Incidental Mutation 'R6405:Wnt5b'
ID 516252
Institutional Source Beutler Lab
Gene Symbol Wnt5b
Ensembl Gene ENSMUSG00000030170
Gene Name wingless-type MMTV integration site family, member 5B
Synonyms Wnt-5b
MMRRC Submission 044550-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6405 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 119409492-119521308 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 119410457 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 328 (S328G)
Ref Sequence ENSEMBL: ENSMUSP00000137065 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000117171] [ENSMUST00000118120] [ENSMUST00000119369] [ENSMUST00000178696]
AlphaFold P22726
Predicted Effect probably benign
Transcript: ENSMUST00000117171
AA Change: S328G

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000113188
Gene: ENSMUSG00000030170
AA Change: S328G

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
WNT1 50 359 3.47e-215 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000118120
AA Change: S290G

PolyPhen 2 Score 0.052 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000112819
Gene: ENSMUSG00000030170
AA Change: S290G

DomainStartEndE-ValueType
WNT1 12 321 3.47e-215 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000119369
AA Change: S341G

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000112448
Gene: ENSMUSG00000030170
AA Change: S341G

DomainStartEndE-ValueType
signal peptide 1 30 N/A INTRINSIC
WNT1 63 372 3.47e-215 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000178696
AA Change: S328G

PolyPhen 2 Score 0.057 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000137065
Gene: ENSMUSG00000030170
AA Change: S328G

