Incidental Mutation 'IGL01154:Olfr574'
ID 51692
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr574
Ensembl Gene ENSMUSG00000045824
Gene Name olfactory receptor 574
Synonyms GA_x6K02T2PBJ9-5659738-5660748, MOR14-9
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.138) question?
Stock # IGL01154
Quality Score
Status
Chromosome 7
Chromosomal Location 102948467-102949507 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 102948839 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 115 (S115P)
Ref Sequence ENSEMBL: ENSMUSP00000147694 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052997] [ENSMUST00000211329] [ENSMUST00000213477] [ENSMUST00000216420]
AlphaFold F8VQ18
Predicted Effect probably damaging
Transcript: ENSMUST00000052997
AA Change: S125P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000095815
Gene: ENSMUSG00000045824
AA Change: S125P

DomainStartEndE-ValueType
low complexity region 14 31 N/A INTRINSIC
Pfam:7tm_4 44 323 3.8e-96 PFAM
Pfam:7TM_GPCR_Srsx 48 195 1.2e-8 PFAM
Pfam:7tm_1 54 305 2e-17 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000211329
AA Change: S115P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably benign
Transcript: ENSMUST00000213477
Predicted Effect probably benign
Transcript: ENSMUST00000216420
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,950,275 V124I probably damaging Het
2210408I21Rik T G 13: 77,281,094 F767V probably benign Het
A2m C A 6: 121,673,542 S1203* probably null Het
Abcc3 T C 11: 94,359,232 probably benign Het
Adamts13 T C 2: 27,006,194 Y1200H probably benign Het
Aldh1l2 T C 10: 83,520,373 D51G probably damaging Het
Apc2 A G 10: 80,313,069 E1319G possibly damaging Het
Arap3 A T 18: 37,996,734 S125T probably benign Het
Atp2b1 T A 10: 98,996,888 V417E probably damaging Het
Bpifa1 T A 2: 154,144,000 D78E probably benign Het
Catsperb C A 12: 101,625,681 A1090E possibly damaging Het
Ceacam9 C A 7: 16,723,961 T138K probably damaging Het
Cenpf T A 1: 189,680,333 E244D probably benign Het
Cep135 A T 5: 76,606,796 probably benign Het
Cfap206 C T 4: 34,721,562 S162N probably damaging Het
Col15a1 A C 4: 47,208,450 T6P possibly damaging Het
Cyp11b1 T A 15: 74,838,534 Q306L probably benign Het
Defa22 T A 8: 21,163,037 probably null Het
Dnah5 A T 15: 28,458,656 T4480S possibly damaging Het
Fastkd1 T C 2: 69,690,060 probably null Het
Flt1 A G 5: 147,576,156 Y1124H possibly damaging Het
Fsd1l A G 4: 53,701,074 M469V probably benign Het
Fxr2 T C 11: 69,641,433 probably benign Het
Gm10801 A T 2: 98,663,983 Y135F probably benign Het
Grm4 A T 17: 27,434,737 C699* probably null Het
Hcn4 A G 9: 58,859,079 T677A unknown Het
Igkv9-123 G T 6: 67,954,534 probably benign Het
Irf4 T A 13: 30,757,421 H253Q possibly damaging Het
Jakmip2 T C 18: 43,590,679 probably benign Het
Kmt2c A G 5: 25,284,399 V1134A probably damaging Het
Limch1 G T 5: 66,745,958 E17* probably null Het
Nap1l1 T A 10: 111,486,675 N72K probably damaging Het
Olfr1265 T C 2: 90,037,468 L183P probably damaging Het
Otud6b A T 4: 14,811,732 Y304N probably damaging Het
Pdcd10 A C 3: 75,541,233 M8R probably damaging Het
