Incidental Mutation 'IGL01069:Ces3b'
ID 51719
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ces3b
Ensembl Gene ENSMUSG00000062181
Gene Name carboxylesterase 3B
Synonyms Gm4738, ES31L
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # IGL01069
Quality Score
Status
Chromosome 8
Chromosomal Location 105810385-105820561 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 105818206 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 92 (S92P)
Ref Sequence ENSEMBL: ENSMUSP00000134204 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074403] [ENSMUST00000093221] [ENSMUST00000173088]
AlphaFold Q8VCU1
Predicted Effect probably benign
Transcript: ENSMUST00000074403
AA Change: S403P

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000074004
Gene: ENSMUSG00000062181
AA Change: S403P

DomainStartEndE-ValueType
Pfam:COesterase 13 436 1.8e-127 PFAM
Pfam:Abhydrolase_3 147 303 2.8e-13 PFAM
Pfam:COesterase 423 497 5.8e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000093221
AA Change: S403P

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000090909
Gene: ENSMUSG00000062181
AA Change: S403P

DomainStartEndE-ValueType
Pfam:COesterase 13 547 9.5e-163 PFAM
Pfam:Abhydrolase_3 147 304 2.1e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000173088
AA Change: S92P

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000134204
Gene: ENSMUSG00000062181
AA Change: S92P

