Incidental Mutation 'R6416:Shprh'
| ID |
517945 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Shprh
|
| Ensembl Gene |
ENSMUSG00000090112 |
| Gene Name |
SNF2 histone linker PHD RING helicase |
| Synonyms |
2610103K11Rik, D230017O13Rik |
| MMRRC Submission |
044558-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R6416 (G1)
|
| Quality Score |
153.008 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
11149427-11217595 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 11167873 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tryptophan to Arginine
at position 835
(W835R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125457
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044053]
[ENSMUST00000054814]
[ENSMUST00000159541]
[ENSMUST00000159810]
[ENSMUST00000160461]
|
| AlphaFold |
Q7TPQ3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000044053
AA Change: W835R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000039422
Gene: ENSMUSG00000090112
AA Change: W835R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
Pfam:Helicase_C
|
1500 |
1613 |
1.6e-8 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000054814
AA Change: W835R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000125849
Gene: ENSMUSG00000090112
AA Change: W835R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
SCOP:d1fuka_
|
1504 |
1616 |
6e-8 |
SMART |
|
Blast:HELICc
|
1533 |
1613 |
4e-46 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159541
AA Change: W835R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000132870
Gene: ENSMUSG00000090112
AA Change: W835R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
SCOP:d1fuka_
|
1504 |
1619 |
4e-8 |
SMART |
|
Blast:HELICc
|
1533 |
1613 |
6e-46 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159553
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159810
AA Change: W835R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000125457
Gene: ENSMUSG00000090112
AA Change: W835R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
2e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
Blast:DEXDc
|
948 |
1026 |
2e-9 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160461
|
| SMART Domains |
Protein: ENSMUSP00000125127
Gene: ENSMUSG00000090112
| Domain | Start | End | E-Value | Type |
|---|
|
PHD
|
131 |
178 |
2.33e-5 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.8%
- 10x: 98.4%
- 20x: 94.6%
|
| Validation Efficiency |
99% (67/68) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]
PHENOTYPE: The gene product is an E3 ligase involved in poly-ubiquitination of Pcna. Neither homozygous truncation nor KO affect B cell somatic hypermutation or class switching. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 68 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310061N02Rik |
C |
A |
16: 88,707,891 (GRCm38) |
R6L |
unknown |
Het |
| Anxa11 |
A |
G |
14: 25,874,270 (GRCm38) |
Q235R |
possibly damaging |
Het |
| Ap2b1 |
T |
A |
11: 83,308,239 (GRCm38) |
M1K |
probably null |
Het |
| Atl2 |
G |
A |
17: 79,850,223 (GRCm38) |
T563I |
probably benign |
Het |
| Azin1 |
A |
T |
15: 38,492,343 (GRCm38) |
S307R |
possibly damaging |
Het |
| Ccdc153 |
A |
G |
9: 44,245,780 (GRCm38) |
T118A |
