Incidental Mutation 'IGL01137:Olfr685'
ID51638
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr685
Ensembl Gene ENSMUSG00000047794
Gene Nameolfactory receptor 685
SynonymsGA_x6K02T2PBJ9-7810071-7809121, MOR37-1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.111) question?
Stock #IGL01137
Quality Score
Status
Chromosome7
Chromosomal Location105178416-105186012 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 105180488 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 290 (V290A)
Ref Sequence ENSEMBL: ENSMUSP00000148994 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051355] [ENSMUST00000209409] [ENSMUST00000214712] [ENSMUST00000217432]
Predicted Effect probably benign
Transcript: ENSMUST00000051355
AA Change: V275A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000061561
Gene: ENSMUSG00000047794
AA Change: V275A

DomainStartEndE-ValueType
Pfam:7tm_4 34 313 3e-107 PFAM
Pfam:7TM_GPCR_Srsx 38 217 2.9e-8 PFAM
Pfam:7tm_1 44 295 7e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000209409
AA Change: V290A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000214712
AA Change: V290A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect probably benign
Transcript: ENSMUST00000217432
AA Change: V290A

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts20 C A 15: 94,394,611 probably null Het
Ankrd11 T C 8: 122,884,336 T2583A probably damaging Het
Anxa7 G A 14: 20,456,580 Q431* probably null Het
Asb15 T A 6: 24,556,522 D5E probably benign Het
Bex1 C A X: 136,214,494 D29Y probably damaging Het
Cadm2 G A 16: 66,815,350 T108I probably damaging Het
Cecr2 T G 6: 120,762,028 L1211V probably damaging Het
Cntn2 T C 1: 132,521,297 probably benign Het
Ctrc C A 4: 141,838,754 V198L possibly damaging Het
Cyp2g1 A G 7: 26,814,259 S208G possibly damaging Het
Ddx46 T A 13: 55,669,717 Y718* probably null Het
Dlec1 T C 9: 119,137,311 I1116T probably damaging Het
Dnajc13 A G 9: 104,160,490 Y2177H probably benign Het
Dpp6 T C 5: 27,714,488 F661S probably damaging Het
Dpy19l2 G A 9: 24,658,562 T365I possibly damaging Het
Flot2 T C 11: 78,049,507 Y27H probably damaging Het
Gsta4 T C 9: 78,205,922 Y95H possibly damaging Het
Kir3dl1 A G X: 136,526,611 T192A probably damaging Het
Llgl1 T A 11: 60,709,999 N640K probably benign Het
Lrch1 C T 14: 74,757,092 V691M probably damaging Het
Myh9 T C 15: 77,769,542 D1302G probably benign Het
Myo18a T G 11: 77,827,829 F935V probably damaging Het
Mypn T C 10: 63,152,854 E464G probably benign Het
Olfr1085 A T 2: 86,657,711 I249N possibly damaging Het
Olfr1453 A T 19: 13,028,030 F100I possibly damaging Het
Olfr209 A C 16: 59,361,972 M82R probably benign Het
R3hdm1 C T 1: 128,181,875 R39C probably damaging Het
Rps3a3 A T 13: 108,671,132 probably benign Het
Sec24b C T 3: 130,007,444 S401N probably benign Het
Slc22a22 C A 15: 57,254,278 G289V probably damaging Het
Stk33 T C 7: 109,329,568 I246V probably benign Het
Tedc1 C T 12: 113,163,188 R357* probably null Het
Timmdc1 A T 16: 38,518,385 H114Q probably benign Het
Tlcd2 T C 11: 75,469,511 Y127H probably damaging Het
Tnfrsf11a G A 1: 105,809,422 D85N possibly damaging Het
Trbc2 T C 6: 41,547,817 probably benign Het
Unc13b G A 4: 43,091,291 R39H probably damaging Het
Vwa8 T C 14: 79,103,647 L1521P probably damaging Het
Zbtb17 T A 4: 141,466,367 C607* probably null Het
Other mutations in Olfr685
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01612:Olfr685 APN 7 105180722 missense probably damaging 1.00
IGL02598:Olfr685 APN 7 105180956 missense probably damaging 1.00
R0841:Olfr685 UTSW 7 105180854 missense probably damaging 0.96
R1164:Olfr685 UTSW 7 105180833 missense probably benign 0.02
R1711:Olfr685 UTSW 7 105180760 missense probably damaging 0.99
R1891:Olfr685 UTSW 7 105180547 nonsense probably null
R1901:Olfr685 UTSW 7 105180872 missense possibly damaging 0.88
R1990:Olfr685 UTSW 7 105181014 missense probably damaging 1.00
R3766:Olfr685 UTSW 7 105180881 missense probably damaging 0.98
R4750:Olfr685 UTSW 7 105180926 missense probably damaging 1.00
R5056:Olfr685 UTSW 7 105180572 missense probably damaging 1.00
R5061:Olfr685 UTSW 7 105180657 missense possibly damaging 0.56
R6227:Olfr685 UTSW 7 105180710 missense probably damaging 1.00
R7619:Olfr685 UTSW 7 105180749 missense probably damaging 1.00
R8075:Olfr685 UTSW 7 105181136 missense probably damaging 0.98
R8250:Olfr685 UTSW 7 105181311 missense
Posted On2013-06-21