Incidental Mutation 'R6478:Klra10'
ID 517812
Institutional Source Beutler Lab
Gene Symbol Klra10
Ensembl Gene ENSMUSG00000072718
Gene Name killer cell lectin-like receptor subfamily A, member 10
Synonyms Ly49i2, Ly49J
MMRRC Submission 044610-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R6478 (G1)
Quality Score 142.008
Status Validated
Chromosome 6
Chromosomal Location 130246157-130258891 bp(-) (GRCm39)
Type of Mutation splice site (112 bp from exon)
DNA Base Change (assembly) T to C at 130249507 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000107651 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112020]
AlphaFold Q9R1G6
Predicted Effect probably null
Transcript: ENSMUST00000112020
SMART Domains Protein: ENSMUSP00000107651
Gene: ENSMUSG00000072718

DomainStartEndE-ValueType
low complexity region 56 66 N/A INTRINSIC
Blast:CLECT 73 117 2e-9 BLAST
CLECT 143 258 6.43e-14 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.8%
  • 20x: 93.3%
Validation Efficiency 95% (75/79)
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk T A 11: 119,901,817 (GRCm39) S803C probably benign Het
Abcc9 C T 6: 142,625,034 (GRCm39) A454T probably damaging Het
Abr T C 11: 76,343,158 (GRCm39) E565G probably damaging Het
Adam33 C A 2: 130,893,266 (GRCm39) R753L probably benign Het
Adgre1 A G 17: 57,708,955 (GRCm39) T49A possibly damaging Het
Ankra2 A T 13: 98,404,950 (GRCm39) H153L probably damaging Het
Ankrd26 T G 6: 118,488,599 (GRCm39) E1353D probably benign Het
Ankrd52 T G 10: 128,215,200 (GRCm39) probably null Het
Arhgef10l T A 4: 140,270,068 (GRCm39) T619S possibly damaging Het
Armh4 A G 14: 50,010,789 (GRCm39) V306A possibly damaging Het
Asgr1 T C 11: 69,947,720 (GRCm39) V130A possibly damaging Het
Atg10 C A 13: 91,085,466 (GRCm39) C161F probably damaging Het
Atm A T 9: 53,401,554 (GRCm39) N1438K probably damaging Het
BC107364 T A 3: 96,343,322 (GRCm39) probably null Het
Bcar3 G T 3: 122,220,225 (GRCm39) A41S probably benign Het
Btbd6 A G 12: 112,940,932 (GRCm39) probably benign Het
Cchcr1 A G 17: 35,835,600 (GRCm39) T318A possibly damaging Het
Celsr1 A T 15: 85,809,719 (GRCm39) I2221N probably damaging Het
Cept1 C T 3: 106,440,761 (GRCm39) W48* probably null Het
Cfap161 T A 7: 83,442,484 (GRCm39) I85L probably benign Het
Clasp1 A T 1: 118,439,910 (GRCm39) R640* probably null Het
Col5a1 T A 2: 27,842,448 (GRCm39) I441N unknown Het
Col9a1 C A 1: 24,224,486 (GRCm39) L223I unknown Het
Dnah2 T C 11: 69,406,836 (GRCm39) D223G probably benign Het
Dnah8 G A 17: 30,967,542 (GRCm39) D2585N probably benign Het
Dpy19l1 A T 9: 24,361,992 (GRCm39) M129K possibly damaging Het
Ecpas A T 4: 58,810,785 (GRCm39) I1524N probably damaging Het
Fcgbpl1 C G 7: 27,854,798 (GRCm39) P1808R probably damaging Het
Fcrl1 C A 3: 87,296,946 (GRCm39) H318Q probably benign Het
Fer1l5 A G 1: 36,441,612 (GRCm39) N609S probably damaging Het
Fkbp4 C T 6: 128,410,194 (GRCm39) E256K probably damaging Het
Fsip2 A G 2: 82,820,430 (GRCm39) T5388A possibly damaging Het
Glrx G A 13: 75,995,418 (GRCm39) probably null Het
Gm7356 A T 17: 14,221,726 (GRCm39) M101K probably damaging Het
Gstp2 A T 19: 4,090,499 (GRCm39) I162N probably benign Het
Hectd3 A C 4: 116,856,783 (GRCm39) K443N probably damaging Het
Hmcn1 T A 1: 150,540,535 (GRCm39) R2925W probably damaging Het
Hspa1a G T 17: 35,189,282 (GRCm39) N540K probably damaging Het
Ints6 A T 14: 62,938,235 (GRCm39) M649K probably benign Het
Katnb1 T C 8: 95,822,084 (GRCm39) V270A possibly damaging Het
Kctd3 A G 1: 188,704,561 (GRCm39) S737P probably benign Het
Lmtk3 A G 7: 45,448,013 (GRCm39) D1353G unknown Het
Lrrk1 A G 7: 65,912,481 (GRCm39) V1693A probably damaging Het
Mpnd A T 17: 56,316,575 (GRCm39) I85F probably damaging Het
Myo3b A G 2: 70,179,304 (GRCm39) T1173A probably benign Het
Myof G A 19: 37,892,279 (GRCm39) P1158L probably damaging Het
Naip2 A C 13: 100,298,549 (GRCm39) S496A probably benign Het
Ncor2 A G 5: 125,187,069 (GRCm39) probably benign Het
Npepps C T 11: 97,149,099 (GRCm39) probably null Het
Opn5 T A 17: 42,891,640 (GRCm39) I266F probably benign Het
Or4a74 T G 2: 89,439,790 (GRCm39) I219L probably damaging Het
