Incidental Mutation 'R6416:Il17f'
ID 517907
Institutional Source Beutler Lab
Gene Symbol Il17f
Ensembl Gene ENSMUSG00000041872
Gene Name interleukin 17F
MMRRC Submission 044558-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.100) question?
Stock # R6416 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 20777146-20790617 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 20777907 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 116 (M116L)
Ref Sequence ENSEMBL: ENSMUSP00000046960 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039046] [ENSMUST00000189301]
AlphaFold Q7TNI7
Predicted Effect probably benign
Transcript: ENSMUST00000039046
AA Change: M116L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000046960
Gene: ENSMUSG00000041872
AA Change: M116L

signal peptide 1 28 N/A INTRINSIC
Pfam:IL17 75 153 3.8e-32 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000189301
AA Change: M116L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000140122
Gene: ENSMUSG00000041872
AA Change: M116L

signal peptide 1 28 N/A INTRINSIC
Pfam:IL17 74 154 5.4e-33 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191111
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.8%
  • 10x: 98.4%
  • 20x: 94.6%
Validation Efficiency 99% (67/68)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for one null allele exhibit increased susceptibility to oral bacterial infection while mice homozygous for another null allele exhibit decreased susceptibility to experimental models of colitis and CNS inflammation but have enhanced inflammatory responses to a chronic asthma model. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310061N02Rik C A 16: 88,707,891 (GRCm38) R6L unknown Het
Anxa11 A G 14: 25,874,270 (GRCm38) Q235R possibly damaging Het
Ap2b1 T A 11: 83,308,239 (GRCm38) M1K probably null Het
Atl2 G A 17: 79,850,223 (GRCm38) T563I probably benign Het
Azin1 A T 15: 38,492,343 (GRCm38) S307R possibly damaging Het
Ccdc153 A G 9: 44,245,780 (GRCm38) T118A probably benign Het
Chac1 G A 2: 119,353,534 (GRCm38) V206I probably damaging Het
Chrm3 A G 13: 9,877,662 (GRCm38) V446A probably benign Het
Cped1 T C 6: 22,123,649 (GRCm38) F467S probably damaging Het
Csmd3 G A 15: 48,673,560 (GRCm38) P82L probably damaging Het
Ddx60 C T 8: 61,998,681 (GRCm38) H1202Y probably benign Het
Ddx60 T A 8: 61,977,950 (GRCm38) S840T probably benign Het
Dnah8 T A 17: 30,765,635 (GRCm38) N3102K probably benign Het
Dst A T 1: 34,116,128 (GRCm38) K85M probably damaging Het
Ehbp1l1 T C 19: 5,718,757 (GRCm38) I839M probably benign Het
Fam184b T A 5: 45,537,653 (GRCm38) M750L probably benign Het
Frem2 T C 3: 53,572,378 (GRCm38) T1965A probably benign Het
Ftl1 A T 7: 45,459,210 (GRCm38) D41E probably benign Het
Garem2 G A 5: 30,116,737 (GRCm38) W698* probably null Het
Glt8d2 T C 10: 82,652,906 (GRCm38) Y283C probably damaging Het
Hars T C 18: 36,773,590 (GRCm38) E109G possibly damaging Het
Hspb9 T C 11: 100,714,210 (GRCm38) S121P probably damaging Het
Hus1b A T 13: 30,947,205 (GRCm38) L157Q probably damaging Het
Hykk A G 9: 54,946,359 (GRCm38) M322V probably benign Het
Igkv4-61 C A 6: 69,417,154 (GRCm38) A31S possibly damaging Het
Kif22 T C 7: 127,028,932 (GRCm38) K9E possibly damaging Het
