Incidental Mutation 'R6435:Kif15'
ID 518749
Institutional Source Beutler Lab
Gene Symbol Kif15
Ensembl Gene ENSMUSG00000036768
Gene Name kinesin family member 15
Synonyms N-10 kinesin, 3930402I10Rik, 3110023M17Rik, HKLP2, Knsl7
MMRRC Submission 044573-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R6435 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 122780146-122847798 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 122815556 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Valine at position 222 (E222V)
Ref Sequence ENSEMBL: ENSMUSP00000150678 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040717] [ENSMUST00000213745] [ENSMUST00000214652]
AlphaFold Q6P9L6
Predicted Effect probably damaging
Transcript: ENSMUST00000040717
AA Change: E450V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000035490
Gene: ENSMUSG00000036768
AA Change: E450V

DomainStartEndE-ValueType
KISc 24 371 2.86e-179 SMART
Pfam:Kinesin-relat_1 463 551 6.6e-26 PFAM
coiled coil region 579 643 N/A INTRINSIC
coiled coil region 706 1037 N/A INTRINSIC
coiled coil region 1065 1133 N/A INTRINSIC
Pfam:HMMR_C 1265 1387 3.5e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213745
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214183
Predicted Effect probably damaging
Transcript: ENSMUST00000214652
AA Change: E222V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214880
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216491
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217415
Meta Mutation Damage Score 0.1573 question?
Coding Region Coverage
  • 1x: 99.9%
  • 3x: 99.6%
  • 10x: 98.1%
  • 20x: 94.2%
Validation Efficiency 100% (32/32)
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abl1 A T 2: 31,691,561 (GRCm39) T1027S possibly damaging Het
Ablim1 T C 19: 57,049,787 (GRCm39) I159V possibly damaging Het
Adcy1 A G 11: 7,111,367 (GRCm39) N886S possibly damaging Het
Baz1b G A 5: 135,266,799 (GRCm39) D1203N probably damaging Het
Chmp2a A T 7: 12,766,701 (GRCm39) Y72* probably null Het
Col6a1 A T 10: 76,546,957 (GRCm39) I755N unknown Het
Defa24 T A 8: 22,224,690 (GRCm39) F46L possibly damaging Het
Eml2 G A 7: 18,935,088 (GRCm39) V432I probably damaging Het
Gcn1 A T 5: 115,749,081 (GRCm39) probably null Het
Gfpt2 A G 11: 49,726,478 (GRCm39) S628G probably benign Het
Hsdl2 C A 4: 59,610,668 (GRCm39) Q222K unknown Het
Ighv1-9 T A 12: 114,547,206 (GRCm39) I111F probably benign Het
Itch G A 2: 155,051,049 (GRCm39) D579N probably benign Het
Jdp2 A T 12: 85,655,132 (GRCm39) K65M probably damaging Het
Map1b A G 13: 99,652,871 (GRCm39) V42A probably damaging Het
Mecom T A 3: 30,034,398 (GRCm39) E426V probably damaging Het
Meiosin T C 7: 18,834,844 (GRCm39) probably benign Het
Mfsd6 G T 1: 52,748,603 (GRCm39) Y87* probably null Het
Mybpc2 A G 7: 44,155,481 (GRCm39) V924A possibly damaging Het
Naip6 A T 13: 100,431,249 (GRCm39) M1196K probably benign Het
Nscme3l T C 19: 5,553,446 (GRCm39) I112V probably benign Het
Or52n5 A G 7: 104,588,041 (GRCm39) M103V probably damaging Het
Pcdh9 G A 14: 94,125,280 (GRCm39) P297S probably benign Het
Pold1 G A 7: 44,188,202 (GRCm39) R559C probably damaging Het
Rgs21 A G 1: 144,395,565 (GRCm39) F108L probably damaging Het
Runx1 A T 16: 92,441,183 (GRCm39) S209T possibly damaging Het
Sdccag8 G T 1: 176,642,428 (GRCm39) probably benign Het
Smc1b C T 15: 84,976,232 (GRCm39) R825Q probably benign Het
Srgap1 T C 10: 121,636,732 (GRCm39) D741G possibly damaging Het
Srsf11 C T 3: 157,728,981 (GRCm39) probably benign Homo
Tsc1 G A 2: 28,566,464 (GRCm39) V627M probably benign Het
Vmn2r106 C T 17: 20,488,725 (GRCm39) C558Y probably damaging Het
Zfp612 A G 8: 110,815,952 (GRCm39) I347M probably damaging Het
Other mutations in Kif15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01459:Kif15 APN 9 122,804,820 (GRCm39) missense probably damaging 1.00
IGL01577:Kif15 APN 9 122,825,399 (GRCm39) missense probably benign 0.06
IGL01647:Kif15 APN 9 122,792,536 (GRCm39) intron probably benign
