Incidental Mutation 'R6436:Gm35315'
ID 518771
Institutional Source Beutler Lab
Gene Symbol Gm35315
Ensembl Gene ENSMUSG00000109771
Gene Name predicted gene, 35315
Synonyms Gm20090
MMRRC Submission 044574-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R6436 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 110224001-110241292 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 110226578 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 287 (T287I)
Ref Sequence ENSEMBL: ENSMUSP00000147534 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000210052] [ENSMUST00000211397]
AlphaFold A0A1B0GRI2
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209865
Predicted Effect probably benign
Transcript: ENSMUST00000210052
AA Change: T287I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000211397
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.7%
  • 10x: 98.1%
  • 20x: 93.5%
Validation Efficiency 100% (33/33)
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arc C A 15: 74,544,098 (GRCm39) V42L possibly damaging Het
Clip1 C T 5: 123,779,848 (GRCm39) E433K probably damaging Het
Cmya5 T C 13: 93,225,723 (GRCm39) T3122A probably damaging Het
Ctf2 G T 7: 127,318,603 (GRCm39) A92E probably damaging Het
Ctsw G T 19: 5,516,322 (GRCm39) R184S possibly damaging Het
D130043K22Rik A G 13: 25,061,918 (GRCm39) E629G probably damaging Het
Dmbt1 T C 7: 130,718,370 (GRCm39) V1523A probably benign Het
Eml2 G A 7: 18,935,088 (GRCm39) V432I probably damaging Het
Fanci T C 7: 79,090,446 (GRCm39) I982T probably benign Het
Fnbp1 T C 2: 30,986,139 (GRCm39) D3G probably damaging Het
Gm10770 G A 2: 150,020,830 (GRCm39) T229I probably benign Het
Itgb3 T A 11: 104,524,318 (GRCm39) D151E probably damaging Het
Lcn8 A T 2: 25,544,990 (GRCm39) probably null Het
Ninl A G 2: 150,808,098 (GRCm39) L310P probably damaging Het
Nop2 A G 6: 125,114,274 (GRCm39) D215G probably benign Het
Or4d10c T C 19: 12,065,299 (GRCm39) T286A probably benign Het
Or6c3 A G 10: 129,308,773 (GRCm39) T71A probably damaging Het
Parg T C 14: 31,993,634 (GRCm39) W289R probably damaging Het
Pdcd4 A G 19: 53,915,362 (GRCm39) probably null Het
Plk2 G T 13: 110,532,570 (GRCm39) E95* probably null Het
Pold1 G A 7: 44,188,202 (GRCm39) R559C probably damaging Het
Ptprc T C 1: 138,011,377 (GRCm39) D560G possibly damaging Het
Rasal3 T C 17: 32,616,478 (GRCm39) Y290C probably damaging Het
Rcsd1 T A 1: 165,485,184 (GRCm39) S90C probably damaging Het
Rttn T C 18: 89,128,853 (GRCm39) L1935P probably damaging Het
Smc1b C T 15: 84,976,232 (GRCm39) R825Q probably benign Het
Srsf11 C T 3: 157,728,981 (GRCm39) probably benign Homo
Tmc3 T C 7: 83,247,695 (GRCm39) Y230H probably damaging Het
Tnfrsf25 A T 4: 152,204,084 (GRCm39) probably null Het
Ubl7 T C 9: 57,827,793 (GRCm39) L160P probably damaging Het
Vmn2r106 C T 17: 20,488,725 (GRCm39) C558Y probably damaging Het
Zfp646 T A 7: 127,479,113 (GRCm39) V430E probably benign Het
Other mutations in Gm35315
AlleleSourceChrCoordTypePredicted EffectPPH Score
R6103:Gm35315 UTSW 5 110,226,137 (GRCm39) missense probably damaging 0.97
R6219:Gm35315 UTSW 5 110,226,410 (GRCm39) missense probably benign 0.23
R6429:Gm35315 UTSW 5 110,226,525 (GRCm39) missense possibly damaging 0.67
R6482:Gm35315 UTSW 5 110,225,955 (GRCm39) missense possibly damaging 0.92
R6632:Gm35315 UTSW 5 110,227,129 (GRCm39) nonsense probably null
R7313:Gm35315 UTSW 5 110,227,091 (GRCm39) missense probably benign
R8699:Gm35315 UTSW 5 110,228,392 (GRCm39) missense probably benign 0.13
Predicted Primers PCR Primer
(F):5'- ATGCAAAGGCCTTACCACATTGAT -3'
(R):5'- AAGCCTTTGCATTTCCTGGTCA -3'

Sequencing Primer
(F):5'- CCACATTGATCACATTCATAGGG -3'
(R):5'- CCTGGTCATCTTCAAAGACATG -3'
Posted On 2018-05-24