Mutagenetix > Incidental Mutation

Incidental Mutation 'R6467:Vmn2r107'

516679

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r107

Ensembl Gene

ENSMUSG00000056910

Gene Name

vomeronasal 2, receptor 107

Synonyms

V2r6

MMRRC Submission

Accession Numbers

Genbank: NM_001104569; MGI: 1316664

Essential gene?

Probably non essential (E-score: 0.085) question?

Stock #

R6467 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

20345425-20375772 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 20375677 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 831 (I831F)

Ref Sequence

ENSEMBL: ENSMUSP00000048706 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000042090]

AlphaFold

E9PZJ7

Predicted Effect

probably damaging
Transcript: ENSMUST00000042090
AA Change: I831F

PolyPhen 2 Score 0.987 (Sensitivity: 0.73; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000048706
Gene: ENSMUSG00000056910
AA Change: I831F

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	466	3.6e-40	PFAM
Pfam:NCD3G	509	562	5.1e-21	PFAM
Pfam:7tm_3	593	830	8e-51	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.9%
3x: 99.6%
10x: 97.9%
20x: 93.5%

Validation Efficiency

99% (72/73)

Allele List at MGI

Other mutations in this stock

Total: 73 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acvr1b	T	C	15: 101,194,841	W122R	possibly damaging	Het
Adgrv1	C	T	13: 81,444,538	R4294H	probably benign	Het
Afdn	A	G	17: 13,804,053	T74A	probably damaging	Het
Aff3	T	A	1: 38,208,017	D829V	probably benign	Het
Akr1c12	T	C	13: 4,275,773	Q107R	probably benign	Het
Apc	T	A	18: 34,269,199	F131I	probably benign	Het
Atp13a1	T	A	8: 69,806,774	L1036H	probably damaging	Het
BC035044	A	C	6: 128,890,892		probably benign	Het
C1rl	A	G	6: 124,508,576	D302G	probably benign	Het
C2cd6	A	C	1: 59,077,934	D133E	probably benign	Het
Cacna1c	T	A	6: 118,652,710	Y1061F	probably damaging	Het
Cav1	A	G	6: 17,308,035	D62G	probably damaging	Het
Ccdc130	T	C	8: 84,258,689	E317G	probably benign	Het
Ccdc77	T	C	6: 120,350,281	M68V	probably damaging	Het
Cd55	A	T	1: 130,447,611		probably benign	Het
Cdc27	C	A	11: 104,522,776	A380S	probably damaging	Het
Cenpb	A	T	2: 131,179,557	I107K	probably damaging	Het
Cep135	T	G	5: 76,621,340	H612Q	possibly damaging	Het
Chd1l	A	T	3: 97,563,533	N815K	probably damaging	Het
Cldn20	C	T	17: 3,532,717	T55M	possibly damaging	Het
Depdc1a	A	T	3: 159,516,042	I208L	probably benign	Het
Dgkb	C	T	12: 38,084,224	A43V	possibly damaging	Het
Dgkb	C	T	12: 38,604,105	T741I	probably damaging	Het
Dhx16	A	G	17: 35,886,184	N653S	probably damaging	Het
