Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL01090:Clec4g'

51747

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Clec4g

Ensembl Gene

ENSMUSG00000074491

Gene Name

C-type lectin domain family 4, member g

Synonyms

4930572L20Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01090

Quality Score

Status

Chromosome

Chromosomal Location

3757064-3770651 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 3769482 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 54 (S54P)

Ref Sequence

ENSEMBL: ENSMUSP00000059574 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000058040] [ENSMUST00000062037]

AlphaFold

Q8BNX1

Predicted Effect

probably benign
Transcript: ENSMUST00000058040

Predicted Effect

probably damaging
Transcript: ENSMUST00000062037
AA Change: S54P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000059574
Gene: ENSMUSG00000074491
AA Change: S54P

Domain	Start	End	E-Value	Type
transmembrane domain	31	53	N/A	INTRINSIC
coiled coil region	98	153	N/A	INTRINSIC
CLECT	165	288	8.85e-35	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000159612

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160490

Predicted Effect

probably benign
Transcript: ENSMUST00000160527

SMART Domains

Protein: ENSMUSP00000124493
Gene: ENSMUSG00000074491

Domain	Start	End	E-Value	Type
CLECT	2	97	7.75e-8	SMART

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the T-cell immune response. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased intrahepatic T cell immunity, enhanced immune-mediated liver injury during Con A-induced experimental acute hepatitis, and accelerated CTL-dependent adenovirus clearance. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930590J08Rik	T	C	6: 91,896,099 (GRCm39)	S316P	possibly damaging	Het
Actn1	A	T	12: 80,245,846 (GRCm39)		probably null	Het
Agbl3	T	C	6: 34,776,822 (GRCm39)	Y443H	probably benign	Het
Akap13	T	A	7: 75,316,279 (GRCm39)	D578E	probably benign	Het
Aldoa	A	T	7: 126,395,207 (GRCm39)	H292Q	probably benign	Het
Als2	T	C	1: 59,254,775 (GRCm39)	K194R	possibly damaging	Het
Bivm	C	A	1: 44,168,451 (GRCm39)	H244N	probably damaging	Het
Cabp5	G	A	7: 13,139,412 (GRCm39)	E146K	probably damaging	Het
Cfap206	C	T	4: 34,721,562 (GRCm39)	S162N	probably damaging	Het
Cfap251	A	C	5: 123,418,052 (GRCm39)		probably benign	Het
Clcn4	A	G	7: 7,297,035 (GRCm39)	V129A	probably benign	Het
Crim1	G	T	17: 78,654,658 (GRCm39)	V645L	probably damaging	Het
Csta1	T	C	16: 35,945,421 (GRCm39)	T31A	probably damaging	Het
D930048N14Rik	T	C	11: 51,544,610 (GRCm39)		probably benign	Het
Dhx34	G	T	7: 15,950,181 (GRCm39)	P329Q	probably damaging	Het
Dusp16	T	C	6: 134,702,912 (GRCm39)	N193S	probably benign	Het
Fbn1	A	G	2: 125,236,696 (GRCm39)		probably benign	Het
Fbxo46	A	G	7: 18,870,728 (GRCm39)	Y449C	probably damaging	Het
Fmo4	C	A	1: 162,637,354 (GRCm39)		probably null	Het
Foxi3	C	A	6: 70,937,729 (GRCm39)	N320K	probably damaging	Het
Gm9964	A	G	11: 79,187,210 (GRCm39)	L79P	unknown	Het
Gpr161	T	C	1: 165,134,149 (GRCm39)	I137T	probably damaging	Het
Herc1	C	T	9: 66,376,457 (GRCm39)	Q3426*	probably null	Het
Hps5	C	T	7: 46,437,751 (GRCm39)	R108H	probably benign	Het
Itch	T	A	2: 155,048,256 (GRCm39)	V540E	probably damaging	Het
L3mbtl1	C	A	2: 162,807,925 (GRCm39)	P520H	probably damaging	Het
Mvp	A	G	7: 126,588,859 (GRCm39)	V636A	probably benign	Het
Odf4	A	G	11: 68,812,778 (GRCm39)		probably benign	Het
Or7g18	A	G	9: 18,787,538 (GRCm39)	K305R	probably benign	Het
Pld1	T	C	3: 28,142,816 (GRCm39)	S675P	probably benign	Het
Plod3	A	G	5: 137,019,090 (GRCm39)	D325G	probably benign	Het
Prss12	T	C	3: 123,276,388 (GRCm39)	V339A	possibly damaging	Het
Ptpn13	T	A	5: 103,689,180 (GRCm39)	L991Q	probably null	Het
Ptpn3	T	A	4: 57,240,833 (GRCm39)	I261F	probably damaging	Het
Rab3gap1	T	C	1: 127,858,124 (GRCm39)		probably benign	Het
Rasa4	A	G	5: 136,130,847 (GRCm39)	R373G	possibly damaging	Het
Rmi1	T	C	13: 58,557,208 (GRCm39)	S486P	probably damaging	Het
Slc25a23	A	G	17: 57,354,233 (GRCm39)	I139T	probably benign	Het
Sspo	T	A	6: 48,467,059 (GRCm39)	S4017T	probably benign	Het
Tcaf1	C	A	6: 42,663,556 (GRCm39)	C108F	probably benign	Het
Tnc	T	C	4: 63,918,317 (GRCm39)	Q1198R	probably damaging	Het
Tnni3k	G	T	3: 154,645,320 (GRCm39)	Q522K	possibly damaging	Het
Trio	T	A	15: 27,773,093 (GRCm39)	E713V	probably damaging	Het
Ugt2b34	C	A	5: 87,041,679 (GRCm39)	V338F	probably damaging	Het
Usp40	T	A	1: 87,890,187 (GRCm39)	M892L	probably benign	Het
Usp54	A	T	14: 20,636,225 (GRCm39)		probably benign	Het
Vmn2r53	T	C	7: 12,334,835 (GRCm39)	E275G	possibly damaging	Het
Vmn2r87	A	G	10: 130,333,247 (GRCm39)	M1T	probably null	Het
Wdr83os	A	T	8: 85,808,476 (GRCm39)	D76V	probably damaging	Het