probably benign |
Het |
| Chac1 |
G |
A |
2: 119,353,534 (GRCm38) |
V206I |
probably damaging |
Het |
| Chrm3 |
A |
G |
13: 9,877,662 (GRCm38) |
V446A |
probably benign |
Het |
| Cped1 |
T |
C |
6: 22,123,649 (GRCm38) |
F467S |
probably damaging |
Het |
| Csmd3 |
G |
A |
15: 48,673,560 (GRCm38) |
P82L |
probably damaging |
Het |
| Ddx60 |
T |
A |
8: 61,977,950 (GRCm38) |
S840T |
probably benign |
Het |
| Ddx60 |
C |
T |
8: 61,998,681 (GRCm38) |
H1202Y |
probably benign |
Het |
| Dnah8 |
T |
A |
17: 30,765,635 (GRCm38) |
N3102K |
probably benign |
Het |
| Dst |
A |
T |
1: 34,116,128 (GRCm38) |
K85M |
probably damaging |
Het |
| Ehbp1l1 |
T |
C |
19: 5,718,757 (GRCm38) |
I839M |
probably benign |
Het |
| Fam184b |
T |
A |
5: 45,537,653 (GRCm38) |
M750L |
probably benign |
Het |
| Frem2 |
T |
C |
3: 53,572,378 (GRCm38) |
T1965A |
probably benign |
Het |
| Ftl1 |
A |
T |
7: 45,459,210 (GRCm38) |
D41E |
probably benign |
Het |
| Garem2 |
G |
A |
5: 30,116,737 (GRCm38) |
W698* |
probably null |
Het |
| Glt8d2 |
T |
C |
10: 82,652,906 (GRCm38) |
Y283C |
probably damaging |
Het |
| Hars |
T |
C |
18: 36,773,590 (GRCm38) |
E109G |
possibly damaging |
Het |
| Hspb9 |
T |
C |
11: 100,714,210 (GRCm38) |
S121P |
probably damaging |
Het |
| Hus1b |
A |
T |
13: 30,947,205 (GRCm38) |
L157Q |
probably damaging |
Het |
| Hykk |
A |
G |
9: 54,946,359 (GRCm38) |
M322V |
probably benign |
Het |
| Igkv4-61 |
C |
A |
6: 69,417,154 (GRCm38) |
A31S |
possibly damaging |
Het |
| Il17f |
T |
A |
1: 20,777,907 (GRCm38) |
M116L |
probably benign |
Het |
| Kif22 |
T |
C |
7: 127,028,932 (GRCm38) |
K9E |
possibly damaging |
Het |
| Krt90 |
T |
C |
15: 101,559,244 (GRCm38) |
E233G |
probably benign |
Het |
| Lipg |
T |
C |
18: 74,957,236 (GRCm38) |
M81V |
probably benign |
Het |
| Mocos |
C |
T |
18: 24,701,456 (GRCm38) |
S850L |
probably damaging |
Het |
| Mug2 |
T |
A |
6: 122,082,754 (GRCm38) |
S1364T |
probably damaging |
Het |
| Neb |
A |
T |
2: 52,185,328 (GRCm38) |
N208K |
probably benign |
Het |
| Oca2 |
G |
T |
7: 56,328,767 (GRCm38) |
R561L |
probably benign |
Het |
| Olfm5 |
A |
G |
7: 104,154,053 (GRCm38) |
L401P |
probably damaging |
Het |
| Olfr109 |
T |
A |
17: 37,467,080 (GRCm38) |
Y291* |
probably null |
Het |
| Olfr1238 |
C |
A |
2: 89,406,522 (GRCm38) |
A186S |
possibly damaging |
Het |
| Olfr331 |
T |
C |
11: 58,502,340 (GRCm38) |
D72G |
probably damaging |
Het |
| Olfr828 |
G |
A |
9: 18,815,892 (GRCm38) |
T134M |
probably benign |
Het |
| Olfr952 |
T |
A |
9: 39,426,891 (GRCm38) |
Y60F |
probably damaging |
Het |
| Oxgr1 |
T |
C |
14: 120,022,448 (GRCm38) |
N116D |
probably damaging |
Het |
| Pcdha11 |
G |
T |
18: 37,012,169 (GRCm38) |
|
probably null |
Het |
| Pi4ka |
T |
C |
16: 17,358,322 (GRCm38) |
I418V |
probably benign |
Het |
| Pih1d2 |
T |
C |
9: 50,618,609 (GRCm38) |
V62A |
probably benign |
Het |
| Pkib |
T |
A |
10: 57,728,138 (GRCm38) |
V46E |
probably damaging |
Het |
| Pum1 |
A |
G |
4: 130,728,287 (GRCm38) |
|
probably null |
Het |
| Rbak |
G |
T |
5: 143,176,552 (GRCm38) |
Q19K |
possibly damaging |
Het |
| Sema3c |
A |
G |
5: 17,576,961 (GRCm38) |
T32A |
probably damaging |
Het |
| Sis |
T |
G |
3: 72,911,854 (GRCm38) |
K1456N |
probably damaging |
Het |
