Incidental Mutation 'R6420:Zfp959'
| ID |
518169 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp959
|
| Ensembl Gene |
ENSMUSG00000003198 |
| Gene Name |
zinc finger protein 959 |
| Synonyms |
BC011426 |
| MMRRC Submission |
044562-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.057)
|
| Stock # |
R6420 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
56199093-56205928 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 56205094 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Aspartic acid
at position 377
(G377D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000053979
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000054780]
[ENSMUST00000224379]
|
| AlphaFold |
Q91VM8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000054780
AA Change: G377D
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000053979
Gene: ENSMUSG00000003198
AA Change: G377D
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
5.28e-14 |
SMART |
|
ZnF_C2H2
|
155 |
177 |
2.57e2 |
SMART |
|
ZnF_C2H2
|
287 |
309 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
315 |
337 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
343 |
365 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
371 |
393 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
399 |
421 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
427 |
449 |
1.98e-4 |
SMART |
|
ZnF_C2H2
|
455 |
477 |
2.57e-3 |
SMART |
|
ZnF_C2H2
|
483 |
505 |
7.26e-3 |
SMART |
|
ZnF_C2H2
|
511 |
533 |
1.72e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000224294
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000224379
|
| Coding Region Coverage |
- 1x: 99.9%
- 3x: 99.7%
- 10x: 98.4%
- 20x: 95.5%
|
| Validation Efficiency |
100% (38/38) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 37 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A530064D06Rik |
A |
T |
17: 48,473,566 (GRCm39) |
I117N |
probably damaging |
Het |
| Abca15 |
A |
G |
7: 119,996,351 (GRCm39) |
K1426E |
possibly damaging |
Het |
| Arhgef17 |
A |
G |
7: 100,579,269 (GRCm39) |
S560P |
probably damaging |
Het |
| Asb13 |
G |
A |
13: 3,693,574 (GRCm39) |
V111I |
probably damaging |
Het |
| Dhx16 |
A |
G |
17: 36,193,906 (GRCm39) |
E367G |
possibly damaging |
Het |
| Epc2 |
T |
C |
2: 49,341,912 (GRCm39) |
V32A |
probably damaging |
Het |
| Gm10549 |
C |
A |
18: 33,597,358 (GRCm39) |
|
probably benign |
Het |
| Hdlbp |
T |
C |
1: 93,358,726 (GRCm39) |
E275G |
probably damaging |
Het |
| Kdm7a |
T |
C |
6: 39,142,102 (GRCm39) |
D392G |
probably damaging |
Het |
| Lgmn |
T |
A |
12: 102,389,978 (GRCm39) |
R4* |
probably null |
Het |
| Lrrk2 |
C |
T |
15: 91,696,549 (GRCm39) |
R2446C |
probably benign |
Het |
| Map3k10 |
A |
G |
7: 27,362,709 (GRCm39) |
F459S |
probably damaging |
Het |
| Mup1 |
C |
G |
4: 60,457,758 (GRCm39) |
E31Q |
possibly damaging |
Het |
| Nckap1l |
G |
C |
15: 103,399,893 (GRCm39) |
G1025A |
possibly damaging |
Het |
| Or4d10 |
T |
G |
19: 12,051,324 (GRCm39) |
K224T |
probably benign |
Het |
| Or5b24 |
A |
C |
19: 12,912,584 (GRCm39) |
T161P |
probably damaging |
Het |
| Or8b39 |
T |
A |
9: 37,996,890 (GRCm39) |
S253T |
probably benign |
Het |
| Or8b41 |
T |
G |
9: 38,054,611 (GRCm39) |
L55R |
probably damaging |
Het |
| Or8k38 |
A |
T |
2: 86,488,510 (GRCm39) |
C97* |
probably null |
Het |
| Pik3r5 |
G |
A |
11: 68,366,250 (GRCm39) |
W42* |
probably null |
Het |
| Pkd1l2 |
C |
T |
8: 117,740,638 (GRCm39) |
C2153Y |
probably damaging |
Het |
| Rad1 |
T |
C |
15: 10,488,098 (GRCm39) |
V74A |
probably benign |
Het |
| Scara3 |
C |
T |
14: 66,175,701 (GRCm39) |
G22D |
possibly damaging |
Het |
| Scn1a |
A |
G |
2: 66,103,542 (GRCm39) |
I1906T |
probably damaging |
Het |
| Sema5b |
T |
A |
16: 35,483,516 (GRCm39) |
D1051E |
probably benign |
Het |
| Slc16a12 |
T |
C |
19: 34,650,097 (GRCm39) |
|
probably null |
Het |
| Slc25a23 |
T |
C |
17: 57,359,780 (GRCm39) |
I324V |
probably damaging |
