Incidental Mutation 'R6415:Or7e165'
ID 517870
Institutional Source Beutler Lab
Gene Symbol Or7e165
Ensembl Gene ENSMUSG00000058659
Gene Name olfactory receptor family 7 subfamily E member 165
Synonyms Olfr58, MOR146-7P, IG6, GA_x6K02T2PVTD-13523015-13523944, MOR146-3
MMRRC Submission 044557-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R6415 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 19691579-19695360 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 19695044 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 205 (I205N)
Ref Sequence ENSEMBL: ENSMUSP00000150309 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000212363] [ENSMUST00000215112]
AlphaFold Q7TRF6
Predicted Effect probably benign
Transcript: ENSMUST00000212363
Predicted Effect probably damaging
Transcript: ENSMUST00000215112
AA Change: I205N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.8%
  • 20x: 93.1%
Validation Efficiency 100% (65/65)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930563M21Rik G A 9: 55,881,296 (GRCm39) T482M probably benign Het
Adam9 A G 8: 25,468,498 (GRCm39) Y513H probably damaging Het
Adamts20 C T 15: 94,222,540 (GRCm39) probably null Het
B3gnt5 A G 16: 19,588,759 (GRCm39) D326G probably damaging Het
Cacna1g A G 11: 94,354,243 (GRCm39) I224T probably damaging Het
Ccdc18 A G 5: 108,309,612 (GRCm39) I402M probably benign Het
Cckar A T 5: 53,860,398 (GRCm39) C73S probably damaging Het
Cdk13 C T 13: 17,913,739 (GRCm39) R880H probably damaging Het
Col1a1 A G 11: 94,830,986 (GRCm39) N218D unknown Het
Csnk1g2 T C 10: 80,474,130 (GRCm39) I145T possibly damaging Het
Cul5 T C 9: 53,557,983 (GRCm39) D207G probably benign Het
Cyp2c69 A G 19: 39,831,365 (GRCm39) F483L probably benign Het
Ddx60 A G 8: 62,436,939 (GRCm39) D963G probably benign Het
Dhx8 G T 11: 101,628,513 (GRCm39) A142S unknown Het
Dock7 C T 4: 98,880,685 (GRCm39) R926Q probably damaging Het
Dscaml1 C T 9: 45,594,975 (GRCm39) Q693* probably null Het
Dysf G A 6: 84,117,024 (GRCm39) C1234Y probably damaging Het
Ercc1 G A 7: 19,089,102 (GRCm39) probably null Het
Fam91a1 T C 15: 58,314,766 (GRCm39) L549P probably damaging Het
Fxyd2 T A 9: 45,314,592 (GRCm39) Y5N possibly damaging Het
Gab1 C A 8: 81,515,226 (GRCm39) R364L possibly damaging Het
Gpr182 T A 10: 127,586,375 (GRCm39) D192V possibly damaging Het
Gps1 T C 11: 120,678,548 (GRCm39) V286A possibly damaging Het
Grk1 A G 8: 13,463,127 (GRCm39) Y383C probably damaging Het
H2bc15 T C 13: 21,938,656 (GRCm39) Y122H probably benign Het
Hic1 G A 11: 75,057,143 (GRCm39) P582L possibly damaging Het
Igkv4-61 C A 6: 69,394,138 (GRCm39) A31S possibly damaging Het
Khdc4 T C 3: 88,607,279 (GRCm39) F328L probably benign Het
Lactb T C 9: 66,877,927 (GRCm39) K301E possibly damaging Het
Lrp3 A T 7: 34,903,593 (GRCm39) V251E probably benign Het
Mapt G A 11: 104,189,824 (GRCm39) G265S probably benign Het
Obscn A T 11: 58,925,956 (GRCm39) D6245E probably damaging Het
Or10al2 G T 17: 37,983,448 (GRCm39) C178F possibly damaging Het
Or1j12 A G 2: 36,342,617 (GRCm39) S7G probably damaging Het
Or4b1c T A 2: 90,126,381 (GRCm39) I275F probably damaging Het
Or4c10b T C 2: 89,711,206 (GRCm39) L12P probably damaging Het
Or6c207 T C 10: 129,104,890 (GRCm39) T101A probably benign Het
Or7g19 T C 9: 18,856,415 (GRCm39) L157P probably damaging Het
Oxsm A T 14: 16,241,904 (GRCm38) H288Q probably benign Het
Pcdh9 C T 14: 93,253,278 (GRCm39) M1128I possibly damaging Het
Pcdha8 T C 18: 37,127,614 (GRCm39) Y699H probably damaging Het
Pgk2 A T 17: 40,518,459 (GRCm39) I323N probably benign Het
