Incidental Mutation 'IGL01080:Prmt7'
ID51731
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Prmt7
Ensembl Gene ENSMUSG00000060098
Gene Nameprotein arginine N-methyltransferase 7
Synonyms
Accession Numbers
Is this an essential gene? Probably essential (E-score: 0.921) question?
Stock #IGL01080
Quality Score
Status
Chromosome8
Chromosomal Location106210936-106252794 bp(+) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) T to G at 106237214 bp
ZygosityHeterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000071592] [ENSMUST00000109297]
Predicted Effect probably benign
Transcript: ENSMUST00000071592
SMART Domains Protein: ENSMUSP00000071521
Gene: ENSMUSG00000060098

DomainStartEndE-ValueType
Pfam:PrmA 53 148 1.6e-7 PFAM
internal_repeat_1 382 652 1.71e-8 PROSPERO
Predicted Effect probably benign
Transcript: ENSMUST00000109297
SMART Domains Protein: ENSMUSP00000104920
Gene: ENSMUSG00000060098

DomainStartEndE-ValueType
Pfam:PrmA 51 148 1.5e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000128201
SMART Domains Protein: ENSMUSP00000119992
Gene: ENSMUSG00000060098

DomainStartEndE-ValueType
Pfam:PrmA 37 132 3.2e-8 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134151
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147063
Predicted Effect noncoding transcript
Transcript: ENSMUST00000153272
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180410
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Arginine methylation is an apparently irreversible protein modification catalyzed by arginine methyltransferases, such as PMT7, using S-adenosylmethionine (AdoMet) as the methyl donor. Arginine methylation is implicated in signal transduction, RNA transport, and RNA splicing (Miranda et al., 2004 [PubMed 15044439]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb4 A T 5: 8,934,258 R663W probably damaging Het
Cacng5 A T 11: 107,877,928 F179L probably damaging Het
Cacng5 C T 11: 107,881,705 V106I probably benign Het
Cd96 T C 16: 46,049,693 E471G possibly damaging Het
Cpt1c T C 7: 44,960,909 D621G probably damaging Het
Csmd3 T C 15: 47,881,403 I1503V probably benign Het
Dmgdh T C 13: 93,703,778 probably benign Het
Flg A T 3: 93,279,599 K119N probably benign Het
Gale T C 4: 135,966,078 Y104H probably damaging Het
Gm8005 T C 14: 42,437,014 D119G unknown Het
Gstk1 A T 6: 42,246,626 D50V possibly damaging Het
Kmt2a T C 9: 44,809,092 D3866G unknown Het
Mastl A G 2: 23,146,148 S119P probably damaging Het
Olfr169 A T 16: 19,566,208 V225E probably damaging Het
Phf11c G A 14: 59,393,199 T19I probably benign Het
Ppp1r16b A G 2: 158,757,172 T355A probably damaging Het
Rad50 T C 11: 53,706,068 T44A probably damaging Het
Rangap1 C T 15: 81,705,752 probably benign Het
Slc27a3 A T 3: 90,385,460 V634E probably benign Het
Tbxas1 T A 6: 39,021,181 L228I probably damaging Het
Tnfaip3 T C 10: 19,011,655 K41E probably benign Het
Tti1 C T 2: 157,982,459 V1025I probably damaging Het
Tyrobp T C 7: 30,417,416 probably null Het
Wfdc16 A T 2: 164,638,486 W30R probably damaging Het
Zyg11b A T 4: 108,237,416 L657Q probably damaging Het
Other mutations in Prmt7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01565:Prmt7 APN 8 106250409 missense probably damaging 0.97
IGL02245:Prmt7 APN 8 106237305 missense probably benign 0.10
R0104:Prmt7 UTSW 8 106237350 missense probably damaging 0.99
R0255:Prmt7 UTSW 8 106227207 splice site probably benign
R1432:Prmt7 UTSW 8 106237284 nonsense probably null
R1551:Prmt7 UTSW 8 106237382 missense probably benign
R1848:Prmt7 UTSW 8 106237008 missense probably benign
R2117:Prmt7 UTSW 8 106227298 missense probably damaging 0.96
R3784:Prmt7 UTSW 8 106242136 missense probably benign 0.01
R4599:Prmt7 UTSW 8 106250329 missense possibly damaging 0.80
R4940:Prmt7 UTSW 8 106237278 missense probably benign 0.01
R4983:Prmt7 UTSW 8 106250363 missense probably damaging 1.00
R5285:Prmt7 UTSW 8 106248359 missense probably benign 0.15
R6015:Prmt7 UTSW 8 106235008 intron probably benign
R6520:Prmt7 UTSW 8 106234884 missense probably damaging 1.00
R7097:Prmt7 UTSW 8 106235100 missense unknown
R7122:Prmt7 UTSW 8 106235100 missense unknown
R7233:Prmt7 UTSW 8 106220010 missense probably damaging 0.99
R7538:Prmt7 UTSW 8 106237386 missense probably benign 0.02
R7577:Prmt7 UTSW 8 106242203 missense probably damaging 1.00
R7659:Prmt7 UTSW 8 106237286 missense probably benign 0.00
R7858:Prmt7 UTSW 8 106244688 missense possibly damaging 0.47
R7941:Prmt7 UTSW 8 106244688 missense possibly damaging 0.47
Posted On2013-06-21