Incidental Mutation 'IGL01129:Lypd3'
ID51612
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lypd3
Ensembl Gene ENSMUSG00000057454
Gene NameLy6/Plaur domain containing 3
Synonyms2310061G07Rik, C4.4A
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.153) question?
Stock #IGL01129
Quality Score
Status
Chromosome7
Chromosomal Location24636550-24641118 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 24640593 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Valine at position 362 (M362V)
Ref Sequence ENSEMBL: ENSMUSP00000079543 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080718]
Predicted Effect probably benign
Transcript: ENSMUST00000080718
AA Change: M362V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000079543
Gene: ENSMUSG00000057454
AA Change: M362V

DomainStartEndE-ValueType
signal peptide 1 32 N/A INTRINSIC
LU 33 128 7.26e-26 SMART
Pfam:UPAR_LY6 142 224 1.3e-16 PFAM
low complexity region 234 255 N/A INTRINSIC
low complexity region 258 278 N/A INTRINSIC
low complexity region 303 320 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180699
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous null mice show no overt epidermal phenotype and have normal squamous epithelia morphology but are lighter and leaner than controls. Males display delayed wound healing whereas females show reduced food intake and a lower incidence of invasive lesions in a BBN-induced bladder cancer model. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933436I01Rik A T X: 67,920,604 F216L possibly damaging Het
Bace2 T G 16: 97,408,430 N181K probably damaging Het
Cc2d1a G T 8: 84,143,404 H161N probably benign Het
Ckap2 C T 8: 22,169,758 G569D probably damaging Het
Col11a1 T C 3: 114,185,873 probably benign Het
Col1a2 G A 6: 4,535,846 D939N unknown Het
Creb3l2 A T 6: 37,353,634 probably benign Het
Cuedc1 T A 11: 88,183,254 S205T possibly damaging Het
Cux1 G A 5: 136,304,718 probably benign Het
Cyp3a59 A G 5: 146,098,279 M256V probably benign Het
Gzf1 C A 2: 148,690,996 P690Q probably damaging Het
Lrch3 T A 16: 32,994,965 D575E probably benign Het
Mppe1 C A 18: 67,237,444 G61* probably null Het
Nr2c2 T A 6: 92,158,416 D328E probably benign Het
Olfr6 T C 7: 106,956,427 N170D probably damaging Het
Pfn4 T A 12: 4,775,505 V114E probably damaging Het
Rab14 T C 2: 35,183,386 probably benign Het
Slc30a9 G T 5: 67,342,143 G315C probably damaging Het
Spag16 A T 1: 69,896,522 S303C probably benign Het
Spata16 C T 3: 26,913,184 probably benign Het
Srcap T C 7: 127,521,651 V161A probably damaging Het
Srd5a3 A G 5: 76,149,746 probably benign Het
Vmn1r18 A T 6: 57,390,497 F24Y probably benign Het
Vmn1r78 A T 7: 12,153,238 T259S probably benign Het
Zc3h13 G A 14: 75,335,999 D1527N probably damaging Het
Other mutations in Lypd3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01443:Lypd3 APN 7 24636638 missense probably benign 0.03
R0200:Lypd3 UTSW 7 24640231 missense probably damaging 1.00
R0726:Lypd3 UTSW 7 24638544 nonsense probably null
R1706:Lypd3 UTSW 7 24640330 missense probably benign 0.00
R5714:Lypd3 UTSW 7 24639069 missense possibly damaging 0.86
R5771:Lypd3 UTSW 7 24640362 missense probably benign
R6137:Lypd3 UTSW 7 24640494 missense probably benign 0.00
R6908:Lypd3 UTSW 7 24638433 missense probably damaging 1.00
R6932:Lypd3 UTSW 7 24638433 missense probably damaging 1.00
R6935:Lypd3 UTSW 7 24638433 missense probably damaging 1.00
R7632:Lypd3 UTSW 7 24638440 missense possibly damaging 0.60
Posted On2013-06-21