Incidental Mutation 'R6430:Slco6c1'
ID 518466
Institutional Source Beutler Lab
Gene Symbol Slco6c1
Ensembl Gene ENSMUSG00000026331
Gene Name solute carrier organic anion transporter family, member 6c1
Synonyms 4933404A18Rik
MMRRC Submission 044568-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6430 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 96986763-97056026 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 97003699 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Leucine at position 466 (Q466L)
Ref Sequence ENSEMBL: ENSMUSP00000140791 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027569] [ENSMUST00000189547]
AlphaFold Q8C0X7
Predicted Effect probably benign
Transcript: ENSMUST00000027569
AA Change: Q483L

PolyPhen 2 Score 0.434 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000027569
Gene: ENSMUSG00000026331
AA Change: Q483L

DomainStartEndE-ValueType
low complexity region 44 55 N/A INTRINSIC
Pfam:OATP 95 654 3e-101 PFAM
Pfam:MFS_1 207 474 6.5e-14 PFAM
Pfam:Kazal_2 497 538 7.4e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000189547
AA Change: Q466L

PolyPhen 2 Score 0.434 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000140791
Gene: ENSMUSG00000026331
AA Change: Q466L

DomainStartEndE-ValueType
low complexity region 44 55 N/A INTRINSIC
Pfam:OATP 93 197 7.4e-12 PFAM
Pfam:MFS_1 99 457 2.2e-15 PFAM
Pfam:OATP 192 638 2.5e-64 PFAM
Pfam:Kazal_2 480 521 2.1e-8 PFAM
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.7%
Validation Efficiency 100% (47/47)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AI661453 C A 17: 47,777,722 (GRCm39) probably benign Het
Ank1 T A 8: 23,622,125 (GRCm39) L1513Q probably damaging Het
Ap2a1 C A 7: 44,553,253 (GRCm39) V676L probably benign Het
Arid2 T C 15: 96,261,575 (GRCm39) V477A probably benign Het
Auh C A 13: 53,083,446 (GRCm39) G17C probably benign Het
B3gnt7 T C 1: 86,233,839 (GRCm39) F362L possibly damaging Het
Cd207 C T 6: 83,652,869 (GRCm39) R87H probably benign Het
Cdyl A G 13: 36,055,589 (GRCm39) K503R possibly damaging Het
Cep350 A G 1: 155,770,419 (GRCm39) S1824P probably damaging Het
Cmas T A 6: 142,713,650 (GRCm39) M225K probably benign Het
Dhx29 T C 13: 113,081,153 (GRCm39) S396P possibly damaging Het
Epg5 T C 18: 78,019,100 (GRCm39) S958P probably damaging Het
Espnl T C 1: 91,249,970 (GRCm39) L39P possibly damaging Het
Fcsk A G 8: 111,610,748 (GRCm39) V915A probably benign Het
Flacc1 T A 1: 58,717,448 (GRCm39) K154N probably damaging Het
Gatb A G 3: 85,544,345 (GRCm39) N438D probably benign Het
Hspg2 T C 4: 137,266,707 (GRCm39) C1932R probably damaging Het
Jmjd1c C T 10: 67,059,939 (GRCm39) T662I possibly damaging Het
Kcng4 A G 8: 120,359,789 (GRCm39) S196P probably damaging Het
Kcnh7 T G 2: 62,680,876 (GRCm39) H237P probably benign Het
Klhl38 T C 15: 58,185,707 (GRCm39) T341A probably benign Het
Klra9 G T 6: 130,155,995 (GRCm39) Y253* probably null Het
Man2c1 T C 9: 57,038,517 (GRCm39) V59A possibly damaging Het
Nr2c1 A T 10: 94,031,203 (GRCm39) H588L possibly damaging Het
