Incidental Mutation 'R6432:Ly6m'
ID 518605
Institutional Source Beutler Lab
Gene Symbol Ly6m
Ensembl Gene ENSMUSG00000063522
Gene Name lymphocyte antigen 6 family member M
Synonyms 2010109I03Rik
MMRRC Submission 044570-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R6432 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 74750185-74753553 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 74751813 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 74 (T74A)
Ref Sequence ENSEMBL: ENSMUSP00000076264 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077004]
AlphaFold Q9CQ11
Predicted Effect probably benign
Transcript: ENSMUST00000077004
AA Change: T74A

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000076264
Gene: ENSMUSG00000063522
AA Change: T74A

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
LU 21 100 6.96e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000190826
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.5%
  • 10x: 97.6%
  • 20x: 92.3%
Validation Efficiency 100% (42/42)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adora3 T A 3: 105,814,991 (GRCm39) L101* probably null Het
Atf7ip2 T C 16: 10,022,534 (GRCm39) I71T probably damaging Het
Atp2c1 A G 9: 105,322,512 (GRCm39) C206R probably damaging Het
Cacna1d A G 14: 29,845,411 (GRCm39) L606P probably damaging Het
Cass4 T C 2: 172,269,639 (GRCm39) F574L probably damaging Het
Cdcp3 G A 7: 130,846,601 (GRCm39) probably null Het
Col17a1 C A 19: 47,668,847 (GRCm39) E126* probably null Het
Cxadr A C 16: 78,122,147 (GRCm39) D49A probably damaging Het
Dact1 T C 12: 71,365,327 (GRCm39) S703P probably damaging Het
Dchs2 T A 3: 83,178,425 (GRCm39) H1159Q possibly damaging Het
Dnmt3a T A 12: 3,952,399 (GRCm39) F697I probably damaging Het
Dnpep T A 1: 75,292,022 (GRCm39) K199N probably benign Het
Ear2 G T 14: 44,340,660 (GRCm39) C106F probably damaging Het
Gnl2 A T 4: 124,946,353 (GRCm39) I525F possibly damaging Het
Hsph1 C A 5: 149,542,441 (GRCm39) K692N probably damaging Het
Itga6 T A 2: 71,664,116 (GRCm39) C489S possibly damaging Het
Kdm2b C T 5: 123,018,254 (GRCm39) C1007Y probably damaging Het
Mast4 T C 13: 103,042,185 (GRCm39) S22G possibly damaging Het
Ms4a12 A G 19: 11,192,376 (GRCm39) *264Q probably null Het
Myh8 G T 11: 67,189,405 (GRCm39) A1194S probably benign Het
Ncapd3 T A 9: 26,955,805 (GRCm39) N131K probably damaging Het
Or10g6 T C 9: 39,933,824 (GRCm39) I45T probably damaging Het
Or5w13 A T 2: 87,523,872 (GRCm39) M118K probably damaging Het
Rbm14 G T 19: 4,853,191 (GRCm39) probably benign Het
Rnf130 T A 11: 49,986,617 (GRCm39) C320* probably null Het
Rnf5 A G 17: 34,821,101 (GRCm39) V77A possibly damaging Het
Sh3pxd2a G T 19: 47,258,366 (GRCm39) P418T probably damaging Het
Shank3 G T 15: 89,387,616 (GRCm39) V262F possibly damaging Het
Six5 T A 7: 18,830,696 (GRCm39) V441E probably damaging Het
Tbc1d9b T A 11: 50,037,155 (GRCm39) I268N probably benign Het
Terb1 G A 8: 105,212,078 (GRCm39) T301I possibly damaging Het
Tnxb A C 17: 34,936,891 (GRCm39) D2820A probably damaging Het
Tram2 C T 1: 21,074,457 (GRCm39) E242K possibly damaging Het
Trps1 T C 15: 50,694,793 (GRCm39) K210E probably damaging Het
Tulp2 T A 7: 45,168,012 (GRCm39) D141E probably benign Het
Umodl1 C T 17: 31,205,121 (GRCm39) T572I probably benign Het
Upf2 C A 2: 5,984,588 (GRCm39) A501E unknown Het
Vmn2r102 A G 17: 19,901,483 (GRCm39) T537A possibly damaging Het
Wdr11 T A 7: 129,208,242 (GRCm39) D332E possibly damaging Het
Wdr38 A G 2: 38,890,723 (GRCm39) N199S probably damaging Het
Zfp672 T A 11: 58,207,758 (GRCm39) I188F possibly damaging Het
Other mutations in Ly6m
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01471:Ly6m APN 15 74,751,749 (GRCm39) missense probably benign
IGL02550:Ly6m APN 15 74,752,604 (GRCm39) missense probably damaging 1.00
IGL02555:Ly6m APN 15 74,753,457 (GRCm39) splice site probably benign
R2905:Ly6m UTSW 15 74,751,716 (GRCm39) missense probably benign
R3547:Ly6m UTSW 15 74,753,463 (GRCm39) missense probably null 0.96
R4777:Ly6m UTSW 15 74,752,532 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TTGGAGTTCAAGAAGTGCCC -3'
(R):5'- TGTCTGACCCTTTGAACTGGAG -3'

Sequencing Primer
(F):5'- ACACATTCCGGTTGCATGATG -3'
(R):5'- CCTTTGAACTGGAGGCTGCAG -3'
Posted On 2018-05-24