Incidental Mutation 'R6428:Vmn2r106'
ID 518403
Institutional Source Beutler Lab
Gene Symbol Vmn2r106
Ensembl Gene ENSMUSG00000091656
Gene Name vomeronasal 2, receptor 106
Synonyms EG224576
MMRRC Submission 044421-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.166) question?
Stock # R6428 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 20487809-20505692 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 20488725 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 558 (C558Y)
Ref Sequence ENSEMBL: ENSMUSP00000126534 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167464]
AlphaFold E9PY92
Predicted Effect probably damaging
Transcript: ENSMUST00000167464
AA Change: C558Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000126534
Gene: ENSMUSG00000091656
AA Change: C558Y

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:ANF_receptor 83 471 3.8e-37 PFAM
Pfam:NCD3G 514 567 5.7e-22 PFAM
Pfam:7tm_3 596 835 1.3e-49 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 22 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abat C T 16: 8,420,300 (GRCm39) probably benign Het
Cts6 T G 13: 61,344,237 (GRCm39) N272H probably damaging Het
Daam2 C T 17: 49,776,404 (GRCm39) E828K probably damaging Het
Dhx9 C T 1: 153,332,324 (GRCm39) probably benign Het
Glb1l3 T C 9: 26,770,748 (GRCm39) N106S probably damaging Het
Hdlbp T C 1: 93,359,167 (GRCm39) D175G possibly damaging Het
Hectd4 A G 5: 121,488,508 (GRCm39) K3600E possibly damaging Het
Hspa13 A T 16: 75,554,874 (GRCm39) L404Q probably damaging Het
Iws1 A G 18: 32,219,343 (GRCm39) D475G probably damaging Het
Klhdc10 T C 6: 30,439,855 (GRCm39) S13P probably damaging Het
Lepr C T 4: 101,637,295 (GRCm39) T728I probably damaging Het
Ncapd3 A G 9: 26,963,960 (GRCm39) probably null Het
Pasd1 CATCTTTACCATCATGTCAAGTATCTTTACCATCATGTCAAGTATCTTTACC CATCTTTACCATCATGTCAAGTATCTTTACC X: 70,983,126 (GRCm39) probably benign Homo
Phb2 A G 6: 124,692,954 (GRCm39) D276G probably benign Het
Prrc2b A G 2: 32,116,508 (GRCm39) probably null Het
Rasgrf2 T C 13: 92,136,100 (GRCm39) K604R probably damaging Het
Rp1l1 T A 14: 64,269,838 (GRCm39) M1808K possibly damaging Het
Setd3 T C 12: 108,079,597 (GRCm39) D302G probably damaging Het
Slc38a10 T A 11: 119,996,298 (GRCm39) Q933L probably benign Het
Slco1a1 A G 6: 141,871,416 (GRCm39) L250S probably damaging Het
Vmn2r26 A G 6: 124,003,039 (GRCm39) I150V probably benign Het
Zfp318 C T 17: 46,710,262 (GRCm39) R662C probably damaging Het
Other mutations in Vmn2r106
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00979:Vmn2r106 APN 17 20,497,837 (GRCm39) missense possibly damaging 0.90
IGL01313:Vmn2r106 APN 17 20,498,651 (GRCm39) missense probably damaging 0.99
IGL01419:Vmn2r106 APN 17 20,499,807 (GRCm39) missense probably benign 0.06
IGL01574:Vmn2r106 APN 17 20,488,572 (GRCm39) missense possibly damaging 0.94
IGL01796:Vmn2r106 APN 17 20,488,314 (GRCm39) missense possibly damaging 0.79
IGL01893:Vmn2r106 APN 17 20,497,730 (GRCm39) missense probably benign 0.06
IGL01895:Vmn2r106 APN 17 20,499,227 (GRCm39) missense probably benign 0.02
IGL02378:Vmn2r106 APN 17 20,497,791 (GRCm39) missense probably damaging 1.00
IGL02430:Vmn2r106 APN 17 20,499,158 (GRCm39) missense probably benign 0.38
IGL02664:Vmn2r106 APN 17 20,488,344 (GRCm39) missense possibly damaging 0.88
IGL03308:Vmn2r106 APN 17 20,498,785 (GRCm39) nonsense probably null
IGL03384:Vmn2r106 APN 17 20,488,405 (GRCm39) missense probably damaging 0.99
R0401:Vmn2r106 UTSW 17 20,499,281 (GRCm39) missense possibly damaging 0.86
R0842:Vmn2r106 UTSW 17 20,488,465 (GRCm39) missense probably damaging 1.00
R0964:Vmn2r106 UTSW 17 20,487,859 (GRCm39) missense probably benign 0.00
R1235:Vmn2r106 UTSW 17 20,499,741 (GRCm39) missense probably benign 0.00
R1709:Vmn2r106 UTSW 17 20,499,373 (GRCm39) missense probably benign 0.12
R1712:Vmn2r106 UTSW 17 20,498,997 (GRCm39) missense probably benign 0.01
R1770:Vmn2r106 UTSW 17 20,488,560 (GRCm39) missense probably damaging 0.99
