Incidental Mutation 'R6416:Or12d17'
ID 517967
Institutional Source Beutler Lab
Gene Symbol Or12d17
Ensembl Gene ENSMUSG00000029184
Gene Name olfactory receptor family 12 subfamily D member 17
Synonyms GA_x6K02T2PSCP-1914078-1915022, Olfr109, MOR250-1
MMRRC Submission 044558-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R6416 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 37777099-37778043 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 37777971 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 291 (Y291*)
Ref Sequence ENSEMBL: ENSMUSP00000150044 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000031086] [ENSMUST00000214668] [ENSMUST00000214938] [ENSMUST00000217602]
AlphaFold Q8VG96
Predicted Effect probably null
Transcript: ENSMUST00000031086
AA Change: Y291*
SMART Domains Protein: ENSMUSP00000031086
Gene: ENSMUSG00000029184
AA Change: Y291*

DomainStartEndE-ValueType
Pfam:7tm_4 29 309 3.4e-54 PFAM
Pfam:7tm_1 39 291 6.3e-23 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000214668
AA Change: Y291*
Predicted Effect probably null
Transcript: ENSMUST00000214938
AA Change: Y291*
Predicted Effect probably null
Transcript: ENSMUST00000217602
AA Change: Y291*
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.8%
  • 10x: 98.4%
  • 20x: 94.6%
Validation Efficiency 99% (67/68)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310061N02Rik C A 16: 88,504,779 (GRCm39) R6L unknown Het
Anxa11 A G 14: 25,874,694 (GRCm39) Q235R possibly damaging Het
Ap2b1 T A 11: 83,199,065 (GRCm39) M1K probably null Het
Atl2 G A 17: 80,157,652 (GRCm39) T563I probably benign Het
Azin1 A T 15: 38,492,587 (GRCm39) S307R possibly damaging Het
Ccdc153 A G 9: 44,157,077 (GRCm39) T118A probably benign Het
Chac1 G A 2: 119,184,015 (GRCm39) V206I probably damaging Het
Chrm3 A G 13: 9,927,698 (GRCm39) V446A probably benign Het
Cped1 T C 6: 22,123,648 (GRCm39) F467S probably damaging Het
Csmd3 G A 15: 48,536,956 (GRCm39) P82L probably damaging Het
Ddx60 T A 8: 62,430,984 (GRCm39) S840T probably benign Het
Ddx60 C T 8: 62,451,715 (GRCm39) H1202Y probably benign Het
Dnah8 T A 17: 30,984,609 (GRCm39) N3102K probably benign Het
Dst A T 1: 34,155,209 (GRCm39) K85M probably damaging Het
Ehbp1l1 T C 19: 5,768,785 (GRCm39) I839M probably benign Het
Fam184b T A 5: 45,694,995 (GRCm39) M750L probably benign Het
Frem2 T C 3: 53,479,799 (GRCm39) T1965A probably benign Het
Ftl1 A T 7: 45,108,634 (GRCm39) D41E probably benign Het
Garem2 G A 5: 30,321,735 (GRCm39) W698* probably null Het
Glt8d2 T C 10: 82,488,740 (GRCm39) Y283C probably damaging Het
Hars1 T C 18: 36,906,643 (GRCm39) E109G possibly damaging Het
Hspb9 T C 11: 100,605,036 (GRCm39) S121P probably damaging Het
Hus1b A T 13: 31,131,188 (GRCm39) L157Q probably damaging Het
Hykk A G 9: 54,853,643 (GRCm39) M322V probably benign Het
Igkv4-61 C A 6: 69,394,138 (GRCm39) A31S possibly damaging Het
Il17f T A 1: 20,848,131 (GRCm39) M116L probably benign Het
Kif22 T C 7: 126,628,104 (GRCm39) K9E possibly damaging Het
Krt90 T C 15: 101,467,679 (GRCm39) E233G probably benign Het
Lipg T C 18: 75,090,307 (GRCm39) M81V probably benign Het
Mocos C T 18: 24,834,513 (GRCm39) S850L probably damaging Het
Mug2 T A 6: 122,059,713 (GRCm39) S1364T probably damaging Het
Neb A T 2: 52,075,340 (GRCm39) N208K probably benign Het
Oca2 G T 7: 55,978,515 (GRCm39) R561L probably benign Het
Olfm5 A G 7: 103,803,260 (GRCm39) L401P probably damaging Het
Or2t49 T C 11: 58,393,166 (GRCm39) D72G probably damaging Het
Or4a39 C A 2: 89,236,866 (GRCm39) A186S possibly damaging Het
Or7g16 G A 9: 18,727,188 (GRCm39) T134M probably benign Het
Or8g33 T A 9: 39,338,187 (GRCm39) Y60F probably damaging Het
Oxgr1 T C 14: 120,259,860 (GRCm39) N116D probably damaging Het
Pcdha11 G T 18: 37,145,222 (GRCm39) probably null Het
Pi4ka T C 16: 17,176,186 (GRCm39) I418V probably benign Het
Pih1d2 T C 9: 50,529,909 (GRCm39) V62A probably benign Het
Pkib T A 10: 57,604,234 (GRCm39) V46E probably damaging Het