| Slc4a4 |
A |
T |
5: 89,179,729 (GRCm38) |
N675I |
probably benign |
Het |
| Slc8a3 |
C |
A |
12: 81,315,627 (GRCm38) |
M139I |
probably damaging |
Het |
| Sorcs3 |
T |
C |
19: 48,802,759 (GRCm38) |
F1182S |
probably damaging |
Het |
| St8sia2 |
A |
T |
7: 73,971,921 (GRCm38) |
I96N |
probably damaging |
Het |
| Stx19 |
T |
C |
16: 62,822,057 (GRCm38) |
S79P |
probably damaging |
Het |
| Tecta |
C |
T |
9: 42,375,267 (GRCm38) |
V698M |
probably damaging |
Het |
| Timm22 |
T |
C |
11: 76,411,139 (GRCm38) |
S150P |
probably damaging |
Het |
| Tjp1 |
C |
T |
7: 65,313,205 (GRCm38) |
D995N |
possibly damaging |
Het |
| Tmem135 |
T |
A |
7: 89,147,794 (GRCm38) |
T365S |
probably benign |
Het |
| Tmem174 |
T |
C |
13: 98,636,981 (GRCm38) |
T114A |
probably benign |
Het |
| Tnc |
A |
G |
4: 64,007,816 (GRCm38) |
I909T |
probably benign |
Het |
| Trcg1 |
A |
G |
9: 57,241,330 (GRCm38) |
I62V |
possibly damaging |
Het |
| Tulp1 |
A |
T |
17: 28,356,031 (GRCm38) |
*487K |
probably null |
Het |
| Unc79 |
T |
A |
12: 103,131,646 (GRCm38) |
V1826E |
possibly damaging |
Het |
| Vmn2r13 |
A |
T |
5: 109,174,116 (GRCm38) |
N238K |
probably damaging |
Het |
| Vmn2r22 |
T |
A |
6: 123,637,738 (GRCm38) |
N298Y |
probably damaging |
Het |
| Vmn2r23 |
T |
A |
6: 123,712,902 (GRCm38) |
F246I |
probably damaging |
Het |
| Vps9d1 |
A |
C |
8: 123,248,639 (GRCm38) |
V194G |
probably damaging |
Het |
| Zfp260 |
A |
T |
7: 30,104,810 (GRCm38) |
H45L |
possibly damaging |
Het |
| Zfp846 |
A |
T |
9: 20,593,720 (GRCm38) |
H292L |
possibly damaging |
Het |
|
| Other mutations in Shprh |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00492:Shprh
|
APN |
10 |
11,188,158 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00583:Shprh
|
APN |
10 |
11,188,020 (GRCm38) |
missense |
probably benign |
0.37 |
|
IGL00684:Shprh
|
APN |
10 |
11,163,037 (GRCm38) |
missense |
probably benign |
0.11 |
|
IGL01295:Shprh
|
APN |
10 |
11,183,868 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL01387:Shprh
|
APN |
10 |
11,170,254 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01635:Shprh
|
APN |
10 |
11,170,019 (GRCm38) |
nonsense |
probably null |
|
|
IGL01833:Shprh
|
APN |
10 |
11,191,062 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02013:Shprh
|
APN |
10 |
11,181,502 (GRCm38) |
splice site |
probably benign |
|
|
IGL02502:Shprh
|
APN |
10 |
11,194,357 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
IGL02819:Shprh
|
APN |
10 |
11,154,765 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
PIT4581001:Shprh
|
UTSW |
10 |
11,192,494 (GRCm38) |
frame shift |
probably null |
|
|
R0010:Shprh
|
UTSW |
10 |
11,151,931 (GRCm38) |
missense |
probably benign |
|
|
R0010:Shprh
|
UTSW |
10 |
11,151,931 (GRCm38) |
missense |
probably benign |
|
|
R0053:Shprh
|
UTSW |
10 |
11,194,372 (GRCm38) |
splice site |
probably null |
|
|
R0053:Shprh
|
UTSW |
10 |
11,194,372 (GRCm38) |
splice site |
probably null |
|
|
R0255:Shprh
|
UTSW |
10 |
11,186,391 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R0325:Shprh
|
UTSW |
10 |
11,170,109 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0331:Shprh
|
UTSW |
10 |
11,194,170 (GRCm38) |
splice site |
probably benign |
|
|
R0494:Shprh
|
UTSW |
10 |
