Mutagenetix > Incidental Mutation

Incidental Mutation 'R6405:Vmn2r112'

516274

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r112

Ensembl Gene

ENSMUSG00000094921

Gene Name

vomeronasal 2, receptor 112

Synonyms

EG628185

MMRRC Submission

044550-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.105) question?

Stock #

R6405 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

22820129-22838114 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 22837216 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Phenylalanine at position 559 (C559F)

Ref Sequence

ENSEMBL: ENSMUSP00000094994 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000097381]

AlphaFold

L7N221

Predicted Effect

probably damaging
Transcript: ENSMUST00000097381
AA Change: C559F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000094994
Gene: ENSMUSG00000094921
AA Change: C559F

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	2.8e-32	PFAM
Pfam:NCD3G	512	565	5.8e-21	PFAM
Pfam:7tm_3	598	833	6.5e-54	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.4%
20x: 98.2%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 40 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930562C15Rik	T	C	16: 4,669,742 (GRCm39)	V769A	probably damaging	Het
Abca4	A	G	3: 121,967,311 (GRCm39)		probably null	Het
Ahnak2	A	T	12: 112,739,771 (GRCm39)	S628T	probably damaging	Het
Ano8	T	C	8: 71,935,674 (GRCm39)	T315A	probably damaging	Het
Arhgap32	T	A	9: 32,159,784 (GRCm39)	V267E	probably benign	Het
Asnsd1	A	T	1: 53,387,154 (GRCm39)	S158T	probably damaging	Het
Asxl2	T	A	12: 3,543,758 (GRCm39)	V309E	probably damaging	Het
Bhlhe40	TG	TGG	6: 108,641,818 (GRCm39)	254	probably null	Het
Ccdc110	T	A	8: 46,394,734 (GRCm39)	Y208*	probably null	Het
Cfap157	G	T	2: 32,671,408 (GRCm39)	Q133K	probably damaging	Het
Cfap53	A	G	18: 74,492,677 (GRCm39)	E467G	probably damaging	Het
Csmd3	T	C	15: 47,683,767 (GRCm39)	I1688M	probably damaging	Het
Cyp3a11	A	T	5: 145,799,230 (GRCm39)	L319Q	probably damaging	Het
Dchs2	A	G	3: 83,261,570 (GRCm39)	I2613V	probably benign	Het
Dhx35	T	A	2: 158,636,839 (GRCm39)	W11R	probably damaging	Het
Dscam	C	T	16: 96,479,625 (GRCm39)	G1174D	probably damaging	Het
Fan1	T	A	7: 64,022,234 (GRCm39)	N340Y	probably damaging	Het
Fsip2	A	G	2: 82,820,430 (GRCm39)	T5388A	possibly damaging	Het
Gm10549	C	A	18: 33,597,358 (GRCm39)		probably benign	Het
Greb1l	T	A	18: 10,501,076 (GRCm39)	I402K	probably benign	Het
Hectd3	A	T	4: 116,857,821 (GRCm39)	M585L	probably benign	Het
Inpp5k	T	C	11: 75,524,004 (GRCm39)		probably null	Het
Lalba	T	G	15: 98,378,632 (GRCm39)		probably null	Het
Lgals9	C	A	11: 78,862,211 (GRCm39)	V125L	probably benign	Het
Ncbp2	CGTCTGGATG	CG	16: 31,775,161 (GRCm39)		probably null	Het
Or2g25	A	G	17: 37,971,014 (GRCm39)	I70T	possibly damaging	Het
Peg10	C	CTCG	6: 4,756,453 (GRCm39)		probably benign	Het
Rab4b	T	A	7: 26,872,379 (GRCm39)	D94V	probably damaging	Het
Rhpn2	A	G	7: 35,071,864 (GRCm39)	E243G	probably benign	Het
Rp1	T	C	1: 4,415,994 (GRCm39)	D1706G	probably damaging	Het
Slc29a3	A	T	10: 60,551,805 (GRCm39)	I413N	probably damaging	Het
Slc7a9	T	C	7: 35,154,064 (GRCm39)	L229P	probably damaging	Het
Tenm2	T	C	11: 36,755,686 (GRCm39)	H104R	probably benign	Het
Tmem87a	A	G	2: 120,210,231 (GRCm39)	Y241H	probably damaging	Het
Trpv5	G	T	6: 41,651,602 (GRCm39)	T192K	probably damaging	Het
Unc79	T	C	12: 103,134,595 (GRCm39)	V2189A	probably damaging	Het
Vmn2r106	A	C	17: 20,499,361 (GRCm39)	S183R	probably benign	Het
Wdhd1	T	C	14: 47,481,324 (GRCm39)	D1031G	possibly damaging	Het
Wnt5b	T	C	6: 119,410,457 (GRCm39)	S328G	probably benign	Het
Zcchc7	T	C	4: 44,926,032 (GRCm39)	Y344H	probably damaging	Het