Pum1 A G 4: 130,455,598 (GRCm39) probably null Het
Rbak G T 5: 143,162,307 (GRCm39) Q19K possibly damaging Het
Sema3c A G 5: 17,781,959 (GRCm39) T32A probably damaging Het
Shprh T C 10: 11,043,617 (GRCm39) W835R probably damaging Het
Sis T G 3: 72,819,187 (GRCm39) K1456N probably damaging Het
Slc4a4 A T 5: 89,327,588 (GRCm39) N675I probably benign Het
Slc8a3 C A 12: 81,362,401 (GRCm39) M139I probably damaging Het
Sorcs3 T C 19: 48,791,198 (GRCm39) F1182S probably damaging Het
St8sia2 A T 7: 73,621,669 (GRCm39) I96N probably damaging Het
Stx19 T C 16: 62,642,420 (GRCm39) S79P probably damaging Het
Tecta C T 9: 42,286,563 (GRCm39) V698M probably damaging Het
Timm22 T C 11: 76,301,965 (GRCm39) S150P probably damaging Het
Tjp1 C T 7: 64,962,953 (GRCm39) D995N possibly damaging Het
Tmem135 T A 7: 88,797,002 (GRCm39) T365S probably benign Het
Tmem174 T C 13: 98,773,489 (GRCm39) T114A probably benign Het
Tnc A G 4: 63,926,053 (GRCm39) I909T probably benign Het
Trcg1 A G 9: 57,148,613 (GRCm39) I62V possibly damaging Het
Tulp1 A T 17: 28,575,005 (GRCm39) *487K probably null Het
Unc79 T A 12: 103,097,905 (GRCm39) V1826E possibly damaging Het
Vmn2r13 A T 5: 109,321,982 (GRCm39) N238K probably damaging Het
Vmn2r22 T A 6: 123,614,697 (GRCm39) N298Y probably damaging Het
Vmn2r23 T A 6: 123,689,861 (GRCm39) F246I probably damaging Het
Vps9d1 A C 8: 123,975,378 (GRCm39) V194G probably damaging Het
Zfp260 A T 7: 29,804,235 (GRCm39) H45L possibly damaging Het
Zfp846 A T 9: 20,505,016 (GRCm39) H292L possibly damaging Het
Other mutations in Or12d17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01813:Or12d17 APN 17 37,777,649 (GRCm39) missense probably damaging 1.00
IGL02039:Or12d17 APN 17 37,777,340 (GRCm39) missense possibly damaging 0.49
IGL02391:Or12d17 APN 17 37,777,477 (GRCm39) missense probably damaging 1.00
IGL02730:Or12d17 APN 17 37,777,750 (GRCm39) missense probably damaging 1.00
IGL02751:Or12d17 APN 17 37,777,306 (GRCm39) missense probably damaging 0.98
IGL02891:Or12d17 APN 17 37,777,835 (GRCm39) missense probably damaging 1.00
IGL03023:Or12d17 APN 17 37,777,885 (GRCm39) missense probably benign
IGL03343:Or12d17 APN 17 37,777,300 (GRCm39) missense probably damaging 1.00
R0026:Or12d17 UTSW 17 37,777,694 (GRCm39) missense probably damaging 0.99
R0579:Or12d17 UTSW 17 37,777,238 (GRCm39) missense probably benign 0.01
R1751:Or12d17 UTSW 17 37,777,792 (GRCm39) missense probably benign 0.00
R1848:Or12d17 UTSW 17 37,777,938 (GRCm39) missense probably damaging 0.99
R2392:Or12d17 UTSW 17 37,777,310 (GRCm39) missense probably damaging 1.00
R4249:Or12d17 UTSW 17 37,777,715 (GRCm39) missense probably damaging 0.98
R4464:Or12d17 UTSW 17 37,777,742 (GRCm39) missense probably damaging 1.00
R4857:Or12d17 UTSW 17 37,777,714 (GRCm39) missense possibly damaging 0.80
R4947:Or12d17 UTSW 17 37,777,634 (GRCm39) missense probably damaging 1.00
R5107:Or12d17 UTSW 17 37,777,144 (GRCm39) missense probably damaging 0.97
R5526:Or12d17 UTSW 17 37,778,003 (GRCm39) missense unknown
R6147:Or12d17 UTSW 17 37,777,430 (GRCm39) missense probably benign 0.00
R7450:Or12d17 UTSW 17 37,777,507 (GRCm39) missense probably benign 0.00
R7487:Or12d17 UTSW 17 37,777,457 (GRCm39) missense probably damaging 0.96
R7822:Or12d17 UTSW 17 37,777,994 (GRCm39) missense probably benign 0.00
R8041:Or12d17 UTSW 17 37,777,540 (GRCm39) missense probably benign
R8051:Or12d17 UTSW 17 37,777,213 (GRCm39) missense probably damaging 1.00
R9013:Or12d17 UTSW 17 37,777,441 (GRCm39) missense probably benign 0.13
X0063:Or12d17 UTSW 17 37,777,415 (GRCm39) missense probably damaging 1.00
X0065:Or12d17 UTSW 17 37,777,209 (GRCm39) missense probably damaging 1.00
Z1176:Or12d17 UTSW 17 37,777,552 (GRCm39) missense possibly damaging 0.93
Predicted Primers PCR Primer
(F):5'- GGTCCTGCAGAATGCTTAAGAAGG -3'
(R):5'- TGAAACTTGAACTTTCTGTCTTGCC -3'

Sequencing Primer
(F):5'- AAGAAGGCTCTGTCTACCTGC -3'
(R):5'- AACTTTCTGTCTTGCCTGAAATATTC -3'
Posted On 2018-05-24