11,157,191 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0532:Shprh
|
UTSW |
10 |
11,162,812 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R0546:Shprh
|
UTSW |
10 |
11,183,887 (GRCm38) |
splice site |
probably benign |
|
|
R0574:Shprh
|
UTSW |
10 |
11,163,077 (GRCm38) |
unclassified |
probably benign |
|
|
R0605:Shprh
|
UTSW |
10 |
11,207,112 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0662:Shprh
|
UTSW |
10 |
11,186,847 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1148:Shprh
|
UTSW |
10 |
11,213,482 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1148:Shprh
|
UTSW |
10 |
11,213,482 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1263:Shprh
|
UTSW |
10 |
11,159,530 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1588:Shprh
|
UTSW |
10 |
11,164,744 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1638:Shprh
|
UTSW |
10 |
11,157,078 (GRCm38) |
missense |
probably benign |
|
|
R1830:Shprh
|
UTSW |
10 |
11,186,911 (GRCm38) |
splice site |
probably null |
|
|
R1898:Shprh
|
UTSW |
10 |
11,186,869 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1903:Shprh
|
UTSW |
10 |
11,183,797 (GRCm38) |
nonsense |
probably null |
|
|
R2060:Shprh
|
UTSW |
10 |
11,152,120 (GRCm38) |
missense |
probably benign |
0.03 |
|
R2225:Shprh
|
UTSW |
10 |
11,162,235 (GRCm38) |
unclassified |
probably benign |
|
|
R2363:Shprh
|
UTSW |
10 |
11,171,953 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2509:Shprh
|
UTSW |
10 |
11,166,724 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2891:Shprh
|
UTSW |
10 |
11,164,356 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3077:Shprh
|
UTSW |
10 |
11,170,413 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3150:Shprh
|
UTSW |
10 |
11,170,030 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3796:Shprh
|
UTSW |
10 |
11,178,757 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R4196:Shprh
|
UTSW |
10 |
11,207,860 (GRCm38) |
utr 3 prime |
probably benign |
|
|
R4423:Shprh
|
UTSW |
10 |
11,186,518 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R4488:Shprh
|
UTSW |
10 |
11,160,471 (GRCm38) |
missense |
probably benign |
0.17 |
|
R4748:Shprh
|
UTSW |
10 |
11,170,476 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4768:Shprh
|
UTSW |
10 |
11,181,540 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4867:Shprh
|
UTSW |
10 |
11,164,557 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4937:Shprh
|
UTSW |
10 |
11,157,119 (GRCm38) |
missense |
probably benign |
|
|
R5140:Shprh
|
UTSW |
10 |
11,154,705 (GRCm38) |
missense |
probably benign |
0.03 |
|
R5318:Shprh
|
UTSW |
10 |
11,166,557 (GRCm38) |
missense |
probably benign |
0.04 |
|
R5323:Shprh
|
UTSW |
10 |
11,170,297 (GRCm38) |
splice site |
probably null |
|
|
R5450:Shprh
|
UTSW |
10 |
11,212,330 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R5872:Shprh
|
UTSW |
10 |
11,188,073 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6030:Shprh
|
UTSW |
10 |
11,151,991 (GRCm38) |
missense |
probably benign |
0.37 |
|
R6030:Shprh
|
UTSW |
10 |
11,151,991 (GRCm38) |
missense |
probably benign |
0.37 |
|
R6392:Shprh
|
UTSW |
10 |
11,178,741 (GRCm38) |
nonsense |
probably null |
|
|
R6470:Shprh
|
UTSW |
10 |
