Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01153:Zfp768'

51690

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp768

Ensembl Gene

ENSMUSG00000047371

Gene Name

zinc finger protein 768

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.114) question?

Stock #

IGL01153

Quality Score

Status

Chromosome

Chromosomal Location

126941967-126944486 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 126943703 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 145 (Y145H)

Ref Sequence

ENSEMBL: ENSMUSP00000055374 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060783] [ENSMUST00000205266]

AlphaFold

Q8R0T2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000060783
AA Change: Y145H

PolyPhen 2 Score 0.795 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000055374
Gene: ENSMUSG00000047371
AA Change: Y145H

Domain	Start	End	E-Value	Type
low complexity region	62	80	N/A	INTRINSIC
Pfam:RNA_pol_Rpb1_R	112	130	3.7e-4	PFAM
Pfam:RNA_pol_Rpb1_R	133	152	1.3e-4	PFAM
low complexity region	271	288	N/A	INTRINSIC
ZnF_C2H2	289	311	7.15e-2	SMART
ZnF_C2H2	317	339	1.22e-4	SMART
ZnF_C2H2	345	367	1.5e-4	SMART
ZnF_C2H2	373	395	4.3e-5	SMART
ZnF_C2H2	401	423	4.24e-4	SMART
ZnF_C2H2	429	451	9.58e-3	SMART
ZnF_C2H2	457	479	1.47e-3	SMART
ZnF_C2H2	485	507	7.49e-5	SMART
ZnF_C2H2	513	535	1.03e-2	SMART
ZnF_C2H2	541	563	6.52e-5	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000205266
AA Change: Y142H

PolyPhen 2 Score 0.645 (Sensitivity: 0.87; Specificity: 0.91)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrv1	T	C	13: 81,567,247 (GRCm39)	I5309V	probably benign	Het
Amy1	A	G	3: 113,349,724 (GRCm39)	V482A	possibly damaging	Het
Ankrd22	A	T	19: 34,106,229 (GRCm39)	V81E	probably damaging	Het
Ccr5	C	A	9: 123,924,649 (GRCm39)	T84K	probably damaging	Het
Cfap206	C	T	4: 34,721,562 (GRCm39)	S162N	probably damaging	Het
Chchd3	A	T	6: 32,985,502 (GRCm39)		probably benign	Het
Cpt1c	C	T	7: 44,616,092 (GRCm39)	E307K	probably damaging	Het
Cyth2	T	C	7: 45,457,813 (GRCm39)	Y120C	probably damaging	Het
Dnajb11	T	A	16: 22,681,430 (GRCm39)	D69E	probably benign	Het
Ece2	T	A	16: 20,451,544 (GRCm39)	M215K	possibly damaging	Het
Enox2	C	A	X: 48,151,015 (GRCm39)		probably null	Het
Fam120c	T	C	X: 150,182,801 (GRCm39)		probably null	Het
Fam149b	A	G	14: 20,427,949 (GRCm39)	T319A	possibly damaging	Het
Fndc1	A	T	17: 7,998,874 (GRCm39)		probably null	Het
Gcsh	T	A	8: 117,710,549 (GRCm39)	D138V	probably benign	Het
Herc3	T	A	6: 58,837,321 (GRCm39)	H331Q	probably benign	Het
Iars1	A	G	13: 49,865,281 (GRCm39)	N586D	probably damaging	Het
Idh3g	A	G	X: 72,823,668 (GRCm39)	V280A	probably damaging	Het
Kctd18	A	G	1: 58,004,550 (GRCm39)	S115P	probably damaging	Het
Lims2	A	G	18: 32,090,370 (GRCm39)		probably null	Het
Lyset	T	A	12: 102,711,135 (GRCm39)	Y119*	probably null	Het
Mael	T	C	1: 166,029,919 (GRCm39)	K334E	possibly damaging	Het
Me3	A	C	7: 89,498,844 (GRCm39)	T475P	probably damaging	Het
Mrpl18	A	G	17: 13,134,693 (GRCm39)	L24P	possibly damaging	Het
Nol4	C	A	18: 22,902,850 (GRCm39)	R460L	probably damaging	Het
Numa1	A	T	7: 101,643,951 (GRCm39)	E181V	probably damaging	Het
Or6c2	T	A	10: 129,362,864 (GRCm39)	I256N	probably damaging	Het
Pex2	A	T	3: 5,626,424 (GRCm39)	H128Q	probably benign	Het
Pex3	A	T	10: 13,428,597 (GRCm39)		probably null	Het
Psmb8	A	G	17: 34,420,215 (GRCm39)	Y269C	possibly damaging	Het
Sh2d3c	A	G	2: 32,615,096 (GRCm39)	K62R	probably benign	Het
Strn4	G	A	7: 16,571,846 (GRCm39)	G613D	probably damaging	Het
Taok2	A	G	7: 126,470,204 (GRCm39)	W875R	probably damaging	Het
Tbc1d4	T	C	14: 101,845,451 (GRCm39)	D149G	possibly damaging	Het
Zfp473	A	G	7: 44,383,992 (GRCm39)	S113P	probably damaging	Het
Zgrf1	G	A	3: 127,396,055 (GRCm39)	G534R	probably damaging	Het

Other mutations in Zfp768

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03236:Zfp768	APN	7	126,943,142 (GRCm39)	missense	possibly damaging	0.93
R1490:Zfp768	UTSW	7	126,942,803 (GRCm39)	missense	probably damaging	1.00
R1497:Zfp768	UTSW	7	126,942,733 (GRCm39)	missense	probably damaging	1.00
R2251:Zfp768	UTSW	7	126,943,550 (GRCm39)	missense	probably benign
R2298:Zfp768	UTSW	7	126,943,361 (GRCm39)	missense	probably benign	0.11
R2360:Zfp768	UTSW	7	126,943,810 (GRCm39)	missense	probably benign	0.43
R4751:Zfp768	UTSW	7	126,943,934 (GRCm39)	missense	possibly damaging	0.94
R4795:Zfp768	UTSW	7	126,942,547 (GRCm39)	missense	possibly damaging	0.60
R5011:Zfp768	UTSW	7	126,942,875 (GRCm39)	missense	probably damaging	1.00
R5518:Zfp768	UTSW	7	126,943,583 (GRCm39)	missense	probably benign
R5602:Zfp768	UTSW	7	126,943,804 (GRCm39)	missense	possibly damaging	0.73
R5876:Zfp768	UTSW	7	126,943,718 (GRCm39)	missense	probably benign	0.01
R6245:Zfp768	UTSW	7	126,943,263 (GRCm39)	nonsense	probably null
R6273:Zfp768	UTSW	7	126,944,319 (GRCm39)	critical splice donor site	probably null
R6376:Zfp768	UTSW	7	126,943,892 (GRCm39)	missense	probably benign	0.34
R6475:Zfp768	UTSW	7	126,943,827 (GRCm39)	missense	probably damaging	0.97
R7125:Zfp768	UTSW	7	126,943,959 (GRCm39)	missense	probably damaging	0.98
R7905:Zfp768	UTSW	7	126,943,831 (GRCm39)	missense	probably damaging	0.99
R8781:Zfp768	UTSW	7	126,942,476 (GRCm39)	missense	probably damaging	1.00

Posted On

2013-06-21