P2rx4 A G 5: 122,845,763 (GRCm39) D16G probably damaging Het
Padi2 G T 4: 140,644,948 (GRCm39) V61L probably benign Het
Pkd1l1 G A 11: 8,813,911 (GRCm39) T1480I probably benign Het
Plcb1 T C 2: 135,177,371 (GRCm39) S568P probably damaging Het
Rassf10 A G 7: 112,554,914 (GRCm39) E505G probably damaging Het
Rcan2 A G 17: 44,147,225 (GRCm39) E21G probably benign Het
Rhob G T 12: 8,549,585 (GRCm39) C16* probably null Het
Ryr3 T C 2: 112,490,413 (GRCm39) N3807S probably damaging Het
Sass6 T A 3: 116,415,046 (GRCm39) N519K probably benign Het
Slco1a8 A T 6: 141,939,368 (GRCm39) N208K possibly damaging Het
Smad9 A T 3: 54,689,864 (GRCm39) D28V probably damaging Het
Spmip8 A T 8: 96,047,894 (GRCm39) probably null Het
Tex14 G T 11: 87,405,199 (GRCm39) G704C probably benign Het
Tmc3 A G 7: 83,271,524 (GRCm39) N892S probably benign Het
Tnfaip2 T A 12: 111,412,097 (GRCm39) L166Q probably damaging Het
Triml2 A G 8: 43,638,165 (GRCm39) probably null Het
Trio A G 15: 27,856,193 (GRCm39) V666A probably benign Het
Tshz2 G T 2: 169,726,584 (GRCm39) L393F probably damaging Het
Ttn T G 2: 76,672,115 (GRCm39) probably benign Het
Tubb5 A G 17: 36,146,734 (GRCm39) Y159H probably damaging Het
Umodl1 A G 17: 31,178,129 (GRCm39) Y35C probably damaging Het
Utp4 T C 8: 107,631,078 (GRCm39) probably null Het
Vmn1r60 A T 7: 5,547,864 (GRCm39) C79S probably damaging Het
Wnt5b T C 6: 119,410,751 (GRCm39) T230A probably damaging Het
Zfp618 A T 4: 63,050,943 (GRCm39) I575F probably damaging Het
Zmym6 G T 4: 127,017,176 (GRCm39) V894L possibly damaging Het
Zpbp T C 11: 11,412,318 (GRCm39) probably benign Het
Other mutations in Klra10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01505:Klra10 APN 6 130,249,680 (GRCm39) missense probably damaging 1.00
IGL02060:Klra10 APN 6 130,249,688 (GRCm39) missense probably damaging 0.99
IGL02249:Klra10 APN 6 130,256,367 (GRCm39) missense probably benign 0.07
IGL02681:Klra10 APN 6 130,256,382 (GRCm39) missense probably damaging 0.98
IGL02684:Klra10 APN 6 130,258,845 (GRCm39) missense possibly damaging 0.85
FR4342:Klra10 UTSW 6 130,249,710 (GRCm39) missense probably benign 0.01
R0324:Klra10 UTSW 6 130,249,613 (GRCm39) splice site probably null
R1072:Klra10 UTSW 6 130,258,811 (GRCm39) missense probably benign 0.11
R1466:Klra10 UTSW 6 130,256,394 (GRCm39) missense probably damaging 0.98
R1466:Klra10 UTSW 6 130,256,394 (GRCm39) missense probably damaging 0.98
R1466:Klra10 UTSW 6 130,256,278 (GRCm39) missense probably damaging 1.00
R1466:Klra10 UTSW 6 130,256,278 (GRCm39) missense probably damaging 1.00
R2125:Klra10 UTSW 6 130,256,241 (GRCm39) missense probably damaging 0.98
R2266:Klra10 UTSW 6 130,246,264 (GRCm39) missense probably benign 0.13
R2427:Klra10 UTSW 6 130,256,298 (GRCm39) missense probably benign 0.00
R4260:Klra10 UTSW 6 130,249,644 (GRCm39) missense probably damaging 1.00
R4495:Klra10 UTSW 6 130,256,311 (GRCm39) missense probably benign 0.00
R5897:Klra10 UTSW 6 130,258,792 (GRCm39) nonsense probably null
R6123:Klra10 UTSW 6 130,256,339 (GRCm39) missense probably benign 0.04
R6221:Klra10 UTSW 6 130,246,235 (GRCm39) missense probably benign
R6520:Klra10 UTSW 6 130,252,755 (GRCm39) missense probably benign 0.03
R6551:Klra10 UTSW 6 130,252,718 (GRCm39) missense probably benign 0.36
R7445:Klra10 UTSW 6 130,252,819 (GRCm39) missense probably benign 0.38
R7453:Klra10 UTSW 6 130,257,327 (GRCm39) missense probably damaging 0.98
R7744:Klra10 UTSW 6 130,249,724 (GRCm39) critical splice acceptor site probably null
R8079:Klra10 UTSW 6 130,252,738 (GRCm39) missense probably benign
R8320:Klra10 UTSW 6 130,246,211 (GRCm39) missense probably damaging 1.00
R8963:Klra10 UTSW 6 130,249,617 (GRCm39) critical splice donor site probably null
R9419:Klra10 UTSW 6 130,256,435 (GRCm39) missense probably damaging 1.00
R9725:Klra10 UTSW 6 130,252,849 (GRCm39) missense probably benign
RF060:Klra10 UTSW 6 130,252,784 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- AGACTCATTGTATCTGTCATGACC -3'
(R):5'- AACGCCATGTTATTCCAGAGAG -3'

Sequencing Primer
(F):5'- GTCATGACCATTCCCTCACATTACAC -3'
(R):5'- CGCCATGTTATTCCAGAGAGTTACTG -3'
Posted On 2018-05-21