IGL01921:Kif15 APN 9 122,808,569 (GRCm39) missense probably damaging 1.00
IGL02040:Kif15 APN 9 122,846,450 (GRCm39) missense probably damaging 0.99
IGL02191:Kif15 APN 9 122,804,744 (GRCm39) missense probably damaging 1.00
IGL02218:Kif15 APN 9 122,824,892 (GRCm39) splice site probably benign
IGL02537:Kif15 APN 9 122,822,914 (GRCm39) missense probably benign 0.08
IGL02814:Kif15 APN 9 122,832,705 (GRCm39) missense possibly damaging 0.83
PIT4480001:Kif15 UTSW 9 122,840,608 (GRCm39) missense probably benign
R0034:Kif15 UTSW 9 122,828,350 (GRCm39) missense possibly damaging 0.47
R0458:Kif15 UTSW 9 122,838,424 (GRCm39) missense probably benign
R0526:Kif15 UTSW 9 122,826,862 (GRCm39) missense probably damaging 0.96
R0533:Kif15 UTSW 9 122,838,498 (GRCm39) unclassified probably benign
R0726:Kif15 UTSW 9 122,788,993 (GRCm39) missense probably benign 0.21
R1580:Kif15 UTSW 9 122,789,021 (GRCm39) missense probably benign 0.22
R1597:Kif15 UTSW 9 122,823,074 (GRCm39) missense probably benign 0.22
R2096:Kif15 UTSW 9 122,815,252 (GRCm39) missense probably damaging 1.00
R3125:Kif15 UTSW 9 122,817,026 (GRCm39) missense probably damaging 0.99
R3176:Kif15 UTSW 9 122,816,905 (GRCm39) splice site probably benign
R4088:Kif15 UTSW 9 122,815,254 (GRCm39) missense probably benign 0.29
R4308:Kif15 UTSW 9 122,843,047 (GRCm39) missense probably benign 0.00
R4597:Kif15 UTSW 9 122,822,914 (GRCm39) missense probably benign 0.08
R4705:Kif15 UTSW 9 122,789,058 (GRCm39) splice site probably null
R4832:Kif15 UTSW 9 122,831,191 (GRCm39) splice site probably null
R5100:Kif15 UTSW 9 122,821,059 (GRCm39) missense probably damaging 0.98
R5126:Kif15 UTSW 9 122,804,823 (GRCm39) missense probably damaging 1.00
R5180:Kif15 UTSW 9 122,828,275 (GRCm39) missense probably damaging 0.99
R5247:Kif15 UTSW 9 122,815,507 (GRCm39) missense possibly damaging 0.65
R5376:Kif15 UTSW 9 122,823,036 (GRCm39) missense probably benign 0.04
R5392:Kif15 UTSW 9 122,825,360 (GRCm39) missense probably damaging 0.99
R5422:Kif15 UTSW 9 122,813,954 (GRCm39) splice site probably null
R5562:Kif15 UTSW 9 122,807,081 (GRCm39) missense probably damaging 1.00
R5663:Kif15 UTSW 9 122,820,916 (GRCm39) splice site probably null
R5767:Kif15 UTSW 9 122,843,039 (GRCm39) missense possibly damaging 0.78
R5927:Kif15 UTSW 9 122,846,326 (GRCm39) missense probably benign 0.00
R6049:Kif15 UTSW 9 122,840,687 (GRCm39) missense probably damaging 0.98
R7040:Kif15 UTSW 9 122,840,679 (GRCm39) missense possibly damaging 0.67
R7158:Kif15 UTSW 9 122,828,379 (GRCm39) missense probably benign
R7163:Kif15 UTSW 9 122,846,722 (GRCm39) missense probably damaging 1.00
R7197:Kif15 UTSW 9 122,838,991 (GRCm39) critical splice donor site probably null
R7318:Kif15 UTSW 9 122,817,014 (GRCm39) missense probably damaging 1.00
R7360:Kif15 UTSW 9 122,820,202 (GRCm39) missense probably benign
R8039:Kif15 UTSW 9 122,836,490 (GRCm39) missense possibly damaging 0.82
R8228:Kif15 UTSW 9 122,821,041 (GRCm39) missense possibly damaging 0.82
R8549:Kif15 UTSW 9 122,815,236 (GRCm39) missense probably benign
R9001:Kif15 UTSW 9 122,826,855 (GRCm39) missense probably benign 0.00
R9031:Kif15 UTSW 9 122,846,492 (GRCm39) intron probably benign
R9044:Kif15 UTSW 9 122,840,781 (GRCm39) missense probably benign 0.01
R9063:Kif15 UTSW 9 122,833,706 (GRCm39) missense probably damaging 1.00
R9306:Kif15 UTSW 9 122,807,056 (GRCm39) missense probably damaging 1.00
R9490:Kif15 UTSW 9 122,788,203 (GRCm39) missense probably benign 0.10
R9554:Kif15 UTSW 9 122,828,585 (GRCm39) missense probably damaging 1.00
R9682:Kif15 UTSW 9 122,815,712 (GRCm39) missense probably damaging 0.98
R9752:Kif15 UTSW 9 122,824,890 (GRCm39) critical splice donor site probably null
Z1177:Kif15 UTSW 9 122,780,116 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- CAGGTGTAAAACGAAAAGGCTTTC -3'
(R):5'- TAGATGGTGAACACTAGTCACAC -3'

Sequencing Primer
(F):5'- GCTTTCAAAAGTCTTGCCTTTGAG -3'
(R):5'- ACACAGAGGTAGGCTGCACTC -3'
Posted On 2018-05-24