Incidental Mutation 'R6462:Ly6c1'
ID 517652
Institutional Source Beutler Lab
Gene Symbol Ly6c1
Ensembl Gene ENSMUSG00000079018
Gene Name lymphocyte antigen 6 family member C1
Synonyms Ly6c, Ly-6C
MMRRC Submission 044596-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R6462 (G1)
Quality Score 210.009
Status Validated
Chromosome 15
Chromosomal Location 74915867-74920679 bp(-) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to A at 74916178 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000140722 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065408] [ENSMUST00000179762] [ENSMUST00000185200] [ENSMUST00000185372] [ENSMUST00000187347] [ENSMUST00000188845] [ENSMUST00000191216]
AlphaFold P0CW02
Predicted Effect probably benign
Transcript: ENSMUST00000065408
SMART Domains Protein: ENSMUSP00000066954
Gene: ENSMUSG00000079018

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
LU 27 115 1.62e-32 SMART
low complexity region 117 131 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000179762
SMART Domains Protein: ENSMUSP00000137401
Gene: ENSMUSG00000079018

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
LU 27 115 1.62e-32 SMART
low complexity region 117 131 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000185200
SMART Domains Protein: ENSMUSP00000140622
Gene: ENSMUSG00000079018

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:UPAR_LY6 29 77 2.3e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000185372
SMART Domains Protein: ENSMUSP00000139948
Gene: ENSMUSG00000079018

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:UPAR_LY6 29 77 6.3e-6 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000187347
SMART Domains Protein: ENSMUSP00000139799
Gene: ENSMUSG00000079018

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
LU 27 115 1.62e-32 SMART
low complexity region 117 131 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000188845
AA Change: L147F
SMART Domains Protein: ENSMUSP00000139559
Gene: ENSMUSG00000079018
AA Change: L147F

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
LU 27 115 1.52e-28 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000191216
SMART Domains Protein: ENSMUSP00000140722
Gene: ENSMUSG00000079018

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
LU 27 111 5.2e-27 SMART
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.7%
  • 20x: 92.6%
Validation Efficiency 95% (37/39)
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arpc1a C T 5: 145,045,197 (GRCm39) S362F probably benign Het
Brd9 C T 13: 74,088,788 (GRCm39) A171V probably damaging Het
Camta1 A G 4: 151,170,621 (GRCm39) V62A probably damaging Het
Cdc5l G A 17: 45,703,975 (GRCm39) R750C probably benign Het
Ctdp1 C T 18: 80,463,689 (GRCm39) E116K probably damaging Het
Dync2i1 T C 12: 116,193,251 (GRCm39) N567S probably benign Het
Enpp5 G A 17: 44,396,155 (GRCm39) G356S probably damaging Het
Epor T C 9: 21,870,551 (GRCm39) E443G probably benign Het
Fam90a1a A T 8: 22,449,298 (GRCm39) Q14L probably benign Het
Herc4 T C 10: 63,124,880 (GRCm39) L498P probably benign Het
Kif1b T C 4: 149,277,053 (GRCm39) M1337V probably benign Het
Lmod2 T G 6: 24,604,300 (GRCm39) V425G probably benign Het
Me2 C A 18: 73,908,470 (GRCm39) V490F probably benign Het
Mllt3 T C 4: 87,692,338 (GRCm39) T27A probably damaging Het
Mmp1a T C 9: 7,467,039 (GRCm39) Y239H probably benign Het
Mycbp2 A G 14: 103,373,993 (GRCm39) probably null Het
Myo15b A C 11: 115,750,268 (GRCm39) E346A probably benign Het
Myo3a T C 2: 22,448,423 (GRCm39) F66S probably damaging Het
Ncor2 T C 5: 125,101,236 (GRCm39) Y137C probably damaging Het
Nup98 A T 7: 101,844,223 (GRCm39) F37L probably benign Het
Odf2l T G 3: 144,852,672 (GRCm39) L472R probably damaging Het
Or10al2 T C 17: 37,983,111 (GRCm39) Y66H probably damaging Het
P4ha3 T A 7: 99,963,873 (GRCm39) I463N probably damaging Het
Pappa C A 4: 65,043,128 (GRCm39) T117K probably damaging Het
Ppme1 C A 7: 99,987,599 (GRCm39) R271M probably benign Het
Rps6ka4 T G 19: 6,814,957 (GRCm39) E249A possibly damaging Het
Rxfp1 T A 3: 79,555,596 (GRCm39) I587F probably benign Het
Sipa1l2 A G 8: 126,217,969 (GRCm39) V456A probably damaging Het
Slc25a23 T A 17: 57,359,720 (GRCm39) I344F probably damaging Het
St3gal1 A G 15: 66,983,195 (GRCm39) V187A possibly damaging Het
Tbc1d10c T C 19: 4,234,893 (GRCm39) I389M possibly damaging Het
Tep1 A G 14: 51,081,836 (GRCm39) F1205L probably benign Het
Tgfbr1 T A 4: 47,402,846 (GRCm39) H214Q probably damaging Het
Traf3ip2 T A 10: 39,515,243 (GRCm39) N340K probably benign Het
Zbbx T C 3: 74,985,966 (GRCm39) E362G probably benign Het
Zfp46 A C 4: 136,017,924 (GRCm39) T253P probably damaging Het
Other mutations in Ly6c1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2002:Ly6c1 UTSW 15 74,920,342 (GRCm39) missense possibly damaging 0.62
R3881:Ly6c1 UTSW 15 74,917,436 (GRCm39) missense probably benign 0.07
R5986:Ly6c1 UTSW 15 74,917,457 (GRCm39) missense probably damaging 1.00
R6966:Ly6c1 UTSW 15 74,917,289 (GRCm39) unclassified probably benign
R7169:Ly6c1 UTSW 15 74,916,495 (GRCm39) missense probably benign 0.00
R7355:Ly6c1 UTSW 15 74,919,256 (GRCm39) missense possibly damaging 0.78
R7583:Ly6c1 UTSW 15 74,920,346 (GRCm39) missense probably damaging 1.00
R9037:Ly6c1 UTSW 15 74,917,300 (GRCm39) missense probably damaging 1.00
R9038:Ly6c1 UTSW 15 74,917,300 (GRCm39) missense probably damaging 1.00
R9039:Ly6c1 UTSW 15 74,917,300 (GRCm39) missense probably damaging 1.00
R9224:Ly6c1 UTSW 15 74,916,465 (GRCm39) missense probably benign 0.00
R9354:Ly6c1 UTSW 15 74,916,471 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- ATGGCCTTGGGGTTACAAC -3'
(R):5'- GCCCAGAAGTGAAAACCATTTC -3'

Sequencing Primer
(F):5'- TGATCGACTCAGCTCCATGAG -3'
(R):5'- ATTTCCTGGCTTTTGGCTTAC -3'
Posted On 2018-05-21