Incidental Mutation 'R6478:Lrrk1'
| ID |
516911 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrrk1
|
| Ensembl Gene |
ENSMUSG00000015133 |
| Gene Name |
leucine-rich repeat kinase 1 |
| Synonyms |
|
| MMRRC Submission |
044610-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R6478 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
66226912-66388350 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 66262733 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 1693
(V1693A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000015277
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000015277]
[ENSMUST00000145954]
|
| AlphaFold |
Q3UHC2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000015277
AA Change: V1693A
PolyPhen 2
Score 0.958 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000015277
Gene: ENSMUSG00000015133
AA Change: V1693A
| Domain | Start | End | E-Value | Type |
|---|
|
ANK
|
86 |
116 |
9.33e2 |
SMART |
|
ANK
|
119 |
148 |
1.14e2 |
SMART |
|
ANK
|
152 |
182 |
8.36e1 |
SMART |
|
ANK
|
193 |
223 |
2.6e1 |
SMART |
|
LRR
|
278 |
300 |
2.84e2 |
SMART |
|
LRR
|
301 |
325 |
7.79e0 |
SMART |
|
LRR
|
328 |
351 |
3.27e1 |
SMART |
|
LRR_TYP
|
379 |
401 |
2.53e-2 |
SMART |
|
LRR
|
403 |
427 |
5.89e1 |
SMART |
|
LRR
|
472 |
493 |
5.27e1 |
SMART |
|
LRR
|
548 |
569 |
2.92e2 |
SMART |
|
LRR
|
570 |
594 |
5.88e0 |
SMART |
|
Pfam:Arf
|
625 |
786 |
2e-8 |
PFAM |
|
Pfam:Roc
|
640 |
761 |
3.1e-24 |
PFAM |
|
Pfam:Ras
|
640 |
782 |
2.2e-7 |
PFAM |
|
Pfam:COR
|
844 |
1046 |
4.7e-26 |
PFAM |
|
low complexity region
|
1109 |
1119 |
N/A |
INTRINSIC |
|
low complexity region
|
1209 |
1222 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
1243 |
1521 |
7.8e-40 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1244 |
1520 |
9.4e-39 |
PFAM |
|
low complexity region
|
1642 |
1654 |
N/A |
INTRINSIC |
|
low complexity region
|
1839 |
1846 |
N/A |
INTRINSIC |
|
low complexity region
|
1852 |
1871 |
N/A |
INTRINSIC |
|
low complexity region
|
1957 |
1970 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131239
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000137181
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000145954
|
| SMART Domains |
Protein: ENSMUSP00000114938
Gene: ENSMUSG00000015133
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
124 |
137 |
N/A |
INTRINSIC |
|
Pfam:Pkinase
|
158 |
435 |
6.6e-46 |
PFAM |
|
Pfam:Pkinase_Tyr
|
159 |
435 |
5.8e-40 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000167705
|
| Meta Mutation Damage Score |
0.1926 |
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.6%
- 10x: 97.8%
- 20x: 93.3%
|
| Validation Efficiency |
95% (75/79) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit preweaning lethality. Mice homozygous for another knock-out allele exhibit severe osteopetrosis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aatk |
T |
A |
11: 120,010,991 (GRCm38) |
S803C |
probably benign |
Het |
| Abcc9 |
C |
T |
6: 142,679,308 (GRCm38) |
A454T |
probably damaging |
Het |
| Abr |
T |
C |
11: 76,452,332 (GRCm38) |
E565G |
probably damaging |
Het |
| Adam33 |
C |
A |
2: 131,051,346 (GRCm38) |
R753L |
probably benign |
Het |
| Adgre1 |
A |
G |
17: 57,401,955 (GRCm38) |
T49A |
possibly damaging |
Het |
| Ankra2 |
A |
T |
13: 98,268,442 (GRCm38) |
H153L |
probably damaging |
Het |
| Ankrd26 |
T |
G |
6: 118,511,638 (GRCm38) |
E1353D |
probably benign |
Het |
| Ankrd52 |
T |
G |
10: 128,379,331 (GRCm38) |