Plin4 A G 17: 56,410,264 (GRCm39) V1216A probably damaging Het
Ppargc1a T C 5: 51,620,176 (GRCm39) probably benign Het
Prelp A T 1: 133,840,516 (GRCm39) I322N probably benign Het
Prelp A T 1: 133,842,395 (GRCm39) I250N probably damaging Het
Prss27 T A 17: 24,261,882 (GRCm39) C63* probably null Het
Rab38 G A 7: 88,079,748 (GRCm39) A47T possibly damaging Het
Rprd2 G A 3: 95,681,531 (GRCm39) A436V probably benign Het
Sacs A T 14: 61,442,808 (GRCm39) N1618I probably damaging Het
Scp2 T G 4: 107,962,337 (GRCm39) S63R probably benign Het
Sftpb T G 6: 72,281,633 (GRCm39) W9G probably damaging Het
Slco1a4 A T 6: 141,780,415 (GRCm39) L125* probably null Het
Sptlc1 T C 13: 53,505,728 (GRCm39) probably null Het
Sub1 T A 15: 11,986,560 (GRCm39) M96L probably benign Het
Tanc1 T C 2: 59,667,458 (GRCm39) V1233A probably benign Het
Tmem140 A T 6: 34,849,658 (GRCm39) D58V probably damaging Het
Tmem231 G A 8: 112,653,524 (GRCm39) probably benign Het
Tpt1 T C 14: 76,083,811 (GRCm39) Y91H probably benign Het
Trap1 C T 16: 3,861,856 (GRCm39) R636H possibly damaging Het
Ttc14 A G 3: 33,857,724 (GRCm39) H275R possibly damaging Het
Tut7 T A 13: 59,964,110 (GRCm39) probably null Het
Vps35l T C 7: 118,391,869 (GRCm39) W494R probably damaging Het
Ypel1 A G 16: 16,921,438 (GRCm39) probably null Het
Zbtb44 T A 9: 30,975,510 (GRCm39) I380N possibly damaging Het
Zswim5 T C 4: 116,838,063 (GRCm39) F798L possibly damaging Het
Other mutations in Or7e165
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01461:Or7e165 APN 9 19,695,245 (GRCm39) splice site probably null
IGL01815:Or7e165 APN 9 19,695,311 (GRCm39) missense probably damaging 1.00
IGL02408:Or7e165 APN 9 19,694,711 (GRCm39) missense probably benign 0.31
IGL02644:Or7e165 APN 9 19,695,010 (GRCm39) missense probably benign 0.30
IGL03243:Or7e165 APN 9 19,694,564 (GRCm39) missense probably damaging 0.99
R0603:Or7e165 UTSW 9 19,695,235 (GRCm39) missense probably damaging 1.00
R2363:Or7e165 UTSW 9 19,694,892 (GRCm39) missense probably benign 0.00
R2570:Or7e165 UTSW 9 19,695,305 (GRCm39) missense probably damaging 1.00
R3890:Or7e165 UTSW 9 19,695,011 (GRCm39) missense probably benign 0.03
R3892:Or7e165 UTSW 9 19,695,011 (GRCm39) missense probably benign 0.03
R4163:Or7e165 UTSW 9 19,695,086 (GRCm39) missense possibly damaging 0.69
R4610:Or7e165 UTSW 9 19,694,442 (GRCm39) nonsense probably null
R4691:Or7e165 UTSW 9 19,694,678 (GRCm39) missense probably benign 0.33
R4707:Or7e165 UTSW 9 19,694,596 (GRCm39) missense probably damaging 1.00
R4825:Or7e165 UTSW 9 19,694,872 (GRCm39) missense possibly damaging 0.74
R4950:Or7e165 UTSW 9 19,695,027 (GRCm39) missense probably benign
R5185:Or7e165 UTSW 9 19,694,672 (GRCm39) missense probably damaging 1.00
R5202:Or7e165 UTSW 9 19,694,514 (GRCm39) missense possibly damaging 0.46
R5439:Or7e165 UTSW 9 19,695,161 (GRCm39) missense probably damaging 1.00
R5669:Or7e165 UTSW 9 19,695,053 (GRCm39) missense probably benign 0.02
R5672:Or7e165 UTSW 9 19,694,507 (GRCm39) missense possibly damaging 0.92
R6038:Or7e165 UTSW 9 19,694,858 (GRCm39) missense probably benign
R6038:Or7e165 UTSW 9 19,694,858 (GRCm39) missense probably benign
R6212:Or7e165 UTSW 9 19,694,585 (GRCm39) missense probably damaging 1.00
R7385:Or7e165 UTSW 9 19,694,507 (GRCm39) missense possibly damaging 0.92
R7669:Or7e165 UTSW 9 19,694,839 (GRCm39) missense possibly damaging 0.79
Predicted Primers PCR Primer
(F):5'- GATGGGTGGCCATTTGTCAC -3'
(R):5'- GGAACTGAGGTAAACTCCTATACCTG -3'

Sequencing Primer
(F):5'- AAGTCATTCTGAATCCTTGTCGG -3'
(R):5'- CCTATACCTGTTCCATAAAATAGGC -3'
Posted On 2018-05-24