Incidental Mutation 'IGL01135:Or2ag12'
ID 51632
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or2ag12
Ensembl Gene ENSMUSG00000051680
Gene Name olfactory receptor family 2 subfamily AG member 12
Synonyms Olfr693, MOR283-8, GA_x6K02T2PBJ9-9055944-9054994
Accession Numbers
Essential gene? Probably non essential (E-score: 0.105) question?
Stock # IGL01135
Quality Score
Chromosome 7
Chromosomal Location 106276741-106277692 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 106277400 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Threonine at position 98 (A98T)
Ref Sequence ENSEMBL: ENSMUSP00000150203 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057817] [ENSMUST00000215541]
AlphaFold Q8VF89
Predicted Effect probably benign
Transcript: ENSMUST00000057817
AA Change: A98T

PolyPhen 2 Score 0.411 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000059679
Gene: ENSMUSG00000051680
AA Change: A98T

Pfam:7tm_4 31 308 5.2e-48 PFAM
Pfam:7tm_1 41 290 5.7e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215541
AA Change: A98T

PolyPhen 2 Score 0.411 (Sensitivity: 0.89; Specificity: 0.90)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,834,475 (GRCm39) V124I probably damaging Het
5730507C01Rik G A 12: 18,583,375 (GRCm39) R145H possibly damaging Het
Acox3 T A 5: 35,746,096 (GRCm39) V93E probably benign Het
Ankar T C 1: 72,704,378 (GRCm39) N848S probably benign Het
Blzf1 A G 1: 164,131,499 (GRCm39) probably benign Het
Cc2d1a G T 8: 84,870,033 (GRCm39) H161N probably benign Het
Ceacam23 A T 7: 17,636,396 (GRCm39) noncoding transcript Het
Cfap206 C T 4: 34,721,562 (GRCm39) S162N probably damaging Het
Ckmt1 A C 2: 121,191,631 (GRCm39) D267A probably damaging Het
Dtl G T 1: 191,280,442 (GRCm39) T364K probably damaging Het
Fat1 T A 8: 45,477,877 (GRCm39) F2308I probably damaging Het
Fbxo41 A T 6: 85,454,890 (GRCm39) S673T probably benign Het
Flnb G A 14: 7,909,736 (GRCm38) V1397I probably benign Het
Gdi2 A G 13: 3,598,855 (GRCm39) probably benign Het
Grik3 C T 4: 125,526,208 (GRCm39) T147I probably benign Het
Htr1a T C 13: 105,581,792 (GRCm39) V344A possibly damaging Het
Isg20l2 A T 3: 87,839,068 (GRCm39) D93V probably damaging Het
Kcnt2 T C 1: 140,282,293 (GRCm39) probably null Het
Mfsd4b3-ps A G 10: 39,824,068 (GRCm39) M64T probably benign Het
Nox3 T A 17: 3,746,527 (GRCm39) probably benign Het
Pikfyve T A 1: 65,290,794 (GRCm39) N1204K probably damaging Het
Pou4f3 C T 18: 42,529,031 (GRCm39) Q325* probably null Het
Rap1a T A 3: 105,639,351 (GRCm39) T103S probably benign Het
Rfc4 G A 16: 22,934,526 (GRCm39) R165C probably damaging Het
Smtnl1 A G 2: 84,649,231 (GRCm39) S8P probably benign Het
Syt17 C T 7: 117,981,270 (GRCm39) G351S possibly damaging Het
Tcf20 T A 15: 82,738,101 (GRCm39) M1117L probably benign Het
Tent5a A G 9: 85,208,652 (GRCm39) V57A probably damaging Het
Tgfbr3 A T 5: 107,362,894 (GRCm39) H39Q probably damaging Het
Trdmt1 T C 2: 13,526,071 (GRCm39) probably null Het
Twf2 A G 9: 106,090,027 (GRCm39) I127V probably benign Het
Unc13c A G 9: 73,392,175 (GRCm39) V2059A probably damaging Het
Other mutations in Or2ag12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00911:Or2ag12 APN 7 106,277,040 (GRCm39) missense probably damaging 1.00
IGL03247:Or2ag12 APN 7 106,276,754 (GRCm39) missense probably benign 0.01
R0206:Or2ag12 UTSW 7 106,276,781 (GRCm39) missense probably benign 0.03
R1125:Or2ag12 UTSW 7 106,277,214 (GRCm39) missense possibly damaging 0.46
R1873:Or2ag12 UTSW 7 106,277,691 (GRCm39) start codon destroyed probably damaging 1.00
R1969:Or2ag12 UTSW 7 106,276,877 (GRCm39) missense probably damaging 0.99
R1970:Or2ag12 UTSW 7 106,276,877 (GRCm39) missense probably damaging 0.99
R1971:Or2ag12 UTSW 7 106,276,877 (GRCm39) missense probably damaging 0.99
R1972:Or2ag12 UTSW 7 106,277,426 (GRCm39) missense probably benign 0.01
R1973:Or2ag12 UTSW 7 106,277,426 (GRCm39) missense probably benign 0.01
R2570:Or2ag12 UTSW 7 106,276,874 (GRCm39) missense probably benign 0.41
R3975:Or2ag12 UTSW 7 106,276,992 (GRCm39) missense probably damaging 1.00
R4840:Or2ag12 UTSW 7 106,277,330 (GRCm39) missense probably damaging 1.00
R5569:Or2ag12 UTSW 7 106,277,690 (GRCm39) start codon destroyed probably null 1.00
R6759:Or2ag12 UTSW 7 106,277,100 (GRCm39) missense probably benign
R6842:Or2ag12 UTSW 7 106,277,093 (GRCm39) missense probably damaging 1.00
R7108:Or2ag12 UTSW 7 106,277,255 (GRCm39) missense probably benign 0.03
R7565:Or2ag12 UTSW 7 106,277,333 (GRCm39) missense probably damaging 1.00
R7800:Or2ag12 UTSW 7 106,276,781 (GRCm39) missense probably benign 0.03
R9225:Or2ag12 UTSW 7 106,276,976 (GRCm39) missense probably benign 0.01
X0025:Or2ag12 UTSW 7 106,277,456 (GRCm39) missense probably damaging 1.00
Z1088:Or2ag12 UTSW 7 106,277,664 (GRCm39) missense probably benign 0.02
Posted On 2013-06-21