Dnah5	T	A	15: 28,438,183	S3987T	probably benign	Het
Dst	T	A	1: 34,295,196	I4835N	probably damaging	Het
Esrrb	A	G	12: 86,514,340	I288V	probably damaging	Het
Fam214b	A	T	4: 43,033,687	F489I	probably damaging	Het
Fnta	C	T	8: 26,007,313	W169*	probably null	Het
Golga4	T	C	9: 118,536,792	L304P	probably damaging	Het
Hace1	A	G	10: 45,590,266		probably null	Het
Ino80b	G	T	6: 83,124,131		probably null	Het
Kcmf1	G	A	6: 72,843,099	R306C	probably damaging	Het
Lrrc46	G	A	11: 97,036,479	T92I	possibly damaging	Het
Man2b1	T	C	8: 85,097,447	V991A	possibly damaging	Het
Mga	A	G	2: 119,946,295	N1770S	probably damaging	Het
Mgat4e	T	C	1: 134,541,206	T367A	probably benign	Het
Mtr	A	G	13: 12,188,106	S1204P	probably damaging	Het
Myo15	G	A	11: 60,526,661		probably null	Het
Nktr	T	C	9: 121,731,519	S74P	probably damaging	Het
Noct	T	C	3: 51,250,087	V282A	possibly damaging	Het
Nol11	A	T	11: 107,181,086	I227K	possibly damaging	Het
Nsd3	T	A	8: 25,640,630	S4T	probably damaging	Het
Olfr1022	T	A	2: 85,869,370	Y259*	probably null	Het
Olfr488	A	G	7: 108,255,902	S79P	probably damaging	Het
Pds5a	T	A	5: 65,652,439	L393F	probably damaging	Het
Prex2	C	T	1: 11,266,035	R1486C	probably damaging	Het
Rc3h2	T	C	2: 37,382,016	T768A	probably damaging	Het
Rin3	A	T	12: 102,369,325	E418D	probably benign	Het
Rnf214	G	T	9: 45,867,588	T586N	probably damaging	Het
Samd4b	A	G	7: 28,401,860	S667P	probably damaging	Het
Sec14l2	T	C	11: 4,111,161	Y100C	probably damaging	Het
Slc46a2	T	C	4: 59,914,077	E282G	probably benign	Het
Themis	A	C	10: 28,781,766	N110T	possibly damaging	Het
Tln1	C	A	4: 43,543,165	S1333I	probably benign	Het
Tmem53	T	C	4: 117,268,428	V224A	possibly damaging	Het
Tmtc4	T	A	14: 122,925,979	K664N	possibly damaging	Het
Tnni3k	T	C	3: 154,969,285	D201G	probably damaging	Het
Tnxb	A	G	17: 34,693,924	E1681G	probably damaging	Het
Trhde	A	T	10: 114,504,198	D567E	probably damaging	Het
Tsc2	T	C	17: 24,609,127	M788V	probably benign	Het
Ube3a	A	G	7: 59,276,902	Y476C	probably damaging	Het
Ubiad1	T	C	4: 148,436,225	N314S	possibly damaging	Het
Unc79	T	A	12: 103,173,512	N2375K	probably damaging	Het
Vwa3b	T	A	1: 37,085,286	C322S	probably benign	Het
Wdr78	T	C	4: 103,049,561	D685G	probably damaging	Het
Wnk1	A	T	6: 119,962,955	H238Q	probably benign	Het
Wnk2	A	G	13: 49,146,605	Y210H	probably damaging	Het
Wwc2	T	C	8: 47,851,908	D894G	unknown	Het
Yes1	T	A	5: 32,653,037	F180Y	probably damaging	Het
Zbtb46	T	C	2: 181,391,269	Y533C	probably damaging	Het
Zfp57	T	C	17: 37,006,050	S7P	possibly damaging	Het
Zzef1	T	C	11: 72,911,264		probably null	Het