Or14a259 A T 7: 86,013,181 (GRCm39) Y121* probably null Het
Or2j3 T C 17: 38,616,249 (GRCm39) I34M probably benign Het
Osbpl6 A G 2: 76,409,620 (GRCm39) E494G probably damaging Het
Per1 T C 11: 68,995,122 (GRCm39) L638S probably damaging Het
Plekhn1 T C 4: 156,306,261 (GRCm39) E603G probably benign Het
Prss12 A T 3: 123,273,243 (GRCm39) S280C probably damaging Het
Pudp A G 18: 50,701,307 (GRCm39) I142T probably benign Het
Rabl6 A T 2: 25,474,849 (GRCm39) N620K probably damaging Het
Rttn T A 18: 89,039,809 (GRCm39) C837S probably null Het
Slc16a7 A G 10: 125,066,887 (GRCm39) S251P probably damaging Het
Slc7a10 A G 7: 34,897,083 (GRCm39) I195V probably benign Het
Slc9a4 A T 1: 40,640,014 (GRCm39) R269* probably null Het
Smc6 A G 12: 11,359,235 (GRCm39) N953S probably benign Het
Tex15 T C 8: 34,061,329 (GRCm39) V527A probably benign Het
Tln2 T C 9: 67,179,947 (GRCm39) Y808C probably damaging Het
Tmem145 T C 7: 25,008,463 (GRCm39) L289P possibly damaging Het
Trim3 A G 7: 105,267,212 (GRCm39) V389A probably benign Het
Vmn1r3 G A 4: 3,184,971 (GRCm39) T112I probably benign Het
Vps11 C A 9: 44,272,847 (GRCm39) A28S probably benign Het
Zbtb41 T A 1: 139,374,945 (GRCm39) S802T probably benign Het
Zmynd10 A T 9: 107,425,911 (GRCm39) K82* probably null Het
Other mutations in Slco6c1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00547:Slco6c1 APN 1 97,015,674 (GRCm39) missense probably benign 0.00
IGL00571:Slco6c1 APN 1 97,015,676 (GRCm39) missense probably benign 0.04
IGL01483:Slco6c1 APN 1 97,055,832 (GRCm39) missense probably benign
IGL01543:Slco6c1 APN 1 97,053,553 (GRCm39) missense possibly damaging 0.95
IGL01860:Slco6c1 APN 1 97,003,548 (GRCm39) splice site probably benign
IGL03106:Slco6c1 APN 1 96,993,748 (GRCm39) splice site probably benign
R0087:Slco6c1 UTSW 1 97,046,303 (GRCm39) missense probably benign 0.00
R0543:Slco6c1 UTSW 1 97,055,623 (GRCm39) missense probably damaging 0.99
R0674:Slco6c1 UTSW 1 97,032,498 (GRCm39) splice site probably benign
R0826:Slco6c1 UTSW 1 97,055,826 (GRCm39) missense probably benign 0.00
R0928:Slco6c1 UTSW 1 97,032,573 (GRCm39) missense possibly damaging 0.88
R0969:Slco6c1 UTSW 1 97,047,685 (GRCm39) missense probably benign 0.05
R1366:Slco6c1 UTSW 1 97,055,928 (GRCm39) start gained probably null
R1559:Slco6c1 UTSW 1 97,026,223 (GRCm39) missense probably damaging 1.00
R1594:Slco6c1 UTSW 1 96,990,163 (GRCm39) missense probably benign 0.36
R1901:Slco6c1 UTSW 1 97,000,707 (GRCm39) missense probably damaging 0.98
R2005:Slco6c1 UTSW 1 97,009,214 (GRCm39) missense probably damaging 0.99
R2101:Slco6c1 UTSW 1 97,000,595 (GRCm39) nonsense probably null
R2102:Slco6c1 UTSW 1 97,055,656 (GRCm39) missense probably benign 0.02
R2120:Slco6c1 UTSW 1 96,993,808 (GRCm39) missense possibly damaging 0.57
R2135:Slco6c1 UTSW 1 97,032,542 (GRCm39) missense probably benign 0.01
R2295:Slco6c1 UTSW 1 97,053,473 (GRCm39) missense probably damaging 1.00
R2437:Slco6c1 UTSW 1 96,990,201 (GRCm39) missense probably benign 0.22
R4004:Slco6c1 UTSW 1 97,003,610 (GRCm39) missense probably damaging 1.00