R2049:Vmn2r106 UTSW 17 20,488,566 (GRCm39) missense possibly damaging 0.90
R2245:Vmn2r106 UTSW 17 20,488,423 (GRCm39) missense probably benign 0.13
R2336:Vmn2r106 UTSW 17 20,488,470 (GRCm39) missense probably benign 0.18
R2910:Vmn2r106 UTSW 17 20,498,946 (GRCm39) missense probably damaging 1.00
R3025:Vmn2r106 UTSW 17 20,499,147 (GRCm39) missense probably benign 0.00
R3944:Vmn2r106 UTSW 17 20,487,913 (GRCm39) missense probably damaging 1.00
R4081:Vmn2r106 UTSW 17 20,487,818 (GRCm39) nonsense probably null
R4153:Vmn2r106 UTSW 17 20,488,080 (GRCm39) missense probably damaging 1.00
R4356:Vmn2r106 UTSW 17 20,499,910 (GRCm39) missense probably benign 0.06
R4426:Vmn2r106 UTSW 17 20,505,641 (GRCm39) missense probably benign 0.00
R4590:Vmn2r106 UTSW 17 20,497,728 (GRCm39) missense probably damaging 0.99
R4661:Vmn2r106 UTSW 17 20,487,885 (GRCm39) missense probably benign 0.10
R5106:Vmn2r106 UTSW 17 20,499,395 (GRCm39) critical splice acceptor site probably null
R5341:Vmn2r106 UTSW 17 20,497,788 (GRCm39) missense probably benign 0.00
R5509:Vmn2r106 UTSW 17 20,498,684 (GRCm39) missense probably damaging 0.99
R5826:Vmn2r106 UTSW 17 20,499,133 (GRCm39) missense probably benign
R5859:Vmn2r106 UTSW 17 20,505,583 (GRCm39) missense possibly damaging 0.72
R5937:Vmn2r106 UTSW 17 20,505,667 (GRCm39) nonsense probably null
R5972:Vmn2r106 UTSW 17 20,498,738 (GRCm39) missense probably benign
R6056:Vmn2r106 UTSW 17 20,487,806 (GRCm39) splice site probably null
R6108:Vmn2r106 UTSW 17 20,488,638 (GRCm39) missense probably benign 0.11
R6114:Vmn2r106 UTSW 17 20,488,638 (GRCm39) missense probably benign 0.11
R6115:Vmn2r106 UTSW 17 20,488,638 (GRCm39) missense probably benign 0.11
R6132:Vmn2r106 UTSW 17 20,488,666 (GRCm39) missense probably benign
R6208:Vmn2r106 UTSW 17 20,488,591 (GRCm39) missense probably damaging 0.99
R6217:Vmn2r106 UTSW 17 20,488,501 (GRCm39) missense probably benign 0.10
R6289:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6378:Vmn2r106 UTSW 17 20,498,667 (GRCm39) missense probably benign 0.19
R6390:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6391:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6392:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6405:Vmn2r106 UTSW 17 20,499,361 (GRCm39) missense probably benign 0.22
R6427:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6435:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6436:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6437:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6511:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6512:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6587:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6703:Vmn2r106 UTSW 17 20,488,725 (GRCm39) missense probably damaging 1.00
R6730:Vmn2r106 UTSW 17 20,499,096 (GRCm39) missense possibly damaging 0.64
R6961:Vmn2r106 UTSW 17 20,488,646 (GRCm39) nonsense probably null
R7054:Vmn2r106 UTSW 17 20,499,182 (GRCm39) missense probably damaging 0.96
R7379:Vmn2r106 UTSW 17 20,488,037 (GRCm39) missense possibly damaging 0.75
R7402:Vmn2r106 UTSW 17 20,487,883 (GRCm39) missense probably damaging 0.99
R7497:Vmn2r106 UTSW 17 20,488,201 (GRCm39) missense probably damaging 1.00
R7692:Vmn2r106 UTSW 17 20,505,490 (GRCm39) missense possibly damaging 0.96
R8539:Vmn2r106 UTSW 17 20,499,271 (GRCm39) missense probably benign 0.00
R8827:Vmn2r106 UTSW 17 20,487,868 (GRCm39) missense probably benign 0.05
R8872:Vmn2r106 UTSW 17 20,488,401 (GRCm39) missense probably benign 0.19
R9118:Vmn2r106 UTSW 17 20,505,667 (GRCm39) missense probably benign 0.00
R9254:Vmn2r106 UTSW 17 20,496,066 (GRCm39) missense probably damaging 1.00
R9379:Vmn2r106 UTSW 17 20,496,066 (GRCm39) missense probably damaging 1.00
R9571:Vmn2r106 UTSW 17 20,505,641 (GRCm39) missense probably benign 0.17
Predicted Primers PCR Primer
(F):5'- TGAGAGCTCGGTTATTGGCC -3'
(R):5'- AGGCTAGTTCAACTTCAGTCAG -3'

Sequencing Primer
(F):5'- GCCTTGACAATAGGAGTGTCTC -3'
(R):5'- GTTCAACTTCAGTCAGTATAAGGAAG -3'
Posted On 2018-05-24