Het |
| Sord |
A |
T |
2: 122,094,602 (GRCm39) |
K330M |
possibly damaging |
Het |
| Spag9 |
T |
C |
11: 93,977,128 (GRCm39) |
V78A |
probably damaging |
Het |
| St3gal1 |
A |
G |
15: 66,983,195 (GRCm39) |
V187A |
possibly damaging |
Het |
| Tnrc6a |
A |
G |
7: 122,770,297 (GRCm39) |
T696A |
probably benign |
Het |
| Ttn |
A |
G |
2: 76,542,619 (GRCm39) |
Y33456H |
possibly damaging |
Het |
| Unc45a |
C |
G |
7: 79,989,400 (GRCm39) |
E23Q |
probably benign |
Het |
| Urb2 |
C |
T |
8: 124,773,938 (GRCm39) |
R1490W |
probably damaging |
Het |
| Zfp62 |
A |
T |
11: 49,107,340 (GRCm39) |
N477I |
probably damaging |
Het |
| Zfp846 |
T |
C |
9: 20,505,007 (GRCm39) |
L289P |
probably damaging |
Het |
| Zswim3 |
G |
A |
2: 164,662,653 (GRCm39) |
V378M |
probably damaging |
Het |
|
| Other mutations in Zfp959 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00698:Zfp959
|
APN |
17 |
56,204,565 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02731:Zfp959
|
APN |
17 |
56,202,956 (GRCm39) |
splice site |
probably benign |
|
|
IGL03206:Zfp959
|
APN |
17 |
56,204,613 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0141:Zfp959
|
UTSW |
17 |
56,205,139 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0347:Zfp959
|
UTSW |
17 |
56,204,180 (GRCm39) |
nonsense |
probably null |
|
|
R0522:Zfp959
|
UTSW |
17 |
56,203,201 (GRCm39) |
missense |
probably null |
1.00 |
|
R1692:Zfp959
|
UTSW |
17 |
56,205,299 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1771:Zfp959
|
UTSW |
17 |
56,204,677 (GRCm39) |
splice site |
probably null |
|
|
R1891:Zfp959
|
UTSW |
17 |
56,204,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1945:Zfp959
|
UTSW |
17 |
56,204,231 (GRCm39) |
nonsense |
probably null |
|
|
R1959:Zfp959
|
UTSW |
17 |
56,204,404 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2317:Zfp959
|
UTSW |
17 |
56,204,326 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R4726:Zfp959
|
UTSW |
17 |
56,205,260 (GRCm39) |
splice site |
probably null |
|
|
R4869:Zfp959
|
UTSW |
17 |
56,204,228 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5436:Zfp959
|
UTSW |
17 |
56,204,626 (GRCm39) |
missense |
probably benign |
|
|
R6235:Zfp959
|
UTSW |
17 |
56,204,427 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6365:Zfp959
|
UTSW |
17 |
56,204,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6391:Zfp959
|
UTSW |
17 |
56,202,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6417:Zfp959
|
UTSW |
17 |
56,205,094 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7114:Zfp959
|
UTSW |
17 |
56,205,501 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7380:Zfp959
|
UTSW |
17 |
56,205,551 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7437:Zfp959
|
UTSW |
17 |
56,205,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7568:Zfp959
|
UTSW |
17 |
56,204,886 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8114:Zfp959
|
UTSW |
17 |
56,205,496 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8197:Zfp959
|
UTSW |
17 |
56,204,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8389:Zfp959
|
UTSW |
17 |
56,204,299 (GRCm39) |
missense |
probably benign |
|
|
R8970:Zfp959
|
UTSW |
17 |
56,204,836 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9063:Zfp959
|
UTSW |
17 |
56,204,221 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9504:Zfp959
|
UTSW |
17 |
56,204,793 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9648:Zfp959
|
UTSW |
17 |
56,204,212 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R9733:Zfp959
|
UTSW |
17 |
56,204,866 (GRCm39) |
missense |
probably benign |
0.06 |
|
Z1088:Zfp959
|
UTSW |
17 |
56,205,135 (GRCm39) |
missense |
probably damaging |
0.96 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACATCAGAATTGTAATCAAGTAGGT -3'
(R):5'- TCATTTCTTAGATGGCTAGGGGAT -3'
Sequencing Primer
(F):5'- ATGGGGTAAAGCCTTCACATGTCC -3'
(R):5'- CGATCAAAGGGTTTACCACATTGG -3'
|
| Posted On |
2018-05-24 |
Incidental Mutation