11,171,937 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6513:Shprh
|
UTSW |
10 |
11,186,893 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6530:Shprh
|
UTSW |
10 |
11,194,267 (GRCm38) |
missense |
probably benign |
0.02 |
|
R6678:Shprh
|
UTSW |
10 |
11,166,545 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6757:Shprh
|
UTSW |
10 |
11,181,508 (GRCm38) |
splice site |
probably null |
|
|
R6971:Shprh
|
UTSW |
10 |
11,166,693 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7158:Shprh
|
UTSW |
10 |
11,166,730 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7582:Shprh
|
UTSW |
10 |
11,164,705 (GRCm38) |
missense |
probably benign |
|
|
R7757:Shprh
|
UTSW |
10 |
11,162,180 (GRCm38) |
missense |
probably benign |
0.30 |
|
R7812:Shprh
|
UTSW |
10 |
11,151,991 (GRCm38) |
missense |
probably benign |
|
|
R7998:Shprh
|
UTSW |
10 |
11,185,341 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8061:Shprh
|
UTSW |
10 |
11,212,333 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R8082:Shprh
|
UTSW |
10 |
11,151,811 (GRCm38) |
missense |
probably benign |
0.22 |
|
R8116:Shprh
|
UTSW |
10 |
11,213,461 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8390:Shprh
|
UTSW |
10 |
11,187,983 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R8445:Shprh
|
UTSW |
10 |
11,181,569 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R8530:Shprh
|
UTSW |
10 |
11,151,934 (GRCm38) |
missense |
probably benign |
0.37 |
|
R8759:Shprh
|
UTSW |
10 |
11,157,164 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R8937:Shprh
|
UTSW |
10 |
11,185,437 (GRCm38) |
missense |
possibly damaging |
0.60 |
|
R8995:Shprh
|
UTSW |
10 |
11,164,830 (GRCm38) |
nonsense |
probably null |
|
|
R9053:Shprh
|
UTSW |
10 |
11,154,702 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9131:Shprh
|
UTSW |
10 |
11,162,845 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R9176:Shprh
|
UTSW |
10 |
11,160,576 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9391:Shprh
|
UTSW |
10 |
11,162,889 (GRCm38) |
missense |
probably benign |
0.05 |
|
R9423:Shprh
|
UTSW |
10 |
11,205,263 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9563:Shprh
|
UTSW |
10 |
11,166,491 (GRCm38) |
nonsense |
probably null |
|
|
R9668:Shprh
|
UTSW |
10 |
11,206,332 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R9709:Shprh
|
UTSW |
10 |
11,162,830 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R9718:Shprh
|
UTSW |
10 |
11,213,504 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9750:Shprh
|
UTSW |
10 |
11,164,460 (GRCm38) |
missense |
probably damaging |
0.98 |
|
RF012:Shprh
|
UTSW |
10 |
11,164,841 (GRCm38) |
missense |
probably benign |
0.02 |
|
V8831:Shprh
|
UTSW |
10 |
11,186,862 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Shprh
|
UTSW |
10 |
11,186,447 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Shprh
|
UTSW |
10 |
11,164,553 (GRCm38) |
missense |
probably benign |
|
|
Z1177:Shprh
|
UTSW |
10 |
11,151,762 (GRCm38) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACCTGAAATGGGCTATAGTGGG -3'
(R):5'- TGAAGCATCACCCACGTTC -3'
Sequencing Primer
(F):5'- CTGGAACTCACTTTGTAGACCAGG -3'
(R):5'- CCCACGTTCCATTTACAAGTTAATTG -3'
|
| Posted On |
2018-05-24 |
Incidental Mutation