|
probably null |
Het |
| Arhgef10l |
T |
A |
4: 140,542,757 (GRCm38) |
T619S |
possibly damaging |
Het |
| Armh4 |
A |
G |
14: 49,773,332 (GRCm38) |
V306A |
possibly damaging |
Het |
| Asgr1 |
T |
C |
11: 70,056,894 (GRCm38) |
V130A |
possibly damaging |
Het |
| Atg10 |
C |
A |
13: 90,937,347 (GRCm38) |
C161F |
probably damaging |
Het |
| Atm |
A |
T |
9: 53,490,254 (GRCm38) |
N1438K |
probably damaging |
Het |
| BC107364 |
T |
A |
3: 96,436,006 (GRCm38) |
|
probably null |
Het |
| Bcar3 |
G |
T |
3: 122,426,576 (GRCm38) |
A41S |
probably benign |
Het |
| Btbd6 |
A |
G |
12: 112,977,312 (GRCm38) |
|
probably benign |
Het |
| Cchcr1 |
A |
G |
17: 35,524,703 (GRCm38) |
T318A |
possibly damaging |
Het |
| Celsr1 |
A |
T |
15: 85,925,518 (GRCm38) |
I2221N |
probably damaging |
Het |
| Cept1 |
C |
T |
3: 106,533,445 (GRCm38) |
W48* |
probably null |
Het |
| Cfap161 |
T |
A |
7: 83,793,276 (GRCm38) |
I85L |
probably benign |
Het |
| Clasp1 |
A |
T |
1: 118,512,180 (GRCm38) |
R640* |
probably null |
Het |
| Col5a1 |
T |
A |
2: 27,952,436 (GRCm38) |
I441N |
unknown |
Het |
| Col9a1 |
C |
A |
1: 24,185,405 (GRCm38) |
L223I |
unknown |
Het |
| Dnah2 |
T |
C |
11: 69,516,010 (GRCm38) |
D223G |
probably benign |
Het |
| Dnah8 |
G |
A |
17: 30,748,568 (GRCm38) |
D2585N |
probably benign |
Het |
| Dpy19l1 |
A |
T |
9: 24,450,696 (GRCm38) |
M129K |
possibly damaging |
Het |
| Ecpas |
A |
T |
4: 58,810,785 (GRCm38) |
I1524N |
probably damaging |
Het |
| Fcgbpl1 |
C |
G |
7: 28,155,373 (GRCm38) |
P1808R |
probably damaging |
Het |
| Fcrl1 |
C |
A |
3: 87,389,639 (GRCm38) |
H318Q |
probably benign |
Het |
| Fer1l5 |
A |
G |
1: 36,402,531 (GRCm38) |
N609S |
probably damaging |
Het |
| Fkbp4 |
C |
T |
6: 128,433,231 (GRCm38) |
E256K |
probably damaging |
Het |
| Fsip2 |
A |
G |
2: 82,990,086 (GRCm38) |
T5388A |
possibly damaging |
Het |
| Glrx |
G |
A |
13: 75,847,299 (GRCm38) |
|
probably null |
Het |
| Gm7356 |
A |
T |
17: 14,001,464 (GRCm38) |
M101K |
probably damaging |
Het |
| Gstp2 |
A |
T |
19: 4,040,499 (GRCm38) |
I162N |
probably benign |
Het |
| Hectd3 |
A |
C |
4: 116,999,586 (GRCm38) |
K443N |
probably damaging |
Het |
| Hmcn1 |
T |
A |
1: 150,664,784 (GRCm38) |
R2925W |
probably damaging |
Het |
| Hspa1a |
G |
T |
17: 34,970,306 (GRCm38) |
N540K |
probably damaging |
Het |
| Ints6 |
A |
T |
14: 62,700,786 (GRCm38) |
M649K |
probably benign |
Het |
| Katnb1 |
T |
C |
8: 95,095,456 (GRCm38) |
V270A |
possibly damaging |
Het |
| Kctd3 |
A |
G |
1: 188,972,364 (GRCm38) |
S737P |
probably benign |
Het |
| Klra10 |
T |
C |
6: 130,272,544 (GRCm38) |
|
probably null |
Het |
| Lmtk3 |
A |
G |
7: 45,798,589 (GRCm38) |
D1353G |
unknown |
Het |
| Mpnd |
A |
T |
17: 56,009,575 (GRCm38) |
I85F |
probably damaging |
Het |
| Myo3b |
A |
G |
2: 70,348,960 (GRCm38) |
T1173A |
probably benign |
Het |
| Myof |
G |
A |
19: 37,903,831 (GRCm38) |
P1158L |
probably damaging |
Het |
| Naip2 |
A |
C |
13: 100,162,041 (GRCm38) |
S496A |
probably benign |
Het |
| Ncor2 |
A |
G |
5: 125,110,005 (GRCm38) |
|
probably benign |
Het |
| Npepps |
C |
T |
11: 97,258,273 (GRCm38) |
|
probably null |
Het |
| Opn5 |
T |
A |
17: 42,580,749 (GRCm38) |
I266F |
probably benign |
Het |
| Or4a74 |
T |
G |
2: 89,609,446 (GRCm38) |
I219L |
probably damaging |
Het |
| P2rx4 |
A |
G |
5: 122,707,700 (GRCm38) |
D16G |
probably damaging |
Het |
| Padi2 |
G |
T |
4: 140,917,637 (GRCm38) |
V61L |
probably benign |
Het |
| Pkd1l1 |
G |
A |