DomainStartEndE-ValueType
Pfam:COesterase 1 114 2e-11 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173838
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110038F14Rik G A 15: 76,834,475 (GRCm39) V124I probably damaging Het
1700123K08Rik C T 5: 138,560,751 (GRCm39) A215T probably benign Het
Aen G A 7: 78,557,050 (GRCm39) M299I probably damaging Het
Apc2 G A 10: 80,147,820 (GRCm39) C929Y probably damaging Het
Arap2 T C 5: 62,807,199 (GRCm39) H1156R probably benign Het
Arhgap9 A G 10: 127,164,821 (GRCm39) T582A probably damaging Het
Ccdc57 T A 11: 120,752,085 (GRCm39) H832L probably benign Het
Ces5a A G 8: 94,252,172 (GRCm39) probably null Het
Cfap206 C T 4: 34,721,562 (GRCm39) S162N probably damaging Het
Cpb2 T A 14: 75,508,215 (GRCm39) D225E probably damaging Het
Cpne8 C T 15: 90,499,313 (GRCm39) probably null Het
Cux2 G A 5: 122,005,414 (GRCm39) T924M possibly damaging Het
Dtl T A 1: 191,293,651 (GRCm39) probably null Het
Dysf T A 6: 84,176,767 (GRCm39) I1912N possibly damaging Het
Edc4 T A 8: 106,613,766 (GRCm39) F369I probably benign Het
Fibcd1 T C 2: 31,711,531 (GRCm39) E298G probably benign Het
Focad C A 4: 88,244,383 (GRCm39) H788N unknown Het
Frem1 C T 4: 82,932,104 (GRCm39) R199H probably benign Het
Gadl1 T C 9: 115,783,907 (GRCm39) probably null Het
Hipk1 G A 3: 103,685,015 (GRCm39) T200I possibly damaging Het
Ighv14-2 C T 12: 113,958,379 (GRCm39) V21I possibly damaging Het
Kank4 A T 4: 98,666,632 (GRCm39) I605N probably damaging Het
Krt88 T G 15: 101,351,508 (GRCm39) *172G probably null Het
Lmf2 C A 15: 89,237,091 (GRCm39) A408S probably benign Het
Lsm12 T C 11: 102,054,896 (GRCm39) probably benign Het
Myo3b A G 2: 70,075,735 (GRCm39) I580V probably benign Het
Myt1 T C 2: 181,467,749 (GRCm39) M1061T probably damaging Het
Nup133 G A 8: 124,657,721 (GRCm39) R405* probably null Het
Or1ad1 A T 11: 50,875,830 (GRCm39) I101F possibly damaging Het
Or5m3 A G 2: 85,838,891 (GRCm39) Y257C probably damaging Het
Or8g2 A T 9: 39,821,902 (GRCm39) M268L possibly damaging Het
Pcnx1 A G 12: 81,964,918 (GRCm39) R362G probably benign Het
Pomt2 G T 12: 87,157,078 (GRCm39) T747K probably damaging Het
Rgma G A 7: 73,067,239 (GRCm39) A165T probably damaging Het
Rhbdf2 T C 11: 116,492,577 (GRCm39) D437G possibly damaging Het
Rpl5 T C 5: 108,055,145 (GRCm39) probably null Het
Rtkn2 A G 10: 67,877,494 (GRCm39) D518G probably benign Het
Sclt1 T C 3: 41,696,426 (GRCm39) probably benign Het
Sidt2 C T 9: 45,854,375 (GRCm39) V616I possibly damaging Het
Ska2 A G 11: 87,000,091 (GRCm39) probably benign Het
Slc13a4 C A 6: 35,245,817 (GRCm39) L609F probably damaging Het
Sorbs3 T C 14: 70,428,604 (GRCm39) E390G probably damaging Het
Syt15 T C 14: 33,946,881 (GRCm39) V220A possibly damaging Het
Tob1 T C 11: 94,104,881 (GRCm39) F139S probably damaging Het
Yars2 C T 16: 16,124,406 (GRCm39) R338* probably null Het
Other mutations in Ces3b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01324:Ces3b APN 8 105,819,884 (GRCm39) missense probably damaging 0.99
IGL02418:Ces3b APN 8 105,812,279 (GRCm39) missense probably damaging 1.00
IGL02612:Ces3b APN 8 105,811,901 (GRCm39) missense possibly damaging 0.83
IGL03400:Ces3b APN 8 105,819,568 (GRCm39) missense probably damaging 1.00
R0244:Ces3b UTSW 8 105,819,267 (GRCm39) missense probably damaging 1.00
R0282:Ces3b UTSW 8 105,810,483 (GRCm39) missense probably benign 0.00
R0800:Ces3b UTSW 8 105,811,901 (GRCm39) missense possibly damaging 0.83
R1833:Ces3b UTSW 8 105,812,271 (GRCm39) missense probably damaging 0.98
R2130:Ces3b UTSW 8 105,819,607 (GRCm39) critical splice donor site probably null
R3790:Ces3b UTSW 8 105,813,520 (GRCm39) missense possibly damaging 0.50
R4827:Ces3b UTSW 8 105,813,527 (GRCm39) missense probably benign 0.12
R5411:Ces3b UTSW 8 105,815,264 (GRCm39) missense possibly damaging 0.94
R5790:Ces3b UTSW 8 105,819,270 (GRCm39) missense probably damaging 1.00
R5798:Ces3b UTSW 8 105,815,072 (GRCm39) missense probably damaging 1.00
R5929:Ces3b UTSW 8 105,819,797 (GRCm39) missense probably damaging 1.00
R6437:Ces3b UTSW 8 105,819,238 (GRCm39) missense probably damaging 1.00
R6470:Ces3b UTSW 8 105,815,285 (GRCm39) missense possibly damaging 0.87
R6943:Ces3b UTSW 8 105,819,710 (GRCm39) missense probably damaging 1.00
R7828:Ces3b UTSW 8 105,813,228 (GRCm39) missense probably damaging 1.00
R7856:Ces3b UTSW 8 105,819,894 (GRCm39) makesense probably null
R8162:Ces3b UTSW 8 105,817,385 (GRCm39) missense possibly damaging 0.83
R8924:Ces3b UTSW 8 105,811,619 (GRCm39) missense probably benign 0.08
R9369:Ces3b UTSW 8 105,813,502 (GRCm39) missense probably damaging 1.00
R9381:Ces3b UTSW 8 105,811,670 (GRCm39) missense probably benign 0.30
R9651:Ces3b UTSW 8 105,812,257 (GRCm39) missense probably damaging 1.00
R9652:Ces3b UTSW 8 105,812,257 (GRCm39) missense probably damaging 1.00
R9653:Ces3b UTSW 8 105,812,257 (GRCm39) missense probably damaging 1.00
Z1177:Ces3b UTSW 8 105,811,715 (GRCm39) missense probably damaging 0.99
Posted On 2013-06-21