Incidental Mutation 'R6429:Or4c11c'
ID 518412
Institutional Source Beutler Lab
Gene Symbol Or4c11c
Ensembl Gene ENSMUSG00000057447
Gene Name olfactory receptor family 4 subfamily C member 11C
Synonyms GA_x6K02T2Q125-50336588-50337313, MOR230-1, MOR230-3, Olfr1205, GA_x6K02T2Q125-50304328-50305251, Olfr1203
MMRRC Submission 044567-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R6429 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 88660101-88662386 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 88661869 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glutamine at position 136 (R136Q)
Ref Sequence ENSEMBL: ENSMUSP00000150206 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076438] [ENSMUST00000215929]
AlphaFold A2ATJ7
Predicted Effect probably benign
Transcript: ENSMUST00000076438
AA Change: R136Q

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000075769
Gene: ENSMUSG00000057447
AA Change: R136Q

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 5e-45 PFAM
Pfam:7tm_1 39 285 9.1e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215929
AA Change: R136Q

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acacb G A 5: 114,366,652 (GRCm39) E1565K probably damaging Het
Amy1 T C 3: 113,363,158 (GRCm39) N63S probably damaging Het
Arhgef15 G T 11: 68,838,622 (GRCm39) N591K probably damaging Het
AW551984 A G 9: 39,511,910 (GRCm39) S34P probably damaging Het
C2cd3 A G 7: 100,081,298 (GRCm39) D127G probably damaging Het
Ccdc87 T A 19: 4,891,263 (GRCm39) V585E probably benign Het
Cemip2 T C 19: 21,779,272 (GRCm39) C361R probably benign Het
Cul2 T C 18: 3,421,345 (GRCm39) I223T probably damaging Het
Dgkq C T 5: 108,801,574 (GRCm39) V495M probably damaging Het
Dpp10 A G 1: 123,295,330 (GRCm39) I570T possibly damaging Het
Dstyk C T 1: 132,377,542 (GRCm39) Q383* probably null Het
Emilin2 C A 17: 71,617,951 (GRCm39) probably benign Het
Fnip1 A G 11: 54,406,393 (GRCm39) I1163M probably damaging Het
Fryl C T 5: 73,248,094 (GRCm39) E1008K possibly damaging Het
Gm35315 A T 5: 110,226,525 (GRCm39) Y305N possibly damaging Het
Grhl3 T A 4: 135,284,507 (GRCm39) D195V probably damaging Het
Ift56 T A 6: 38,375,248 (GRCm39) S250T possibly damaging Het
Il33 T C 19: 29,929,400 (GRCm39) F41S probably benign Het
Il4 A G 11: 53,504,736 (GRCm39) S15P possibly damaging Het
Inf2 C T 12: 112,570,690 (GRCm39) P410S probably benign Het
Kalrn T A 16: 34,152,534 (GRCm39) D349V possibly damaging Het
Krt4 A G 15: 101,831,229 (GRCm39) M224T probably benign Het
Lrp2 C T 2: 69,291,631 (GRCm39) S3516N probably damaging Het
Macf1 A T 4: 123,295,387 (GRCm39) probably null Het
Msr1 G A 8: 40,068,858 (GRCm39) P213S probably damaging Het
Nptx1 G T 11: 119,435,547 (GRCm39) C256* probably null Het
Nr1d1 T C 11: 98,662,840 (GRCm39) Y51C probably damaging Het
Panx3 T C 9: 37,572,461 (GRCm39) D363G probably damaging Het
Pira13 A T 7: 3,825,345 (GRCm39) H432Q possibly damaging Het
Prkag1 A G 15: 98,712,404 (GRCm39) F143L probably damaging Het
Ptger4 T C 15: 5,272,478 (GRCm39) K72R possibly damaging Het
Pvrig-ps A G 5: 138,340,312 (GRCm39) T28A probably benign Het
Rhod C T 19: 4,476,133 (GRCm39) C206Y probably benign Het
Rngtt C A 4: 33,320,606 (GRCm39) S51* probably null Het
Rreb1 T G 13: 38,116,105 (GRCm39) S1155A probably benign Het