11: 8,863,911 (GRCm38) |
T1480I |
probably benign |
Het |
| Plcb1 |
T |
C |
2: 135,335,451 (GRCm38) |
S568P |
probably damaging |
Het |
| Rassf10 |
A |
G |
7: 112,955,707 (GRCm38) |
E505G |
probably damaging |
Het |
| Rcan2 |
A |
G |
17: 43,836,334 (GRCm38) |
E21G |
probably benign |
Het |
| Rhob |
G |
T |
12: 8,499,585 (GRCm38) |
C16* |
probably null |
Het |
| Ryr3 |
T |
C |
2: 112,660,068 (GRCm38) |
N3807S |
probably damaging |
Het |
| Sass6 |
T |
A |
3: 116,621,397 (GRCm38) |
N519K |
probably benign |
Het |
| Slco1a8 |
A |
T |
6: 141,993,642 (GRCm38) |
N208K |
possibly damaging |
Het |
| Smad9 |
A |
T |
3: 54,782,443 (GRCm38) |
D28V |
probably damaging |
Het |
| Spmip8 |
A |
T |
8: 95,321,266 (GRCm38) |
|
probably null |
Het |
| Tex14 |
G |
T |
11: 87,514,373 (GRCm38) |
G704C |
probably benign |
Het |
| Tmc3 |
A |
G |
7: 83,622,316 (GRCm38) |
N892S |
probably benign |
Het |
| Tnfaip2 |
T |
A |
12: 111,445,663 (GRCm38) |
L166Q |
probably damaging |
Het |
| Triml2 |
A |
G |
8: 43,185,128 (GRCm38) |
|
probably null |
Het |
| Trio |
A |
G |
15: 27,856,107 (GRCm38) |
V666A |
probably benign |
Het |
| Tshz2 |
G |
T |
2: 169,884,664 (GRCm38) |
L393F |
probably damaging |
Het |
| Ttn |
T |
G |
2: 76,841,771 (GRCm38) |
|
probably benign |
Het |
| Tubb5 |
A |
G |
17: 35,835,842 (GRCm38) |
Y159H |
probably damaging |
Het |
| Umodl1 |
A |
G |
17: 30,959,155 (GRCm38) |
Y35C |
probably damaging |
Het |
| Utp4 |
T |
C |
8: 106,904,446 (GRCm38) |
|
probably null |
Het |
| Vmn1r60 |
A |
T |
7: 5,544,865 (GRCm38) |
C79S |
probably damaging |
Het |
| Wnt5b |
T |
C |
6: 119,433,790 (GRCm38) |
T230A |
probably damaging |
Het |
| Zfp618 |
A |
T |
4: 63,132,706 (GRCm38) |
I575F |
probably damaging |
Het |
| Zmym6 |
G |
T |
4: 127,123,383 (GRCm38) |
V894L |
possibly damaging |
Het |
| Zpbp |
T |
C |
11: 11,462,318 (GRCm38) |
|
probably benign |
Het |
|
| Other mutations in Lrrk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01365:Lrrk1
|
APN |
7 |
66,287,701 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01511:Lrrk1
|
APN |
7 |
66,265,450 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
IGL02337:Lrrk1
|
APN |
7 |
66,279,416 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
IGL02636:Lrrk1
|
APN |
7 |
66,308,659 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL02679:Lrrk1
|
APN |
7 |
66,274,872 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02711:Lrrk1
|
APN |
7 |
66,330,767 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02742:Lrrk1
|
APN |
7 |
66,308,691 (GRCm38) |
missense |
probably benign |
0.12 |
|
IGL02878:Lrrk1
|
APN |
7 |
66,262,563 (GRCm38) |
missense |
probably benign |
|
|
IGL03135:Lrrk1
|
APN |
7 |
66,262,890 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03191:Lrrk1
|
APN |
7 |
66,259,959 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03198:Lrrk1
|
APN |
7 |
66,306,894 (GRCm38) |
missense |
probably damaging |
1.00 |
|
combustion
|
UTSW |
7 |
66,262,665 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
fluorine
|
UTSW |
7 |
66,302,710 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
halide
|
UTSW |
7 |
66,265,474 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
Heiland
|
UTSW |
7 |
66,262,733 (GRCm38) |
missense |
probably damaging |
0.96 |
|
liebster
|
UTSW |
7 |
66,294,981 (GRCm38) |
missense |
probably damaging |
1.00 |
|
magi
|
UTSW |
7 |
66,281,648 (GRCm38) |
missense |
probably damaging |
1.00 |
|
oxidation
|
UTSW |
7 |
