Incidental Mutation 'R6436:Lcn8'
ID 518766
Institutional Source Beutler Lab
Gene Symbol Lcn8
Ensembl Gene ENSMUSG00000036449
Gene Name lipocalin 8
Synonyms mEP17, 9230106L18Rik, EP17
MMRRC Submission 044574-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R6436 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 25543132-25546229 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 25544990 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000097888 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028306] [ENSMUST00000038482] [ENSMUST00000100312] [ENSMUST00000100313]
AlphaFold Q924P3
Predicted Effect probably null
Transcript: ENSMUST00000028306
SMART Domains Protein: ENSMUSP00000028306
Gene: ENSMUSG00000026937

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
Pfam:Lipocalin 41 180 1.6e-23 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000038482
SMART Domains Protein: ENSMUSP00000043902
Gene: ENSMUSG00000036449

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:Lipocalin 33 159 2.9e-18 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000100312
SMART Domains Protein: ENSMUSP00000097887
Gene: ENSMUSG00000026937

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
Pfam:Lipocalin 41 180 1.6e-23 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000100313
SMART Domains Protein: ENSMUSP00000097888
Gene: ENSMUSG00000026937

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
Pfam:Lipocalin 41 180 2.5e-23 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.7%
  • 10x: 98.1%
  • 20x: 93.5%
Validation Efficiency 100% (33/33)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the lipocalin family, such as LCN8, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arc C A 15: 74,544,098 (GRCm39) V42L possibly damaging Het
Clip1 C T 5: 123,779,848 (GRCm39) E433K probably damaging Het
Cmya5 T C 13: 93,225,723 (GRCm39) T3122A probably damaging Het
Ctf2 G T 7: 127,318,603 (GRCm39) A92E probably damaging Het
Ctsw G T 19: 5,516,322 (GRCm39) R184S possibly damaging Het
D130043K22Rik A G 13: 25,061,918 (GRCm39) E629G probably damaging Het
Dmbt1 T C 7: 130,718,370 (GRCm39) V1523A probably benign Het
Eml2 G A 7: 18,935,088 (GRCm39) V432I probably damaging Het
Fanci T C 7: 79,090,446 (GRCm39) I982T probably benign Het
Fnbp1 T C 2: 30,986,139 (GRCm39) D3G probably damaging Het
Gm10770 G A 2: 150,020,830 (GRCm39) T229I probably benign Het
Gm35315 G A 5: 110,226,578 (GRCm39) T287I probably benign Het
Itgb3 T A 11: 104,524,318 (GRCm39) D151E probably damaging Het
Ninl A G 2: 150,808,098 (GRCm39) L310P probably damaging Het
Nop2 A G 6: 125,114,274 (GRCm39) D215G probably benign Het
Or4d10c T C 19: 12,065,299 (GRCm39) T286A probably benign Het
Or6c3 A G 10: 129,308,773 (GRCm39) T71A probably damaging Het
Parg T C 14: 31,993,634 (GRCm39) W289R probably damaging Het
Pdcd4 A G 19: 53,915,362 (GRCm39) probably null Het
Plk2 G T 13: 110,532,570 (GRCm39) E95* probably null Het
Pold1 G A 7: 44,188,202 (GRCm39) R559C probably damaging Het
Ptprc T C 1: 138,011,377 (GRCm39) D560G possibly damaging Het
Rasal3 T C 17: 32,616,478 (GRCm39) Y290C probably damaging Het
Rcsd1 T A 1: 165,485,184 (GRCm39) S90C probably damaging Het
Rttn T C 18: 89,128,853 (GRCm39) L1935P probably damaging Het
Smc1b C T 15: 84,976,232 (GRCm39) R825Q probably benign Het
Srsf11 C T 3: 157,728,981 (GRCm39) probably benign Homo
Tmc3 T C 7: 83,247,695 (GRCm39) Y230H probably damaging Het
Tnfrsf25 A T 4: 152,204,084 (GRCm39) probably null Het
Ubl7 T C 9: 57,827,793 (GRCm39) L160P probably damaging Het
Vmn2r106 C T 17: 20,488,725 (GRCm39) C558Y probably damaging Het
Zfp646 T A 7: 127,479,113 (GRCm39) V430E probably benign Het
Other mutations in Lcn8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00501:Lcn8 APN 2 25,545,119 (GRCm39) unclassified probably benign
IGL01554:Lcn8 APN 2 25,544,198 (GRCm39) missense possibly damaging 0.95
IGL01947:Lcn8 APN 2 25,545,157 (GRCm39) missense probably damaging 1.00
IGL03107:Lcn8 APN 2 25,545,377 (GRCm39) missense probably damaging 1.00
R5945:Lcn8 UTSW 2 25,545,509 (GRCm39) missense probably damaging 1.00
R7835:Lcn8 UTSW 2 25,545,308 (GRCm39) splice site probably null
R8072:Lcn8 UTSW 2 25,545,184 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCACTGGGTTCAGAAAGAGACAC -3'
(R):5'- TTCAGGATGGTGTAGCGCTC -3'

Sequencing Primer
(F):5'- AGACACTGTGGGGGAATTTGC -3'
(R):5'- ATGGTGTAGCGCTCATAGTCC -3'
Posted On 2018-05-24