Scn9a A C 2: 66,357,307 (GRCm39) I998S possibly damaging Het
Sfmbt1 T A 14: 30,495,868 (GRCm39) F50L probably damaging Het
Six4 A T 12: 73,150,247 (GRCm39) V766D probably damaging Het
Smpd1 T C 7: 105,206,135 (GRCm39) I421T probably damaging Het
Son T A 16: 91,455,054 (GRCm39) M1267K probably benign Het
Styk1 T A 6: 131,287,027 (GRCm39) D156V possibly damaging Het
Supt3 A G 17: 45,430,030 (GRCm39) E361G probably benign Het
Tbx3 T A 5: 119,812,256 (GRCm39) Y185* probably null Het
Trpm1 A T 7: 63,918,252 (GRCm39) T531S probably benign Het
Tspan32 T A 7: 142,572,479 (GRCm39) W172R possibly damaging Het
Urb1 A T 16: 90,559,318 (GRCm39) probably null Het
Vmn2r70 T A 7: 85,208,276 (GRCm39) I734F probably damaging Het
Vwa7 A G 17: 35,243,175 (GRCm39) T618A probably benign Het
Wac T A 18: 7,920,163 (GRCm39) V339E probably damaging Het
Wrn G A 8: 33,833,024 (GRCm39) T156M probably damaging Het
Zeb1 T A 18: 5,770,498 (GRCm39) C884S probably damaging Het
Zfp747l1 T C 7: 126,984,214 (GRCm39) probably benign Het
Zmpste24 A G 4: 120,952,867 (GRCm39) V10A probably damaging Het
Other mutations in Or4c11c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00923:Or4c11c APN 2 88,661,456 (GRCm39) splice site probably null
IGL02079:Or4c11c APN 2 88,661,991 (GRCm39) missense probably damaging 1.00
IGL02183:Or4c11c APN 2 88,662,372 (GRCm39) missense probably benign
IGL02813:Or4c11c APN 2 88,661,495 (GRCm39) missense probably benign 0.34
IGL02839:Or4c11c APN 2 88,661,992 (GRCm39) missense probably damaging 1.00
IGL02895:Or4c11c APN 2 88,661,986 (GRCm39) missense probably damaging 1.00
R0680:Or4c11c UTSW 2 88,662,124 (GRCm39) missense probably benign
R2029:Or4c11c UTSW 2 88,661,749 (GRCm39) missense possibly damaging 0.88
R2095:Or4c11c UTSW 2 88,661,634 (GRCm39) missense probably damaging 1.00
R6158:Or4c11c UTSW 2 88,661,490 (GRCm39) missense probably damaging 1.00
R6216:Or4c11c UTSW 2 88,661,655 (GRCm39) missense probably damaging 1.00
R6240:Or4c11c UTSW 2 88,661,707 (GRCm39) missense probably benign 0.22
R6377:Or4c11c UTSW 2 88,661,613 (GRCm39) nonsense probably null
R6521:Or4c11c UTSW 2 88,661,700 (GRCm39) missense probably benign 0.03
R7065:Or4c11c UTSW 2 88,661,730 (GRCm39) missense probably damaging 1.00
R7343:Or4c11c UTSW 2 88,662,190 (GRCm39) missense probably damaging 1.00
R7476:Or4c11c UTSW 2 88,661,932 (GRCm39) missense probably benign 0.07
R7570:Or4c11c UTSW 2 88,661,472 (GRCm39) missense possibly damaging 0.82
R8303:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8306:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8307:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8308:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8344:Or4c11c UTSW 2 88,661,727 (GRCm39) missense probably benign 0.00
R8386:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8387:Or4c11c UTSW 2 88,661,633 (GRCm39) missense possibly damaging 0.90
R8809:Or4c11c UTSW 2 88,662,256 (GRCm39) missense probably benign 0.01
R8894:Or4c11c UTSW 2 88,661,809 (GRCm39) missense probably benign 0.12
Z1176:Or4c11c UTSW 2 88,661,922 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- GGGGTCCCATGTACTTCTTC -3'
(R):5'- ATGTGTGTATCCATGCAGGC -3'

Sequencing Primer
(F):5'- AGCCCCAAGACTCATTGTGGATG -3'
(R):5'- TGTATCCATGCAGGCAAGCTC -3'
Posted On 2018-05-24