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
WNT1 50 359 3.47e-215 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit normal numbers of thoracic motor neurons and proportions of motor columnar subtypes. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930562C15Rik T C 16: 4,669,742 (GRCm39) V769A probably damaging Het
Abca4 A G 3: 121,967,311 (GRCm39) probably null Het
Ahnak2 A T 12: 112,739,771 (GRCm39) S628T probably damaging Het
Ano8 T C 8: 71,935,674 (GRCm39) T315A probably damaging Het
Arhgap32 T A 9: 32,159,784 (GRCm39) V267E probably benign Het
Asnsd1 A T 1: 53,387,154 (GRCm39) S158T probably damaging Het
Asxl2 T A 12: 3,543,758 (GRCm39) V309E probably damaging Het
Bhlhe40 TG TGG 6: 108,641,818 (GRCm39) 254 probably null Het
Ccdc110 T A 8: 46,394,734 (GRCm39) Y208* probably null Het
Cfap157 G T 2: 32,671,408 (GRCm39) Q133K probably damaging Het
Cfap53 A G 18: 74,492,677 (GRCm39) E467G probably damaging Het
Csmd3 T C 15: 47,683,767 (GRCm39) I1688M probably damaging Het
Cyp3a11 A T 5: 145,799,230 (GRCm39) L319Q probably damaging Het
Dchs2 A G 3: 83,261,570 (GRCm39) I2613V probably benign Het
Dhx35 T A 2: 158,636,839 (GRCm39) W11R probably damaging Het
Dscam C T 16: 96,479,625 (GRCm39) G1174D probably damaging Het
Fan1 T A 7: 64,022,234 (GRCm39) N340Y probably damaging Het
Fsip2 A G 2: 82,820,430 (GRCm39) T5388A possibly damaging Het
Gm10549 C A 18: 33,597,358 (GRCm39) probably benign Het
Greb1l T A 18: 10,501,076 (GRCm39) I402K probably benign Het
Hectd3 A T 4: 116,857,821 (GRCm39) M585L probably benign Het
Inpp5k T C 11: 75,524,004 (GRCm39) probably null Het
Lalba T G 15: 98,378,632 (GRCm39) probably null Het
Lgals9 C A 11: 78,862,211 (GRCm39) V125L probably benign Het
Ncbp2 CGTCTGGATG CG 16: 31,775,161 (GRCm39) probably null Het
Or2g25 A G 17: 37,971,014 (GRCm39) I70T possibly damaging Het
Peg10 C CTCG 6: 4,756,453 (GRCm39) probably benign Het
Rab4b T A 7: 26,872,379 (GRCm39) D94V probably damaging Het
Rhpn2 A G 7: 35,071,864 (GRCm39) E243G probably benign Het
Rp1 T C 1: 4,415,994 (GRCm39) D1706G probably damaging Het
Slc29a3 A T 10: 60,551,805 (GRCm39) I413N probably damaging Het
Slc7a9 T C 7: 35,154,064 (GRCm39) L229P probably damaging Het
Tenm2 T C 11: 36,755,686 (GRCm39) H104R probably benign Het
Tmem87a A G 2: 120,210,231 (GRCm39) Y241H probably damaging Het
Trpv5 G T 6: 41,651,602 (GRCm39) T192K probably damaging Het
Unc79 T C 12: 103,134,595 (GRCm39) V2189A probably damaging Het
Vmn2r106 A C 17: 20,499,361 (GRCm39) S183R probably benign Het
Vmn2r112 G T 17: 22,837,216 (GRCm39) C559F probably damaging Het
Wdhd1 T C 14: 47,481,324 (GRCm39) D1031G possibly damaging Het
Zcchc7 T C 4: 44,926,032 (GRCm39) Y344H probably damaging Het
Other mutations in Wnt5b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01590:Wnt5b APN 6 119,417,515 (GRCm39) missense possibly damaging 0.70
IGL01822:Wnt5b APN 6 119,410,433 (GRCm39) missense probably damaging 1.00
Blizzard UTSW 6 119,423,319 (GRCm39) missense probably damaging 1.00
Invierno UTSW 6 119,417,272 (GRCm39) missense probably damaging 1.00
luftmensch UTSW 6 119,410,813 (GRCm39) missense probably damaging 0.97
R0557:Wnt5b UTSW 6 119,410,779 (GRCm39) missense probably damaging 1.00
R0732:Wnt5b UTSW 6 119,423,543 (GRCm39) nonsense probably null
R1472:Wnt5b UTSW 6 119,410,442 (GRCm39) missense probably damaging 1.00
R1673:Wnt5b UTSW 6 119,423,315 (GRCm39) missense probably benign 0.19
R4202:Wnt5b UTSW 6 119,417,272 (GRCm39) missense probably damaging 1.00
R5100:Wnt5b UTSW 6 119,417,449 (GRCm39) missense probably benign 0.20
R5264:Wnt5b UTSW 6 119,410,813 (GRCm39) missense probably damaging 0.97
R5393:Wnt5b UTSW 6 119,417,394 (GRCm39) missense probably damaging 1.00
R5394:Wnt5b UTSW 6 119,417,283 (GRCm39) missense probably damaging 0.98
R5482:Wnt5b UTSW 6 119,423,392 (GRCm39) missense probably benign 0.19
R5741:Wnt5b UTSW 6 119,410,690 (GRCm39) missense probably damaging 1.00
R5902:Wnt5b UTSW 6 119,425,199 (GRCm39) missense probably benign 0.00
R6005:Wnt5b UTSW 6 119,410,615 (GRCm39) missense probably benign 0.04
R6061:Wnt5b UTSW 6 119,410,603 (GRCm39) missense probably damaging 0.98
R6208:Wnt5b UTSW 6 119,423,473 (GRCm39) missense probably damaging 1.00
R6478:Wnt5b UTSW 6 119,410,751 (GRCm39) missense probably damaging 1.00
R6482:Wnt5b UTSW 6 119,410,573 (GRCm39) missense possibly damaging 0.88
R7047:Wnt5b UTSW 6 119,425,217 (GRCm39) start gained probably benign
R7338:Wnt5b UTSW 6 119,425,092 (GRCm39) splice site probably null
R8044:Wnt5b UTSW 6 119,423,319 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTCCAGCAAAATCCAGTCCTC -3'
(R):5'- CCGTTTGAAGGAGAAGTACGAC -3'

Sequencing Primer
(F):5'- AGAGGGCCAGCATCTCCTAAG -3'
(R):5'- AGAAGTACGACAGCGCCGC -3'
Posted On 2018-05-04