66,279,372 (GRCm38) |
missense |
probably benign |
0.00 |
|
phlogiston
|
UTSW |
7 |
66,278,520 (GRCm38) |
splice site |
probably benign |
|
|
Savior
|
UTSW |
7 |
66,262,487 (GRCm38) |
missense |
probably damaging |
1.00 |
|
wenig
|
UTSW |
7 |
66,273,001 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
66,292,341 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0105:Lrrk1
|
UTSW |
7 |
66,292,341 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0276:Lrrk1
|
UTSW |
7 |
66,296,263 (GRCm38) |
splice site |
probably benign |
|
|
R0505:Lrrk1
|
UTSW |
7 |
66,290,908 (GRCm38) |
splice site |
probably null |
|
|
R0609:Lrrk1
|
UTSW |
7 |
66,266,615 (GRCm38) |
splice site |
probably null |
|
|
R0650:Lrrk1
|
UTSW |
7 |
66,292,336 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0676:Lrrk1
|
UTSW |
7 |
66,294,981 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1157:Lrrk1
|
UTSW |
7 |
66,262,283 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1435:Lrrk1
|
UTSW |
7 |
66,273,028 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
66,259,974 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1468:Lrrk1
|
UTSW |
7 |
66,259,974 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1498:Lrrk1
|
UTSW |
7 |
66,302,671 (GRCm38) |
nonsense |
probably null |
|
|
R1620:Lrrk1
|
UTSW |
7 |
66,381,538 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1884:Lrrk1
|
UTSW |
7 |
66,262,437 (GRCm38) |
missense |
probably benign |
|
|
R1891:Lrrk1
|
UTSW |
7 |
66,279,300 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1989:Lrrk1
|
UTSW |
7 |
66,281,684 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2107:Lrrk1
|
UTSW |
7 |
66,279,282 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2140:Lrrk1
|
UTSW |
7 |
66,330,750 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2144:Lrrk1
|
UTSW |
7 |
66,296,163 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2147:Lrrk1
|
UTSW |
7 |
66,285,411 (GRCm38) |
splice site |
probably null |
|
|
R3176:Lrrk1
|
UTSW |
7 |
66,305,521 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R3276:Lrrk1
|
UTSW |
7 |
66,305,521 (GRCm38) |
missense |
possibly damaging |
0.69 |
|
R3886:Lrrk1
|
UTSW |
7 |
66,292,364 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3893:Lrrk1
|
UTSW |
7 |
66,278,520 (GRCm38) |
splice site |
probably benign |
|
|
R3906:Lrrk1
|
UTSW |
7 |
66,294,903 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R4259:Lrrk1
|
UTSW |
7 |
66,330,764 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4649:Lrrk1
|
UTSW |
7 |
66,273,053 (GRCm38) |
missense |
probably benign |
0.12 |
|
R4653:Lrrk1
|
UTSW |
7 |
66,273,053 (GRCm38) |
missense |
probably benign |
0.12 |
|
R4672:Lrrk1
|
UTSW |
7 |
66,279,372 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4693:Lrrk1
|
UTSW |
7 |
66,262,487 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4729:Lrrk1
|
UTSW |
7 |
66,262,293 (GRCm38) |
missense |
probably benign |
|
|
R4737:Lrrk1
|
UTSW |
7 |
66,306,873 (GRCm38) |
missense |
probably benign |
0.09 |
|
R4795:Lrrk1
|
UTSW |
7 |
66,262,665 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R4911:Lrrk1
|
UTSW |
7 |
66,295,454 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R5002:Lrrk1
|
UTSW |
7 |
66,332,363 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5254:Lrrk1
|
UTSW |
7 |
66,307,107 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5407:Lrrk1
|
UTSW |
7 |
66,270,797 (GRCm38) |
missense |
probably benign |
0.20 |
|
