Incidental Mutation 'R6430:Klra9'
ID 518477
Institutional Source Beutler Lab
Gene Symbol Klra9
Ensembl Gene ENSMUSG00000033024
Gene Name killer cell lectin-like receptor subfamily A, member 9
Synonyms Ly49I, LY49I1
MMRRC Submission 044568-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R6430 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 130155638-130170075 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) G to T at 130155995 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 253 (Y253*)
Ref Sequence ENSEMBL: ENSMUSP00000107663 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071554] [ENSMUST00000112032]
AlphaFold Q2TJJ8
Predicted Effect probably null
Transcript: ENSMUST00000071554
AA Change: Y253*
SMART Domains Protein: ENSMUSP00000071485
Gene: ENSMUSG00000033024
AA Change: Y253*

DomainStartEndE-ValueType
Blast:CLECT 73 116 4e-9 BLAST
CLECT 143 258 1.55e-16 SMART
Predicted Effect probably null
Transcript: ENSMUST00000112032
AA Change: Y253*
SMART Domains Protein: ENSMUSP00000107663
Gene: ENSMUSG00000033024
AA Change: Y253*

DomainStartEndE-ValueType
Blast:CLECT 73 116 4e-9 BLAST
CLECT 143 258 1.55e-16 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000178922
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 97.9%
  • 20x: 93.7%
Validation Efficiency 100% (47/47)
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AI661453 C A 17: 47,777,722 (GRCm39) probably benign Het
Ank1 T A 8: 23,622,125 (GRCm39) L1513Q probably damaging Het
Ap2a1 C A 7: 44,553,253 (GRCm39) V676L probably benign Het
Arid2 T C 15: 96,261,575 (GRCm39) V477A probably benign Het
Auh C A 13: 53,083,446 (GRCm39) G17C probably benign Het
B3gnt7 T C 1: 86,233,839 (GRCm39) F362L possibly damaging Het
Cd207 C T 6: 83,652,869 (GRCm39) R87H probably benign Het
Cdyl A G 13: 36,055,589 (GRCm39) K503R possibly damaging Het
Cep350 A G 1: 155,770,419 (GRCm39) S1824P probably damaging Het
Cmas T A 6: 142,713,650 (GRCm39) M225K probably benign Het
Dhx29 T C 13: 113,081,153 (GRCm39) S396P possibly damaging Het
Epg5 T C 18: 78,019,100 (GRCm39) S958P probably damaging Het
Espnl T C 1: 91,249,970 (GRCm39) L39P possibly damaging Het
Fcsk A G 8: 111,610,748 (GRCm39) V915A probably benign Het
Flacc1 T A 1: 58,717,448 (GRCm39) K154N probably damaging Het
Gatb A G 3: 85,544,345 (GRCm39) N438D probably benign Het
Hspg2 T C 4: 137,266,707 (GRCm39) C1932R probably damaging Het
Jmjd1c C T 10: 67,059,939 (GRCm39) T662I possibly damaging Het
Kcng4 A G 8: 120,359,789 (GRCm39) S196P probably damaging Het
Kcnh7 T G 2: 62,680,876 (GRCm39) H237P probably benign Het
Klhl38 T C 15: 58,185,707 (GRCm39) T341A probably benign Het
Man2c1 T C 9: 57,038,517 (GRCm39) V59A possibly damaging Het
Nr2c1 A T 10: 94,031,203 (GRCm39) H588L possibly damaging Het
Or14a259 A T 7: 86,013,181 (GRCm39) Y121* probably null Het
Or2j3 T C 17: 38,616,249 (GRCm39) I34M probably benign Het
Osbpl6 A G 2: 76,409,620 (GRCm39) E494G probably damaging Het
Per1 T C 11: 68,995,122 (GRCm39) L638S probably damaging Het
Plekhn1 T C 4: 156,306,261 (GRCm39) E603G probably benign Het
Prss12 A T 3: 123,273,243 (GRCm39) S280C probably damaging Het
Pudp A G 18: 50,701,307 (GRCm39) I142T probably benign Het
Rabl6 A T 2: 25,474,849 (GRCm39) N620K probably damaging Het
Rttn T A 18: 89,039,809 (GRCm39) C837S probably null Het
Slc16a7 A G 10: 125,066,887 (GRCm39) S251P probably damaging Het
Slc7a10 A G 7: 34,897,083 (GRCm39) I195V probably benign Het
Slc9a4 A T 1: 40,640,014 (GRCm39) R269* probably null Het
Slco6c1 T A 1: 97,003,699 (GRCm39) Q466L probably benign Het
Smc6 A G 12: 11,359,235 (GRCm39) N953S probably benign Het