Krt90 T C 15: 101,559,244 (GRCm38) E233G probably benign Het
Lipg T C 18: 74,957,236 (GRCm38) M81V probably benign Het
Mocos C T 18: 24,701,456 (GRCm38) S850L probably damaging Het
Mug2 T A 6: 122,082,754 (GRCm38) S1364T probably damaging Het
Neb A T 2: 52,185,328 (GRCm38) N208K probably benign Het
Oca2 G T 7: 56,328,767 (GRCm38) R561L probably benign Het
Olfm5 A G 7: 104,154,053 (GRCm38) L401P probably damaging Het
Olfr109 T A 17: 37,467,080 (GRCm38) Y291* probably null Het
Olfr1238 C A 2: 89,406,522 (GRCm38) A186S possibly damaging Het
Olfr331 T C 11: 58,502,340 (GRCm38) D72G probably damaging Het
Olfr828 G A 9: 18,815,892 (GRCm38) T134M probably benign Het
Olfr952 T A 9: 39,426,891 (GRCm38) Y60F probably damaging Het
Oxgr1 T C 14: 120,022,448 (GRCm38) N116D probably damaging Het
Pcdha11 G T 18: 37,012,169 (GRCm38) probably null Het
Pi4ka T C 16: 17,358,322 (GRCm38) I418V probably benign Het
Pih1d2 T C 9: 50,618,609 (GRCm38) V62A probably benign Het
Pkib T A 10: 57,728,138 (GRCm38) V46E probably damaging Het
Pum1 A G 4: 130,728,287 (GRCm38) probably null Het
Rbak G T 5: 143,176,552 (GRCm38) Q19K possibly damaging Het
Sema3c A G 5: 17,576,961 (GRCm38) T32A probably damaging Het
Shprh T C 10: 11,167,873 (GRCm38) W835R probably damaging Het
Sis T G 3: 72,911,854 (GRCm38) K1456N probably damaging Het
Slc4a4 A T 5: 89,179,729 (GRCm38) N675I probably benign Het
Slc8a3 C A 12: 81,315,627 (GRCm38) M139I probably damaging Het
Sorcs3 T C 19: 48,802,759 (GRCm38) F1182S probably damaging Het
St8sia2 A T 7: 73,971,921 (GRCm38) I96N probably damaging Het
Stx19 T C 16: 62,822,057 (GRCm38) S79P probably damaging Het
Tecta C T 9: 42,375,267 (GRCm38) V698M probably damaging Het
Timm22 T C 11: 76,411,139 (GRCm38) S150P probably damaging Het
Tjp1 C T 7: 65,313,205 (GRCm38) D995N possibly damaging Het
Tmem135 T A 7: 89,147,794 (GRCm38) T365S probably benign Het
Tmem174 T C 13: 98,636,981 (GRCm38) T114A probably benign Het
Tnc A G 4: 64,007,816 (GRCm38) I909T probably benign Het
Trcg1 A G 9: 57,241,330 (GRCm38) I62V possibly damaging Het
Tulp1 A T 17: 28,356,031 (GRCm38) *487K probably null Het
Unc79 T A 12: 103,131,646 (GRCm38) V1826E possibly damaging Het
Vmn2r13 A T 5: 109,174,116 (GRCm38) N238K probably damaging Het
Vmn2r22 T A 6: 123,637,738 (GRCm38) N298Y probably damaging Het
Vmn2r23 T A 6: 123,712,902 (GRCm38) F246I probably damaging Het
Vps9d1 A C 8: 123,248,639 (GRCm38) V194G probably damaging Het
Zfp260 A T 7: 30,104,810 (GRCm38) H45L possibly damaging Het
Zfp846 A T 9: 20,593,720 (GRCm38) H292L possibly damaging Het
Other mutations in Il17f
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0800:Il17f UTSW 1 20,777,953 (GRCm38) nonsense probably null
R2224:Il17f UTSW 1 20,779,375 (GRCm38) missense probably damaging 0.97
R4074:Il17f UTSW 1 20,777,763 (GRCm38) unclassified probably benign
R4594:Il17f UTSW 1 20,777,802 (GRCm38) missense probably damaging 1.00
R5386:Il17f UTSW 1 20,777,957 (GRCm38) missense probably benign 0.00
R6009:Il17f UTSW 1 20,779,286 (GRCm38) splice site probably null
R6751:Il17f UTSW 1 20,779,489 (GRCm38) missense probably benign 0.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2018-05-24