Other mutations in Clec4g

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00566:Clec4g	APN	8	3,766,410 (GRCm39)	intron	probably benign
IGL01331:Clec4g	APN	8	3,767,190 (GRCm39)	splice site	probably benign
IGL01593:Clec4g	APN	8	3,769,474 (GRCm39)	critical splice donor site	probably null
IGL02942:Clec4g	APN	8	3,768,356 (GRCm39)	missense	probably damaging	0.96
IGL03176:Clec4g	APN	8	3,768,441 (GRCm39)	missense	possibly damaging	0.90
bluedog	UTSW	8	3,768,766 (GRCm39)	critical splice donor site	probably null
R0071:Clec4g	UTSW	8	3,767,489 (GRCm39)	start gained	probably benign
R0379:Clec4g	UTSW	8	3,768,440 (GRCm39)	missense	probably benign	0.00
R4571:Clec4g	UTSW	8	3,768,766 (GRCm39)	critical splice donor site	probably null
R4854:Clec4g	UTSW	8	3,766,534 (GRCm39)	missense	probably damaging	1.00
R4856:Clec4g	UTSW	8	3,766,419 (GRCm39)	intron	probably benign
R4886:Clec4g	UTSW	8	3,766,419 (GRCm39)	intron	probably benign
R5370:Clec4g	UTSW	8	3,768,344 (GRCm39)	missense	probably benign	0.13
R5390:Clec4g	UTSW	8	3,768,441 (GRCm39)	missense	probably benign	0.02
R6522:Clec4g	UTSW	8	3,768,803 (GRCm39)	missense	probably benign	0.11
R6737:Clec4g	UTSW	8	3,757,716 (GRCm39)	utr 3 prime	probably benign
R7097:Clec4g	UTSW	8	3,769,518 (GRCm39)	missense	possibly damaging	0.58
R7834:Clec4g	UTSW	8	3,766,500 (GRCm39)	missense	probably damaging	1.00
R8372:Clec4g	UTSW	8	3,757,990 (GRCm39)	utr 3 prime	probably benign
R9297:Clec4g	UTSW	8	3,766,500 (GRCm39)	missense	probably damaging	1.00
R9312:Clec4g	UTSW	8	3,768,371 (GRCm39)	missense	probably null	1.00
R9318:Clec4g	UTSW	8	3,766,500 (GRCm39)	missense	probably damaging	1.00
R9517:Clec4g	UTSW	8	3,767,452 (GRCm39)	missense	probably damaging	0.98
R9526:Clec4g	UTSW	8	3,768,565 (GRCm39)	missense	probably benign	0.33
R9682:Clec4g	UTSW	8	3,757,713 (GRCm39)	missense	unknown
Z1088:Clec4g	UTSW	8	3,766,548 (GRCm39)	missense	probably damaging	1.00
Z1088:Clec4g	UTSW	8	3,757,796 (GRCm39)	utr 3 prime	probably benign

Posted On

2013-06-21