Other mutations in Vmn2r112

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00341:Vmn2r112	APN	17	22,837,917 (GRCm39)	missense	probably benign	0.13
IGL01021:Vmn2r112	APN	17	22,837,885 (GRCm39)	missense	probably damaging	1.00
IGL01122:Vmn2r112	APN	17	22,821,988 (GRCm39)	missense	probably benign	0.00
IGL01360:Vmn2r112	APN	17	22,837,603 (GRCm39)	missense	probably benign	0.03
IGL01536:Vmn2r112	APN	17	22,824,136 (GRCm39)	missense	probably damaging	1.00
IGL02148:Vmn2r112	APN	17	22,838,013 (GRCm39)	missense	probably damaging	1.00
IGL02465:Vmn2r112	APN	17	22,833,975 (GRCm39)	missense	probably damaging	1.00
PIT4576001:Vmn2r112	UTSW	17	22,833,912 (GRCm39)	missense	probably benign	0.00
R0278:Vmn2r112	UTSW	17	22,821,987 (GRCm39)	missense	probably benign	0.44
R0328:Vmn2r112	UTSW	17	22,824,251 (GRCm39)	missense	probably benign	0.01
R0583:Vmn2r112	UTSW	17	22,837,930 (GRCm39)	missense	probably damaging	1.00
R0831:Vmn2r112	UTSW	17	22,833,980 (GRCm39)	missense	probably damaging	0.99
R1080:Vmn2r112	UTSW	17	22,837,980 (GRCm39)	missense	probably damaging	1.00
R1245:Vmn2r112	UTSW	17	22,822,228 (GRCm39)	missense	probably benign	0.03
R1321:Vmn2r112	UTSW	17	22,837,500 (GRCm39)	nonsense	probably null
R1381:Vmn2r112	UTSW	17	22,837,467 (GRCm39)	missense	probably damaging	1.00
R1514:Vmn2r112	UTSW	17	22,821,825 (GRCm39)	missense	probably benign	0.40
R1519:Vmn2r112	UTSW	17	22,837,884 (GRCm39)	missense	possibly damaging	0.83
R1572:Vmn2r112	UTSW	17	22,822,125 (GRCm39)	missense	possibly damaging	0.61
R1590:Vmn2r112	UTSW	17	22,833,989 (GRCm39)	critical splice donor site	probably null
R1640:Vmn2r112	UTSW	17	22,824,097 (GRCm39)	missense	probably benign	0.01
R2221:Vmn2r112	UTSW	17	22,820,214 (GRCm39)	missense	possibly damaging	0.86
R2223:Vmn2r112	UTSW	17	22,820,214 (GRCm39)	missense	possibly damaging	0.86
R2310:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2312:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2337:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2339:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2340:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2341:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2342:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2401:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2860:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2861:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R2926:Vmn2r112	UTSW	17	22,833,984 (GRCm39)	missense	possibly damaging	0.90
R3236:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R3237:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R3977:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R3979:Vmn2r112	UTSW	17	22,822,096 (GRCm39)	missense	probably damaging	0.98
R4168:Vmn2r112	UTSW	17	22,822,069 (GRCm39)	missense	probably benign	0.01
