Incidental Mutation 'R6435:Rgs21'
ID 518732
Institutional Source Beutler Lab
Gene Symbol Rgs21
Ensembl Gene ENSMUSG00000098509
Gene Name regulator of G-protein signalling 21
Synonyms EG624910
MMRRC Submission 044573-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.123) question?
Stock # R6435 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 144392388-144443405 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 144395565 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 108 (F108L)
Ref Sequence ENSEMBL: ENSMUSP00000139265 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000184189]
AlphaFold V9GXQ3
Predicted Effect noncoding transcript
Transcript: ENSMUST00000184008
Predicted Effect probably damaging
Transcript: ENSMUST00000184189
AA Change: F108L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000139265
Gene: ENSMUSG00000098509
AA Change: F108L

DomainStartEndE-ValueType
RGS 21 137 2.84e-50 SMART
Meta Mutation Damage Score 0.3747 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.2%
Validation Efficiency 100% (32/32)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM, Nov 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abl1 A T 2: 31,691,561 (GRCm39) T1027S possibly damaging Het
Ablim1 T C 19: 57,049,787 (GRCm39) I159V possibly damaging Het
Adcy1 A G 11: 7,111,367 (GRCm39) N886S possibly damaging Het
Baz1b G A 5: 135,266,799 (GRCm39) D1203N probably damaging Het
Chmp2a A T 7: 12,766,701 (GRCm39) Y72* probably null Het
Col6a1 A T 10: 76,546,957 (GRCm39) I755N unknown Het
Defa24 T A 8: 22,224,690 (GRCm39) F46L possibly damaging Het
Eml2 G A 7: 18,935,088 (GRCm39) V432I probably damaging Het
Gcn1 A T 5: 115,749,081 (GRCm39) probably null Het
Gfpt2 A G 11: 49,726,478 (GRCm39) S628G probably benign Het
Hsdl2 C A 4: 59,610,668 (GRCm39) Q222K unknown Het
Ighv1-9 T A 12: 114,547,206 (GRCm39) I111F probably benign Het
Itch G A 2: 155,051,049 (GRCm39) D579N probably benign Het
Jdp2 A T 12: 85,655,132 (GRCm39) K65M probably damaging Het
Kif15 A T 9: 122,815,556 (GRCm39) E222V probably damaging Het
Map1b A G 13: 99,652,871 (GRCm39) V42A probably damaging Het
Mecom T A 3: 30,034,398 (GRCm39) E426V probably damaging Het
Meiosin T C 7: 18,834,844 (GRCm39) probably benign Het
Mfsd6 G T 1: 52,748,603 (GRCm39) Y87* probably null Het
Mybpc2 A G 7: 44,155,481 (GRCm39) V924A possibly damaging Het
Naip6 A T 13: 100,431,249 (GRCm39) M1196K probably benign Het
Nscme3l T C 19: 5,553,446 (GRCm39) I112V probably benign Het
Or52n5 A G 7: 104,588,041 (GRCm39) M103V probably damaging Het
Pcdh9 G A 14: 94,125,280 (GRCm39) P297S probably benign Het
Pold1 G A 7: 44,188,202 (GRCm39) R559C probably damaging Het
Runx1 A T 16: 92,441,183 (GRCm39) S209T possibly damaging Het
Sdccag8 G T 1: 176,642,428 (GRCm39) probably benign Het
Smc1b C T 15: 84,976,232 (GRCm39) R825Q probably benign Het
Srgap1 T C 10: 121,636,732 (GRCm39) D741G possibly damaging Het
Srsf11 C T 3: 157,728,981 (GRCm39) probably benign Homo
Tsc1 G A 2: 28,566,464 (GRCm39) V627M probably benign Het
Vmn2r106 C T 17: 20,488,725 (GRCm39) C558Y probably damaging Het
Zfp612 A G 8: 110,815,952 (GRCm39) I347M probably damaging Het
Other mutations in Rgs21
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4489:Rgs21 UTSW 1 144,395,613 (GRCm39) missense possibly damaging 0.92
R5666:Rgs21 UTSW 1 144,412,680 (GRCm39) missense probably benign 0.43
R5670:Rgs21 UTSW 1 144,412,680 (GRCm39) missense probably benign 0.43
R6164:Rgs21 UTSW 1 144,417,035 (GRCm39) missense probably benign 0.04
R7664:Rgs21 UTSW 1 144,416,987 (GRCm39) missense probably benign
R9136:Rgs21 UTSW 1 144,412,653 (GRCm39) missense
Z1189:Rgs21 UTSW 1 144,395,529 (GRCm39) missense possibly damaging 0.68
Predicted Primers PCR Primer
(F):5'- TCTCCCAGAAGATTGTTAAGAACC -3'
(R):5'- GCATGACCTTGCTGCAATTTTC -3'

Sequencing Primer
(F):5'- CCAGAAGATTGTTAAGAACCTGATAC -3'
(R):5'- CTTGCTGCAATTTTCTATCCAATAAC -3'
Posted On 2018-05-24