Incidental Mutation 'R6421:Gm7276'
| ID |
518197 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Gm7276
|
| Ensembl Gene |
ENSMUSG00000073532 |
| Gene Name |
predicted gene 7276 |
| Synonyms |
|
| MMRRC Submission |
044420-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.095)
|
| Stock # |
R6421 (G1)
|
| Quality Score |
103.008 |
|
Status
|
Not validated
|
| Chromosome |
18 |
| Chromosomal Location |
77271965-77274059 bp(-) (GRCm39) |
| Type of Mutation |
unclassified |
| DNA Base Change (assembly) |
T to C
at 77273366 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000078566
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000075290]
[ENSMUST00000079618]
[ENSMUST00000097520]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000075290
|
| SMART Domains |
Protein: ENSMUSP00000074764
Gene: ENSMUSG00000025425
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
12 |
34 |
N/A |
INTRINSIC |
|
Pfam:Glyco_transf_29
|
152 |
407 |
6.4e-74 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000079618
|
| SMART Domains |
Protein: ENSMUSP00000078566
Gene: ENSMUSG00000025425
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
12 |
34 |
N/A |
INTRINSIC |
|
Pfam:Glyco_transf_29
|
112 |
372 |
5.4e-79 |
PFAM |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000097520
AA Change: T123A
|
| SMART Domains |
Protein: ENSMUSP00000095127
Gene: ENSMUSG00000073532
AA Change: T123A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
61 |
82 |
N/A |
INTRINSIC |
|
low complexity region
|
143 |
157 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.8%
- 10x: 98.3%
- 20x: 94.4%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 22 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrf4 |
A |
T |
17: 42,983,392 (GRCm39) |
F97I |
probably damaging |
Het |
| Adgrv1 |
A |
G |
13: 81,656,855 (GRCm39) |
S2160P |
possibly damaging |
Het |
| Anapc15-ps |
T |
C |
10: 95,509,076 (GRCm39) |
D68G |
probably benign |
Het |
| Arel1 |
T |
C |
12: 84,981,119 (GRCm39) |
Y296C |
probably damaging |
Het |
| Dcbld1 |
T |
C |
10: 52,162,450 (GRCm39) |
I147T |
probably damaging |
Het |
| Frem1 |
G |
A |
4: 82,912,365 (GRCm39) |
T669I |
probably damaging |
Het |
| Grin2c |
A |
C |
11: 115,141,956 (GRCm39) |
M821R |
probably damaging |
Het |
| Lrp1b |
A |
T |
2: 40,779,282 (GRCm39) |
C2587S |
probably damaging |
Het |
| Lrriq4 |
T |
C |
3: 30,704,551 (GRCm39) |
L193P |
probably damaging |
Het |
| Myo3b |
A |
G |
2: 70,143,700 (GRCm39) |
S1011G |
probably benign |
Het |
| Or6c6 |
A |
T |
10: 129,187,370 (GRCm39) |
K313* |
probably null |
Het |
| Peg10 |
GAT |
GATCAT |
6: 4,756,449 (GRCm39) |
|
probably benign |
Het |
| Ptprj |
A |
G |
2: 90,301,484 (GRCm39) |
I123T |
possibly damaging |
Het |
| Scn1a |
T |
G |
2: 66,103,271 (GRCm39) |
K1985N |
probably damaging |
Het |
| Serpinb9f |
A |
C |
13: 33,518,516 (GRCm39) |
I339L |
probably benign |
Het |
| Spata31e4 |
A |
G |
13: 50,855,987 (GRCm39) |
R542G |
probably benign |
Het |
| St3gal1 |
A |
G |
15: 66,983,195 (GRCm39) |
V187A |
possibly damaging |
Het |
| Stx4a |
C |
A |
7: 127,445,673 (GRCm39) |
T193K |
probably damaging |
Het |
| Traf3ip2 |
T |
C |
10: 39,515,400 (GRCm39) |
|
probably null |
Het |
| Wwc2 |
A |
T |
8: 48,353,781 (GRCm39) |
Y118N |
probably damaging |
Het |
| Xpo1 |
A |
G |
11: 23,241,490 (GRCm39) |
T846A |
possibly damaging |
Het |
| Zfp616 |
A |
G |
11: 73,974,696 (GRCm39) |
N413D |
possibly damaging |
Het |
|
| Other mutations in Gm7276 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL03156:Gm7276
|
APN |
18 |
77,273,299 (GRCm39) |
unclassified |
probably benign |
|
|
R1661:Gm7276
|
UTSW |
18 |
77,273,266 (GRCm39) |
unclassified |
probably benign |
|
|
R1665:Gm7276
|
UTSW |
18 |
77,273,266 (GRCm39) |
unclassified |
probably benign |
|
|
R1791:Gm7276
|
UTSW |
18 |
77,273,431 (GRCm39) |
unclassified |
probably benign |
|
|
R7319:Gm7276
|
UTSW |
18 |
77,273,216 (GRCm39) |
missense |
unknown |
|
|
R7412:Gm7276
|
UTSW |
18 |
77,273,183 (GRCm39) |
missense |
unknown |
|
|
R8227:Gm7276
|
UTSW |
18 |
77,273,158 (GRCm39) |
missense |
unknown |
|
|
R9123:Gm7276
|
UTSW |
18 |
77,273,147 (GRCm39) |
missense |
unknown |
|
|
R9125:Gm7276
|
UTSW |
18 |
77,273,147 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AATGCTCGTCTCGATGAGG -3'
(R):5'- TTAGGAGAACTGCGTGGTCAAG -3'
Sequencing Primer
(F):5'- CTCGTCTCGATGAGGTTGCC -3'
(R):5'- CTTGGCGGGGCAAAGTTTCC -3'
|
| Posted On |
2018-05-24 |
Incidental Mutation