R4256:Vmn2r112	UTSW	17	22,837,393 (GRCm39)	missense	probably damaging	1.00
R4386:Vmn2r112	UTSW	17	22,820,303 (GRCm39)	missense	probably benign	0.36
R4912:Vmn2r112	UTSW	17	22,822,363 (GRCm39)	missense	probably damaging	0.99
R4947:Vmn2r112	UTSW	17	22,821,860 (GRCm39)	missense	probably benign	0.02
R5446:Vmn2r112	UTSW	17	22,837,231 (GRCm39)	missense	probably damaging	1.00
R5870:Vmn2r112	UTSW	17	22,838,004 (GRCm39)	missense	probably benign	0.00
R6351:Vmn2r112	UTSW	17	22,820,259 (GRCm39)	missense	probably benign
R6384:Vmn2r112	UTSW	17	22,824,136 (GRCm39)	missense	probably damaging	1.00
R6390:Vmn2r112	UTSW	17	22,824,230 (GRCm39)	missense	probably benign	0.01
R6401:Vmn2r112	UTSW	17	22,822,532 (GRCm39)	nonsense	probably null
R6620:Vmn2r112	UTSW	17	22,822,082 (GRCm39)	missense	probably benign	0.00
R6648:Vmn2r112	UTSW	17	22,837,467 (GRCm39)	missense	probably damaging	1.00
R6649:Vmn2r112	UTSW	17	22,820,160 (GRCm39)	missense	probably null	1.00
R6653:Vmn2r112	UTSW	17	22,820,160 (GRCm39)	missense	probably null	1.00
R6654:Vmn2r112	UTSW	17	22,822,450 (GRCm39)	missense	possibly damaging	0.89
R6700:Vmn2r112	UTSW	17	22,822,462 (GRCm39)	missense	possibly damaging	0.53
R6993:Vmn2r112	UTSW	17	22,822,195 (GRCm39)	missense	probably benign	0.01
R7052:Vmn2r112	UTSW	17	22,821,507 (GRCm39)	missense	probably benign
R7454:Vmn2r112	UTSW	17	22,822,288 (GRCm39)	missense	probably benign	0.00
R7763:Vmn2r112	UTSW	17	22,822,099 (GRCm39)	missense	probably damaging	1.00
R8032:Vmn2r112	UTSW	17	22,822,375 (GRCm39)	missense	probably benign	0.21
R8177:Vmn2r112	UTSW	17	22,822,594 (GRCm39)	missense	possibly damaging	0.47
R8263:Vmn2r112	UTSW	17	22,824,140 (GRCm39)	missense	probably damaging	1.00
R8395:Vmn2r112	UTSW	17	22,837,587 (GRCm39)	missense	possibly damaging	0.94
R8492:Vmn2r112	UTSW	17	22,821,470 (GRCm39)	missense	probably benign	0.03
R8889:Vmn2r112	UTSW	17	22,837,612 (GRCm39)	missense	probably damaging	1.00
R8892:Vmn2r112	UTSW	17	22,837,612 (GRCm39)	missense	probably damaging	1.00
R9246:Vmn2r112	UTSW	17	22,824,088 (GRCm39)	missense	probably benign	0.21
R9269:Vmn2r112	UTSW	17	22,820,213 (GRCm39)	missense	probably benign
R9273:Vmn2r112	UTSW	17	22,837,721 (GRCm39)	missense	probably damaging	1.00
R9288:Vmn2r112	UTSW	17	22,822,323 (GRCm39)	missense	probably damaging	1.00
R9352:Vmn2r112	UTSW	17	22,822,479 (GRCm39)	missense	probably damaging	0.98
R9406:Vmn2r112	UTSW	17	22,824,223 (GRCm39)	nonsense	probably null
R9432:Vmn2r112	UTSW	17	22,821,233 (GRCm39)	missense
R9728:Vmn2r112	UTSW	17	22,824,108 (GRCm39)	missense	probably damaging	0.96
Z1088:Vmn2r112	UTSW	17	22,824,059 (GRCm39)	missense	possibly damaging	0.89

Predicted Primers

PCR Primer
(F):5'- TTCATGTAACAGTGACTTTCAATGA -3'
(R):5'- TAACAATTGGAGTATTGTGGTGC -3'

Sequencing Primer
(F):5'- CCCTGGTTAACCATATCAAAGTG -3'
(R):5'- GTGGTGCTTCACAATGACCC -3'

Posted On

2018-05-04