
|
APN |
7 |
11,886,472 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL02290:Vmn1r78
|
APN |
7 |
11,887,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03012:Vmn1r78
|
APN |
7 |
11,887,291 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL03256:Vmn1r78
|
APN |
7 |
11,886,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03373:Vmn1r78
|
APN |
7 |
11,887,270 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL03384:Vmn1r78
|
APN |
7 |
11,887,136 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0016:Vmn1r78
|
UTSW |
7 |
11,887,279 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1445:Vmn1r78
|
UTSW |
7 |
11,886,508 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R1748:Vmn1r78
|
UTSW |
7 |
11,887,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Vmn1r78
|
UTSW |
7 |
11,887,270 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R2032:Vmn1r78
|
UTSW |
7 |
11,887,210 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2198:Vmn1r78
|
UTSW |
7 |
11,886,487 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4330:Vmn1r78
|
UTSW |
7 |
11,886,386 (GRCm39) |
splice site |
probably null |
|
|
R4564:Vmn1r78
|
UTSW |
7 |
11,886,485 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4769:Vmn1r78
|
UTSW |
7 |
11,886,725 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4801:Vmn1r78
|
UTSW |
7 |
11,886,891 (GRCm39) |
nonsense |
probably null |
|
|
R4802:Vmn1r78
|
UTSW |
7 |
11,886,891 (GRCm39) |
nonsense |
probably null |
|
|
R4860:Vmn1r78
|
UTSW |
7 |
11,886,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4860:Vmn1r78
|
UTSW |
7 |
11,886,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5648:Vmn1r78
|
UTSW |
7 |
11,886,693 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6561:Vmn1r78
|
UTSW |
7 |
11,886,826 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6869:Vmn1r78
|
UTSW |
7 |
11,886,676 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6945:Vmn1r78
|
UTSW |
7 |
11,886,832 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7793:Vmn1r78
|
UTSW |
7 |
11,887,241 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7954:Vmn1r78
|
UTSW |
7 |
11,887,227 (GRCm39) |
nonsense |
probably null |
|
|
R8698:Vmn1r78
|
UTSW |
7 |
11,886,539 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8830:Vmn1r78
|
UTSW |
7 |
11,887,118 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9624:Vmn1r78
|
UTSW |
7 |
11,886,410 (GRCm39) |
missense |
probably benign |
|
|
Z1088:Vmn1r78
|
UTSW |
7 |
11,886,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2013-06-21 |
Incidental Mutation