R5482:Lrrk1
|
UTSW |
7 |
66,330,670 (GRCm38) |
missense |
probably benign |
|
|
R5600:Lrrk1
|
UTSW |
7 |
66,307,215 (GRCm38) |
missense |
probably benign |
0.31 |
|
R5615:Lrrk1
|
UTSW |
7 |
66,287,615 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6041:Lrrk1
|
UTSW |
7 |
66,262,133 (GRCm38) |
missense |
probably benign |
|
|
R6211:Lrrk1
|
UTSW |
7 |
66,302,710 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R6271:Lrrk1
|
UTSW |
7 |
66,307,103 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6276:Lrrk1
|
UTSW |
7 |
66,306,839 (GRCm38) |
splice site |
probably null |
|
|
R6447:Lrrk1
|
UTSW |
7 |
66,302,728 (GRCm38) |
missense |
probably benign |
0.19 |
|
R6615:Lrrk1
|
UTSW |
7 |
66,281,648 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6745:Lrrk1
|
UTSW |
7 |
66,273,001 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6836:Lrrk1
|
UTSW |
7 |
66,342,779 (GRCm38) |
missense |
probably benign |
0.05 |
|
R6995:Lrrk1
|
UTSW |
7 |
66,292,342 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7107:Lrrk1
|
UTSW |
7 |
66,287,443 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R7137:Lrrk1
|
UTSW |
7 |
66,285,279 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7203:Lrrk1
|
UTSW |
7 |
66,270,825 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7224:Lrrk1
|
UTSW |
7 |
66,332,386 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7239:Lrrk1
|
UTSW |
7 |
66,262,155 (GRCm38) |
missense |
probably benign |
|
|
R7440:Lrrk1
|
UTSW |
7 |
66,290,854 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7515:Lrrk1
|
UTSW |
7 |
66,262,562 (GRCm38) |
missense |
probably benign |
|
|
R7593:Lrrk1
|
UTSW |
7 |
66,308,691 (GRCm38) |
missense |
probably benign |
0.12 |
|
R7728:Lrrk1
|
UTSW |
7 |
66,262,715 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7984:Lrrk1
|
UTSW |
7 |
66,300,729 (GRCm38) |
splice site |
probably null |
|
|
R7993:Lrrk1
|
UTSW |
7 |
66,262,454 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8009:Lrrk1
|
UTSW |
7 |
66,265,474 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R8037:Lrrk1
|
UTSW |
7 |
66,285,341 (GRCm38) |
missense |
probably benign |
|
|
R8101:Lrrk1
|
UTSW |
7 |
66,342,782 (GRCm38) |
missense |
probably benign |
|
|
R8116:Lrrk1
|
UTSW |
7 |
66,262,623 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R8126:Lrrk1
|
UTSW |
7 |
66,292,315 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8278:Lrrk1
|
UTSW |
7 |
66,278,684 (GRCm38) |
missense |
probably benign |
0.37 |
|
R8559:Lrrk1
|
UTSW |
7 |
66,282,327 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R8669:Lrrk1
|
UTSW |
7 |
66,262,596 (GRCm38) |
missense |
probably benign |
0.20 |
|
R8690:Lrrk1
|
UTSW |
7 |
66,302,729 (GRCm38) |
missense |
probably benign |
0.02 |
|
R8955:Lrrk1
|
UTSW |
7 |
66,269,825 (GRCm38) |
missense |
probably benign |
0.09 |
|
R9135:Lrrk1
|
UTSW |
7 |
66,278,609 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9380:Lrrk1
|
UTSW |
7 |
66,278,583 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9625:Lrrk1
|
UTSW |
7 |
66,259,918 (GRCm38) |
makesense |
probably null |
|
|
R9721:Lrrk1
|
UTSW |
7 |
66,274,875 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF018:Lrrk1
|
UTSW |
7 |
66,381,502 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAATTGGCCTTGTCGTCGAG -3'
(R):5'- AAGAATATTGTGTGTCCCTGTCC -3'
Sequencing Primer
(F):5'- TTGTCGTCGAGGCACCAGAC -3'
(R):5'- AATATTGTGTGTCCCTGTCCCTTCC -3'
|
| Posted On |
2018-05-21 |
Incidental Mutation