Incidental Mutation 'IGL01072:Fbxw26'
ID51872
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fbxw26
Ensembl Gene ENSMUSG00000059547
Gene NameF-box and WD-40 domain protein 26
SynonymsGm5163
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL01072
Quality Score
Status
Chromosome9
Chromosomal Location109717566-109746089 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 109723837 bp
ZygosityHeterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 290 (F290I)
Ref Sequence ENSEMBL: ENSMUSP00000071811 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071917]
Predicted Effect probably damaging
Transcript: ENSMUST00000071917
AA Change: F290I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000071811
Gene: ENSMUSG00000059547
AA Change: F290I

DomainStartEndE-ValueType
FBOX 5 45 2.54e-6 SMART
SCOP:d1tbga_ 128 249 1e-5 SMART
Blast:WD40 137 176 4e-7 BLAST
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 19 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ccdc65 A T 15: 98,708,396 M1L unknown Het
Cyp3a44 T C 5: 145,791,628 D262G probably benign Het
Dmbt1 C T 7: 131,085,368 probably benign Het
Dnmt3l A G 10: 78,052,771 N169S probably benign Het
Fam129b T C 2: 32,912,415 probably benign Het
Foxj3 A G 4: 119,610,029 M190V probably benign Het
Gm7275 T C 16: 48,074,156 noncoding transcript Het
Ly75 T A 2: 60,354,496 D438V probably damaging Het
Lzts3 T C 2: 130,635,445 E475G probably damaging Het
Mon2 A T 10: 123,010,539 Y1375* probably null Het
Ndufc2 T A 7: 97,400,283 V32D probably damaging Het
Nf2 A C 11: 4,789,713 L431R probably null Het
Ptpn9 C T 9: 57,036,703 T287I possibly damaging Het
Rictor A G 15: 6,789,562 D1422G probably damaging Het
Rpp40 C A 13: 35,902,034 G115C probably damaging Het
Rps6ka5 A G 12: 100,573,898 V522A probably benign Het
Scgb1b24 A T 7: 33,744,009 D31V probably damaging Het
Trrap C A 5: 144,784,255 probably benign Het
Vmn1r214 T C 13: 23,035,130 Y265H possibly damaging Het
Other mutations in Fbxw26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00589:Fbxw26 APN 9 109717948 utr 3 prime probably benign
IGL01151:Fbxw26 APN 9 109721780 missense possibly damaging 0.50
IGL01394:Fbxw26 APN 9 109717989 missense probably benign 0.00
IGL01432:Fbxw26 APN 9 109717975 missense probably benign 0.32
IGL02559:Fbxw26 APN 9 109722164 missense probably benign 0.34
IGL02981:Fbxw26 APN 9 109744794 missense probably benign 0.09
IGL03370:Fbxw26 APN 9 109746019 missense probably damaging 1.00
R0023:Fbxw26 UTSW 9 109718011 missense probably benign 0.01
R0087:Fbxw26 UTSW 9 109724938 missense probably benign
R0369:Fbxw26 UTSW 9 109723712 critical splice donor site probably null
R0446:Fbxw26 UTSW 9 109743720 missense probably benign 0.03
R1844:Fbxw26 UTSW 9 109724878 missense probably benign 0.42
R1891:Fbxw26 UTSW 9 109722164 missense probably benign 0.34
R2042:Fbxw26 UTSW 9 109732704 missense probably damaging 1.00
R3615:Fbxw26 UTSW 9 109743760 nonsense probably null
R3616:Fbxw26 UTSW 9 109743760 nonsense probably null
R4659:Fbxw26 UTSW 9 109744871 missense probably damaging 0.97
R4785:Fbxw26 UTSW 9 109724800 missense possibly damaging 0.50
R4898:Fbxw26 UTSW 9 109717969 missense possibly damaging 0.95
R5791:Fbxw26 UTSW 9 109745153 missense probably damaging 1.00
R5818:Fbxw26 UTSW 9 109732566 missense probably benign
R5921:Fbxw26 UTSW 9 109746018 missense probably damaging 1.00
R5983:Fbxw26 UTSW 9 109717965 missense possibly damaging 0.49
R6145:Fbxw26 UTSW 9 109732623 missense probably benign 0.09
R6209:Fbxw26 UTSW 9 109717965 missense possibly damaging 0.49
R6412:Fbxw26 UTSW 9 109732647 missense probably damaging 0.97
R6842:Fbxw26 UTSW 9 109724920 missense probably damaging 1.00
R7228:Fbxw26 UTSW 9 109724944 missense possibly damaging 0.93
R7451:Fbxw26 UTSW 9 109732623 missense probably benign 0.03
R7467:Fbxw26 UTSW 9 109732697 missense probably benign 0.00
X0020:Fbxw26 UTSW 9 109732632 missense probably damaging 1.00
Posted On2013-06-21