Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL01072:Fbxw26'

51872

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fbxw26

Ensembl Gene

ENSMUSG00000059547

Gene Name

F-box and WD-40 domain protein 26

Synonyms

Gm5163

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL01072

Quality Score

Status

Chromosome

Chromosomal Location

109717566-109746089 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 109723837 bp

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 290 (F290I)

Ref Sequence

ENSEMBL: ENSMUSP00000071811 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071917]

Predicted Effect

probably damaging
Transcript: ENSMUST00000071917
AA Change: F290I

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000071811
Gene: ENSMUSG00000059547
AA Change: F290I

Domain	Start	End	E-Value	Type
FBOX	5	45	2.54e-6	SMART
SCOP:d1tbga_	128	249	1e-5	SMART
Blast:WD40	137	176	4e-7	BLAST

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 19 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ccdc65	A	T	15: 98,708,396	M1L	unknown	Het
Cyp3a44	T	C	5: 145,791,628	D262G	probably benign	Het
Dmbt1	C	T	7: 131,085,368		probably benign	Het
Dnmt3l	A	G	10: 78,052,771	N169S	probably benign	Het
Fam129b	T	C	2: 32,912,415		probably benign	Het
Foxj3	A	G	4: 119,610,029	M190V	probably benign	Het
Gm7275	T	C	16: 48,074,156		noncoding transcript	Het
Ly75	T	A	2: 60,354,496	D438V	probably damaging	Het
Lzts3	T	C	2: 130,635,445	E475G	probably damaging	Het
Mon2	A	T	10: 123,010,539	Y1375*	probably null	Het
Ndufc2	T	A	7: 97,400,283	V32D	probably damaging	Het
Nf2	A	C	11: 4,789,713	L431R	probably null	Het
Ptpn9	C	T	9: 57,036,703	T287I	possibly damaging	Het
Rictor	A	G	15: 6,789,562	D1422G	probably damaging	Het
Rpp40	C	A	13: 35,902,034	G115C	probably damaging	Het
Rps6ka5	A	G	12: 100,573,898	V522A	probably benign	Het
Scgb1b24	A	T	7: 33,744,009	D31V	probably damaging	Het
Trrap	C	A	5: 144,784,255		probably benign	Het
Vmn1r214	T	C	13: 23,035,130	Y265H	possibly damaging	Het

Other mutations in Fbxw26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00589:Fbxw26	APN	9	109717948	utr 3 prime	probably benign
IGL01151:Fbxw26	APN	9	109721780	missense	possibly damaging	0.50
IGL01394:Fbxw26	APN	9	109717989	missense	probably benign	0.00
IGL01432:Fbxw26	APN	9	109717975	missense	probably benign	0.32
IGL02559:Fbxw26	APN	9	109722164	missense	probably benign	0.34
IGL02981:Fbxw26	APN	9	109744794	missense	probably benign	0.09
IGL03370:Fbxw26	APN	9	109746019	missense	probably damaging	1.00
R0023:Fbxw26	UTSW	9	109718011	missense	probably benign	0.01
R0087:Fbxw26	UTSW	9	109724938	missense	probably benign
R0369:Fbxw26	UTSW	9	109723712	critical splice donor site	probably null
R0446:Fbxw26	UTSW	9	109743720	missense	probably benign	0.03
R1844:Fbxw26	UTSW	9	109724878	missense	probably benign	0.42
R1891:Fbxw26	UTSW	9	109722164	missense	probably benign	0.34
R2042:Fbxw26	UTSW	9	109732704	missense	probably damaging	1.00
R3615:Fbxw26	UTSW	9	109743760	nonsense	probably null
R3616:Fbxw26	UTSW	9	109743760	nonsense	probably null
R4659:Fbxw26	UTSW	9	109744871	missense	probably damaging	0.97
R4785:Fbxw26	UTSW	9	109724800	missense	possibly damaging	0.50
R4898:Fbxw26	UTSW	9	109717969	missense	possibly damaging	0.95
R5791:Fbxw26	UTSW	9	109745153	missense	probably damaging	1.00
R5818:Fbxw26	UTSW	9	109732566	missense	probably benign
R5921:Fbxw26	UTSW	9	109746018	missense	probably damaging	1.00
R5983:Fbxw26	UTSW	9	109717965	missense	possibly damaging	0.49
R6145:Fbxw26	UTSW	9	109732623	missense	probably benign	0.09
R6209:Fbxw26	UTSW	9	109717965	missense	possibly damaging	0.49
R6412:Fbxw26	UTSW	9	109732647	missense	probably damaging	0.97
R6842:Fbxw26	UTSW	9	109724920	missense	probably damaging	1.00
R7228:Fbxw26	UTSW	9	109724944	missense	possibly damaging	0.93
R7451:Fbxw26	UTSW	9	109732623	missense	probably benign	0.03
R7467:Fbxw26	UTSW	9	109732697	missense	probably benign	0.00
R8397:Fbxw26	UTSW	9	109732647	missense	probably damaging	0.99
X0020:Fbxw26	UTSW	9	109732632	missense	probably damaging	1.00

Posted On

2013-06-21