Tex15 T C 8: 34,061,329 (GRCm39) V527A probably benign Het
Tln2 T C 9: 67,179,947 (GRCm39) Y808C probably damaging Het
Tmem145 T C 7: 25,008,463 (GRCm39) L289P possibly damaging Het
Trim3 A G 7: 105,267,212 (GRCm39) V389A probably benign Het
Vmn1r3 G A 4: 3,184,971 (GRCm39) T112I probably benign Het
Vps11 C A 9: 44,272,847 (GRCm39) A28S probably benign Het
Zbtb41 T A 1: 139,374,945 (GRCm39) S802T probably benign Het
Zmynd10 A T 9: 107,425,911 (GRCm39) K82* probably null Het
Other mutations in Klra9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00650:Klra9 APN 6 130,156,060 (GRCm39) missense probably benign 0.04
IGL00685:Klra9 APN 6 130,159,369 (GRCm39) missense probably damaging 1.00
IGL01083:Klra9 APN 6 130,166,729 (GRCm39) missense possibly damaging 0.61
IGL01704:Klra9 APN 6 130,166,744 (GRCm39) nonsense probably null
IGL02510:Klra9 APN 6 130,168,185 (GRCm39) missense probably benign 0.17
IGL02728:Klra9 APN 6 130,168,149 (GRCm39) splice site probably null
IGL02792:Klra9 APN 6 130,165,643 (GRCm39) missense probably benign 0.19
Ashen UTSW 6 130,155,995 (GRCm39) nonsense probably null
FR4589:Klra9 UTSW 6 130,159,366 (GRCm39) missense probably benign 0.37
PIT4453001:Klra9 UTSW 6 130,168,284 (GRCm39) start gained probably benign
R0410:Klra9 UTSW 6 130,165,707 (GRCm39) missense probably benign 0.01
R0926:Klra9 UTSW 6 130,155,993 (GRCm39) missense probably damaging 0.98
R1712:Klra9 UTSW 6 130,166,659 (GRCm39) critical splice donor site probably null
R1897:Klra9 UTSW 6 130,162,555 (GRCm39) missense possibly damaging 0.86
R1972:Klra9 UTSW 6 130,159,345 (GRCm39) critical splice donor site probably null
R3683:Klra9 UTSW 6 130,168,260 (GRCm39) missense probably benign
R4066:Klra9 UTSW 6 130,165,707 (GRCm39) missense probably benign 0.02
R4687:Klra9 UTSW 6 130,162,480 (GRCm39) missense probably benign 0.36
R5062:Klra9 UTSW 6 130,156,072 (GRCm39) missense possibly damaging 0.77
R5184:Klra9 UTSW 6 130,165,675 (GRCm39) missense probably benign 0.15
R5479:Klra9 UTSW 6 130,156,075 (GRCm39) missense probably benign 0.02
R5809:Klra9 UTSW 6 130,156,036 (GRCm39) missense probably damaging 1.00
R6410:Klra9 UTSW 6 130,155,957 (GRCm39) missense probably damaging 1.00
R6433:Klra9 UTSW 6 130,155,995 (GRCm39) nonsense probably null
R6434:Klra9 UTSW 6 130,155,995 (GRCm39) nonsense probably null
R6449:Klra9 UTSW 6 130,155,995 (GRCm39) nonsense probably null
R6450:Klra9 UTSW 6 130,155,995 (GRCm39) nonsense probably null
R6464:Klra9 UTSW 6 130,155,995 (GRCm39) nonsense probably null
R6466:Klra9 UTSW 6 130,155,995 (GRCm39) nonsense probably null
R6488:Klra9 UTSW 6 130,155,995 (GRCm39) nonsense probably null
R6882:Klra9 UTSW 6 130,155,985 (GRCm39) missense probably damaging 1.00
R6902:Klra9 UTSW 6 130,156,003 (GRCm39) missense probably benign 0.11
R6946:Klra9 UTSW 6 130,156,003 (GRCm39) missense probably benign 0.11
R7204:Klra9 UTSW 6 130,165,643 (GRCm39) missense possibly damaging 0.53
R7229:Klra9 UTSW 6 130,168,224 (GRCm39) missense probably damaging 0.98
R7544:Klra9 UTSW 6 130,168,183 (GRCm39) missense probably benign 0.27
R7821:Klra9 UTSW 6 130,162,563 (GRCm39) missense probably damaging 1.00
R8680:Klra9 UTSW 6 130,165,639 (GRCm39) missense probably damaging 1.00
R8912:Klra9 UTSW 6 130,159,368 (GRCm39) missense probably damaging 0.96
R9788:Klra9 UTSW 6 130,159,385 (GRCm39) missense possibly damaging 0.65
Predicted Primers PCR Primer
(F):5'- AGTCCCAATGTTCTTGCAGC -3'
(R):5'- AGAGTTTTGGTGTGATAAGAGACC -3'

Sequencing Primer
(F):5'- AGCTTTGTTTCTCTTCACAGCAGAC -3'
(R):5'- CATGATGAACTTAGGCTAAACTTAGG -3'
Posted On 2018-05-24