R4133:Slco6c1 UTSW 1 97,009,218 (GRCm39) missense probably benign 0.02
R4643:Slco6c1 UTSW 1 96,990,149 (GRCm39) missense probably benign 0.00
R4786:Slco6c1 UTSW 1 97,015,720 (GRCm39) missense probably benign 0.04
R4942:Slco6c1 UTSW 1 97,009,049 (GRCm39) missense probably damaging 1.00
R5485:Slco6c1 UTSW 1 97,053,481 (GRCm39) missense probably damaging 1.00
R5573:Slco6c1 UTSW 1 97,055,656 (GRCm39) missense probably benign 0.00
R5810:Slco6c1 UTSW 1 97,003,598 (GRCm39) missense probably damaging 1.00
R6033:Slco6c1 UTSW 1 97,009,041 (GRCm39) splice site probably null
R6033:Slco6c1 UTSW 1 97,009,041 (GRCm39) splice site probably null
R6191:Slco6c1 UTSW 1 96,993,808 (GRCm39) missense possibly damaging 0.57
R6197:Slco6c1 UTSW 1 97,000,518 (GRCm39) critical splice donor site probably null
R6286:Slco6c1 UTSW 1 97,053,445 (GRCm39) missense possibly damaging 0.90
R6404:Slco6c1 UTSW 1 97,046,330 (GRCm39) missense probably damaging 1.00
R6492:Slco6c1 UTSW 1 97,053,538 (GRCm39) missense probably damaging 0.99
R6649:Slco6c1 UTSW 1 97,053,436 (GRCm39) missense probably benign 0.44
R6940:Slco6c1 UTSW 1 97,000,626 (GRCm39) missense possibly damaging 0.80
R7138:Slco6c1 UTSW 1 97,047,706 (GRCm39) missense possibly damaging 0.95
R7213:Slco6c1 UTSW 1 97,055,671 (GRCm39) missense probably benign
R7234:Slco6c1 UTSW 1 97,053,466 (GRCm39) missense probably benign 0.06
R7320:Slco6c1 UTSW 1 97,055,887 (GRCm39) missense possibly damaging 0.83
R7375:Slco6c1 UTSW 1 97,009,146 (GRCm39) missense possibly damaging 0.58
R7383:Slco6c1 UTSW 1 97,003,608 (GRCm39) nonsense probably null
R7422:Slco6c1 UTSW 1 97,009,207 (GRCm39) missense probably benign 0.17
R7491:Slco6c1 UTSW 1 97,055,579 (GRCm39) missense probably benign 0.32
R7561:Slco6c1 UTSW 1 97,000,691 (GRCm39) missense probably damaging 1.00
R7890:Slco6c1 UTSW 1 96,990,192 (GRCm39) missense possibly damaging 0.59
R8115:Slco6c1 UTSW 1 97,000,686 (GRCm39) missense probably damaging 1.00
R8409:Slco6c1 UTSW 1 97,003,663 (GRCm39) missense probably damaging 0.99
R8422:Slco6c1 UTSW 1 97,053,508 (GRCm39) missense probably damaging 1.00
R8824:Slco6c1 UTSW 1 97,055,884 (GRCm39) missense possibly damaging 0.84
R8905:Slco6c1 UTSW 1 97,053,391 (GRCm39) missense possibly damaging 0.68
R9183:Slco6c1 UTSW 1 96,996,775 (GRCm39) critical splice acceptor site probably null
R9300:Slco6c1 UTSW 1 96,993,809 (GRCm39) missense probably benign 0.37
R9359:Slco6c1 UTSW 1 96,990,248 (GRCm39) missense possibly damaging 0.94
R9374:Slco6c1 UTSW 1 97,055,827 (GRCm39) missense probably benign 0.00
R9403:Slco6c1 UTSW 1 96,990,248 (GRCm39) missense possibly damaging 0.94
R9499:Slco6c1 UTSW 1 97,055,827 (GRCm39) missense probably benign 0.00
R9551:Slco6c1 UTSW 1 97,055,827 (GRCm39) missense probably benign 0.00
R9674:Slco6c1 UTSW 1 97,047,565 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCTAATCACTACCTACGCATTAAGC -3'
(R):5'- AGGTCAACCATGTCTCTAGGAC -3'

Sequencing Primer
(F):5'- TTAAGCACCTTCCCGGAGATG -3'
(R):5'- GTCTCTAGGACTATATAGACTAATC -3'
Posted On 2018-05-24