Incidental Mutation 'IGL01141:Mrgprb1'
ID 51652
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mrgprb1
Ensembl Gene ENSMUSG00000070547
Gene Name MAS-related GPR, member B1
Synonyms MrgB1
Accession Numbers
Essential gene? Probably non essential (E-score: 0.048) question?
Stock # IGL01141
Quality Score
Status
Chromosome 7
Chromosomal Location 48093861-48106090 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 48097775 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Proline at position 46 (T46P)
Ref Sequence ENSEMBL: ENSMUSP00000140432 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094384] [ENSMUST00000188095] [ENSMUST00000188918]
AlphaFold Q3UG61
Predicted Effect probably benign
Transcript: ENSMUST00000094384
AA Change: T46P

PolyPhen 2 Score 0.034 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000091946
Gene: ENSMUSG00000070547
AA Change: T46P

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srx 50 227 5.5e-11 PFAM
Pfam:7tm_1 59 290 4.3e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000188095
Predicted Effect probably benign
Transcript: ENSMUST00000188918
AA Change: T46P

PolyPhen 2 Score 0.360 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000140432
Gene: ENSMUSG00000070547
AA Change: T46P

DomainStartEndE-ValueType
SCOP:d1l9ha_ 23 84 3e-6 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b A T 11: 109,828,556 (GRCm39) D1447E probably damaging Het
Atp2a3 T C 11: 72,873,491 (GRCm39) I788T probably damaging Het
Axin1 G A 17: 26,409,015 (GRCm39) E672K probably damaging Het
Ccno A G 13: 113,125,561 (GRCm39) D175G probably damaging Het
Cep83 C A 10: 94,624,619 (GRCm39) T632K probably benign Het
Ckmt1 A T 2: 121,193,474 (GRCm39) I345F probably benign Het
Cntnap1 G A 11: 101,069,633 (GRCm39) probably benign Het
Cstdc3 A G 16: 36,128,426 (GRCm39) E7G probably benign Het
Edem2 A G 2: 155,550,948 (GRCm39) Y340H probably benign Het
Erich3 A G 3: 154,419,653 (GRCm39) K249R probably benign Het
Fndc9 T C 11: 46,128,526 (GRCm39) I15T probably benign Het
Grip2 G T 6: 91,759,878 (GRCm39) Q300K probably benign Het
Herc2 T C 7: 55,862,589 (GRCm39) V4050A possibly damaging Het
Jup A T 11: 100,277,075 (GRCm39) D44E probably benign Het
Lingo3 G T 10: 80,671,147 (GRCm39) P261Q probably damaging Het
Lrrfip2 C T 9: 111,048,783 (GRCm39) R311W probably damaging Het
Mansc1 C A 6: 134,598,748 (GRCm39) L56F probably benign Het
Map1b A G 13: 99,571,269 (GRCm39) I484T probably damaging Het
Mpeg1 T A 19: 12,440,149 (GRCm39) F536I probably damaging Het
Mug1 A G 6: 121,847,458 (GRCm39) N612S probably benign Het
Or5p56 T C 7: 107,589,758 (GRCm39) F62S probably damaging Het
Or6c212 T A 10: 129,558,814 (GRCm39) I200L probably benign Het
Pax8 A G 2: 24,331,162 (GRCm39) S178P probably damaging Het
Peak1 A G 9: 56,165,811 (GRCm39) F706L probably benign Het
Prkdc A G 16: 15,544,568 (GRCm39) T1853A probably damaging Het
Reln G T 5: 22,124,067 (GRCm39) P2813Q probably damaging Het
Reln A C 5: 22,174,031 (GRCm39) F2024C probably damaging Het
Riox1 A G 12: 83,998,568 (GRCm39) Q368R probably damaging Het
Rspry1 T C 8: 95,376,483 (GRCm39) V335A probably benign Het
Scn3a T C 2: 65,325,457 (GRCm39) N1020S possibly damaging Het
Scyl2 A G 10: 89,476,497 (GRCm39) V876A probably benign Het
