Incidental Mutation 'R6421:Or6c6'
ID 518187
Institutional Source Beutler Lab
Gene Symbol Or6c6
Ensembl Gene ENSMUSG00000095075
Gene Name olfactory receptor family 6 subfamily C member 6
Synonyms MOR110-8, GA_x6K02T2PULF-11031172-11032116, Olfr782
MMRRC Submission 044420-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.061) question?
Stock # R6421 (G1)
Quality Score 225.009
Status Not validated
Chromosome 10
Chromosomal Location 129186434-129187378 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 129187370 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Stop codon at position 313 (K313*)
Ref Sequence ENSEMBL: ENSMUSP00000150951 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077024] [ENSMUST00000213970]
AlphaFold Q7TRI2
Predicted Effect probably null
Transcript: ENSMUST00000077024
AA Change: K313*
SMART Domains Protein: ENSMUSP00000076282
Gene: ENSMUSG00000095075
AA Change: K313*

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1e-48 PFAM
Pfam:7tm_1 39 288 8.5e-23 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000213970
AA Change: K313*
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.8%
  • 10x: 98.3%
  • 20x: 94.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrf4 A T 17: 42,983,392 (GRCm39) F97I probably damaging Het
Adgrv1 A G 13: 81,656,855 (GRCm39) S2160P possibly damaging Het
Anapc15-ps T C 10: 95,509,076 (GRCm39) D68G probably benign Het
Arel1 T C 12: 84,981,119 (GRCm39) Y296C probably damaging Het
Dcbld1 T C 10: 52,162,450 (GRCm39) I147T probably damaging Het
Frem1 G A 4: 82,912,365 (GRCm39) T669I probably damaging Het
Gm7276 T C 18: 77,273,366 (GRCm39) probably benign Het
Grin2c A C 11: 115,141,956 (GRCm39) M821R probably damaging Het
Lrp1b A T 2: 40,779,282 (GRCm39) C2587S probably damaging Het
Lrriq4 T C 3: 30,704,551 (GRCm39) L193P probably damaging Het
Myo3b A G 2: 70,143,700 (GRCm39) S1011G probably benign Het
Peg10 GAT GATCAT 6: 4,756,449 (GRCm39) probably benign Het
Ptprj A G 2: 90,301,484 (GRCm39) I123T possibly damaging Het
Scn1a T G 2: 66,103,271 (GRCm39) K1985N probably damaging Het
Serpinb9f A C 13: 33,518,516 (GRCm39) I339L probably benign Het
Spata31e4 A G 13: 50,855,987 (GRCm39) R542G probably benign Het
St3gal1 A G 15: 66,983,195 (GRCm39) V187A possibly damaging Het
Stx4a C A 7: 127,445,673 (GRCm39) T193K probably damaging Het
Traf3ip2 T C 10: 39,515,400 (GRCm39) probably null Het
Wwc2 A T 8: 48,353,781 (GRCm39) Y118N probably damaging Het
Xpo1 A G 11: 23,241,490 (GRCm39) T846A possibly damaging Het
Zfp616 A G 11: 73,974,696 (GRCm39) N413D possibly damaging Het
Other mutations in Or6c6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01286:Or6c6 APN 10 129,186,519 (GRCm39) missense probably damaging 1.00
IGL01469:Or6c6 APN 10 129,186,449 (GRCm39) missense probably benign
IGL01980:Or6c6 APN 10 129,187,386 (GRCm39) utr 3 prime probably benign
IGL03309:Or6c6 APN 10 129,187,178 (GRCm39) missense probably benign 0.01
R0449:Or6c6 UTSW 10 129,187,103 (GRCm39) missense probably benign 0.00
R1994:Or6c6 UTSW 10 129,186,561 (GRCm39) missense probably damaging 1.00
R3121:Or6c6 UTSW 10 129,186,552 (GRCm39) missense possibly damaging 0.74
R7268:Or6c6 UTSW 10 129,187,263 (GRCm39) missense possibly damaging 0.60
R7399:Or6c6 UTSW 10 129,186,426 (GRCm39) start gained probably benign
R7647:Or6c6 UTSW 10 129,187,326 (GRCm39) missense probably benign
R8384:Or6c6 UTSW 10 129,186,695 (GRCm39) nonsense probably null
R8795:Or6c6 UTSW 10 129,187,194 (GRCm39) missense probably damaging 0.99
R9224:Or6c6 UTSW 10 129,186,450 (GRCm39) missense probably benign
R9375:Or6c6 UTSW 10 129,186,989 (GRCm39) missense probably damaging 1.00
R9478:Or6c6 UTSW 10 129,186,960 (GRCm39) missense possibly damaging 0.70
X0027:Or6c6 UTSW 10 129,187,202 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGTATACTAAACCATCTGCAAGGG -3'
(R):5'- TCTCTGTGTGAAATAACTGCTGAC -3'

Sequencing Primer
(F):5'- CCATCTGCAAGGGAGAGAGTGTC -3'
(R):5'- CTGTGTGAAATAACTGCTGACATAGG -3'
Posted On 2018-05-24