Ppip5k1 T C 2: 121,343,179 T404A probably damaging Het
Ppp2r2d C T 7: 138,882,211 A197V probably benign Het
Psg25 C T 7: 18,524,699 D351N probably benign Het
Sbno1 A T 5: 124,410,249 I87N probably damaging Het
Stfa2l1 C T 16: 36,159,937 probably benign Het
Sugp2 T A 8: 70,242,699 D107E probably damaging Het
Syne1 G T 10: 5,360,848 F576L probably damaging Het
Syne3 A G 12: 104,958,069 F357S probably benign Het
Tenm2 A G 11: 36,041,544 L1741P probably damaging Het
Tgs1 A T 4: 3,585,473 K117* probably null Het
Tram1 C T 1: 13,579,449 probably null Het
Trank1 T A 9: 111,386,400 D1799E probably benign Het
Ttc14 A T 3: 33,803,099 Y198F probably benign Het
Ube3b A G 5: 114,406,252 N570S probably null Het
Ube4b A G 4: 149,365,470 F412S probably benign Het
Vac14 T C 8: 110,653,607 probably benign Het
Vmn2r65 T C 7: 84,943,521 T493A probably benign Het
Zfp408 T C 2: 91,648,006 probably benign Het
Zfp580 C T 7: 5,053,268 T209I possibly damaging Het
Other mutations in Olfr574
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01732:Olfr574 APN 7 102949239 missense probably damaging 1.00
IGL02185:Olfr574 APN 7 102948514 missense probably damaging 0.96
PIT4382001:Olfr574 UTSW 7 102949449 missense probably benign
PIT4520001:Olfr574 UTSW 7 102948714 missense probably damaging 1.00
R0765:Olfr574 UTSW 7 102948732 missense probably damaging 1.00
R1616:Olfr574 UTSW 7 102948514 missense probably damaging 0.96
R2041:Olfr574 UTSW 7 102948963 missense probably damaging 0.98
R2079:Olfr574 UTSW 7 102949495 missense probably benign 0.00
R2261:Olfr574 UTSW 7 102949257 missense probably damaging 1.00
R2263:Olfr574 UTSW 7 102949257 missense probably damaging 1.00
R2513:Olfr574 UTSW 7 102949493 missense probably benign
R2903:Olfr574 UTSW 7 102949454 missense probably benign 0.05
R4445:Olfr574 UTSW 7 102948798 missense possibly damaging 0.93
R4512:Olfr574 UTSW 7 102948738 missense probably damaging 1.00
R4513:Olfr574 UTSW 7 102948738 missense probably damaging 1.00
R4528:Olfr574 UTSW 7 102948806 missense probably damaging 1.00
R4904:Olfr574 UTSW 7 102949065 missense probably damaging 1.00
R5935:Olfr574 UTSW 7 102948810 missense probably benign 0.01
R6784:Olfr574 UTSW 7 102948515 missense possibly damaging 0.91
R6889:Olfr574 UTSW 7 102948768 missense possibly damaging 0.94
R7082:Olfr574 UTSW 7 102949248 missense probably damaging 1.00
R7125:Olfr574 UTSW 7 102949179 missense probably damaging 0.99
R7549:Olfr574 UTSW 7 102948591 missense possibly damaging 0.92
R7564:Olfr574 UTSW 7 102949266 missense probably damaging 1.00
R7947:Olfr574 UTSW 7 102949071 missense probably damaging 1.00
R8460:Olfr574 UTSW 7 102949324 nonsense probably null
R8518:Olfr574 UTSW 7 102948597 missense probably damaging 1.00
R8859:Olfr574 UTSW 7 102949166 missense probably damaging 1.00
R9116:Olfr574 UTSW 7 102949320 missense possibly damaging 0.87
R9327:Olfr574 UTSW 7 102948480 missense probably benign 0.00
R9408:Olfr574 UTSW 7 102949236 missense probably damaging 1.00
Z1177:Olfr574 UTSW 7 102948752 missense probably damaging 1.00
Posted On 2013-06-21