Other mutations in Vmn2r107

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01402:Vmn2r107	APN	17	20375747	missense	probably damaging	0.98
IGL01768:Vmn2r107	APN	17	20345606	missense	probably benign	0.32
IGL02086:Vmn2r107	APN	17	20357800	missense	probably benign	0.00
IGL02136:Vmn2r107	APN	17	20374906	missense	probably benign	0.02
IGL02266:Vmn2r107	APN	17	20356777	missense	probably damaging	1.00
IGL02285:Vmn2r107	APN	17	20375561	missense	probably damaging	1.00
IGL02724:Vmn2r107	APN	17	20356744	missense	possibly damaging	0.49
IGL02998:Vmn2r107	APN	17	20357755	missense	probably damaging	0.99
IGL03089:Vmn2r107	APN	17	20375712	missense	probably benign	0.05
IGL03284:Vmn2r107	APN	17	20356911	missense	probably benign	0.07
IGL03307:Vmn2r107	APN	17	20356776	missense	probably benign	0.09
IGL03399:Vmn2r107	APN	17	20357958	splice site	probably benign
3-1:Vmn2r107	UTSW	17	20345504	missense	probably benign
BB006:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
BB016:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R0285:Vmn2r107	UTSW	17	20345611	missense	probably benign	0.00
R0455:Vmn2r107	UTSW	17	20374823	splice site	probably benign
R0497:Vmn2r107	UTSW	17	20375132	missense	probably damaging	1.00
R0506:Vmn2r107	UTSW	17	20357759	missense	probably benign
R0621:Vmn2r107	UTSW	17	20374990	missense	probably benign	0.01
R0667:Vmn2r107	UTSW	17	20355654	missense	possibly damaging	0.91
R1118:Vmn2r107	UTSW	17	20356598	missense	probably benign	0.03
R1204:Vmn2r107	UTSW	17	20357769	missense	probably benign
R1237:Vmn2r107	UTSW	17	20356685	nonsense	probably null
R1485:Vmn2r107	UTSW	17	20374847	missense	possibly damaging	0.95
R1783:Vmn2r107	UTSW	17	20356513	missense	possibly damaging	0.51
R1873:Vmn2r107	UTSW	17	20345578	missense	probably benign	0.10
R1974:Vmn2r107	UTSW	17	20355617	splice site	probably null
R2009:Vmn2r107	UTSW	17	20375467	missense	probably benign	0.01
R2029:Vmn2r107	UTSW	17	20375287	missense	probably benign	0.01
R2164:Vmn2r107	UTSW	17	20375642	missense	probably damaging	1.00
R2269:Vmn2r107	UTSW	17	20375555	missense	possibly damaging	0.58
R3087:Vmn2r107	UTSW	17	20360345	missense	probably benign	0.03
R3740:Vmn2r107	UTSW	17	20374889	missense	probably benign	0.00
R3961:Vmn2r107	UTSW	17	20375455	missense	probably damaging	1.00
R4031:Vmn2r107	UTSW	17	20375221	missense	probably benign	0.00
R4270:Vmn2r107	UTSW	17	20355779	missense	probably benign
R4963:Vmn2r107	UTSW	17	20375141	missense	probably damaging	1.00
R5121:Vmn2r107	UTSW	17	20355753	missense	probably benign	0.01
R5640:Vmn2r107	UTSW	17	20375164	missense	probably damaging	1.00
R6007:Vmn2r107	UTSW	17	20375054	missense	probably benign	0.19
R6238:Vmn2r107	UTSW	17	20345587	missense	probably benign	0.43
R6298:Vmn2r107	UTSW	17	20355782	missense	probably benign	0.00
R6726:Vmn2r107	UTSW	17	20375375	missense	probably damaging	0.96
R6782:Vmn2r107	UTSW	17	20356879	missense	probably damaging	1.00
R7299:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7301:Vmn2r107	UTSW	17	20345616	missense	probably benign	0.01
R7375:Vmn2r107	UTSW	17	20355876	missense	probably benign
R7448:Vmn2r107	UTSW	17	20375732	missense	probably benign	0.00
R7495:Vmn2r107	UTSW	17	20375009	missense	possibly damaging	0.71
R7589:Vmn2r107	UTSW	17	20375372	missense	probably benign	0.05
R7594:Vmn2r107	UTSW	17	20360373	missense	probably benign	0.03
R7678:Vmn2r107	UTSW	17	20356639	missense	probably benign	0.01
R7929:Vmn2r107	UTSW	17	20345444	missense	probably null	0.96
R7974:Vmn2r107	UTSW	17	20357008	missense	probably benign	0.00
R8040:Vmn2r107	UTSW	17	20375546	missense	probably damaging	1.00
R8263:Vmn2r107	UTSW	17	20360352	missense	probably damaging	1.00
R8426:Vmn2r107	UTSW	17	20356977	missense	possibly damaging	0.91
R9175:Vmn2r107	UTSW	17	20356789	missense	possibly damaging	0.79
R9537:Vmn2r107	UTSW	17	20374887	missense	probably benign	0.00
R9642:Vmn2r107	UTSW	17	20360399	missense	probably damaging	1.00
R9711:Vmn2r107	UTSW	17	20357000	missense	probably damaging	1.00
X0022:Vmn2r107	UTSW	17	20356968	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- TGCCTGATACATTCAACGAATCC -3'
(R):5'- CCAGAGCAAATGTGGTTTTCTAAC -3'

Sequencing Primer
(F):5'- GGAAGGTCATGGTAGCTA -3'
(R):5'- TCTAACAAGGAAAACAAATGGCTATC -3'

Posted On

2018-05-21