Sdhaf3 T A 6: 6,956,141 (GRCm39) F39I probably damaging Het
Sfxn4 T C 19: 60,839,452 (GRCm39) E202G possibly damaging Het
Slc1a4 A T 11: 20,258,644 (GRCm39) probably benign Het
Sln A G 9: 53,760,784 (GRCm39) I10V probably benign Het
Ssh2 A G 11: 77,340,552 (GRCm39) E568G probably damaging Het
Supt7l G A 5: 31,675,779 (GRCm39) P270S probably benign Het
Tanc2 A G 11: 105,777,300 (GRCm39) probably benign Het
Tatdn1 A T 15: 58,781,416 (GRCm39) probably benign Het
Tfip11 C T 5: 112,477,369 (GRCm39) P117L possibly damaging Het
Vpreb1a T C 16: 16,686,951 (GRCm39) M9V probably benign Het
Other mutations in Mrgprb1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00540:Mrgprb1 APN 7 48,097,291 (GRCm39) missense probably damaging 0.99
IGL01393:Mrgprb1 APN 7 48,097,754 (GRCm39) missense possibly damaging 0.48
IGL02430:Mrgprb1 APN 7 48,097,409 (GRCm39) missense possibly damaging 0.95
IGL02485:Mrgprb1 APN 7 48,097,465 (GRCm39) missense possibly damaging 0.88
R0026:Mrgprb1 UTSW 7 48,096,952 (GRCm39) missense possibly damaging 0.66
R0051:Mrgprb1 UTSW 7 48,096,962 (GRCm39) missense probably benign 0.01
R0789:Mrgprb1 UTSW 7 48,105,932 (GRCm39) splice site probably benign
R1223:Mrgprb1 UTSW 7 48,097,435 (GRCm39) missense possibly damaging 0.61
R1327:Mrgprb1 UTSW 7 48,097,177 (GRCm39) missense possibly damaging 0.87
R1456:Mrgprb1 UTSW 7 48,097,777 (GRCm39) missense probably damaging 0.98
R1561:Mrgprb1 UTSW 7 48,096,873 (GRCm39) splice site probably null
R1567:Mrgprb1 UTSW 7 48,097,201 (GRCm39) missense probably damaging 0.97
R2030:Mrgprb1 UTSW 7 48,097,076 (GRCm39) missense possibly damaging 0.83
R2165:Mrgprb1 UTSW 7 48,097,070 (GRCm39) missense probably benign 0.00
R2885:Mrgprb1 UTSW 7 48,097,469 (GRCm39) missense probably damaging 1.00
R3108:Mrgprb1 UTSW 7 48,097,076 (GRCm39) missense possibly damaging 0.93
R3919:Mrgprb1 UTSW 7 48,097,829 (GRCm39) missense probably benign 0.03
R4021:Mrgprb1 UTSW 7 48,096,871 (GRCm39) missense possibly damaging 0.95
R4613:Mrgprb1 UTSW 7 48,097,456 (GRCm39) missense possibly damaging 0.91
R4809:Mrgprb1 UTSW 7 48,097,739 (GRCm39) missense possibly damaging 0.89
R5249:Mrgprb1 UTSW 7 48,097,225 (GRCm39) missense possibly damaging 0.91
R5425:Mrgprb1 UTSW 7 48,097,719 (GRCm39) missense possibly damaging 0.81
R5555:Mrgprb1 UTSW 7 48,097,523 (GRCm39) missense probably benign 0.06
R5595:Mrgprb1 UTSW 7 48,097,432 (GRCm39) missense probably damaging 0.99
R5982:Mrgprb1 UTSW 7 48,097,568 (GRCm39) missense probably benign 0.01
R6746:Mrgprb1 UTSW 7 48,097,645 (GRCm39) missense possibly damaging 0.82
R7066:Mrgprb1 UTSW 7 48,097,424 (GRCm39) missense probably benign 0.27
R7141:Mrgprb1 UTSW 7 48,097,435 (GRCm39) missense possibly damaging 0.61
R7633:Mrgprb1 UTSW 7 48,097,331 (GRCm39) missense probably benign 0.01
R8072:Mrgprb1 UTSW 7 48,097,895 (GRCm39) nonsense probably null
R8080:Mrgprb1 UTSW 7 48,096,658 (GRCm39) splice site probably null
R8112:Mrgprb1 UTSW 7 48,097,682 (GRCm39) missense probably damaging 0.97
R8493:Mrgprb1 UTSW 7 48,097,321 (GRCm39) missense probably damaging 0.99
R8817:Mrgprb1 UTSW 7 48,097,070 (GRCm39) missense probably benign 0.01
R9135:Mrgprb1 UTSW 7 48,097,046 (GRCm39) missense possibly damaging 0.95
Posted On 2013-06-21